Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: Identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 2, 2009, Pages 513-521

  Robinson, Samuel D ^a   Aitken, Jacqueline F ^a   Bailey, Richard J ^a   Poyner, David R ^b   Hay, Debbie L ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 3;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ADRENOMEDULLIN; AMINO ACID SEQUENCE; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CERCOPITHECUS AETHIOPS; CIRCULAR DICHROISM; COS CELLS; CYCLIC AMP; GENE EXPRESSION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PEPTIDES; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; RECEPTOR ACTIVITY-MODIFYING PROTEIN 2; RECEPTOR ACTIVITY-MODIFYING PROTEIN 3; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; TRANSFECTION;

EID: 70350434125     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.156448     Document Type: Article

References (20)

1. Bailey RJ and Hay DL (2006) Pharmacology of the human CGRP1 receptor in Cos 7 cells. Peptides 27:1367-1375. (Pubitemid 44236008)
2. Breeze AL, Harvey TS, Bazzo R, and Campbell ID (1991) Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics. Biochemistry 30:575-582.
3. Choksi T, Hay DL, Legon S, Poyner DR, Hagner S, Bloom SR, and Smith DM (2002) Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. Br J Pharmacol 136:784-792. (Pubitemid 34785721)
4. Conner AC, Hay DL, Howitt SG, Kilk K, Langel U, Wheatley M, Smith DM, and Poyner DR (2002) Interaction of calcitonin-gene-related peptide with its receptors. Biochem Soc Trans 30:451-455. (Pubitemid 35001575)
5. Eguchi S, Hirata Y, Iwasaki H, Sato K, Watanabe TX, Inui T, Nakajima K, Sakakibara S, and Marumo F (1994) Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 135:2454-2458. (Pubitemid 24377402)
6. Fritz-Six KL, Dunworth WP, Li M, and Caron KM (2008) Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest 118:40-50.
7. García MA, Martín-Santamaría S, de Pascual-Teresa B, Ramos A, Julián M, and Martínez A (2006) Adrenomedullin: a new and promising target for drug discovery. Expert Opin Ther Targets 10:303-317.
8. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, and Sexton PM (2005) Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol Pharmacol 67:1655-1665. (Pubitemid 40594165)
9. Hay DL, Howitt SG, Conner AC, Schindler M, Smith DM, and Poyner DR (2003) CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Br J Pharmacol 140:477-486. (Pubitemid 37330492)
10. Hay DL, Poyner DR, and Sexton PM (2006) GPCR modulation by RAMPs. Pharmacol Ther 109:173-197.
11. Hubbard JA, Martin SR, Chaplin LC, Bose C, Kelly SM, and Price NC (1991) Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin. Biochem J 275:785-788.
12. Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, et al. (2008) The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest 118:29-39.
13. Mimeault M, Quirion R, Dumont Y, St-Pierre S, and Fournier A (1992) Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist. J Med Chem 35:2163-2168.
14. Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, and Foord SM (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54:233-246. (Pubitemid 34575714)
15. Poyner DR, Soomets U, Howitt SG, and Langel U (1998) Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br J Pharmacol 124:1659-1666. (Pubitemid 28377097)
16. Qi T, Christopoulos G, Bailey RJ, Christopoulos A, Sexton PM, and Hay DL (2008) Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. Mol Pharmacol 74:1059-1071.
17. Roh J, Chang CL, Bhalla A, Klein C, and Hsu SY (2004) Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 279:7264-7274. (Pubitemid 38248876)
18. Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, and Christopoulos A (2006) Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs. Ann N Y Acad Sci 1070:90-104. (Pubitemid 44126627)
19. Whitmore L and Wallace BA (2004) DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data. Nucleic Acids Res 32:W668-W673. (Pubitemid 38997420)
20. Whitmore L and Wallace BA (2008) Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases. Biopolymers 89:392-400.