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Volumn 3, Issue NOV, 2012, Pages

Role of cannabinoids in the regulation of bone remodeling

Author keywords

Adipocytes; Bone; Cannabinoid; CB1,CB2; GPR55; Osteoblasts; Osteoclasts

Indexed keywords


EID: 84876329281     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2012.00136     Document Type: Review
Times cited : (71)

References (88)
  • 1
    • 61349135466 scopus 로고    scopus 로고
    • Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells
    • Abed, E., Labelle, D., Martineau, C., Loghin, A., and Moreau, R. (2009). Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells. Mol. Membr. Biol. 26, 146-158.
    • (2009) Mol. Membr. Biol. , vol.26 , pp. 146-158
    • Abed, E.1    Labelle, D.2    Martineau, C.3    Loghin, A.4    Moreau, R.5
  • 2
    • 42349086864 scopus 로고    scopus 로고
    • Endo-cannabinoids and the regulation of bone metabolism
    • Bab, I., Ofek, O., Tam, J., Rehnelt, J., and Zimmer, A. (2008). Endo-cannabinoids and the regulation of bone metabolism. J. Neuroendocrinol. 20(Suppl. 1), 69-74.
    • (2008) J. Neuroendocrinol. , vol.20 , Issue.SUPPL. 1 , pp. 69-74
    • Bab, I.1    Ofek, O.2    Tam, J.3    Rehnelt, J.4    Zimmer, A.5
  • 3
    • 33847702499 scopus 로고    scopus 로고
    • Critical enzymes involved in endocannabinoid metabolism
    • Basavarajappa, B. S., (2007). Critical enzymes involved in endocannabinoid metabolism. Protein Pept.Lett. 14,237-246.
    • (2007) Protein Pept.Lett. , vol.14 , pp. 237-246
    • Basavarajappa, B.S.1
  • 5
    • 0033575258 scopus 로고    scopus 로고
    • Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses
    • Bouaboula, M., Dussossoy, D., and Casellas, P. (1999). Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. J.Biol.Chem. 274, 20397-20405.
    • (1999) J.Biol.Chem. , vol.274 , pp. 20397-20405
    • Bouaboula, M.1    Dussossoy, D.2    Casellas, P.3
  • 6
    • 0030826705 scopus 로고    scopus 로고
    • A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
    • Bouaboula, M., Perrachon, S., Milligan, L., Canat, X., Rinaldi-Carmona, M., Portier, M., et al. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J. Biol. Chem. 272, 22330-22339.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22330-22339
    • Bouaboula, M.1    Perrachon, S.2    Milligan, L.3    Canat, X.4    Rinaldi-Carmona, M.5    Portier, M.6
  • 7
    • 0029989044 scopus 로고    scopus 로고
    • Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression
    • Bouaboula, M., Poinot-Chazel, C., Marchand, J., Canat, X., Bour-rie, B., Rinaldi-Carmona, M., et al. (1996). Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur. J. Biochem. 237, 704-711.
    • (1996) Eur. J. Biochem. , vol.237 , pp. 704-711
    • Bouaboula, M.1    Poinot-Chazel, C.2    Marchand, J.3    Canat, X.4    Bour-rie, B.5    Rinaldi-Carmona, M.6
  • 9
    • 0032533247 scopus 로고    scopus 로고
    • Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation
    • Carayon, P., Marchand, J., Dussossoy, D., Derocq, J. M., Jbilo, O., Bord, A., et al. (1998). Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood 92,3605-3615.
    • (1998) Blood , vol.92 , pp. 3605-3615
    • Carayon, P.1    Marchand, J.2    Dussossoy, D.3    Derocq, J.M.4    Jbilo, O.5    Bord, A.6
  • 10
    • 84867267832 scopus 로고    scopus 로고
    • Evidence for bidirectional endocannabinoid transport across cell membranes
    • Chicca, A., Marazzi, J., Nicolussi, S., and Gertsch, J. (2012). Evidence for bidirectional endocannabinoid transport across cell membranes. J.Biol.Chem. 287,34660-34682.
    • (2012) J.Biol.Chem. , vol.287 , pp. 34660-34682
    • Chicca, A.1    Marazzi, J.2    Nicolussi, S.3    Gertsch, J.4
  • 11
    • 0030890230 scopus 로고    scopus 로고
    • Induction of interleukin-2 receptor alpha gene by delta9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CB1 cannabinoid receptor
    • Daaka, Y., Zhu, W., Friedman, H., and Klein, T. W. (1997). Induction of interleukin-2 receptor alpha gene by delta9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CB1 cannabinoid receptor. DNA Cell Biol. 16,301-309.
    • (1997) DNA Cell Biol , vol.16 , pp. 301-309
    • Daaka, Y.1    Zhu, W.2    Friedman, H.3    Klein, T.W.4
  • 12
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • Demuth, D. G., and Molleman, A. (2006). Cannabinoid signalling. Life Sci. 78, 549-563.
    • (2006) Life Sci , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 13
    • 0029842102 scopus 로고    scopus 로고
    • Regulation of a neuronal form of focal adhesion kinase by anandamide
    • Derkinderen, P., Toutant, M., Bur-gaya, F., Le, B. M., Siciliano, J. C., De, F., et al. (1996). Regulation of a neuronal form of focal adhesion kinase by anandamide. Science 273, 1719-1722.
    • (1996) Science , vol.273 , pp. 1719-1722
    • Derkinderen, P.1    Toutant, M.2    Bur-Gaya, F.3    Le, B.M.4    Siciliano, J.C.5    De, F.6
  • 14
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endo-cannabinoid system: to enhance or reduce? Nat
    • DiMarzo,V. (2008). Targeting the endo-cannabinoid system: to enhance or reduce? Nat. Rev. Drug Discov. 7, 438-455.
    • (2008) Rev. Drug Discov. , vol.7 , pp. 438-455
    • DiMarzo, V.1
  • 16
    • 0029756752 scopus 로고    scopus 로고
    • Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neu-roblastoma cells
    • Di Marzo, V., De Petrocellis, L., Sepe, N., and Buono, A. (1996). Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neu-roblastoma cells. Biochem. J. 316, 977-984.
    • (1996) Biochem. J. , vol.316 , pp. 977-984
    • Di Marzo, V.1    De Petrocellis, L.2    Sepe, N.3    Buono, A.4
  • 17
    • 0037207088 scopus 로고    scopus 로고
    • A role for monoglyceride lipase in 2-arachidonoylglycerol inac-tivation
    • Dinh, T. P., Freund, T. F., and Piomelli, D. (2002). A role for monoglyceride lipase in 2-arachidonoylglycerol inac-tivation. Chem. Phys. Lipids 121, 149-158.
    • (2002) Chem. Phys. Lipids , vol.121 , pp. 149-158
    • Dinh, T.P.1    Freund, T.F.2    Piomelli, D.3
  • 18
    • 0027185227 scopus 로고
    • Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
    • Felder, C. C., Briley, E. M., Axelrod, J., Simpson, J. T., Mackie, K., and Devane, W. A. (1993). Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc. Natl. Acad. Sci. U.S.A. 90, 7656-7660.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7656-7660
    • Felder, C.C.1    Briley, E.M.2    Axelrod, J.3    Simpson, J.T.4    Mackie, K.5    Devane, W.A.6
  • 19
    • 0030590440 scopus 로고    scopus 로고
    • Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
    • Felder, C. C., Nielsen, A., Briley, E. M., Palkovits, M., Priller, J., Axelrod, J., et al. (1996). Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS Lett. 393, 231-235.
    • (1996) FEBS Lett , vol.393 , pp. 231-235
    • Felder, C.C.1    Nielsen, A.2    Briley, E.M.3    Palkovits, M.4    Priller, J.5    Axelrod, J.6
  • 20
    • 84859444756 scopus 로고    scopus 로고
    • Anandamide uptake explained? Trends Pharma-col
    • Fowler, C. J. (2012). Anandamide uptake explained? Trends Pharma-col.Sci. 33, 181-185.
    • (2012) Sci , vol.33 , pp. 181-185
    • Fowler, C.J.1
  • 21
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiegue, S., Mary, S., Marchand, J., Dussossoy, D., Carriere, D., Carayon, P., et al. (1995). Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur.J.Biochem. 232,54-61.
    • (1995) Eur.J.Biochem. , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3    Dussossoy, D.4    Carriere, D.5    Carayon, P.6
  • 22
    • 0030568611 scopus 로고    scopus 로고
    • 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
    • Gatley, S. J., Gifford, A. N., Volkow, N. D., Lan, R., and Makriyannis, A. (1996). 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur. J. Pharmacol. 307, 331-338.
    • (1996) Eur. J. Pharmacol. , vol.307 , pp. 331-338
    • Gatley, S.J.1    Gifford, A.N.2    Volkow, N.D.3    Lan, R.4    Makriyannis, A.5
  • 23
    • 4143108422 scopus 로고    scopus 로고
    • Binding of the non-classical cannabinoid CP 55 940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
    • Gatley, S. J., Lan, R., Pyatt, B., Gifford, A. N., Volkow, N. D., and Makriyannis, A. (1997). Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci. 61,PL191-PL197.
    • (1997) Life Sci , vol.61
    • Gatley, S.J.1    Lan, R.2    Pyatt, B.3    Gifford, A.N.4    Volkow, N.D.5    Makriyannis, A.6
  • 24
    • 74449088472 scopus 로고    scopus 로고
    • Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist
    • Geng, D., Xu, Y., Yang, H., Wang, J., Zhu, X., Zhu, G., et al. (2010). Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist. Bio-materials 31,1996-2000.
    • (2010) Bio-materials , vol.31 , pp. 1996-2000
    • Geng, D.1    Xu, Y.2    Yang, H.3    Wang, J.4    Zhu, X.5    Zhu, G.6
  • 25
    • 38449111261 scopus 로고    scopus 로고
    • Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteo-clastogenesis in mononuclear precursor cells, and induces apoptosis in mature osteoclast-like cells
    • George, K. L., Saltman, L. H., Stein, G. S., Lian, J. B., and Zurier, R. B. (2008). Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteo-clastogenesis in mononuclear precursor cells, and induces apoptosis in mature osteoclast-like cells. J. Cell Physiol. 214, 714-720.
    • (2008) J. Cell Physiol. , vol.214 , pp. 714-720
    • George, K.L.1    Saltman, L.H.2    Stein, G.S.3    Lian, J.B.4    Zurier, R.B.5
  • 27
    • 27944440482 scopus 로고    scopus 로고
    • Cannabis and endocannabinoid modulators: therapeutic promises and challenges
    • Grant, I., and Cahn, B. R. (2005). Cannabis and endocannabinoid modulators: therapeutic promises and challenges. Clin. Neurosci. Res. 5, 185-199.
    • (2005) Clin. Neurosci. Res. , vol.5 , pp. 185-199
    • Grant, I.1    Cahn, B.R.2
  • 28
    • 0035147072 scopus 로고    scopus 로고
    • Ceramide: a new second messenger of cannabinoid action
    • Guzman, M., Galve-Roperh, I., and Sanchez, C. (2001a). Ceramide: a new second messenger of cannabinoid action. Trends Pharmacol. Sci. 22, 19-22
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 19-22
    • Guzman, M.1    Galve-Roperh, I.2    Sanchez, C.3
  • 29
    • 0034467577 scopus 로고    scopus 로고
    • Control of the cell survival/death decision by cannabinoids
    • Guzman, M., Sanchez, C., and Galve-Roperh, I. (200 1b).Control of the cell survival/death decision by cannabinoids. J. Mol. Med. 78, 613-625
    • (2001) J. Mol. Med , vol.78 , pp. 613-625
    • Guzman, M.1    Sanchez, C.2    Galve-Roperh, I.3
  • 30
    • 33745641739 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook
    • Hermann, A., Kaczocha, M., and Deutsch, D. G. (2006). 2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook. AAPSJ. 8,E409-E412.
    • (2006) AAPSJ , vol.8
    • Hermann, A.1    Kaczocha, M.2    Deutsch, D.G.3
  • 31
    • 0037014598 scopus 로고    scopus 로고
    • Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)
    • Ho, B. Y., Current, L., and Drewett, J. G. (2002). Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). FEBS Lett. 522, 130-134.
    • (2002) FEBS Lett , vol.522 , pp. 130-134
    • Ho, B.Y.1    Current, L.2    Drewett, J.G.3
  • 32
  • 34
    • 67849129193 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
    • Idris, A. I., Sophocleous, A., Landao-Bassonga, E., Canals, M., Milligan, G., Baker, D., et al. (2009). Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells. Cell Metab. 10, 139-147.
    • (2009) Cell Metab , vol.10 , pp. 139-147
    • Idris, A.I.1    Sophocleous, A.2    Landao-Bassonga, E.3    Canals, M.4    Milligan, G.5    Baker, D.6
  • 35
    • 54349124546 scopus 로고    scopus 로고
    • Regulation of bone mass, osteoclast function and ovariectomy-induced bone loss by the type 2 cannabinoid receptor
    • Idris, A. I., Sophocleous, A., Landao-Bassonga, E., Vant Hof, R. J., and Ralston, S. H. (2008). Regulation of bone mass, osteoclast function and ovariectomy-induced bone loss by the type 2 cannabinoid receptor. Endocrinology 149, 5619-5626.
    • (2008) Endocrinology , vol.149 , pp. 5619-5626
    • Idris, A.I.1    Sophocleous, A.2    Landao-Bassonga, E.3    Vant Hof, R.J.4    Ralston, S.H.5
  • 36
    • 22544439953 scopus 로고    scopus 로고
    • Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
    • Idris, A. I., Van t Hof, R. J., Greig, I. R., Ridge, S. A., Baker, D., Ross, R. A., et al. (2005). Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat. Med. 11,774-779.
    • (2005) Nat. Med. , vol.11 , pp. 774-779
    • Idris, A.I.1    Van Hof, R.J.2    Greig, I.R.3    Ridge, S.A.4    Baker, D.5    Ross, R.A.6
  • 37
    • 70350376735 scopus 로고    scopus 로고
    • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands
    • Kapur, A., Zhao, P., Sharir, H., Bai, Y., Caron, M. G., Barak, L. S., et al. (2009). Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. J. Biol. Chem. 284,29817-29827.
    • (2009) J. Biol. Chem. , vol.284 , pp. 29817-29827
    • Kapur, A.1    Zhao, P.2    Sharir, H.3    Bai, Y.4    Caron, M.G.5    Barak, L.S.6
  • 38
    • 12844263079 scopus 로고    scopus 로고
    • Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus
    • Karanian, D. A., Brown, Q. B., Makriyannis, A., and Bahr, B. A. (2005). Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus. Eur. J. Pharmacol. 508, 47-56.
    • (2005) Eur. J. Pharmacol. , vol.508 , pp. 47-56
    • Karanian, D.A.1    Brown, Q.B.2    Makriyannis, A.3    Bahr, B.A.4
  • 41
    • 84860317417 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 mediates glucocorticoid-induced bone loss in rats by perturbing bone mineral acquisition and marrow adi-pogenesis
    • Ko, J. Y., Wu, R. W., Kuo, S. J., Chen, M. W., Yeh, D. W., Ke, H. C., et al. (2012). Cannabinoid receptor 1 mediates glucocorticoid-induced bone loss in rats by perturbing bone mineral acquisition and marrow adi-pogenesis. Arthritis Rheum. 64,1204-1214.
    • (2012) Arthritis Rheum , vol.64 , pp. 1204-1214
    • Ko, J.Y.1    Wu, R.W.2    Kuo, S.J.3    Chen, M.W.4    Yeh, D.W.5    Ke, H.C.6
  • 42
    • 0032511165 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacyl-glycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms
    • Kondo, S., Kondo, H., Nakane, S., Kodaka, T., Tokumura, A., Waku, K., et al. (1998). 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacyl-glycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. FEBS Lett. 429, 152-156.
    • (1998) FEBS Lett , vol.429 , pp. 152-156
    • Kondo, S.1    Kondo, H.2    Nakane, S.3    Kodaka, T.4    Tokumura, A.5    Waku, K.6
  • 43
    • 0033602129 scopus 로고    scopus 로고
    • Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists
    • Lan, R., Liu, Q., Fan, P., Lin, S., Fernando, S. R., McCallion, D., et al. (1999). Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J. Med. Chem. 42, 769-776.
    • (1999) J. Med. Chem. , vol.42 , pp. 769-776
    • Lan, R.1    Liu, Q.2    Fan, P.3    Lin, S.4    Fernando, S.R.5    McCallion, D.6
  • 45
    • 40649102938 scopus 로고    scopus 로고
    • GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    • Lauckner, J. E., Jensen, J. B., Chen, H. Y., Lu, H. C., Hille, B., and Mackie, K. (2008). GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc. Natl. Acad. Sci. U.S.A. 105, 2699-2704.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 2699-2704
    • Lauckner, J.E.1    Jensen, J.B.2    Chen, H.Y.3    Lu, H.C.4    Hille, B.5    Mackie, K.6
  • 47
    • 0036044615 scopus 로고    scopus 로고
    • Endocannabinoids and their actions
    • Maccarrone, M., and Finazzi-Agro, A. (2002). Endocannabinoids and their actions. Vitam. Horm. 65, 225-255.
    • (2002) Vitam. Horm. , vol.65 , pp. 225-255
    • Maccarrone, M.1    Finazzi-Agro, A.2
  • 48
    • 0035899382 scopus 로고    scopus 로고
    • Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors
    • Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A., and Kano, M. (2001a). Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron 31, 463-475.
    • (2001) Neuron , vol.31 , pp. 463-475
    • Maejima, T.1    Hashimoto, K.2    Yoshida, T.3    Aiba, A.4    Kano, M.5
  • 49
    • 0034930170 scopus 로고    scopus 로고
    • Endogenous cannabinoid as a retrograde messenger from depolarized postsynap-tic neurons to presynaptic terminals
    • Maejima, T., Ohno-Shosaku, T., and Kano, M. (2001b). Endogenous cannabinoid as a retrograde messenger from depolarized postsynap-tic neurons to presynaptic terminals. Neurosci.Res. 40, 205-210.
    • (2001) Neurosci.Res. , vol.40 , pp. 205-210
    • Maejima, T.1    Ohno-Shosaku, T.2    Kano, M.3
  • 50
    • 80054839677 scopus 로고    scopus 로고
    • Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis
    • Marazzi, J., Kleyer, J., Paredes, J. M., and Gertsch, J. (2011). Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. J. Immunol. Methods 373,219-228.
    • (2011) J. Immunol. Methods , vol.373 , pp. 219-228
    • Marazzi, J.1    Kleyer, J.2    Paredes, J.M.3    Gertsch, J.4
  • 51
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., and Bonner, T. I. (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 52
    • 28444487445 scopus 로고    scopus 로고
    • Plant cannabinoids: a neglected pharmacological treasure trove
    • Mechoulam, R. (2005). Plant cannabinoids: a neglected pharmacological treasure trove. Br. J. Pharmacol. 146, 913-915.
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 913-915
    • Mechoulam, R.1
  • 53
    • 0034333417 scopus 로고    scopus 로고
    • Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophen-yl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor
    • Meschler, J. P., Kraichely, D. M., Wilken, G. H., and Howlett, A. C. (2000). Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophen-yl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor. Biochem. Pharmacol. 60, 1315-1323.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1315-1323
    • Meschler, J.P.1    Kraichely, D.M.2    Wilken, G.H.3    Howlett, A.C.4
  • 54
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado, E., Vela, J.x M., revalo-Martin, A., Almazan, G., Molina-Holgado, F., Borrell, J., et al. (2002). Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. J. Neurosci. 22, 9742-9753.
    • (2002) J. Neurosci. , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.X.M.2    Revalo-Martin, A.3    Almazan, G.4    Molina-Holgado, F.5    Borrell, J.6
  • 55
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro, S., Thomas, K. L., and bu-Shaar, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Bu-Shaar, M.3
  • 56
    • 0035669303 scopus 로고    scopus 로고
    • CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types
    • Nong, L., Newton, C., Friedman, H., and Klein, T. W. (2001). CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. Adv. Exp. Med. Biol. 206, 229-233.
    • (2001) Adv. Exp. Med. Biol. , vol.206 , pp. 229-233
    • Nong, L.1    Newton, C.2    Friedman, H.3    Klein, T.W.4
  • 59
    • 45149123400 scopus 로고    scopus 로고
    • The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal mo del of multiple sclerosis
    • Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado,T. Mechoulam, R., et al. (2008). The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal mo del of multiple sclerosis. J. Biol. Chem. 283,13320-13329
    • (2008) J. Biol. Chem. , vol.283 , pp. 13320-13329
    • Palazuelos, J.1    Davoust, N.2    Julien, B.3    Hatterer, E.4    Aguado, T.5    Mechoulam, R.6
  • 60
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee, R. G. (1997). Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 74,129-180
    • (1997) Pharmacol. Ther. , vol.74 , pp. 129-180
    • Pertwee, R.G.1
  • 61
    • 84884474728 scopus 로고    scopus 로고
    • Pharmacological actions of cannabinoids
    • Pertwee, R. G. (2005). Pharmacological actions of cannabinoids. Handb. Exp. Pharmacol. 1-51
    • (2005) Handb. Exp. Pharmacol. , pp. 1-51
    • Pertwee, R.G.1
  • 62
    • 65449146377 scopus 로고    scopus 로고
    • Emerging strategies for exploiting cannabinoid receptor agonists as medicines
    • Pertwee, R. G. (2009). Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br. J. Pharmacol. 156,397-411
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 397-411
    • Pertwee, R.G.1
  • 63
    • 77950653576 scopus 로고    scopus 로고
    • Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
    • Pertwee, R. G. (2010). Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr. Med. Chem. 17, 1360-1381
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1360-1381
    • Pertwee, R.G.1
  • 65
    • 43249115359 scopus 로고    scopus 로고
    • Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
    • Richardson, D., Pearson, R. G., Kurian, N., Latif, M. L., Garle, M. J., Barrett, D. A., et al. (2008). Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res. Ther. 10, R43.
    • (2008) Arthritis Res. Ther. , vol.10
    • Richardson, D.1    Pearson, R.G.2    Kurian, N.3    Latif, M.L.4    Garle, M.J.5    Barrett, D.A.6
  • 66
    • 54349108515 scopus 로고    scopus 로고
    • Endocannabinoids are produced by bone cells and stimulate bone resorp-tion in vitro
    • Ridge, S. A., Ford, L., Cameron, G. A., Ross, R. A., and Rogers, M. J. (2007). Endocannabinoids are produced by bone cells and stimulate bone resorp-tion in vitro. Bone 40(Suppl. 1), S120.
    • (2007) Bone , vol.40 , Issue.SUPPL. 1
    • Ridge, S.A.1    Ford, L.2    Cameron, G.A.3    Ross, R.A.4    Rogers, M.J.5
  • 67
    • 0344873175 scopus 로고    scopus 로고
    • Anandamide and vanilloid TRPV1 receptors
    • Ross, R. A. (2003). Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol. 140,790-801.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 790-801
    • Ross, R.A.1
  • 68
    • 61349143694 scopus 로고    scopus 로고
    • The enigmatic pharmacology of GPR55
    • Ross, R. A. (2009). The enigmatic pharmacology of GPR55. Trends Pharmacol. Sci. 30, 156-163.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 156-163
    • Ross, R.A.1
  • 69
    • 0032982010 scopus 로고    scopus 로고
    • Agonist-inverse agonist characteriza tion at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630
    • Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, E, Makriyannis, A., et al. (1999). Agonist-inverse agonist characteriza tion at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br. J. Pharmacol. 126, 665- 672.
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 665-672
    • Ross, R.A.1    Brockie, H.C.2    Stevenson, L.A.3    Murphy, V.L.4    Templeton, E.5    Makriyannis, A.6
  • 70
    • 59649083643 scopus 로고    scopus 로고
    • The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption
    • Rossi, F., Siniscalco, D., Luongo, L., De Petrocellis, L., Bellini, G., Petrosino, S., et al. (2009). The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. Bone 44, 476-484.
    • (2009) Bone , vol.44 , pp. 476-484
    • Rossi, F.1    Siniscalco, D.2    Luongo, L.3    De Petrocellis, L.4    Bellini, G.5    Petrosino, S.6
  • 72
    • 17144470224 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction
    • Sanchez, M. G., Ruiz-Llorente, L., Sanchez, A. M., and Diaz-Laviada, I. (2003). Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 15,851-859.
    • (2003) Cell Signal. , vol.15 , pp. 851-859
    • Sanchez, M.G.1    Ruiz-Llorente, L.2    Sanchez, A.M.3    Diaz-Laviada, I.4
  • 73
    • 33748792290 scopus 로고    scopus 로고
    • Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood
    • Saunders, C. I., Kunde, D. A., Crawford, A., and Geraghty, D. P. (2007). Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. Mol.Immunol. 44,1429-1435.
    • (2007) Mol.Immunol. , vol.44 , pp. 1429-1435
    • Saunders, C.I.1    Kunde, D.A.2    Crawford, A.3    Geraghty, D.P.4
  • 74
    • 79961228829 scopus 로고    scopus 로고
    • Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists
    • Schuehly, W., Paredes, J. M., Kleyer, J., Huefner, A., Anavi-Goffer, S., Raduner, S., et al. (2011). Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. Chem. Biol. 18,1053-1064.
    • (2011) Chem. Biol. , vol.18 , pp. 1053-1064
    • Schuehly, W.1    Paredes, J.M.2    Kleyer, J.3    Huefner, A.4    Anavi-Goffer, S.5    Raduner, S.6
  • 75
    • 33846223892 scopus 로고    scopus 로고
    • Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors
    • Scutt, A., and Williamson, E. M. (2007). Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif. Tissue Int. 80, 50-59.
    • (2007) Calcif. Tissue Int. , vol.80 , pp. 50-59
    • Scutt, A.1    Williamson, E.M.2
  • 76
    • 33748743637 scopus 로고    scopus 로고
    • Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway
    • Simon, G. M., and Cravatt, B. F. (2006). Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.J. Biol. Chem. 281,26465-26472.
    • (2006) J. Biol. Chem. , vol.281 , pp. 26465-26472
    • Simon, G.M.1    Cravatt, B.F.2
  • 77
    • 0033984992 scopus 로고    scopus 로고
    • The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
    • Smart, D., Gunthorpe, M. J., Jerman, J. C., Nasir, S., Gray, J., Muir, A. I., et al. (2000). The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br. J. Pharmacol. 129, 227-230.
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 227-230
    • Smart, D.1    Gunthorpe, M.J.2    Jerman, J.C.3    Nasir, S.4    Gray, J.5    Muir, A.I.6
  • 78
    • 79956333187 scopus 로고    scopus 로고
    • The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation
    • Sophocleous, A., Landao-Bassonga, E., vant Hof, R. J., Idris, A. I., and Ralston, S. H. (2011). The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation. Endocrinology 152, 2141-2149.
    • (2011) Endocrinology , vol.152 , pp. 2141-2149
    • Sophocleous, A.1    Landao-Bassonga, E.2    Vant Hof, R.J.3    Idris, A.I.4    Ralston, S.H.5
  • 79
    • 84892567076 scopus 로고    scopus 로고
    • Combined deficiency of the CB1 and CB2 receptors enhances peak bone mass by inhibiting osteoclast differentiation but increases age-related bone loss by promoting adipocyte differentiation and reducing osteoblast differentiation
    • Sophocleous, A., Ralston, S. H., and Idris, A. I. (2012). Combined deficiency of the CB1 and CB2 receptors enhances peak bone mass by inhibiting osteoclast differentiation but increases age-related bone loss by promoting adipocyte differentiation and reducing osteoblast differentiation. Bone 50,S32.
    • (2012) Bone , vol.50
    • Sophocleous, A.1    Ralston, S.H.2    Idris, A.I.3
  • 80
    • 0030870722 scopus 로고    scopus 로고
    • A second endogenous cannabinoid that modulates long-term potentiation
    • Stella, N., Schweitzer, P., and Piomelli, D. (1997). A second endogenous cannabinoid that modulates long-term potentiation. Nature 388, 773-778.
    • (1997) Nature , vol.388 , pp. 773-778
    • Stella, N.1    Schweitzer, P.2    Piomelli, D.3
  • 81
    • 33747598488 scopus 로고    scopus 로고
    • Involvement of neuronal cannabinoid receptor, CB1, in regulation of bone mass and bone remodeling
    • Tam, J., Ofek, O., Fride, E., Ledent, C., Gabet, Y., Muller, R., et al. (2006). Involvement of neuronal cannabinoid receptor, CB1, in regulation of bone mass and bone remodeling. Mol. Pharmacol. 70, 786-792.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 786-792
    • Tam, J.1    Ofek, O.2    Fride, E.3    Ledent, C.4    Gabet, Y.5    Muller, R.6
  • 82
    • 38049132712 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    • Tam, J., Trembovler, V., Di, M., Petrosino, V. S., Leo, G., Alexandrovich, A., et al. (2008). The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J. 22, 285-294.
    • (2008) FASEB J , vol.22 , pp. 285-294
    • Tam, J.1    Trembovler, V.2    Di, M.3    Petrosino, V.S.4    Leo, G.5    Alexandrovich, A.6
  • 83
    • 23644444808 scopus 로고    scopus 로고
    • Anandamide as an intracellu-lar messenger regulating ion channel activity
    • Van Der Stelt, M., and Di Marzo, V. (2005). Anandamide as an intracellu-lar messenger regulating ion channel activity. Prostaglandins Other Lipid Mediat. 77, 111-122.
    • (2005) Prostaglandins Other Lipid Mediat , vol.77 , pp. 111-122
    • Van Der Stelt, M.1    Di Marzo, V.2
  • 84
    • 27144529566 scopus 로고    scopus 로고
    • Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels
    • Van Der, S. M., Trevisani, M., Vel-lani, V., De, P. L., Schiano, M. A., Campi, B., et al. (2005). Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J. 24, 3026-3037.
    • (2005) EMBO J , vol.24 , pp. 3026-3037
    • Van Der, S.M.1    Trevisani, M.2    Vel-Lani, V.3    De, P.L.4    Schiano, M.A.5    Campi, B.6
  • 85
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-gamma regulates osteoclastogenesis in mice
    • Wan, Y., Chong, L.W., and Evans, R. M. (2007). PPAR-gamma regulates osteoclastogenesis in mice. Nat.Med. 13,1496-1503.
    • (2007) Nat.Med. , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.W.2    Evans, R.M.3
  • 86
    • 84859049109 scopus 로고    scopus 로고
    • Cannabinoids, and bone: endocannabinoids modulate human osteoclast function in vitro
    • Whyte, L. S., Ford, L., Ridge, S. A., Cameron, G. A., Rogers, M. J., and Ross, R. A. (2012). Cannabinoids, and bone: endocannabinoids modulate human osteoclast function in vitro. Br. J. Pharmacol. 165, 2584-2597..
    • (2012) Br. J. Pharmacol. , vol.165
    • Whyte, L.S.1    Ford, L.2    Ridge, S.A.3    Cameron, G.A.4    Rogers, M.J.5    Ross, R.A.6
  • 87
    • 70349510641 scopus 로고    scopus 로고
    • The putative cannabi-noid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    • Whyte, L. S., Ryberg, E., Sims, N. A., Ridge, S. A., Mackie, K., Greasley, P. J., et al. (2009). The putative cannabi-noid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc. Natl. Acad. Sci. U.S.A. 106,16511-16516.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 16511-16516
    • Whyte, L.S.1    Ryberg, E.2    Sims, N.A.3    Ridge, S.A.4    Mackie, K.5    Greasley, P.J.6
  • 88
    • 81355146697 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 regulates ERK and GSK-3beta-dependent glu-cocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells
    • Wu, R. W., Lin, T. P., Ko, J. Y., Yeh, D. W., Chen, M. W., Ke, H. C., et al. (2011). Cannabinoid receptor 1 regulates ERK and GSK-3beta-dependent glu-cocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells. Bone 49, 1255-1263.
    • (2011) Bone , vol.49 , pp. 1255-1263
    • Wu, R.W.1    Lin, T.P.2    Ko, J.Y.3    Yeh, D.W.4    Chen, M.W.5    Ke, H.C.6


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