-
1
-
-
77958183243
-
Novel insights into the pathophysiology of nonalcoholic fatty liver disease
-
A.E. Feldstein Novel insights into the pathophysiology of nonalcoholic fatty liver disease Semin Liver Dis 30 2010 391 401
-
(2010)
Semin Liver Dis
, vol.30
, pp. 391-401
-
-
Feldstein, A.E.1
-
2
-
-
18244389734
-
KLF6, a candidate tumor suppressor gene mutated in prostate cancer
-
G. Narla, K.E. Heath, H.L. Reeves, D. Li, L.E. Giono, and A.C. Kimmelman KLF6, a candidate tumor suppressor gene mutated in prostate cancer Science 294 2001 2563 2566
-
(2001)
Science
, vol.294
, pp. 2563-2566
-
-
Narla, G.1
Heath, K.E.2
Reeves, H.L.3
Li, D.4
Giono, L.E.5
Kimmelman, A.C.6
-
3
-
-
42949176197
-
Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
-
S. Yea, G. Narla, X. Zhao, R. Garg, S. Tal-Kremer, and E. Hod Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma Gastroenterology 134 2008 1521 1531
-
(2008)
Gastroenterology
, vol.134
, pp. 1521-1531
-
-
Yea, S.1
Narla, G.2
Zhao, X.3
Garg, R.4
Tal-Kremer, S.5
Hod, E.6
-
4
-
-
0031713637
-
Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter
-
T. Suzuki, T. Yamamoto, M. Kurabayashi, R. Nagai, Y. Yazaki, and M. Horikoshi Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter J Biochem 124 1998 389 395
-
(1998)
J Biochem
, vol.124
, pp. 389-395
-
-
Suzuki, T.1
Yamamoto, T.2
Kurabayashi, M.3
Nagai, R.4
Yazaki, Y.5
Horikoshi, M.6
-
5
-
-
22844447990
-
Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1
-
D. Li, S. Yea, S. Li, Z. Chen, G. Narla, and M. Banck Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1 J Biol Chem 280 2005 26941 26952
-
(2005)
J Biol Chem
, vol.280
, pp. 26941-26952
-
-
Li, D.1
Yea, S.2
Li, S.3
Chen, Z.4
Narla, G.5
Banck, M.6
-
6
-
-
73649125812
-
Transcription factors Kruppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein
-
W. Qi, X. Chen, J. Holian, C.Y. Tan, D.J. Kelly, and C.A. Pollock Transcription factors Kruppel-like factor 6 and peroxisome proliferator- activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein Am J Pathol 175 2009 1858 1867
-
(2009)
Am J Pathol
, vol.175
, pp. 1858-1867
-
-
Qi, W.1
Chen, X.2
Holian, J.3
Tan, C.Y.4
Kelly, D.J.5
Pollock, C.A.6
-
7
-
-
46049097550
-
The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease
-
e281
-
L. Miele, G. Beale, G. Patman, V. Nobili, J. Leathart, and A. Grieco The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease Gastroenterology 135 2008 282 291 e281
-
(2008)
Gastroenterology
, vol.135
, pp. 282-291
-
-
Miele, L.1
Beale, G.2
Patman, G.3
Nobili, V.4
Leathart, J.5
Grieco, A.6
-
8
-
-
84862800868
-
Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease
-
L.P. Bechmann, A. Gastaldelli, D. Vetter, G.L. Patman, L. Pascoe, and R.A. Hannivoort Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease Hepatology 55 2012 1083 1093
-
(2012)
Hepatology
, vol.55
, pp. 1083-1093
-
-
Bechmann, L.P.1
Gastaldelli, A.2
Vetter, D.3
Patman, G.L.4
Pascoe, L.5
Hannivoort, R.A.6
-
9
-
-
84858701950
-
The interaction of hepatic lipid and glucose metabolism in liver diseases
-
L.P. Bechmann, R.A. Hannivoort, G. Gerken, G.S. Hotamisligil, M. Trauner, and A. Canbay The interaction of hepatic lipid and glucose metabolism in liver diseases J Hepatol 56 2012 952 964
-
(2012)
J Hepatol
, vol.56
, pp. 952-964
-
-
Bechmann, L.P.1
Hannivoort, R.A.2
Gerken, G.3
Hotamisligil, G.S.4
Trauner, M.5
Canbay, A.6
-
10
-
-
56149127703
-
Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
-
P.D. Berk Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome Hepatology 48 2008 1362 1376
-
(2008)
Hepatology
, vol.48
, pp. 1362-1376
-
-
Berk, P.D.1
-
11
-
-
34748866634
-
Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet
-
D.R. Cha, J.Y. Han, D.M. Su, Y. Zhang, X. Fan, and M.D. Breyer Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet Am J Nephrol 27 2007 479 482
-
(2007)
Am J Nephrol
, vol.27
, pp. 479-482
-
-
Cha, D.R.1
Han, J.Y.2
Su, D.M.3
Zhang, Y.4
Fan, X.5
Breyer, M.D.6
-
12
-
-
14244264780
-
Regulation of carbohydrate metabolism by the farnesoid X receptor
-
K.R. Stayrook, K.S. Bramlett, R.S. Savkur, J. Ficorilli, T. Cook, and M.E. Christe Regulation of carbohydrate metabolism by the farnesoid X receptor Endocrinology 146 2005 984 991
-
(2005)
Endocrinology
, vol.146
, pp. 984-991
-
-
Stayrook, K.R.1
Bramlett, K.S.2
Savkur, R.S.3
Ficorilli, J.4
Cook, T.5
Christe, M.E.6
-
13
-
-
73449136157
-
Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD
-
L. Zheng, G.C. Lv, J. Sheng, and Y.D. Yang Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD J Gastroenterol Hepatol 25 2010 156 163
-
(2010)
J Gastroenterol Hepatol
, vol.25
, pp. 156-163
-
-
Zheng, L.1
Lv, G.C.2
Sheng, J.3
Yang, Y.D.4
-
14
-
-
35148886434
-
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
-
L. Ma, J. Teruya-Feldstein, and R.A. Weinberg Tumour invasion and metastasis initiated by microRNA-10b in breast cancer Nature 449 2007 682 688
-
(2007)
Nature
, vol.449
, pp. 682-688
-
-
Ma, L.1
Teruya-Feldstein, J.2
Weinberg, R.A.3
-
15
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
S.H. Koo, H. Satoh, S. Herzig, C.H. Lee, S. Hedrick, and R. Kulkarni PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3 Nat Med 10 2004 530 534
-
(2004)
Nat Med
, vol.10
, pp. 530-534
-
-
Koo, S.H.1
Satoh, H.2
Herzig, S.3
Lee, C.H.4
Hedrick, S.5
Kulkarni, R.6
-
16
-
-
79953812287
-
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation in a rat model of insulin resistance
-
D. Weismann, D.M. Erion, I. Ignatova-Todorava, Y. Nagai, R. Stark, and J.J. Hsiao Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation in a rat model of insulin resistance Diabetologia 54 2011 935 944
-
(2011)
Diabetologia
, vol.54
, pp. 935-944
-
-
Weismann, D.1
Erion, D.M.2
Ignatova-Todorava, I.3
Nagai, Y.4
Stark, R.5
Hsiao, J.J.6
-
17
-
-
68949103879
-
Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway
-
C.C. Leow, B.E. Wang, J. Ross, S.M. Chan, J. Zha, and R.A. Carano Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway J Biol Chem 284 2009 21057 21065
-
(2009)
J Biol Chem
, vol.284
, pp. 21057-21065
-
-
Leow, C.C.1
Wang, B.E.2
Ross, J.3
Chan, S.M.4
Zha, J.5
Carano, R.A.6
-
18
-
-
84867193519
-
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing
-
D. Vetter, M. Cohen-Naftaly, A. Villanueva, Y.A. Lee, P. Kocabayoglu, and R. Hannivoort Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing Hepatology 56 4 2012 1361 1370
-
(2012)
Hepatology
, vol.56
, Issue.4
, pp. 1361-1370
-
-
Vetter, D.1
Cohen-Naftaly, M.2
Villanueva, A.3
Lee, Y.A.4
Kocabayoglu, P.5
Hannivoort, R.6
-
19
-
-
79960731928
-
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation
-
M. Tarocchi, R. Hannivoort, Y. Hoshida, U.E. Lee, D. Vetter, and G. Narla Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation Hepatology 54 2011 522 531
-
(2011)
Hepatology
, vol.54
, pp. 522-531
-
-
Tarocchi, M.1
Hannivoort, R.2
Hoshida, Y.3
Lee, U.E.4
Vetter, D.5
Narla, G.6
-
20
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, and O.W. Cummings Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
Behling, C.4
Contos, M.J.5
Cummings, O.W.6
-
21
-
-
0034059141
-
DNA excision in liver by an albumin-Cre transgene occurs progressively with age
-
C. Postic, and M.A. Magnuson DNA excision in liver by an albumin-Cre transgene occurs progressively with age Genesis 26 2000 149 150
-
(2000)
Genesis
, vol.26
, pp. 149-150
-
-
Postic, C.1
Magnuson, M.A.2
-
22
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
K. Du, S. Herzig, R.N. Kulkarni, and M. Montminy TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Science 300 2003 1574 1577
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
23
-
-
34447097693
-
Intronic microRNA precursors that bypass Drosha processing
-
J.G. Ruby, C.H. Jan, and D.P. Bartel Intronic microRNA precursors that bypass Drosha processing Nature 448 2007 83 86
-
(2007)
Nature
, vol.448
, pp. 83-86
-
-
Ruby, J.G.1
Jan, C.H.2
Bartel, D.P.3
-
24
-
-
68149098866
-
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
-
M.V. Chakravarthy, I.J. Lodhi, L. Yin, R.R. Malapaka, H.E. Xu, and J. Turk Identification of a physiologically relevant endogenous ligand for PPARalpha in liver Cell 138 2009 476 488
-
(2009)
Cell
, vol.138
, pp. 476-488
-
-
Chakravarthy, M.V.1
Lodhi, I.J.2
Yin, L.3
Malapaka, R.R.4
Xu, H.E.5
Turk, J.6
-
25
-
-
79751524881
-
The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-gamma in the regulation of macrophage inflammatory protein-3alpha at early onset of diabetes
-
W. Qi, J. Holian, C.Y. Tan, D.J. Kelly, X.M. Chen, and C.A. Pollock The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-gamma in the regulation of macrophage inflammatory protein-3alpha at early onset of diabetes Int J Biochem Cell Biol 43 2010 383 392
-
(2010)
Int J Biochem Cell Biol
, vol.43
, pp. 383-392
-
-
Qi, W.1
Holian, J.2
Tan, C.Y.3
Kelly, D.J.4
Chen, X.M.5
Pollock, C.A.6
-
26
-
-
77950509620
-
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
-
H.A. Hirsch, D. Iliopoulos, A. Joshi, Y. Zhang, S.A. Jaeger, and M. Bulyk A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases Cancer Cell 17 2010 348 361
-
(2010)
Cancer Cell
, vol.17
, pp. 348-361
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Joshi, A.3
Zhang, Y.4
Jaeger, S.A.5
Bulyk, M.6
-
27
-
-
84866348839
-
P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice
-
K. Tomita, T. Teratani, T. Suzuki, T. Oshikawa, H. Yokoyama, and K. Shimamura P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice J Hepatol 57 2012 837 843
-
(2012)
J Hepatol
, vol.57
, pp. 837-843
-
-
Tomita, K.1
Teratani, T.2
Suzuki, T.3
Oshikawa, T.4
Yokoyama, H.5
Shimamura, K.6
-
28
-
-
79952701894
-
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis
-
S.H. Ibrahim, Y. Akazawa, S.C. Cazanave, S.F. Bronk, N.A. Elmi, and N.W. Werneburg Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis J Hepatol 54 2011 765 772
-
(2011)
J Hepatol
, vol.54
, pp. 765-772
-
-
Ibrahim, S.H.1
Akazawa, Y.2
Cazanave, S.C.3
Bronk, S.F.4
Elmi, N.A.5
Werneburg, N.W.6
-
29
-
-
84884596944
-
GSK3beta phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21
-
10.1038/onc.2012.457
-
U.E. Lang, P. Kocabayoglu, G.Z. Cheng, Z. Ghiassi-Nejad, U. Munoz, and D. Vetter GSK3beta phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21 Oncogene 2012 10.1038/onc.2012.457
-
(2012)
Oncogene
-
-
Lang, U.E.1
Kocabayoglu, P.2
Cheng, G.Z.3
Ghiassi-Nejad, Z.4
Munoz, U.5
Vetter, D.6
-
30
-
-
38849184816
-
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
-
N. Tanaka, K. Moriya, K. Kiyosawa, K. Koike, F.J. Gonzalez, and T. Aoyama PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice J Clin Invest 118 2008 683 694
-
(2008)
J Clin Invest
, vol.118
, pp. 683-694
-
-
Tanaka, N.1
Moriya, K.2
Kiyosawa, K.3
Koike, K.4
Gonzalez, F.J.5
Aoyama, T.6
-
31
-
-
77955549551
-
Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans
-
H. Oberkofler, A. Pfeifenberger, S. Soyal, T. Felder, P. Hahne, and K. Miller Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans Diabetologia 53 2010 1971 1975
-
(2010)
Diabetologia
, vol.53
, pp. 1971-1975
-
-
Oberkofler, H.1
Pfeifenberger, A.2
Soyal, S.3
Felder, T.4
Hahne, P.5
Miller, K.6
-
32
-
-
0033847132
-
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
-
P. She, M. Shiota, K.D. Shelton, R. Chalkley, C. Postic, and M.A. Magnuson Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism Mol Cell Biol 20 2000 6508 6517
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6508-6517
-
-
She, P.1
Shiota, M.2
Shelton, K.D.3
Chalkley, R.4
Postic, C.5
Magnuson, M.A.6
-
33
-
-
0034812914
-
Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology
-
S.Q. Yang, H.Z. Lin, A.K. Mandal, J. Huang, and A.M. Diehl Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology Hepatology 34 2001 694 706
-
(2001)
Hepatology
, vol.34
, pp. 694-706
-
-
Yang, S.Q.1
Lin, H.Z.2
Mandal, A.K.3
Huang, J.4
Diehl, A.M.5
-
34
-
-
0038353781
-
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation
-
P. She, S.C. Burgess, M. Shiota, P. Flakoll, E.P. Donahue, and C.R. Malloy Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation Diabetes 52 2003 1649 1654
-
(2003)
Diabetes
, vol.52
, pp. 1649-1654
-
-
She, P.1
Burgess, S.C.2
Shiota, M.3
Flakoll, P.4
Donahue, E.P.5
Malloy, C.R.6
-
35
-
-
77954363354
-
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
-
L.P. Bechmann, R.K. Gieseler, J.P. Sowa, A. Kahraman, J. Erhard, and I. Wedemeyer Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis Liver Int 30 2010 850 859
-
(2010)
Liver Int
, vol.30
, pp. 850-859
-
-
Bechmann, L.P.1
Gieseler, R.K.2
Sowa, J.P.3
Kahraman, A.4
Erhard, J.5
Wedemeyer, I.6
-
36
-
-
84880925312
-
Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
-
10.1016/j.jhep.2012.11.042
-
Z. Derdak, K.A. Villegas, R. Harb, A.M. Wu, A. Sousa, and J.R. Wands Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease J Hepatol 2012 10.1016/j.jhep.2012.11.042
-
(2012)
J Hepatol
-
-
Derdak, Z.1
Villegas, K.A.2
Harb, R.3
Wu, A.M.4
Sousa, A.5
Wands, J.R.6
|