β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

Journal of Molecular and Cellular Cardiology

Volumn 58, Issue 1, 2013, Pages 153-161

  Xie, Yuanfang ^a   Grandi, Eleonora ^a   Puglisi, Jose L ^a   Sato, Daisuke ^a   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

adrenergic signaling; Isoproterenol; Phosphorylation kinetics; Spontaneous Ca release; Transient early afterdepolarization

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; PHOSPHOLAMBAN; PHOSPHOLEMMAN; PHOSPHOPROTEIN; POTASSIUM ION; RYANODINE RECEPTOR; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CURRENT; CALCIUM SIGNALING; CONTROLLED STUDY; EARLY AFTERDEPOLARIZATION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; EXCITATION CONTRACTION COUPLING; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART RATE VARIABILITY; MOLECULAR MODEL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN TARGETING; RABBIT; SARCOPLASMIC RETICULUM; SODIUM CURRENT; STEADY STATE;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; EXCITATION CONTRACTION COUPLING; HUMANS; ISOPROTERENOL; KINETICS; MYOCYTES, CARDIAC; PHOSPHORYLATION; RABBITS; RECEPTORS, ADRENERGIC, BETA;

EID: 84876319657     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.02.009     Document Type: Article

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