Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes

Phytotherapy Research

Volumn 27, Issue 5, 2013, Pages 745-752

  Rodeiro, Idania ^a   Jose Gomez Lechon M ^b   Perez, Gabriela ^b   Hernandez, Ivones ^a   Herrera, José Alfredo ^c   Delgado, Rene ^d   Castell, José V ^b,e   Teresa Donato, M ^b,e  

^a Centro de Bioproductos Marinos (CEBIMAR)   (Cuba)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF HAVANA   (Cuba)

^d CENTRO DE INVESTIGACIÓN Y DESARROLLO DE MEDICAMENTOS CIDEM   (Cuba)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

cytochrome P450; Mangifera indica L; mangiferin; polyphenols; UDP glucuronosyltransferases

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; MANGIFERA INDICA EXTRACT; MANGIFERIN; MESSENGER RNA;

ARTICLE; BARK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG INTERACTION; DRUG SAFETY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL; PROTEIN EXPRESSION;

CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; MANGIFERA; PLANT BARK; PLANT EXTRACTS;

MANGIFERA INDICA; RATTUS;

EID: 84876462909     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4782     Document Type: Article

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