Lack of in vivo embryotoxic and genotoxic activities of orally administered stem bark aqueous extract of Mangifera indica L. (Vimang®)

Food and Chemical Toxicology

Volumn 45, Issue 12, 2007, Pages 2526-2532

  Gonzalez J E ^a   Rodriguez M D ^b   Rodeiro, I ^c   Morffi, J ^c   Guerra, E ^c   Leal, F ^b   Garcia H ^b   Goicochea, E ^b   Guerrero, S ^b   Garrido, G ^c   Delgado, R ^c   Nunez Selles A J ^c  

^a Centre for Radiation Protection and Hygiene   (Cuba)

^b NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

^c Center of Pharmaceutical Chemistry Cuba   (Cuba)

Author keywords

Genotoxicity; Mangifera indica L.; Stem bark; Teratogenesis; Vimang

Indexed keywords

CYCLOPHOSPHAMIDE; MANGIFERA INDICA EXTRACT; UNCLASSIFIED DRUG; VIMANG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BARK; BONE DEVELOPMENT; BONE MARROW CELL; CONTROLLED STUDY; CYTOGENETICS; EMBRYOTOXICITY; ERYTHROCYTE; FEEDING; FEMALE; FETAL WELL BEING; FETUS; FETUS DEVELOPMENT; GENOTOXICITY; IMPLANTATION; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREGNANCY; RAT; SPRAGUE DAWLEY RAT; TERATOGENESIS; VISCERA; WEIGHT GAIN;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MANGIFERA; MICE; MICE, INBRED STRAINS; PLANT BARK; PLANT EXTRACTS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TERATOGENS;

MANGIFERA INDICA; MUS; RATTUS; RODENTIA;

EID: 35348992208     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.05.029     Document Type: Article

References (34)

1. Beltran A.E., Alvarez Y., Xavier F.E., Hernanz R., Rodriguez J., Núñez A.J., Alonso M.J., and Salaices M. Vascular effects of the Mangifera indica L. extract (Vimang). Eur. J. Pharmacol. 499 (2004) 297-305
2. Chernoff N., Rogers J.M., Turner C.I., and Francis B.M. Significance of supernumerary ribs in rodent developmental toxicity studies. Fundam. Appl. Toxicol. 17 (1991) 448-453
3. Collins A.R., Duthie S.J., and Dobson V.L. Direct enzymatic detection of endogenous base damage in human lymphocyte DNA. Carcinogenesis 14 (1993) 1733-1735
4. Dawson A.B. A note on the staining of the skeleton of cleared specimens with alizarin red S. Stain. Technol. (1926) 123
5. Delaney B., Phillips K., Vasquez C., Wilson A., Cox D., Wang H.B., and Manthey J. Genetic toxicity of standardized mixture of citrus polymethoxylated flavones. Food Chem. Toxicol. 40 (2002) 617-624
6. Erexson G.L. Lack of in vivo clastogenic activity of grape seed and grape skin extracts in a mouse micronucleus assay. Food Chem. Toxicol. 41 (2003) 347-350
7. Garcia D., Delgado R., Ubeira F., and Leiro J. Modulation of rat macrophage function by the Mangifera indica L. extract (Vimang) and mangiferin. Int. Immunopharmacol. 2 (2002) 797-806
8. Garcia D., Leiro J., Delgado R., Sanmartin M.L., and Ubeira F.M. Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. Phytother. Res. 17 (2003) 1182-1187
9. Garcia D., Escalante M., Delgado R., Ubeira F.M., and Leiro J. Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin. Phytother. Res. 17 (2003) 1203-1208
10. García O., Mandina T., Lamadrid A.I., Díaz A., Remigio A., González Y., Piloto J., González J.E., and Alvarez A. Sensitivity and variability of visual scoring in the comet assay. Results of an inter-laboratory scoring exercise with the use of silver staining. Mutat. Res. 556 (2004) 25-34
11. Garrido G., González D., Delporte C., Backhouse N., Quintero G., Núñez-Sellés A.J., and Morales M.A. Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang). Phytother. Res. 15 (2001) 18-21
12. Garrido G., Delgado R., Lemus Y., Rodríguez J., García D., and Núñez-Sellés A.J. Protection against septic shock and suppression of tumor and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (Vimang). Role of mangiferin isolated from extract. Pharmacol. Res. 50 (2004) 165-172
13. Garrido G., González D., Lemus Y., García D., Lodeiro L., Quintero G., Delporte C., Núñez-Sellés A., and Delgado R. In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (Vimang). Pharmacol. Res. 50 (2004) 143-149
14. ®) inhibits T-cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB. Phytother. Res. 19 (2005) 211-215
15. Garrido G., González D., Lemus Y., Delporte C., Núñez-Sellés A.J., and Delgado R. Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition on eicosanoids production in J774 murine macrophages. Phytomedicine 13 (2006) 412-418
16. Hernandez P., Delgado R., and Walczak H. Mangifera indica L. extract protects T cells from activation-induced cell death. Int. Immunopharmacol. 6 (2006) 1496-1505
17. Hernandez P., Rodriguez P.C., Delgado R., and Walczak H. Protective effect of Mangifera indica L. polyphenols on human T lymphocytes against activation-induced cell death. Pharmacol. Res. 55 (2007) 167-173
18. Khera K.S. Common fetal aberrations and their teratologic significance: A review. Fundam. Appl. Toxicol. 1 (1981) 13-18
19. Leiro J., García D., Arranz J.A., Delgado R., Sanmartìn M.L., and Orallo F. An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages. Int. Immunopharmacol. 4 (2004) 991-1003
20. Manson J., and Kang Y. Test methods for assessing female reproductive and developmental toxicology. In: Wallace Hayes A. (Ed). Principles and Methods of Toxicology. second ed. (1989), Raven Press Ltd., New York 311-359 Chapter X, Developmental Toxicology
21. Martinez G., Candelario-Jalil E., Giuliani A., León O.S., Sam S., Delgado R., and Núnez-Sellés A.J. Mangifera indica L. extract (Vimang) reduces ischemia-induced neuronal loss and oxidative damage in the gerbil brain. Free Rad. Res. 35 (2001) 465-473
22. Martinez G., Re L., Giuliani A., León O.S., Pérez-Davison G.D., and Núnez-Sellés A.J. Effect of Mangifera indica L. extract, on protein and hepatic microsomes peroxidation. Pharmacol. Res. 15 (2001) 581-585
23. Marzin D. New approaches to estimating the mutagenic potential of chemicals. Cell Biol. Toxicol. 15 (1999) 359-365
24. Nuñez-Sellés A., Vélez-Castro H., Aguero-Aguero J., Gonzalez J., Naddeo F., De Simone F., and Rastrelli L. Isolation and quantitative analysis of phenolic antioxidants, free sugars and polyphenols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement. J. Agric. Food Chem. 50 (2002) 762-766
25. Nuñez-Sellés A.J., Durruthy M.D., Rodriguez E., Nieto L., Nicolais V., and Rastrelli L. Comparison of major and trace element concentration in sixteen varieties of Cuban mango stem bark (Mangifera indica L.). J. Agric. Food Chem. 55 (2007) 2176-2181
26. OECD, 1997. Mammalian Erythrocyte Micronucleus Test. Guideline 474.
27. Peters P.W.J. Reproductive toxicology. In: Hollinger M.A., Niesink R.J.M., and De Vries J. (Eds). Toxicology Principles and Applications (1996), CRC press 929-972
28. Rivera D.G., Balmaseda I.H., Leon A.A., Hernandez B.C., Montiel L.M., Garrido G.G., Cuzzocrea S., and Hernandez R.D. Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin. J. Pharm. Pharmacol. 58 (2006) 385-392
29. Rodeiro I., Cancino L., González J.E., Morffi J., Garrido G., González R.M., Núñez-Sellés A.J., and Delgado R. Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food Chem. Toxicol. 44 (2006) 1707-1713
30. Sa-Nunes A., Rogério A.P., Medeiros A.I., Fabris V.E., Andreu G.P., Rivera D.G., Delgado R., and Faccioli L.H. Modulation of eosinophil generation and migration by Mangifera indica L. extract (Vimang). Int. Immunopharmacol. 6 (2006) 1515-1523
31. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
32. Stuckhart J.L., and Poppe S.M. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratog. Carcinog. Mutag. 4 (1984) 181-186
33. Wickramaratne G.A. The post-natal fate of supernumerary ribs in rat teratogenicity studies. J. Appl. Toxicol. 8 (1988) 91-94
34. Wier P.J., and Ventre J.R. Statistical analyses of reproductive and developmental toxicology studies. Drug Inform. 24 (1990) 395-405