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Volumn 24, Issue 2, 2013, Pages 130-135

Nanotechnology and glaucoma: Little particles for a big disease

Author keywords

Gene Therapy; Glaucoma; Microspheres; Nanoparticles

Indexed keywords

ALGINIC ACID; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBONATE DEHYDRATASE INHIBITOR; CHITOSAN; EYE DROPS; GOLD NANOPARTICLE; HEAT SHOCK PROTEIN; MICROSPHERE; NANOPARTICLE;

EID: 84876283807     PISSN: 10408738     EISSN: 15317021     Source Type: Journal    
DOI: 10.1097/ICU.0b013e32835cfe92     Document Type: Review
Times cited : (29)

References (68)
  • 1
    • 33644655886 scopus 로고    scopus 로고
    • The number of people with glaucoma worldwide in 2010 and 2020
    • Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006; 90:262-267.
    • (2006) Br J Ophthalmol , vol.90 , pp. 262-267
    • Quigley, H.A.1    Broman, A.T.2
  • 2
    • 11844256387 scopus 로고    scopus 로고
    • Diabetes mellitus as a risk factor for glaucomatous optic neuropathy
    • Nakamura M, Kanamori A, Negi A. Diabetes mellitus as a risk factor for glaucomatous optic neuropathy. Ophthalmologica 2005; 219:1-10.
    • (2005) Ophthalmologica , vol.219 , pp. 1-10
    • Nakamura, M.1    Kanamori, A.2    Negi, A.3
  • 4
    • 84860427250 scopus 로고    scopus 로고
    • Glaucoma 2.0: Neuroprotection, neuroregeneration, neuroenhancement
    • This review describes the current treatments for glaucoma and the possible new directions for the field that extend beyond intraocular pressure management
    • Chang EE, Goldberg JL. Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement. Ophthalmology 2012; 119:979-986. This review describes the current treatments for glaucoma and the possible new directions for the field that extend beyond intraocular pressure management.
    • (2012) Ophthalmology , vol.119 , pp. 979-986
    • Chang, E.E.1    Goldberg, J.L.2
  • 5
    • 2442643730 scopus 로고    scopus 로고
    • Primary open-angle glaucoma
    • Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004; 363: 1711-1720.
    • (2004) Lancet , vol.363 , pp. 1711-1720
    • Weinreb, R.N.1    Khaw, P.T.2
  • 6
    • 79960194647 scopus 로고    scopus 로고
    • Genome-wide linkage scan for primary open angle glaucoma: Influences of ancestry and age at diagnosis
    • Crooks KR, Allingham RR, Qin X, et al. Genome-wide linkage scan for primary open angle glaucoma: influences of ancestry and age at diagnosis. PLoS One 2011; 6:e21967.
    • (2011) PLoS One , vol.6
    • Crooks, K.R.1    Allingham, R.R.2    Qin, X.3
  • 7
    • 70350127134 scopus 로고    scopus 로고
    • Common variants on chromosome 2 and risk of primary open-angle glaucoma in the afro-caribbean population of barbados
    • Jiao X, Yang Z, Yang X, et al. Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados. Proc Natl Acad Sci USA 2009; 106:17105-17110.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17105-17110
    • Jiao, X.1    Yang, Z.2    Yang, X.3
  • 8
    • 0036261632 scopus 로고    scopus 로고
    • Relationship between age and intraocular pressure: The blue mountains eye study
    • Rochtchina E, Mitchell P, Wang JJ. Relationship between age and intraocular pressure: the Blue Mountains Eye Study. Clin Exp Ophthalmol 2002; 30: 173-175.
    • (2002) Clin Exp Ophthalmol , vol.30 , pp. 173-175
    • Rochtchina, E.1    Mitchell, P.2    Wang, J.J.3
  • 9
    • 70349244877 scopus 로고    scopus 로고
    • The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an asian population
    • Wong TT, Wong T Y, Foster P J, et al. The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an Asian population. Invest Ophthalmol Vis Sci 2009; 50:4097-4102.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 4097-4102
    • Wong, T.T.1    Wong T, Y.2    Foster P, J.3
  • 10
    • 77956341227 scopus 로고    scopus 로고
    • Ocular biometry and open-angle glaucoma: The los angeles latino eye study
    • Kuzin AA, Varma R, Reddy HS, et al. Ocular biometry and open-angle glaucoma: the Los Angeles Latino Eye Study. Ophthalmology 2010; 117: 1713-1719.
    • (2010) Ophthalmology , vol.117 , pp. 1713-1719
    • Kuzin, A.A.1    Varma, R.2    Reddy, H.S.3
  • 11
    • 3242658099 scopus 로고    scopus 로고
    • Open-angle glaucoma and systemic hypertension: The blue mountains eye study
    • Mitchell P, Lee AJ, Rochtchina E, Wang JJ. Open-angle glaucoma and systemic hypertension: the Blue Mountains Eye Study. J Glaucoma 2004; 13: 319-326.
    • (2004) J Glaucoma , vol.13 , pp. 319-326
    • Mitchell, P.1    Lee, A.J.2    Rochtchina, E.3    Wang, J.J.4
  • 12
    • 37349078627 scopus 로고    scopus 로고
    • Risk factors for incident open-angle glaucoma: The barbados eye studies
    • Leske MC, Wu SY, Hennis A, et al. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 2008; 115:85-93.
    • (2008) Ophthalmology , vol.115 , pp. 85-93
    • Leske, M.C.1    Wu, S.Y.2    Hennis, A.3
  • 13
    • 47749120638 scopus 로고    scopus 로고
    • Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head
    • Burgoyne CF, Downs JC. Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J Glaucoma 2008; 17:318-328.
    • (2008) J Glaucoma , vol.17 , pp. 318-328
    • Burgoyne, C.F.1    Downs, J.C.2
  • 14
    • 79955983465 scopus 로고    scopus 로고
    • Primary open-angle glaucoma genes
    • Fingert JH. Primary open-angle glaucoma genes. Eye (Lond) 2011; 25:587-595.
    • (2011) Eye (Lond) , vol.25 , pp. 587-595
    • Fingert, J.H.1
  • 15
    • 64249133288 scopus 로고    scopus 로고
    • Glaucoma-associated myocilin: A better understanding but much more to learn
    • Resch ZT, Fautsch MP. Glaucoma-associated myocilin: a better understanding but much more to learn. Exp Eye Res 2009; 88:704-712.
    • (2009) Exp Eye Res , vol.88 , pp. 704-712
    • Resch, Z.T.1    Fautsch, M.P.2
  • 16
    • 77954167933 scopus 로고    scopus 로고
    • Overexpression of optineurin e50k disrupts rab8 interaction and leads to a progressive retinal degeneration in mice
    • Chi ZL, Akahori M, Obazawa M, et al. Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet 2010; 19:2606-2615.
    • (2010) Hum Mol Genet , vol.19 , pp. 2606-2615
    • Chi, Z.L.1    Akahori, M.2    Obazawa, M.3
  • 17
    • 79953050041 scopus 로고    scopus 로고
    • Vascular risk factors in glaucoma: A review
    • Yanagi M, Kawasaki R, Wang JJ, et al. Vascular risk factors in glaucoma: a review. Clin Exp Ophthalmol 2011; 39:252-258.
    • (2011) Clin Exp Ophthalmol , vol.39 , pp. 252-258
    • Yanagi, M.1    Kawasaki, R.2    Wang, J.J.3
  • 19
    • 0032189255 scopus 로고    scopus 로고
    • Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
    • Collaborative Normal-Tension Glaucoma Study Group
    • Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Collaborative Normal-Tension Glaucoma Study Group. Am J Ophthalmol 1998; 126:487-497.
    • (1998) Am J Ophthalmol , vol.126 , pp. 487-497
  • 20
    • 33644536358 scopus 로고    scopus 로고
    • Patient-reported behavior and problems in using glaucoma medications
    • Sleath B, Robin AL, Covert D, et al. Patient-reported behavior and problems in using glaucoma medications. Ophthalmology 2006; 113:431-436.
    • (2006) Ophthalmology , vol.113 , pp. 431-436
    • Sleath, B.1    Robin, A.L.2    Covert, D.3
  • 21
    • 84863196283 scopus 로고    scopus 로고
    • Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: A systematic review
    • Reardon G, Kotak S, Schwartz GF. Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: a systematic review. Patient Prefer Adherence 2011; 5:441-463.
    • (2011) Patient Prefer Adherence , vol.5 , pp. 441-463
    • Reardon, G.1    Kotak, S.2    Schwartz, G.F.3
  • 22
    • 0027233773 scopus 로고
    • Treatment for glaucoma: Adherence by the elderly
    • Gurwitz JH, Glynn RJ, Monane M, et al. Treatment for glaucoma: adherence by the elderly. Am J Public Health 1993; 83:711-716.
    • (1993) Am J Public Health , vol.83 , pp. 711-716
    • Gurwitz, J.H.1    Glynn, R.J.2    Monane, M.3
  • 23
    • 26844475953 scopus 로고    scopus 로고
    • Persistence and adherence with topical glaucoma therapy
    • Nordstrom BL, Friedman DS, Mozaffari E, et al. Persistence and adherence with topical glaucoma therapy. Am J Ophthalmol 2005; 140:598-606.
    • (2005) Am J Ophthalmol , vol.140 , pp. 598-606
    • Nordstrom, B.L.1    Friedman, D.S.2    Mozaffari, E.3
  • 24
    • 84862299475 scopus 로고    scopus 로고
    • Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes
    • Loch C, Zakelj S, Kristl A, et al. Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes. Eur J Pharm Sci 2012; 47:131-138.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 131-138
    • Loch, C.1    Zakelj, S.2    Kristl, A.3
  • 25
    • 0032006756 scopus 로고    scopus 로고
    • Evaluation of microdialysis sampling of aqueous humor for in vivo models of ocular absorption and disposition
    • Rittenhouse KD, Peiffer RL Jr., Pollack GM. Evaluation of microdialysis sampling of aqueous humor for in vivo models of ocular absorption and disposition. J Pharm Biomed Anal 1998; 16:951-959.
    • (1998) J Pharm Biomed Anal , vol.16 , pp. 951-959
    • Rittenhouse, K.D.1    Peiffer Jr., R.L.2    Pollack, G.M.3
  • 26
    • 0037130557 scopus 로고    scopus 로고
    • Thermosetting gels with modulated gelation temperature for ophthalmic use: The rheological and gamma scintigraphic studies
    • Wei G, Xu H, Ding PT, et al. Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies. J Control Release 2002; 83:65-74.
    • (2002) J Control Release , vol.83 , pp. 65-74
    • Wei, G.1    Xu, H.2    Ding, P.T.3
  • 27
    • 0842283719 scopus 로고    scopus 로고
    • Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
    • Hamalainen KM, Kananen K, Auriola S, et al. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera. Invest Ophthalmol Vis Sci 1997; 38:627-634.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 627-634
    • Hamalainen, K.M.1    Kananen, K.2    Auriola, S.3
  • 28
    • 79955996386 scopus 로고    scopus 로고
    • Novel drug delivery systems for glaucoma
    • Lavik E, Kuehn MH, Kwon YH. Novel drug delivery systems for glaucoma. Eye (Lond) 2011; 25:578-586.
    • (2011) Eye (Lond) , vol.25 , pp. 578-586
    • Lavik, E.1    Kuehn, M.H.2    Kwon, Y.H.3
  • 29
    • 31444441466 scopus 로고    scopus 로고
    • Pharmacokinetics of timolol in aqueous humor sampled by microdialysis after topical administration of thermosetting gels
    • Wei G, Ding PT, Zheng JM, Lu WY. Pharmacokinetics of timolol in aqueous humor sampled by microdialysis after topical administration of thermosetting gels. Biomed Chromatogr 2006; 20:67-71.
    • (2006) Biomed Chromatogr , vol.20 , pp. 67-71
    • Wei, G.1    Ding, P.T.2    Zheng, J.M.3    Lu, W.Y.4
  • 31
    • 79952984499 scopus 로고    scopus 로고
    • A randomized trial of brimonidine versus timolol in preserving visual function: Results from the low-pressure glaucoma treatment study
    • Krupin T, Liebmann JM, Greenfield DS, et al. A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol 2011; 151:671-681.
    • (2011) Am J Ophthalmol , vol.151 , pp. 671-681
    • Krupin, T.1    Liebmann, J.M.2    Greenfield, D.S.3
  • 32
    • 84857236328 scopus 로고    scopus 로고
    • Clinical trials for glaucoma neuroprotection are not impossible
    • Quigley HA. Clinical trials for glaucoma neuroprotection are not impossible. Curr Opin Ophthalmol 2012; 23:144-154.
    • (2012) Curr Opin Ophthalmol , vol.23 , pp. 144-154
    • Quigley, H.A.1
  • 33
    • 0033058028 scopus 로고    scopus 로고
    • Distribution of cyclosporin a in ocular tissues after topical administration to albino rabbits and beagle dogs
    • Acheampong AA, Shackleton M, Tang-Liu DD, et al. Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs. Curr Eye Res 1999; 18:91-103.
    • (1999) Curr Eye Res , vol.18 , pp. 91-103
    • Acheampong, A.A.1    Shackleton, M.2    Tang-Liu, D.D.3
  • 34
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular agerelated macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular agerelated macular degeneration. N Engl J Med 2006; 355:1419-1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 35
    • 84861316754 scopus 로고    scopus 로고
    • Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo
    • Sunshine JC, Sunshine SB, Bhutto I, et al. Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo. PLoS One 2012; 7:e37543.
    • (2012) PLoS One , vol.7
    • Sunshine, J.C.1    Sunshine, S.B.2    Bhutto, I.3
  • 36
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (sln) and nanostructured lipid carriers (nlc) in cosmetic and dermatological preparations
    • [Review]
    • Muller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002; 54 (Suppl. 1):S131-S155. [Review].
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.SUPPL. 1
    • Muller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 37
    • 79954531802 scopus 로고    scopus 로고
    • Polymeric vectors for ocular gene delivery
    • This review compares nanoparticles and viruses as gene delivery vectors
    • Tamboli V, Mishra GP, Mitrat AK. Polymeric vectors for ocular gene delivery. Ther Deliv 2011; 2:523-536. This review compares nanoparticles and viruses as gene delivery vectors.
    • (2011) Ther Deliv , vol.2 , pp. 523-536
    • Tamboli, V.1    Mishra, G.P.2    Mitrat, A.K.3
  • 39
    • 34250367839 scopus 로고    scopus 로고
    • Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides
    • Chen J, Patil S, Seal S, McGinnis JF. Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol 2006; 1:142-150.
    • (2006) Nat Nanotechnol , vol.1 , pp. 142-150
    • Chen, J.1    Patil, S.2    Seal, S.3    McGinnis, J.F.4
  • 40
    • 0029360414 scopus 로고
    • The controlled intravenous delivery of drugs using peg-coated sterically stabilized nanospheres
    • Gref R, Domb A, Quellec P, et al. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev 1995; 19:215-233.
    • (1995) Adv Drug Deliv Rev , vol.19 , pp. 215-233
    • Gref, R.1    Domb, A.2    Quellec, P.3
  • 41
    • 84866880263 scopus 로고    scopus 로고
    • Increased brain uptake of docetaxel and ketoconazole loaded folate-grafted solid lipid nanoparticles
    • (in press
    • Venishetty VK, Komuravelli R, Kuncha M, et al. Increased brain uptake of docetaxel and ketoconazole loaded folate-grafted solid lipid nanoparticles. Nanomed 2012 (in press).
    • (2012) Nanomed
    • Venishetty, V.K.1    Komuravelli, R.2    Kuncha, M.3
  • 42
    • 79955583887 scopus 로고    scopus 로고
    • Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier
    • Tosi G, Fano RA, Bondioli L, et al. Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier. Nanomed 2011; 6:423-436.
    • (2011) Nanomed , vol.6 , pp. 423-436
    • Tosi, G.1    Fano, R.A.2    Bondioli, L.3
  • 43
    • 33750383647 scopus 로고    scopus 로고
    • Luteinizing hormonereleasing hormone agonist and transferrin functionalizations enhance nanoparticle delivery in a novel bovine ex vivo eye model
    • Kompella UB, Sundaram S, Raghava S, Escobar ER. Luteinizing hormonereleasing hormone agonist and transferrin functionalizations enhance nanoparticle delivery in a novel bovine ex vivo eye model. Mol Vis 2006; 12:1185-1198.
    • (2006) Mol Vis , vol.12 , pp. 1185-1198
    • Kompella, U.B.1    Sundaram, S.2    Raghava, S.3    Escobar, E.R.4
  • 44
    • 0035859983 scopus 로고    scopus 로고
    • Chitosan nanoparticles: A new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin a
    • De Campos AM, Sanchez A, Alonso MJ. Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A. Int J Pharm 2001; 224:159-168.
    • (2001) Int J Pharm , vol.224 , pp. 159-168
    • De Campos, A.M.1    Sanchez, A.2    Alonso, M.J.3
  • 45
    • 84866499684 scopus 로고    scopus 로고
    • Chitosan coated sodium alginate-chitosan nanoparticles loaded with 5-fu for ocular delivery: In vitro characterization and in vivo study in rabbit eye
    • In this article, adding sodium alginate to chitosan nanoparticles doubled the rabbit aqueous humor bioavailability of the pyrimidine analog 5-fluorouracil. This modification demonstrates the potential value of increasing drug mucoadhesiveness to and persistence at the cornea
    • Nagarwal RC, Kumar R, Pandit JK. Chitosan coated sodium alginate-chitosan nanoparticles loaded with 5-FU for ocular delivery: in vitro characterization and in vivo study in rabbit eye. Eur J Pharm Sci 2012; 47:678-685. In this article, adding sodium alginate to chitosan nanoparticles doubled the rabbit aqueous humor bioavailability of the pyrimidine analog 5-fluorouracil. This modification demonstrates the potential value of increasing drug mucoadhesiveness to and persistence at the cornea.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 678-685
    • Nagarwal, R.C.1    Kumar, R.2    Pandit, J.K.3
  • 46
    • 77951111096 scopus 로고    scopus 로고
    • Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: Development, characterization, and evaluation
    • Wadhwa S, Paliwal R, Paliwal SR, Vyas SP. Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluation. J Drug Target 2010; 18:292-302.
    • (2010) J Drug Target , vol.18 , pp. 292-302
    • Wadhwa, S.1    Paliwal, R.2    Paliwal, S.R.3    Vyas, S.P.4
  • 47
    • 83555173189 scopus 로고    scopus 로고
    • Brimonidine tartrate-eudragit longacting nanoparticles: Formulation, optimization, in vitro and in vivo evaluation
    • Here, the authors optimized the characteristics of Eudragit nanoparticles for releasing the drug brimonidine. The optimal Eudragit nanoparticles increased drug half-life in the cornea and produced a 72-h reduction of IOP in rabbits, significantly longer than the 8 h achieved by the unmodified drug
    • Bhagav P, Upadhyay H, Chandran S. Brimonidine tartrate-eudragit longacting nanoparticles: formulation, optimization, in vitro and in vivo evaluation. AAPS PharmSciTech 2011; 12:1087-1101. Here, the authors optimized the characteristics of Eudragit nanoparticles for releasing the drug brimonidine. The optimal Eudragit nanoparticles increased drug half-life in the cornea and produced a 72-h reduction of IOP in rabbits, significantly longer than the 8 h achieved by the unmodified drug.
    • (2011) AAPS PharmSciTech , vol.12 , pp. 1087-1101
    • Bhagav, P.1    Upadhyay, H.2    Chandran, S.3
  • 48
    • 84864119719 scopus 로고    scopus 로고
    • Influence of choroidal neovascularization and biodegradable polymeric particle size on transscleral sustained delivery of triamcinolone acetonide
    • This study demonstrated that microspheres injected subconjuctivally in rats lasted for 2 months in that location, releasing drug in ocular structures
    • Kadam RS, Tyagi P, Edelhauser HF, Kompella UB. Influence of choroidal neovascularization and biodegradable polymeric particle size on transscleral sustained delivery of triamcinolone acetonide. Int J Pharm 2012; 434:140-147. This study demonstrated that microspheres injected subconjuctivally in rats lasted for 2 months in that location, releasing drug in ocular structures.
    • (2012) Int J Pharm , vol.434 , pp. 140-147
    • Kadam, R.S.1    Tyagi, P.2    Edelhauser, H.F.3    Kompella, U.B.4
  • 49
    • 57849105925 scopus 로고    scopus 로고
    • Sustained delivery of timolol maleate from poly(lactic-co-glycolic acid)/poly(lactic acid) microspheres for over 3 months
    • Bertram JP, Saluja SS, McKain J, Lavik EB. Sustained delivery of timolol maleate from poly(lactic-co-glycolic acid)/poly(lactic acid) microspheres for over 3 months. J Microencapsul 2009; 26:18-26.
    • (2009) J Microencapsul , vol.26 , pp. 18-26
    • Bertram, J.P.1    Saluja, S.S.2    McKain, J.3    Lavik, E.B.4
  • 50
    • 34250165054 scopus 로고    scopus 로고
    • Fabrication and characterization of contact lenses bearing surface-immobilized layers of intact liposomes
    • Danion A, Brochu H, Martin Y, Vermette P. Fabrication and characterization of contact lenses bearing surface-immobilized layers of intact liposomes. J Biomed Mater Res A 2007; 82:41-51.
    • (2007) J Biomed Mater Res A , vol.82 , pp. 41-51
    • Danion, A.1    Brochu, H.2    Martin, Y.3    Vermette, P.4
  • 51
    • 80855130893 scopus 로고    scopus 로고
    • Retinal ganglion cells survival in a glaucoma model by gdnf/vit e plga microspheres prepared according to a novel microencapsulation procedure
    • In this study, GDNF neuroprotection in rat RGCs was prolonged for several months using a novel microsphere formulation that protects and slowly releases this neurotrophic factor
    • Checa-Casalengua P, Jiang C, Bravo-Osuna I, et al. Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure. J Control Release 2011; 156:92-100. In this study, GDNF neuroprotection in rat RGCs was prolonged for several months using a novel microsphere formulation that protects and slowly releases this neurotrophic factor.
    • (2011) J Control Release , vol.156 , pp. 92-100
    • Checa-Casalengua, P.1    Jiang, C.2    Bravo-Osuna, I.3
  • 52
    • 34848928410 scopus 로고    scopus 로고
    • Intravitreal injections of gdnf-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma
    • Jiang C, Moore MJ, Zhang X, et al. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Mol Vis 2007; 13:1783-1792.
    • (2007) Mol Vis , vol.13 , pp. 1783-1792
    • Jiang, C.1    Moore, M.J.2    Zhang, X.3
  • 53
    • 78449253233 scopus 로고    scopus 로고
    • Engineered superparamagnetic mn0.5zn0.5fe2o4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma
    • The goal of this study was to induce heat shock proteins to protect RGCs from degeneration. The authors optimize metallic nanoparticles for producing controlled heat when a magnetic field is applied, and demonstrate that after intravitreal injection in rats the nanoparticle distribution is close enough to induce hyperthermia inRGCs
    • Jeun M, Jeoung JW, Moon S, et al. Engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma. Biomaterials 2011; 32:387-394. The goal of this study was to induce heat shock proteins to protect RGCs from degeneration. The authors optimize metallic nanoparticles for producing controlled heat when a magnetic field is applied, and demonstrate that after intravitreal injection in rats the nanoparticle distribution is close enough to induce hyperthermia inRGCs.
    • (2011) Biomaterials , vol.32 , pp. 387-394
    • Jeun, M.1    Jeoung, J.W.2    Moon, S.3
  • 54
    • 0025845010 scopus 로고
    • Hyperthermia-induced neuronal protection against ischemic injury in gerbils
    • Kitagawa K, Matsumoto M, Tagaya M, et al. Hyperthermia-induced neuronal protection against ischemic injury in gerbils. J Cereb Blood Flow Metab 1991; 11:449-452.
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 449-452
    • Kitagawa, K.1    Matsumoto, M.2    Tagaya, M.3
  • 55
    • 79952062512 scopus 로고    scopus 로고
    • Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the vldlr knockout mouse
    • The authors took advantage of the antioxidant properties of cerium oxide nanoparticles to revert the retinal neovascularization in Vldlr knockout mice
    • Zhou X, Wong LL, Karakoti AS, et al. Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse. PLoS One 2011; 6:e16733. The authors took advantage of the antioxidant properties of cerium oxide nanoparticles to revert the retinal neovascularization in Vldlr knockout mice.
    • (2011) PLoS One , vol.6
    • Zhou, X.1    Wong, L.L.2    Karakoti, A.S.3
  • 56
    • 24344461732 scopus 로고    scopus 로고
    • Glaucoma: Thinking in new ways-A role for autonomous axonal self-destruction and other compartmentalised processes
    • Whitmore AV, Libby RT, John SW. Glaucoma: thinking in new ways-a role for autonomous axonal self-destruction and other compartmentalised processesProg Retin Eye Res 2005; 24:639-662.
    • (2005) Prog Retin Eye Res , vol.24 , pp. 639-662
    • Whitmore, A.V.1    Libby, R.T.2    John, S.W.3
  • 57
    • 0034078885 scopus 로고    scopus 로고
    • The relationship between neuronal survival and regeneration
    • Goldberg JL, Barres BA. The relationship between neuronal survival and regeneration. Annu Rev Neurosci 2000; 23:579-612.
    • (2000) Annu Rev Neurosci , vol.23 , pp. 579-612
    • Goldberg, J.L.1    Barres, B.A.2
  • 59
    • 79954644136 scopus 로고    scopus 로고
    • Nonarteritic anterior ischemic optic neuropathy (naion) and its experimental models
    • Bernstein SL, Johnson MA, Miller NR. Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models. Prog Retin Eye Res 2011; 30:167-187.
    • (2011) Prog Retin Eye Res , vol.30 , pp. 167-187
    • Bernstein, S.L.1    Johnson, M.A.2    Miller, N.R.3
  • 60
    • 84876290194 scopus 로고    scopus 로고
    • A novel rodent model of posterior ischemic optic neuropathy
    • Wang Y, Brown DPJ, Duan Y, et al. A novel rodent model of posterior ischemic optic neuropathy. Arch Ophthalmol 2012; 8:1-11.
    • (2012) Arch Ophthalmol , vol.8 , pp. 1-11
    • Wang, Y.1    Brown, D.P.J.2    Duan, Y.3
  • 61
  • 62
    • 84860607089 scopus 로고    scopus 로고
    • Advances in glaucoma treatment and management: Gene therapy
    • Borras T. Advances in glaucoma treatment and management: gene therapy. Invest Ophthalmol Vis Sci 2012; 53:2506-2510.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 2506-2510
    • Borras, T.1
  • 63
    • 79955954680 scopus 로고    scopus 로고
    • Aav and compacted dna nanoparticles for the treatment of retinal disorders: Challenges and future prospects
    • Han Z, Conley SM, Naash MI. AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects. Invest Ophthalmol Vis Sci 2011; 52:3051-3059.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 3051-3059
    • Han, Z.1    Conley, S.M.2    Naash, M.I.3
  • 64
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55:329-347.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 329-347
    • Panyam, J.1    Labhasetwar, V.2
  • 65
    • 84862782522 scopus 로고    scopus 로고
    • The movement of self assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection
    • This article demonstrates that the retinal distribution of intravitreally injected nanoparticles depends on the nature of their chemical structures
    • Koo H, Moon H, Han H, et al. The movement of self assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection. Biomaterials 2012; 33:3485-3493. This article demonstrates that the retinal distribution of intravitreally injected nanoparticles depends on the nature of their chemical structures.
    • (2012) Biomaterials , vol.33 , pp. 3485-3493
    • Koo, H.1    Moon, H.2    Han, H.3
  • 66
    • 68049142424 scopus 로고    scopus 로고
    • Nanoparticle mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage
    • Park K, Chen Y, Hu Y, et al. Nanoparticle mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage. Diabetes 2009; 58:1902-1913.
    • (2009) Diabetes , vol.58 , pp. 1902-1913
    • Park, K.1    Chen, Y.2    Hu, Y.3
  • 67
    • 82755168821 scopus 로고    scopus 로고
    • Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth
    • This study demonstrates that 50nm iron oxide nanoparticles functionalized with an agonist trkB antibody are endocytosed by rat RGCs in vitro and in vivo after intravitreal injection and can be used to modulate axon growth when a magnetic field is applied
    • Steketee MB, Moysidis SN, Jin XL, et al. Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth. Proc Natl Acad Sci USA 2011; 108:19042-19047. This study demonstrates that 50nm iron oxide nanoparticles functionalized with an agonist trkB antibody are endocytosed by rat RGCs in vitro and in vivo after intravitreal injection and can be used to modulate axon growth when a magnetic field is applied.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19042-19047
    • Steketee, M.B.1    Moysidis, S.N.2    Jin, X.L.3
  • 68
    • 34248570405 scopus 로고    scopus 로고
    • Efficient nonviral ocular gene transfer with compacted dna nanoparticles
    • Farjo R, Skaggs J, Quiambao AB, et al. Efficient nonviral ocular gene transfer with compacted DNA nanoparticles. PLoS One 2006; 1:e38.
    • (2006) PLoS One , vol.1
    • Farjo, R.1    Skaggs, J.2    Quiambao, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.