Differential effects of beta-adrenergic agonists and antagonist in LQT1, LQT2 and LQT3 models of the long QT syndrome

Journal of the American College of Cardiology

Volumn 35, Issue 3, 2000, Pages 778-786

  Shimizu, Wataru ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATX 2; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHROMAN DERIVATIVE; CHROMANOL 293B; ISOPRENALINE; PROPRANOLOL; SOTALOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTERY PERFUSION; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DISEASE MODEL; DOG; DRUG ANTAGONISM; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; INCIDENCE; LONG QT SYNDROME; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; SODIUM CURRENT; SYMPATHETIC TONE; TORSADE DES POINTES;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARDIOTONIC AGENTS; CHROMANS; CNIDARIAN VENOMS; DISEASE MODELS, ANIMAL; DOGS; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; ISOPROTERENOL; LONG QT SYNDROME; NEUROTOXINS; POTASSIUM CHANNEL BLOCKERS; PROPRANOLOL; SOTALOL; SULFONAMIDES; SYMPATHETIC NERVOUS SYSTEM; TREATMENT OUTCOME;

EID: 0034163543     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00582-3     Document Type: Article

References (33)

1. Schwartz P.J., Periti M., Malliani A. The long QT syndrome. Am Heart J. 89:1975;378-390.
2. Moss A.J., Schwartz P.J., Crampton R.S., Locati E.H., Carleen E. The long QT syndrome a prospective international study . Circulation. 71:1985;17-21.
3. Moss A.J., Schwartz P.J., Crampton R.S., et al. The long QT syndrome prospective longitudinal study of 328 families . Circulation. 84:1991;1136-1144.
4. Zipes D.P. The long QT interval syndrome a Rosetta Stone for sympathetic related ventricular tachyarrhythmias . Circulation. 84:1991;1414-1419.
5. Shimizu W., Ohe T., Kurita T., et al. Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome. Circulation. 84:1991;1915-1923.
6. Shimizu W., Ohe T., Kurita T., et al. Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. J Am Coll Cardiol. 26:1995;1299-1309.
7. Roden D.M., Lazzara R., Rosen M.R., et al. Multiple mechanisms in the long-QT syndrome current knowledge, gaps and future directions . Circulation. 94:1996;1996-2012.
8. Vincent G.M. The molecular genetics of the long QT syndrome genes causing fainting and sudden death . Annu Rev Med. 49:1998;263-274.
9. Priori S.G., Barhanin J., Hauer R.N., et al. Genetic and molecular basis of cardiac arrhythmias impact on clinical management parts I and II . Circulation. 99:1999;518-528.
10. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 97:1999;175-187.
11. Schwartz P.J., Malteo P.S., Moss A.J., et al. Gene-specific influence on the triggers for cardiac arrest in the long QT syndrome (abstr). Circulation. 96:1997;I-212.
12. + channel blockade, beta-adrenergic simulation and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circ Res. 78:1996;1009-1015.
13. Antzelevitch C., Sun Z.Q., Zhang Z.Q., Yan G.X. Cellular and ionic mechanisms underlying erythromycin-induced long QT and torsade de pointes. J Am Coll Cardiol. 28:1996;1836-1848.
14. Shimizu W., Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long QT syndrome. Circulation. 96:1997;2038-2047.
15. Shimizu W., Antzelevitch C. Cellular basis for the electrocardiographic features of the LQT1 form of the long QT syndrome effects of b-adrenergic agonists, antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes . Circulation. 98:1998;2314-2322.
16. Yan G.X., Shimizu W., Antzelevitch C. Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations. Circulation. 98:1998;1921-1927.
17. Yan G.X., Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome. Circulation. 98:1998;1928-1936.
18. Shimizu W., Antzelevitch C. Cellular and ionic basis for T wave alternans under long QT conditions. Circulation. 99:1999;1499-1507.
19. El-Sherif N., Caref E.B., Yin H., Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome tridimensional mapping of activation and recovery patterns . Circ Res. 79:1996;474-492.
20. Chinushi M., Restivo M., Caref E.B., El-Sherif N. The electrophysiological basis of arrhythmogenicity of QT/T alternans in the long QT syndrome tridimensional analysis of the kinetics of cardiac repolarization . Circ Res. 83:1998;614-628.
21. Eddlestone G.T., Zygmunt A.C., Antzelevitch C. Larger late sodium current contributes to the longer action potential of the M cell in canine ventricular myocardium. (abstr) PACE. 19:1996;II-569.
22. 1). J Am Coll Cardiol. 33:1999;327-332.
23. + channel blockade and to increases in heart rate implications for gene-specific therapy . Circulation. 92:1995;3381-3386.
24. Zygmunt A.C. Intracellular calcium activates chloride current in canine ventricular myocytes. Am J Physiol. 267:1994;H1984-H1995.
25. + channel opener in the LQT1 form of congenital long QT syndrome. Circulation. 97:1998;1581-1588.
26. Antzelevitch C., Sicouri S. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations the role of M cells in the generation of U waves, triggered activity and torsade de pointes . J Am Coll Cardiol. 23:1994;259-277.
27. Antzelevitch C, Yan GX, Shimizu W, Burashnikov A. Electrical heterogeneity, the ECG and cardiac arrhythmias. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia, W.B. Saunders Co., 1999:222-8.
28. Ks contributes to the longer action potential of the M cell . Circ Res. 76:1995;351-365.
29. Burashnikov A., Antzelevitch C. Acceleration-induced action potential prolongation and early afterdepolarizations. J Cardiovasc Electrophysiol. 9:1998;934-948.
30. Toivonen L., Helenius K., Viitasalo M. Electrocardiographic repolarization during stress from awakening on alarm call. J Am Coll Cardiol. 30:1997;774-779.
31. Vincent G.M., Fox J., Zhang L., Timothy K.W. Beta-blockers markedly reduce risk and syncope in KVLQT1 long QT patients. (abstr) Circulation. 94:1996;I-204.
32. Lehmann M.H., Suzuki F., Fromm B.S., et al. T-wave "humps" as a potential electrocardiographic marker of the long QT syndrome. J Am Coll Cardiol. 24:1994;746-754.
33. Moss A.J., Zareba W., Benhorin J., et al. ECG T wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation. 92:1995;2929-2934.