Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis

Nature Chemical Biology

Volumn 6, Issue 6, 2010, Pages 424-432

  Ong, Derrick Sek Tong ^a   Mu, Ting Wei ^a   Palmer, Amy E ^b   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALNEXIN; CHAPERONE; DANTROLENE; DILTIAZEM; GLUCOSYLCERAMIDASE; LYSOSOME ENZYME; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2B; UNCLASSIFIED DRUG; VERAPAMIL; ATP2A2 PROTEIN, HUMAN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; VASODILATOR AGENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GAUCHER DISEASE; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEOMICS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; AMINO ACID SUBSTITUTION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; LYSOSOME; METABOLISM; PHYSIOLOGY;

AMINO ACID SUBSTITUTION; CALCIUM; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; ENDOPLASMIC RETICULUM; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; LYSOSOMES; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VASODILATOR AGENTS; VERAPAMIL;

EID: 77952501011     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.368     Document Type: Article

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