Identification of key residues involved in adrenomedullin binding to the AM1 receptor

British Journal of Pharmacology

Volumn 169, Issue 1, 2013, Pages 143-155

  Watkins, H A ^a,b   Au, M ^a,b   Bobby, R ^b   Archbold, J K ^a,b   Abdul Manan, N ^c   Moore, J M ^c   Middleditch, M J ^b   Williams, G M ^a,b   Brimble, M A ^a,b   Dingley, A J ^a,b   Hay, D L ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

adrenomedullin; G protein coupled receptor; GPCR; isothermal titration calorimetry; nuclear magnetic resonance spectroscopy; RAMP; receptor binding

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN 1 RECEPTOR; ADRENOMEDULLIN RECEPTOR; ADRENOMEDULLIN[22-53]; ALANINE; CYCLIC AMP; EPITOPE; FORSKOLIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ISOTHERMAL TITRATION CALORIMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ADRENOMEDULLIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CALORIMETRY; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; EPITOPES; MAGNETIC RESONANCE IMAGING; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ADRENOMEDULLIN;

EID: 84876265651     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12118     Document Type: Article

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