Dibenzoylmethane modulates aryl hydrocarbon receptor function and expression of cytochromes P450 1A1, 1A2, and 1B1

Cancer Research

Volumn 61, Issue 10, 2001, Pages 3919-3924

  MacDonald, C J ^a   Ciolino, H P ^a   Yeh, G C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 7,12 DIMETHYLBENZ[A]ANTHRACENE; AROMATIC HYDROCARBON RECEPTOR; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; DACTINOMYCIN; DIBENZOYLMETHANE DERIVATIVE; MESSENGER RNA; NATURAL PRODUCT; POLYCYCLIC AROMATIC HYDROCARBON;

ADOLESCENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA RESPONSIVE ELEMENT; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER; MODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

ANIMALS; BENZOATES; BINDING, COMPETITIVE; BIOTRANSFORMATION; CARCINOGENS; CHALCONES; CYTOCHROME P-450 ENZYME SYSTEM; DACTINOMYCIN; FEMALE; HUMANS; ISOENZYMES; LIVER; NUCLEIC ACID SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035872470     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Cytochromes P450 5: Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription
2. Drug interactions and the cytochrome P450 system: The role of cytochrome P4501A2
3. Characterization of roles of human cytochrome P450 enzymes in carcinogen metabolism
4. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1
5. cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1
6. Inhibition by diacylmethane derivatives of mutagenicity in Salmonella typhimurium and tRNA-binding of chemical carcinogens
7. Effect of the β-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene
8. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader
9. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially
10. Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin sensitive genes in human breast cancer MCF-7 and MDA-MB-231 cells
11. 3-Methylcholanthhrene-mediated induction of cytochrome P4501A2 in human hepatoma HepG2 cells as quantified by the reverse transcription-polymerase chain reaction
12. Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
13. The DNA recognition site for the dioxin-Ah receptor complex: Nucleotide sequence and functional analysis
14. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
15. Binding characteristics of 4S PAH-binding protein and Ah receptor from rats and mice
16. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice
17. Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane
18. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2
19. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP)
20. Tumor-specific expression of cytochrome P450 CYP1B1
21. Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor
22. Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: Role of the Ah receptor
23. 17 β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1
24. 4-Hydroxylation of estrogens as a marker of human mammary tumors
25. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction
26. Autoregulation of human CYP1A1 gene promoter activity in HepG2 and MCF-7 cells
27. Cloning and expression of a human Ah receptor cDNA
28. Characterization of Ah receptor promoter in human liver cell line, HepG2
29. Constitutive activation of the aromatic hydrocarbon receptor
30. Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells
31. Signal transduction-mediated CYP1A1 induction by omeprazole in human HepG2 cells