Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 1, 2012, Pages 131-138

  Loch, Christian ^a   Zakelj, Simon ^b   Kristl, Albin ^b   Nagel, Stefan ^a   Guthoff, Rudolf ^c   Weitschies, Werner ^a   Seidlitz, Anne ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Ophthalmic implants; Ophthalmic tissues; Permeability coefficient; Side by side diffusion chambers; Ussing chamber

Indexed keywords

AGENTS ACTING ON THE EYE; CIPROFLOXACIN; LIDOCAINE; TIMOLOL MALEATE;

ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CORNEA; COW; DRUG ABSORPTION; DRUG DIFFUSION; DRUG PENETRATION; IMPLANT; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCLERA; SWINE;

ANIMALS; CATTLE; CHOROID; CONJUNCTIVA; CORNEA; DIFFUSION; EYE; EYE DISEASES; OPHTHALMIC SOLUTIONS; PERMEABILITY; RABBITS; RETINA; SCLERA; SWINE; TISSUE DISTRIBUTION;

EID: 84862299475     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.05.007     Document Type: Article

References (44)

1. I. Ahmed, and T.F. Patton Importance of the noncorneal absorption route in topical ophthalmic drug delivery Invest. Ophth. Vis. Sci. 26 1985 584 587
2. M. Ali, S. Horikawa, S. Venkatesh, J. Saha, J.W. Hong, and M.E. Byrne Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow J. Control. Release 124 2007 154 162
3. J. Ambati, C.S. Canakis, J.W. Miller, E.S. Gragoudas, A. Edwards, D.J. Weissgold, I. Kim, F.C. Delori, and A.P. Adamis Diffusion of high molecular weight compounds through sclera Invest. Ophth. Vis. Sci. 41 2000 1181 1185
4. J. Barar, M. Asadi, S. Abdolreza, Mortazavi-Tabatabaei, and Y. Omidi Ocular drug delivery; impact of in vitro cell culture models J. Ophthalmic Vis. Res. 4 2009
5. O. Camber, and P. Edman Influence of some preservatives on the corneal permeability of pilocarpine and dexamethasone, in vitro Int. J. Pharm. 39 1987 229 234
6. O.A. Candia, and L.J. Alvarez Overview of electrolyte and fluid transport across the conjunctiva A.D. Darlene, Encyclopedia of the Eye 2010 Academic Press Oxford 252 260
7. E.P.Y. Choy, T.S.S. To, P. Cho, I.F.F. Benzie, and C.K.M. Choy Viability of porcine corneal epithelium ex vivo and effect of exposure to air: a pilot study for a dry eye model Cornea 23 2004 715 719
8. J. Crank The Mathematics of Diffusion 1979 Oxford University Press
9. M.J. Doughty, S. Petrou, and H. Macmillan Anatomy and morphology of the cornea of bovine eyes from a slaughterhouse Can. J. Zool. 73 1995 2159 2165
10. B.C. Gilger, J.H. Salmon, D.A. Wilkie, L.P. Cruysberg, J. Kim, M. Hayat, H. Kim, S. Kim, P. Yuan, S.S. Lee, S.M. Harrington, P.R. Murray, H.F. Edelhauser, K.G. Csaky, and M.R. Robinson A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis Invest. Ophth. Vis. Sci. 47 2006 2596 2605
11. I. Goldberg, G. Moloney, and P. McCluskey Topical ophthalmic medications: what potential for systemic side effects and interactions with other medications? Med. J. Aust. 189 2008 356 357
12. A. Gwon The rabbit in cataract/IOL surgery A.T. Panagiotis, Animal Models in Eye Research 2008 Academic Press London 184 204
13. J.A. Haller, F. Bandello, R. Belfort Jr, M.S. Blumenkranz, M. Gillies, J. Heier, A. Loewenstein, Y.-H. Yoon, M.-L. Jacques, J. Jiao, X.-Y. Li, and S.M. Whitcup Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion Ophthalmology 117 2010 1134 1146 (e1133)
14. H. Hiratani, A. Fujiwara, Y. Tamiya, Y. Mizutani, and C. Alvarez-Lorenzo Ocular release of timolol from molecularly imprinted soft contact lenses Biomaterials 26 2005 1293 1298
15. K.-i. Hosoya, V.H.L. Lee, and K.-J. Kim Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation Eur. J. Pharm. Biopharm. 60 2005 227 240
16. R.S. Kadam, and U.B. Kompella Cassette analysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina, and vitreous by liquid chromatography-tandem mass spectrometry J. Chromatogr. B 877 2009 253 260
17. R.S. Kadam, N.P.S. Cheruvu, H.F. Edelhauser, and U.B. Kompella Sclera-Choroid-RPE transport of eight β-blockers in human, Bovine, Porcine, Rabbit, and Rat Models Invest. Ophth. Vis. Sci. 52 2011 5387 5399
18. F.E. Kane, J. Burdan, A. Cutino, and K.E. Green Iluvien™: a new sustained delivery technology for posterior eye disease Expert Opin. Drug Deliv. 5 2008 1039 1046
19. N.A. Kasim, M. Whitehouse, C. Ramachandran, M. Bermejo, H. Lennernäs, A.S. Hussain, H.E. Junginger, S.A. Stavchansky, K.K. Midha, V.P. Shah, and G.L. Amidon Molecular properties of WHO essential drugs and provisional biopharmaceutical classification Mol. Pharm. 1 2003 85 96
20. J. Kim, C.-C. Peng, and A. Chauhan Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E J. Control. Release 148 2010 110 116
21. B.D. Kuppermann Implants Can Deliver Corticosteroids, Pharmacologic Agents 2007 RETINA TODAY (March/April, p. 27-31)
22. T. Loftsson, H.H. Sigursson, F. Konrásdóttir, S. Gísladóttir, P. Jansook, and E. Stefánsson Topical drug delivery to the posterior segment of the eye: anatomical and physiological considerations Pharmazie 63 2008 171 179
23. E. Mannermaa, K.-S. Vellonen, and A. Urtti Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics Adv. Drug Deliver. Rev. 58 2006 1136 1163
24. K. Mari Hämäläinen, K. Kontturi, S. Auriola, M. Lasse, and A. Urtti Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach J. Control. Release 49 1997 97 104
25. P.G. McMenamin, and R.J. Steptoe Normal anatomy of the aqueous humour outflow system in the domestic pig eye J. Anat. 178 1991 65 77
26. A.A. Moshfeghi Endophthalmitis following intravitreal anti-vascular endothelial growth factor injections for neovascular age-related macular degeneration Semin. Ophth. 26 2011 139 148
27. D. Myung, K. Derr, P. Huie, J. Noolandi, K.P. Ta, and C.N. Ta Glucose permeability of human, bovine, and porcine corneas in vitro Ophth. Res. 38 2006 158 163
28. S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability Mol. Vis. 15 2009 259 266
29. M.E. Olivera, R.H. Manzo, H.E. Junginger, K.K. Midha, V.P. Shah, S. Stavchansky, J.B. Dressman, and D.M. Barends Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride J. Pharm. Sci. 100 2011 22 33
30. T.W. Olsen, S. Sanderson, X. Feng, and W.C. Hubbard Porcine sclera: thickness and surface area Invest. Ophth. Vis. Sci. 43 2002 2529 2532
31. J. Ostergaard, F. Ye, J. Rantanen, A. Yaghmur, S.W. Larsen, C. Larsen, and H. Jensen Monitoring lidocaine single-crystal dissolution by ultraviolet imaging J. Pharm. Sci. 100 2011 3405 3410
32. L. Pitkänen, V.-P. Ranta, H. Moilanen, and A. Urtti Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity Invest. Ophth. Vis. Sci. 46 2005 641 646
33. M.R. Prausnitz, and J.S. Noonan Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye J. Pharm. Sci. 87 1998 1479 1488
34. H.A. Quigley, and A.T. Broman The number of people with glaucoma worldwide in 2010 and 2020 Br. J. Ophthalmol. 90 2006 262 267
35. K.S. Rathore, D.R.K. Nema, and D.S.S. Sisodia Timolol maleate a gold standard drug in glaucoma used as ocular films and inserts: an overview Int. J. Pharm. Sci. Rev. Res. 3 2010 23 29
36. M.L. Reichle Complications of intravitreal steroid injections, optometry J. Am. Optom. Assoc. 76 2005 450 460
37. J. Ruiz-Ederra, M. García, M. Hernández, H. Urcola, E. Hernández-Barbáchano, J. Araiz, and E. Vecino The pig eye as a novel model of glaucoma Exp. Eye Res. 81 2005 561 569
38. S.A. Schellini, M.C. Creppe, E.A. Gregório, and C.R. Padovani Lidocaine effects on corneal endothelial cell ultrastructure Vet. Ophth. 10 2007 239 244
39. M.H.I. Shiue, A.A. Kulkarni, H.J. Gukasyan, J.B. Swisher, K.-J. Kim, and V.H.L. Lee Pharmacological modulation of fluid secretion in the pigmented rabbit conjunctiva Life Sci. 66 2000 PL105 PL111
40. B. Testa, S.D. Krämer, H. Wunderli-Allenspach, and G. Folkers Pharmacokinetic Profiling in Drug Research 2006 WILEY-VCH Weinheim
41. T.R. Thrimawithana, S. Young, C.R. Bunt, C. Green, and R.G. Alany Drug delivery to the posterior segment of the eye Drug Discov. Today 16 2011 270 277
42. S. Winterhalter, P. Ruokonen, K.H. van der Velden, U. Pleyer, and A.M. Joussen Intravitreal implantate Der. Ophthalmologe 108 2011 222 229
43. Y. Yang, P.J. Faustino, D.A. Volpe, C.D. Ellison, R.C. Lyon, and L.X. Yu Biopharmaceutics classification of selected β-blockers: solubility and permeability class membership Mol. Pharm. 4 2007 608 614
44. Y.H. Zhao, M.H. Abraham, J. Le, A. Hersey, C.N. Luscombe, G. Beck, B. Sherborne, and I. Cooper Rate-limited steps of human oral absorption and QSAR studies Pharmaceut. Res. 19 2002 1446 1457