Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet

American Journal of Nephrology

Volumn 27, Issue 5, 2007, Pages 479-482

  Cha, Dae Ryong ^a,b   Han, Jee Young ^a   Su, Dong Ming ^a   Zhang, Yahua ^a   Fan, Xuefeng ^a   Breyer, Matthew D ^a   Guan, Youfei ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b Korea University   (South Korea)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Aged mice; High fat diet; Insulin resistance; Peroxisome proliferator activated receptor

Indexed keywords

ALBUMIN; CHOLESTEROL; CREATININE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; LIPID DIET; LIVER WEIGHT; MALE; METABOLIC PARAMETERS; MICROALBUMINURIA; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AGING; ALBUMINURIA; ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; CREATININE; DIETARY FATS; FASTING; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, KNOCKOUT; ORGAN SIZE; PPAR ALPHA;

EID: 34748866634     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106485     Document Type: Article

References (10)

1. Fink RI, Kolterman OG, Griffin J, Olefsky JM: Mechanisms of insulin resistance in aging. J Clin Invest 1983;71:1523-1535.
2. Guan Y: Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome. J Am Soc Nephrol 2004;15:2801-2815.
3. Guerre-Millo M, Gervois P, Raspe E, et al: Peroxisome proliferator activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000;275:16638-16642.
4. Lam TK, van de Werve G, Giacca A: Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab 2003;284:E281-E290.
5. Tordjman K, Bernal-Mizrachi C, Zemany L, et al: PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 2001;107:1025-1034.
6. Guerre-Millo M, Rouault C, Poulain P, et al: PPAR-α-null mice are protected from high fat diet-induced insulin resistance. Diabetes 2001;50:2809-2814.
7. Haluzik M, Gavrilova O, Leroith D: Peroxisome proliferator activated receptor-α deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology 2004;145:1662-1667.
8. Xu J, Chang V, Joseph SB, et al: Peroxisome proliferator activated receptor α deficiency diminishes insulin responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux. Endocrinology 2004;145:1087-1095.
9. Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW: Peroxisome proliferator activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats. Diabetes 2001;50:411-417.
10. Randle PJ, Garland BP, Hales CN, Newsholme EA: The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-789.