Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 769-776

  Lan, Ruoxi ^a   Liu, Qian ^a   Fan, Pusheng ^a   Lin, Sonyuan ^a   Fernando, Susanthi R ^a   McCallion, Deirdre ^a   Pertwee, Roger ^a   Makriyannis, Alexandras ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; PYRAZOLE DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; RAT; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; CANNABINOIDS; GUINEA PIGS; HUMANS; INTESTINE, SMALL; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYENTERIC PLEXUS; PIPERIDINES; PROSENCEPHALON; PYRAZOLES; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0033602129     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980363y     Document Type: Article

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