Influence of choroidal neovascularization and biodegradable polymeric particle size on transscleral sustained delivery of triamcinolone acetonide

International Journal of Pharmaceutics

Volumn 434, Issue 1-2, 2012, Pages 140-147

  Kadam, Rajendra S ^a   Tyagi, Puneet ^a   Edelhauser, Henry F ^b   Kompella, Uday B ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b EMORY EYE CENTER   (United States)

Author keywords

Choroidal neovascularization; Microparticles; Nanoparticles; Triamcinolone acetonide

Indexed keywords

POLYLACTIDE; TRIAMCINOLONE ACETONIDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG RELEASE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SCANNING ELECTRON MICROSCOPY; SUBRETINAL NEOVASCULARIZATION; SURFACE PROPERTY; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, OPHTHALMIC; ANIMALS; CELL LINE; CHOROIDAL NEOVASCULARIZATION; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; GLUCOCORTICOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICROSPHERES; NANOPARTICLES; PARTICLE SIZE; POLYESTERS; RATS; RATS, INBRED BN; RETINAL PIGMENT EPITHELIUM; SCLERA; TIME FACTORS; TISSUE DISTRIBUTION; TRIAMCINOLONE ACETONIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864119719     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.05.025     Document Type: Article

References (33)

1. A.C. Amrite, S.P. Ayalasomayajula, N.P. Cheruvu, and U.B. Kompella Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage Invest. Ophthalmol. Vis. Sci. 47 2006 1149 1160
2. S.P. Ayalasomayajula, P. Ashton, and U.B. Kompella Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-alpha-induced angiogenesis in chick chorioallantoic membrane (CAM) J. Ocul. Pharmacol. Ther. 25 2009 97 103
3. N.P. Cheruvu, A.C. Amrite, and U.B. Kompella Effect of eye pigmentation on transscleral drug delivery Invest. Ophthalmol. Vis. Sci. 49 2008 333 341
4. N.P. Cheruvu, A.C. Amrite, and U.B. Kompella Effect of diabetes on transscleral delivery of celecoxib Pharm. Res. 26 2009 404 414
5. H.S. Chin, T.S. Park, Y.S. Moon, and J.H. Oh Difference in clearance of intravitreal triamcinolone acetonide between vitrectomized and nonvitrectomized eyes Retina 25 2005 556 560
6. E.T. Dobi, C.A. Puliafito, and M. Destro A new model of experimental choroidal neovascularization in the rat Arch. Ophthalmol. 107 1989 264 269
7. X. Dong, Y.S. Wang, G.R. Dou, H.Y. Hou, Y.Y. Shi, R. Zhang, K. Ma, L. Wu, L.B. Yao, Y. Cai, and J. Zhang Influence of Dll4 via HIF-1alpha-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions PLoS One 6 2011 e18481
8. J.E. Grunwald, S.M. Hariprasad, J. DuPont, M.G. Maguire, S.L. Fine, A.J. Brucker, A.M. Maguire, and A.C. Ho Foveolar choroidal blood flow in age-related macular degeneration Invest. Ophthalmol. Vis. Sci. 39 1998 385 390
9. J.E. Grunwald, T.I. Metelitsina, J.C. Dupont, G.S. Ying, and M.G. Maguire Reduced foveolar choroidal blood flow in eyes with increasing AMD severity Invest. Ophthalmol. Vis. Sci. 46 2005 1033 1038
10. M.E. Hartnett, A. Lappas, D. Darland, J.R. McColm, S. Lovejoy, and P.A. D'Amore Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism Exp. Eye Res. 77 2003 593 599
11. R.D. Jager, W.F. Mieler, and J.W. Miller Age-related macular degeneration N. Engl. J. Med. 358 2008 2606 2617
12. J.B. Jonas, I. Kreissig, and R. Degenring Repeated intravitreal injections of triamcinolone acetonide as treatment of progressive exudative age-related macular degeneration Graefes Arch. Clin. Exp. Ophthalmol. 240 2002 873 874
13. R.S. Kadam, and U.B. Kompella Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve J. Pharmacol. Exp. Ther. 332 2010 1107 1120
14. U.B. Kompella, N. Bandi, and S.P. Ayalasomayajula Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression Invest. Ophthalmol. Vis. Sci. 44 2003 1192 1201
15. U.B. Kompella, R.S. Kadam, and V.H. Lee Recent advances in ophthalmic drug delivery Ther. Deliv. 1 2010 435 456
16. N. Kwak, N. Okamoto, J.M. Wood, and P.A. Campochiaro VEGF is major stimulator in model of choroidal neovascularization Invest. Ophthalmol. Vis. Sci. 41 2000 3158 3164
17. C. Lecaroz, C. Gamazo, M.J. Renedo, and M.J. Blanco-Prieto Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin J. Microencapsul. 23 2006 782 792
18. J.W. Miller Vascular endothelial growth factor and ocular neovascularization Am. J. Pathol. 151 1997 13 23
19. V.J. Mohanraj, and Y. Chen Nanoparticles - a review Trop. J. Pharm. Res. 5 2006 561 573
20. J.Z. Nowak Age-related macular degeneration (AMD): pathogenesis and therapy Pharmacol. Rep. 58 2006 353 363
21. J.Z. Nowak, and W. Bienias Age-related macular degeneration (AMD): etiopathogenesis and therapeutic strategies Postepy. Hig. Med. Dosw. (Online) 61 2007 83 94
22. A. Ozkiris, and K. Erkilic Complications of intravitreal injection of triamcinolone acetonide Can. J. Ophthalmol. 40 2005 63 68
23. S. Raghava, M. Hammond, and U.B. Kompella Periocular routes for retinal drug delivery Expert. Opin. Drug Deliv. 1 2004 99 114
24. H.M. Redhead, S.S. Davis, and L. Illum Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation J. Control. Release 70 2001 353 363
25. M.R. Robinson, S.S. Lee, H. Kim, S. Kim, R.J. Lutz, C. Galban, P.M. Bungay, P. Yuan, N.S. Wang, J. Kim, and K.G. Csaky A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide Exp. Eye Res. 82 2006 479 487
26. F.C. Schlichtenbrede, W. Mittmann, F. Rensch, F. Vom Hagen, J.B. Jonas, and T. Euler Toxicity assessment of intravitreal triamcinolone and bevacizumab in a retinal explant mouse model using two-photon microscopy Invest. Ophthalmol. Vis. Sci. 50 2009 5880 5887
27. C.P. Shah, S.J. Garg, J.F. Vander, G.C. Brown, R.S. Kaiser, and J.A. Haller Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents Ophthalmology 118 2011 2028 2034
28. N. Shelke, R. Kadam, P. Tyagi, V. Rao, and U. Kompella Intravitreal poly(l-lactide) microparticles sustain retinal and choroidal delivery of TG-0054, a hydrophilic drug intended for neovascular diseases Drug Deliv. Trans. Res. 1 2011 76 90
29. K. Spilsbury, K.L. Garrett, W.Y. Shen, I.J. Constable, and P.E. Rakoczy Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization Am. J. Pathol. 157 2000 135 144
30. G. Sunkara, and U.B. Kompella Membrane transport processes in the eye Ophthalmic drug Delivery Systems 2003 Marcel Dekker Inc. New York
31. A. Thakur, R.S. Kadam, and U.B. Kompella Influence of drug solubility and lipophilicity on transscleral retinal delivery of six corticosteroids Drug Metab. Dispos. 39 2010 771 781
32. J.P. Tong, D.S. Lam, W.M. Chan, K.W. Choy, K.P. Chan, and C.P. Pang Effects of triamcinolone on the expression of VEGF and PEDF in human retinal pigment epithelial and human umbilical vein endothelial cells Mol. Vis. 12 2006 1490 1495
33. Y. Yeo, and K. Park Control of encapsulation efficiency and initial burst in polymeric microparticle systems Arch. Pharm. Res. 27 2004 1 12