Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors

Calcified Tissue International

Volumn 80, Issue 1, 2007, Pages 50-59

  Scutt, A ^a   Williamson, E M ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Cannabinoid; CB2 receptor; Colony forming unit

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ARACHIDONYL 2 CHLOROETHYLAMIDE; BML 190; CANNABIDIOL; CANNABIDIVARINE; CANNABIGEROL; CANNABINOID; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CANNABINOL; ENDOCANNABINOID; ENDOCANNABINOID 2 ARACHIDONYLGLYCEROL; TETRAHYDROCANNABINOL; TETRAHYDROCANNABIVARIN; UNCLASSIFIED DRUG;

ACCESSORY CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BONE MARROW CELL; CELL ASSAY; CELL PROLIFERATION; CELL SUBPOPULATION; COLONY FORMATION; COLONY FORMING UNIT F; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST; FIBROBLAST CULTURE; FLOW CYTOMETRY; IN VIVO CULTURE; MESENCHYMAL STEM CELL; MONOTHERAPY; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; RAT; TARGET CELL;

ANIMALS; ARACHIDONIC ACIDS; BONE MARROW CELLS; CANNABINOIDS; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; GLYCERIDES; INDOMETHACIN; MALE; MESENCHYMAL STEM CELLS; MORPHOLINES; NAPHTHALENES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STEM CELLS;

EID: 33846223892     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-006-0171-7     Document Type: Article

References (73)

1. Pertwee RG (2006) Cannabinoid pharmacology: the first 66 years. Br J Pharmacol 147(suppl 1):S163-S171
2. Elsohly MA, Slade D (2005) Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci 78:539-548
3. Drysdale A, Platt B (2005) Medical marijuana in CNS disorders. Front Med Chem 3:133-159
4. Devane WA, Dysarz FA 3rd, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613
5. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
6. Martin BR (2002) Identification of the endogenous cannabinoid system through integrative pharmacological approaches. J Pharmacol Exp Ther 301:790-796
7. Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65
8. Grundy RI, Rabuffetti M, Beltramo M (2001) Cannabinoids and neuroprotection. Mol Neurobiol 24:29-51
9. Lynn AB, Herkenham M (1994) Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids. J Pharmacol Exp Ther 268:1612-1623
10. 2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J Neurosci 23:11136-11141
11. Ross RA (2003) Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140:790-801
12. Brown A, Wise A (2005) Identification of modulators of GPR55 activity. In: US Patent Document no. 20030113814
13. 2 receptor-dependent mechanism. J Biol Chem 278:24469-24475
14. Parolaro D, Massi P, Rubino T, Monti E (2002) Endocannabinoids in the immune system and cancer. Prostaglandins Leukot Essent Fatty Acids 66:319-332
15. Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL, Guzman M (2003) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111:43-50
16. Bab I, Ofek O, Karsak M, Fogel M, Wright K, Attar-Namdar M, Shohami E, Zimmer K, Mechoulam R (2004) Cannabinoid CB2 receptor and human osteoporosis. 14th Annual Symposium, International Cannabinoid Research Society, Paestum, Italy, p P74, 22-24 June 2004
17. Idris AI, van 't Hof RJ, Greig IR, Ridge SA, Baker D, Ross RA, Ralston SH (2005) Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 11:774-779
18. Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A (2005) Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 14:3389-3396
19. Tam J, Ofek O, Fride E, Ledent C, Gabet Y, Muller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I (2006) Involvement of neuronal cannabinoid receptor, CB1, in regulation of bone mass and bone remodeling. Mol Pharmacol 70:786-792
20. Mbvundula EC, Bunning RA, Rainsford KD (2005) Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. Biochem Pharmacol 69:635-640
21. Friedenstein AJ, Chailakhyan RK, Gerasimov UV (1987) Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 20:263-272
22. Friedenstein AJ (1976) Precursor cells of mechanocytes. Int Rev Cytol 47:327-359
23. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME (1992) Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102:341-351
24. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147
25. Kuznetsov SA, Krebsbach PH, Satomura K, Kerr J, Riminucci M, Benayahu D, Robey PG (1997) Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res 12:1335-1347
26. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD (2002) Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105:93-98
27. Wakitani S, Saito T, Caplan AI (1995) Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18:1417-1426
28. Munoz-Elias G, Woodbury D, Black IB (2003) Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions. Stem Cells 21:437-448
29. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F (1998) Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279:1528-1530
30. Devine MJ, Mierisch CM, Jang E, Anderson PC, Balian G (2002) Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res 20:1232- 1239
31. 2 in young rats increases the osteogenic capacity of bone marrow. Bone 20:521-526
32. Pun S, Dearden RL, Ratkus AM, Liang H, Wronski TJ (2001) Decreased bone anabolic effect of basic fibroblast growth factor at fatty marrow sites in ovariectomized rats. Bone 28:220-226
33. 3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow. Endocrinology 138:4629-4635
34. Nishida S, Yamaguchi A, Tanizawa T, Endo N, Mashiba T, Uchiyama Y, Suda T, Yoshiki S, Takahashi HE (1994) Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow. Bone 15:717-723
35. Scutt A, Kollenkirchen U, Bertram P (1996) Effect of age and ovariectomy on fibroblastic colony-forming unit numbers in rat bone marrow. Calcif Tissue Int 59:309-310
36. Tsuji T, Hughes FJ, McCulloch CA, Melcher AH (1990) Effects of donor age on osteogenic cells of rat bone marrow in vitro. Mech Ageing Dev 51:121-132
37. Egrise D, Martin D, Vienne A, Neve P, Schoutens A (1992) The number of fibroblastic colonies formed from bone marrow is decreased and the in vitro proliferation rate of trabecular bone cells increased in aged rats. Bone 13:355-361
38. Basso N, Jia Y, Bellows CG, Heersche JN (2005) The effect of reloading on bone volume, osteoblast number, and osteoprogenitor characteristics: studies in hind limb unloaded rats. Bone 37:370-378
39. Basso N, Bellows CG, Heersche JN (2005) Effect of simulated weightlessness on osteoprogenitor cell number and proliferation in young and adult rats. Bone 36:173-183
40. Dobson KR, Reading L, Haberey M, Marine X, Scutt A (1999) Centrifugal isolation of bone marrow from bone: an improved method for the recovery and quantitation of bone marrow osteoprogenitor cells from rat tibiae and femurae. Calcif Tissue Int 65:411-413
41. Dobson K, Reading L, Scutt A (1999) A cost-effective method for the automatic quantitative analysis of fibroblastic colony-forming units. Calcif Tissue Int 65:166-172
42. 2 on bone: induction of a transition from nonadherent to adherent osteoblast precursors. J Bone Miner Res 10:474-487
43. Miao D, Murant S, Scutt N, Genever P, Scutt A (2004) Megakaryocyte-bone marrow stromal cell aggregates demonstrate increased colony formation and alkaline phosphatase expression in vitro. Tissue Eng 10:807-817
44. Long MW (2001) Osteogenesis and bone-marrow-derived cells. Blood Cells Mol Dis 27:677-690
45. Abedin M, Tintut Y, Demer LL (2004) Mesenchymal stem cells and the artery wall. Circ Res 95:671-676
46. Caplice NM, Bunch TJ, Stalboerger PG, Wang S, Simper D, Miller DV, Russell SJ, Litzow MR, Edwards WD (2003) Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation. Proc Natl Acad Sci USA 100:4754-4759
47. Lotinun S, Sibonga JD, Turner RT (2005) Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 146:4074-4081
48. Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K (2005) A role for niches in hematopoietic cell development. Hematology 10:247-253
49. Fukuda K (2003) Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes. Bone Marrow Transplant 32(suppl 1):S25-S27
50. Caplan AI (2005) Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 11:1198-1211
51. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C (2005) Application of stem cells for vascular tissue engineering. Tissue Eng 11:1535-1552
52. Prockop DJ (2004) Targeting gene therapy for osteogenesis imperfecta. N Engl J Med 350:2302-2304
53. Goncalves MA, de Vries AA, Holkers M, van de Watering MJ, van der Velde I, van Nierop GP, Valerio D, Knaan-Shanzer S (2006) Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion. Hum Mol Genet 15:213-221
54. 2, regulates bone mass. Proc Natl Acad Sci USA 103:696-701
55. Frolik CA, Black EC, Cain RL, Satterwhite JH, Brown-Augsburger PL, Sato M, Hock JM (2003) Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. Bone 33:372-379
56. Jee WS, Ma YF (1997) The in vivo anabolic actions of prostaglandins in bone. Bone 21:297-304
57. 2 administered by subcutaneous pellets causes local inflammation and systemic bone loss: a model for inflammation-induced bone disease. J Bone Miner Res 8:625-634
58. 3 on bone resorption and natural immunity in osteopetrotic (ia) rats. J Bone Miner Res 9:585-591
59. Davies J, Chambers TJ (2004) Parathyroid hormone activates adhesion in bone marrow stromal precursor cells. J Endocrinol 180:505-513
60. Scutt A, Beier N, Fittschen C (2004) EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis. BMC Pharmacol 4:10
61. Scutt A, Bertram P (1999) Basic fibroblast growth factor in the presence of dexamethasone stimulates colony formation, expansion, and osteoblastic differentiation by rat bone marrow stromal cells. Calcif Tissue Int 64:69-77
62. Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, Le Fur G, Casellas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232:54-61
63. Randall MD, Kendall DA, O'Sullivan S (2004) The complexities of the cardiovascular actions of cannabinoids. Br J Pharmacol 142:20-26
64. Schmitz B, Wickenhauser C, Thiele J, Frimpong S, Brockbals C, Selbach B, Mueller C, Fischer R (1999) Megakaryocyte induced fibroblast proliferation is enhanced by costimulation with IL-6/IL-3 and dependent on secretory and adhesion events. Leuk Res 23:723-729
65. Wickenhauser C, Schmitz B, Baldus SE, Henze F, Farahmand P, Frimpong S, Thiele J, Fischer R (2000) Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte-fibroblast interactions in human bone marrow. Leuk Res 24:1013-1021
66. Villars F, Bordenave L, Bareille R, Amedee J (2000) Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF? J Cell Biochem 79:672-685
67. Villars F, Guillotin B, Amedee T, Dutoya S, Bordenave L, Bareille R, Amedee J (2002) Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communication. Am J Physiol Cell Physiol 282:C775-C785
68. O'Sullivan SE, Kendall DA, Randall MD (2005) Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. Eur J Pharmacol 507:211-221
69. 1 receptors in a smooth muscle cell line. J Physiol 531:95-104
70. Pertwee RG (2005) The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 7:E625-E654
71. Despres JP, Golay A, Sjostrom L (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134
72. Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J (2006) Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295:761-775
73. 2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol 527:172-174