Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs

Current Eye Research

Volumn 18, Issue 2, 1999, Pages 91-103

  Acheampong, Andrew A ^a   Shackleton, Martha ^a   Tang Liu, Diane D S ^a   Ding, Shulin ^a   Stern, Mike E ^a   Decker, Robert ^a  

^a ALLERGAN INC   (United States)

Author keywords

Cyclosporin; Dry eye; Ocular distribution; Ophthalmic; Pharmacokinetics; Topical administration

Indexed keywords

CASTOR OIL; CORN OIL; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CILIARY BODY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG PENETRATION; EMULSION; EYE; FEMALE; IMMUNOMODULATION; IRIS; LACRIMAL GLAND; LENS; MALE; NONHUMAN; OINTMENT; PRIORITY JOURNAL; RABBIT; SCLERA; TOPICAL DRUG ADMINISTRATION;

EID: 0033058028     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.18.2.91.5381     Document Type: Article

References (30)

1. Stern, M. E., Beuerman, R., Fox, R. L., Gao, J., Mircheff, A. K., Pflugfelder, S. (1997) The ocular surface in dry eye: a therapeutic target. Societas Ophthalmologica Europaea 11, 911-919.
2. Damato, B. E., Allan, D., Murray, S. B., Lee, W. R. (1984) Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. Br. J. Ophthalmol. 68, 674-680.
3. Pflugfelder, S. C., Wilhelmus, K. R., Osato, A. S., Matoba, A. Y., Font, R. L. (1986) The autoimmune nature of aqueous tear deficiency. J. Ophthalmol. 93, 1513-1517.
4. Wieczorek, R., Jakobiec, F. A., Sacks, E. H., Knowles, D. M. (1988) The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology, 95, 100-109
5. Palmer, S. L., Bowen, A., Green, K. (1996) Longitudinal tear study after cyclosporine in kidney transplant recipients. Ophthalmology, 103, 670-673.
6. BenEzra, D., Pe'er, J., Brodsky, M., Cohen, E. (1986) Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am. J. Ophthalmol. 101, 278-282.
7. Drosos, A. A., Skopouli, F. N., Costopoulos, J. S., Papadimitriou, C. S., Moutsopoulos, H. M. (1986) Cyclosporin A (CyA) in primary Sjögren's syndrome: a double blind study. Ann. Rheum. Dis. 45, 732-735.
8. Power, W. J., Mullaney, P., Farrell, M., Collum, L. M. (1993) Effect of topical cyclosporin A on conjunctival T cell in patients with secondary Sjögren's syndrome. Cornea 12, 507-511.
9. Belin, M. W., Bouchard, C. S., Phillips, T. M. (1990) Update on topical cyclosporin A. Background, immunology, and pharmacology. Cornea, 9, 184-195.
10. Perry, H. D., Donnenfeld, E. D., Acheampong, A., Kanellopoulos, A. J., Sforza, P. D., D'Aversa, G., Wallerstein, A., Stern, M. (1998) Topical cyclosporine A in the management of postkeratoplasty glaucoma and corticosteroid-induced ocular hypertension (CIOH) and the penetration of topical 0.5% cyclosporine A into the cornea and anterior chamber. CLAO J. 24(3), 159-165.
11. Kaswan, R. L., Salisbury, M.-A., Ward, D. A. (1989) Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops. Arch. Ophtmalmol. 107, 1210-1216.
12. Olivero, D. K., Davidson, M. G., English, R. V., Nasisse, Jamieson, V. E., Gerig, T. M. (1991) Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivits sicca in dogs. JAVMA, 199, 1039-1042.
13. Laibovitz, R. A., Solch, S., Andriano, K., O'Connell, M., Silverman, M. H. (1993) Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. Cornea, 12, 311-323.
14. Alba, R. M., Kanai, A., Takano, T., Kobayashi, C., Narkayima, A., Kurihara, K., Fukami, M. (1989) The effect on the cornea of various vehicles for cyclosporin eye drops. Folia. Ophthalmol. Jpn. 40, 902-908.
15. Angelov, O., Wiese, A., Andersen, J., Acheampong, A., Yuan, Y.-D., Brar, B. (1997) Safety assessment of cyclosporine ophthalmic emulsion in rabbits and dogs. XIth Cong of Eur. Soc. of Ophthalmol. 11, 25-28.
16. Kaswan, R. L. (1988) Intraocular penetration of topically applied cyclosporine. Transplant Proc. 20, 650-665.
17. Wiederholt, M., Kössendrup, D., Schulz, W., Hoffman, F. (1986) Pharmacokinetics of topical cyclosporin A in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 27, 519-524.
18. Acheampong, A. A., Tang-Liu, D. D.-S., Shackleton, M., Lam, S., Angelov, O., Ding, S. (1996) Ocular absorption of cyclosporine from an aqueous emulsion: comparison to other eyedrop formulations. Invest. Ophthalmol. Vis. Sci. 37, S1026. Abstract.
19. Acheampong, A., Shackleton, M., Lam, S., Rudewicz, P., Tang-Liu, D. D.-S. (1996) Cyclosporine distribution into the conjunctiva, cornea, lacrimal gland, and systemic blood following topical dosing of cyclosporine to rabbit, dog and human eyes. Second International Conference on the Lacrimal Gland, Tear film, and Dry Eye Syndromes 2, 179. Abstract.
20. Ding, S., Olejnik, O. (1997) Cyclosporine ophthalmic oil/water emulsions. Formulation and characterization. Pharm Res 14, S41. Abstract.
21. Guillon, J. P. (1986) Tear film structures and contact lenses. In: Holly FJ, ed. The preocular tear film. Lubbock, TX. Dry Eye Institute: chap 3.
22. Acheampong, A. A., Chien, D.-S., Lam, S., Vekich, S., Breau, A., Usansky, J., Harcourt, D., Munk, S. A., Nguyen, H., Garst, M., Tang-Liu, D. (1996) Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human tween fractions and rabbit liver aldyhyde oxidase. Xenobiotica, 26(10), 1035-1055.
23. Bertault-Peres, P., Bonfils, C., Fabre, G., Just, S., Cano, J.-P., Maurel, P. (1987) Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes. Drug Metab. Dispos. 15, 391-398
24. Maurer, G., Loosil, H. R., Schreier, E., Keller, B. (1984) Disposition of cyclosporine in several animal species. I. Structural elucidation of metabolites. Drug Metab. Dispos. 12, 120-126.
25. Calne, R. Y., White, P. J. G. (1982) The use of cyclosporin A in clinical organ grafting. Ann. Surg. 9, 330-335.
26. Task Force on Cyclosporine Monitoring. (1987) Critical issues in cyclosporine monitoring: report of the task force on cyclosporine monitoring. Clin Chem. 33(7), 1269-1288.
27. Schoenwald, R. D. (1992) Pharmacokinetics in Ocular Drug Delivery. In: Edman P. Biopharmaceutics of Ocular Drug Delivery. Ann Arbor MI: CRC Press; Chap 10.
28. Vernillet, L., Lundh, R. L., Acezat-Mispelter, F., Goizel, C., Humbert, H., Pouliquen, Y. (1991) Ocular distribution of cyclosporin A (Sandimmun-) following systemic and topical administration to rabbits. Eur. J. Drug Metab. Pharmacokin. S3, 150-158.
29. Evans, H. E. (1993) Miller's Anatomy of the Dog, 3rd ed. Philadelphia, PA: WB Sauders Co; 1038.
30. Eglitis, I. (1964) The glands. In: Prince JH. The Rabbit in Eye Research. Springfield, ILL: C. C. Thomas Co; chap 3.