메뉴 건너뛰기




Volumn 19, Issue 3, 2013, Pages 254-263

Transcriptional regulatory cascades in Runx2-dependent bone development

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; BONE DEVELOPMENT; COMPLEX PROCESSES; GENE REGULATORY NETWORKS; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; PROMYELOCYTIC LEUKEMIA; TRANSCRIPTIONAL MECHANISMS;

EID: 84876213011     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2012.0527     Document Type: Review
Times cited : (268)

References (96)
  • 2
    • 0033643593 scopus 로고    scopus 로고
    • Embryonic limb mesenchyme micromass culture as an in vitro model for chondrogenesis and cartilage maturation
    • DeLise, A.M., Stringa, E., Woodward, W.A., Mello, M.A., and Tuan, R.S. Embryonic limb mesenchyme micromass culture as an in vitro model for chondrogenesis and cartilage maturation. Methods Mol Biol 137, 359, 2000.
    • (2000) Methods Mol Biol , vol.137 , pp. 359
    • Delise, A.M.1    Stringa, E.2    Woodward, W.A.3    Mello, M.A.4    Tuan, R.S.5
  • 3
    • 0029798819 scopus 로고    scopus 로고
    • Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta
    • Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R., and Boyce, B.F. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med 2, 1132, 1996.
    • (1996) Nat Med , vol.2 , pp. 1132
    • Hughes, D.E.1    Dai, A.2    Tiffee, J.C.3    Li, H.H.4    Mundy, G.R.5    Boyce, B.F.6
  • 4
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    • Weinstein, R.S., Jilka, R.L., Parfitt, A.M., and Manolagas, S.C. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102, 274, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 274
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 5
    • 0036123845 scopus 로고    scopus 로고
    • Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
    • Weinstein, R.S., Chen, J.R., Powers, C.C., Stewart, S.A., Landes, R.D., Bellido, T., et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest 109, 1041, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1041
    • Weinstein, R.S.1    Chen, J.R.2    Powers, C.C.3    Stewart, S.A.4    Landes, R.D.5    Bellido, T.6
  • 6
    • 84864876877 scopus 로고    scopus 로고
    • Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells
    • Heidari, N., Miller, A.V., Hicks, M.A., Marking, C.B., and Harada, H. Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells. Cell Death Dis 3, e349, 2012.
    • (2012) Cell Death Dis , vol.3
    • Heidari, N.1    Miller, A.V.2    Hicks, M.A.3    Marking, C.B.4    Harada, H.5
  • 7
    • 33644966988 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation
    • Phillips, J.E., Gersbach, C.A., Wojtowicz, A.M., and Garća, A.J. Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J Cell Sci 119(Pt 3), 581, 2006.
    • (2006) J Cell Sci , vol.119 , Issue.PART 3 , pp. 581
    • Phillips, J.E.1    Gersbach, C.A.2    Wojtowicz, A.M.3    Garća, A.J.4
  • 8
    • 0033662188 scopus 로고    scopus 로고
    • Cbfa1 a molecular switch in osteoblast biology
    • Ducy, P. Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 219, 461, 2000.
    • (2000) Dev Dyn , vol.219 , pp. 461
    • Ducy, P.1
  • 9
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., and Karsenty, G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747, 1997.
    • (1997) Cell , vol.89 , pp. 747
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 11
    • 0032788735 scopus 로고    scopus 로고
    • Cbfa1 is required for epithelialmesenchymal interactions regulating tooth development in mice
    • D'Souza, R.N., Aberg, T., Gaikwad, J., Cavender, A., Owen, M., Karsenty, G., et al. Cbfa1 is required for epithelialmesenchymal interactions regulating tooth development in mice. Development 126, 2911, 1999.
    • (1999) Development , vol.126 , pp. 2911
    • D'Souza, R.N.1    Aberg, T.2    Gaikwad, J.3    Cavender, A.4    Owen, M.5    Karsenty, G.6
  • 12
    • 0035831510 scopus 로고    scopus 로고
    • RUNX2 contributes to the osteoblast-specific expression of type i collagen genes
    • Kern, B., Shen, J., Starbuck, M., and Karsenty, G. RUNX2 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem 276, 7101, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 7101
    • Kern, B.1    Shen, J.2    Starbuck, M.3    Karsenty, G.4
  • 14
    • 81855184637 scopus 로고    scopus 로고
    • Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes
    • Bond, S.R., Lau, A., Penuela, S., Sampaio, A.V., Underhill, T.M., Laird, D.W., et al. Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res 26, 2911, 2011.
    • (2011) J Bone Miner Res , vol.26 , pp. 2911
    • Bond, S.R.1    Lau, A.2    Penuela, S.3    Sampaio, A.V.4    Underhill, T.M.5    Laird, D.W.6
  • 15
    • 25444473106 scopus 로고    scopus 로고
    • The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
    • Pratap, J., Javed, A., Languino, L.R., Van Wijnen, A.J., Stein, J.L., Stein, G.S., et al. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol 25, 8581, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 8581
    • Pratap, J.1    Javed, A.2    Languino, L.R.3    Van Wijnen, A.J.4    Stein, J.L.5    Stein, G.S.6
  • 16
    • 67749122133 scopus 로고    scopus 로고
    • Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene
    • Boumah, C.E., Lee, M., Selvamurugan, N., Shimizu, E., and Partridge, N.C. Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol Endocrinol 23, 1255, 2009.
    • (2009) Mol Endocrinol , vol.23 , pp. 1255
    • Boumah, C.E.1    Lee, M.2    Selvamurugan, N.3    Shimizu, E.4    Partridge, N.C.5
  • 17
    • 0035494469 scopus 로고    scopus 로고
    • Overexpression of RUNX2 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    • Liu, W., Toyosawa, S., Furuichi, T., Kanatani, N., Yoshida, C., Liu, Y., et al. Overexpression of RUNX2 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol 155, 157, 2001.
    • (2001) J Cell Biol , vol.155 , pp. 157
    • Liu, W.1    Toyosawa, S.2    Furuichi, T.3    Kanatani, N.4    Yoshida, C.5    Liu, Y.6
  • 18
    • 33748958848 scopus 로고    scopus 로고
    • Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo
    • Zhang, X., Yang, M., Lin, L., Chen, P., Ma, K.T., Zhou, C.Y., et al. Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo. Calcif Tissue Int 79, 169, 2006.
    • (2006) Calcif Tissue Int , vol.79 , pp. 169
    • Zhang, X.1    Yang, M.2    Lin, L.3    Chen, P.4    Ma, K.T.5    Zhou, C.Y.6
  • 19
    • 0032949156 scopus 로고    scopus 로고
    • Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    • Inada, M., Yasui, T., Nomura, S., Miyake, S., Deguchi, K., Himeno, M., et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 214, 279, 1999.
    • (1999) Dev Dyn , vol.214 , pp. 279
    • Inada, M.1    Yasui, T.2    Nomura, S.3    Miyake, S.4    Deguchi, K.5    Himeno, M.6
  • 20
    • 0035118709 scopus 로고    scopus 로고
    • Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    • Takeda, S., Bonnamy, J.P., Owen, M.J., Ducy, P., and Karsenty, G. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev 15, 467, 2001.
    • (2001) Genes Dev , vol.15 , pp. 467
    • Takeda, S.1    Bonnamy, J.P.2    Owen, M.J.3    Ducy, P.4    Karsenty, G.5
  • 21
    • 0030666372 scopus 로고    scopus 로고
    • RUNX2, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • Otto, F., Thornell, A.P., Crompton, T., Denzel, A., Gilmour, K.C., Rosewell, I.R., et al. RUNX2, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765, 1997.
    • (1997) Cell , vol.89 , pp. 765
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3    Denzel, A.4    Gilmour, K.C.5    Rosewell, I.R.6
  • 22
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of RUNX2 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., et al. Targeted disruption of RUNX2 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755, 1997.
    • (1997) Cell , vol.89 , pp. 755
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 23
    • 15444351110 scopus 로고    scopus 로고
    • Mutations involving the transcription factor RUNX2 cause cleidocranial dysplasia
    • Mundlos, S., Otto, F., Mundlos, C., Mulliken, J.B., Aylsworth, A.S., Albright, S., et al. Mutations involving the transcription factor RUNX2 cause cleidocranial dysplasia. Cell 89, 773, 1997.
    • (1997) Cell , vol.89 , pp. 773
    • Mundlos, S.1    Otto, F.2    Mundlos, C.3    Mulliken, J.B.4    Aylsworth, A.S.5    Albright, S.6
  • 24
    • 0034641617 scopus 로고    scopus 로고
    • A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
    • Zhang, Y.W., Yasui, N., Ito, K., Huang, G., Fujii, M., Hanai, J., et al. A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci USA 97, 10549, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10549
    • Zhang, Y.W.1    Yasui, N.2    Ito, K.3    Huang, G.4    Fujii, M.5    Hanai, J.6
  • 25
    • 33748940904 scopus 로고    scopus 로고
    • Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo
    • Selvamurugan, N., Jefcoat, S.C., Kwok, S., Kowalewski, R., Tamasi, J.A., and Partridge, N.C. Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo. J Cell Biochem 99, 545, 2006.
    • (2006) J Cell Biochem , vol.99 , pp. 545
    • Selvamurugan, N.1    Jefcoat, S.C.2    Kwok, S.3    Kowalewski, R.4    Tamasi, J.A.5    Partridge, N.C.6
  • 26
    • 20144376339 scopus 로고    scopus 로고
    • The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation
    • Schmidt, K., Schinke, T., Haberland, M., Priemel, M., Schilling, A.F., Mueldner, C., et al. The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation. J Cell Biol 168, 899, 2005.
    • (2005) J Cell Biol , vol.168 , pp. 899
    • Schmidt, K.1    Schinke, T.2    Haberland, M.3    Priemel, M.4    Schilling, A.F.5    Mueldner, C.6
  • 27
    • 33744536200 scopus 로고    scopus 로고
    • SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    • Dobreva, G., Chahrour, M., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñ as, I., et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell 125, 971, 2006.
    • (2006) Cell , vol.125 , pp. 971
    • Dobreva, G.1    Chahrour, M.2    Dautzenberg, M.3    Chirivella, L.4    Kanzler, B.5    Fariñas, I.6
  • 29
    • 33644879150 scopus 로고    scopus 로고
    • Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling
    • Lengner. C.J., Steinman, H.A., Gagnon, J., Smith, T.W., Henderson, J.E., Kream, B.E., et al. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 172, 909, 2006.
    • (2006) J Cell Biol , vol.172 , pp. 909
    • Lengner, C.J.1    Steinman, H.A.2    Gagnon, J.3    Smith, T.W.4    Henderson, J.E.5    Kream, B.E.6
  • 30
    • 77957258122 scopus 로고    scopus 로고
    • Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis
    • Teixeira, C.C., Liu, Y., Thant, L.M., Pang, J., Palmer, G., and Alikhani, M. Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem 285, 31055, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 31055
    • Teixeira, C.C.1    Liu, Y.2    Thant, L.M.3    Pang, J.4    Palmer, G.5    Alikhani, M.6
  • 31
    • 34247608645 scopus 로고    scopus 로고
    • HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes
    • Hassan, M.Q., Tare, R., Lee, S.H., Mandeville, M., Weiner, B., Montecino, M., et al. HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol 27, 3337, 2007.
    • (2007) Mol Cell Biol , vol.27 , pp. 3337
    • Hassan, M.Q.1    Tare, R.2    Lee, S.H.3    Mandeville, M.4    Weiner, B.5    Montecino, M.6
  • 32
    • 33846027131 scopus 로고    scopus 로고
    • BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    • Hassan, M.Q., Tare, R.S., Lee, S.H., Mandeville, M., Morasso, M.I., Javed, A., et al. BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem 281, 40515, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 40515
    • Hassan, M.Q.1    Tare, R.S.2    Lee, S.H.3    Mandeville, M.4    Morasso, M.I.5    Javed, A.6
  • 33
    • 27444447372 scopus 로고    scopus 로고
    • Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
    • Lee, M.H., Kim, Y.J., Yoon, W.J., Kim, J.I., Kim, B.G., Hwang, Y.S., et al. Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter. J Biol Chem 280, 35579, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 35579
    • Lee, M.H.1    Kim, Y.J.2    Yoon, W.J.3    Kim, J.I.4    Kim, B.G.5    Hwang, Y.S.6
  • 34
    • 4744340414 scopus 로고    scopus 로고
    • Dlx3 transcriptional regulation of osteoblast differentiation: Temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    • Hassan, M.Q., Javed, A., Morasso, M.I., Karlin, J., Montecino, M., Van Wijnen, A.J., et al. Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol 24, 9248, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 9248
    • Hassan, M.Q.1    Javed, A.2    Morasso, M.I.3    Karlin, J.4    Montecino, M.5    Van Wijnen, A.J.6
  • 35
    • 0033379122 scopus 로고    scopus 로고
    • The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
    • Tribioli, C., and Lufkin, T. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 126, 5699, 1999.
    • (1999) Development , vol.126 , pp. 5699
    • Tribioli, C.1    Lufkin, T.2
  • 37
    • 84864135448 scopus 로고    scopus 로고
    • Serum response factor regulates bone formation via IGF-1 and Runx2 signals
    • Chen, J., Yuan, K., Mao, X., Miano, J.M., Wu, H., and Chen, Y. Serum response factor regulates bone formation via IGF-1 and Runx2 signals. J Bone Miner Res 27, 1659, 2012.
    • (2012) J Bone Miner Res , vol.27 , pp. 1659
    • Chen, J.1    Yuan, K.2    Mao, X.3    Miano, J.M.4    Wu, H.5    Chen, Y.6
  • 38
    • 70350239862 scopus 로고    scopus 로고
    • TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment
    • Isenmann, S., Arthur, A., Zannettino, A.C., Turner, J.L., Shi, S., Glackin, C.A., et al. TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem Cells 27, 2457, 2009.
    • (2009) Stem Cells , vol.27 , pp. 2457
    • Isenmann, S.1    Arthur, A.2    Zannettino, A.C.3    Turner, J.L.4    Shi, S.5    Glackin, C.A.6
  • 39
    • 0036387218 scopus 로고    scopus 로고
    • TWIST inactivation reduces RUNX2/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts
    • Yousfi, M., Lasmoles, F., and Marie, P.J. TWIST inactivation reduces RUNX2/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts. Biochem Biophys Res Commun 297, 641, 2002.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 641
    • Yousfi, M.1    Lasmoles, F.2    Marie, P.J.3
  • 41
    • 0031021336 scopus 로고    scopus 로고
    • Mutations in TWIST, a basic helix-loop-helix transcription factor, in Sathre-Chotzen syndrome
    • Howard, T.D., Paznekas, W.A., Green, E.D., Chiang, L.C., Ma, N., Ortiz de Luna, R.I., et al. Mutations in TWIST, a basic helix-loop-helix transcription factor, in Sathre-Chotzen syndrome. Nat Genet 15, 36, 1997.
    • (1997) Nat Genet , vol.15 , pp. 36
    • Howard, T.D.1    Paznekas, W.A.2    Green, E.D.3    Chiang, L.C.4    Ma, N.5    Ortiz De Luna, R.I.6
  • 42
    • 12144288066 scopus 로고    scopus 로고
    • A twist code determines the onset of osteoblast differentiation
    • Bialek, P., Kern, B., Yang, X., Schrock, M., Sosic, D., Hong, N., et al. A twist code determines the onset of osteoblast differentiation. Dev Cell 6, 423, 2004.
    • (2004) Dev Cell , vol.6 , pp. 423
    • Bialek, P.1    Kern, B.2    Yang, X.3    Schrock, M.4    Sosic, D.5    Hong, N.6
  • 43
    • 77954889785 scopus 로고    scopus 로고
    • Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: Implication of FGFR2 signaling
    • Miraoui, H., Severe, N., Vaudin, P., Pagès, J.C., and Marie, P.J. Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling. J Cell Biochem 110, 1147, 2010.
    • (2010) J Cell Biochem , vol.110 , pp. 1147
    • Miraoui, H.1    Severe, N.2    Vaudin, P.3    Pagès, J.C.4    Marie, P.J.5
  • 44
    • 0027431005 scopus 로고
    • A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis
    • Jabs, E.W., Mü ller, U., Li, X., Ma, L., Luo, W., Haworth, I.S, et al. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75, 443, 1993.
    • (1993) Cell , vol.75 , pp. 443
    • Jabs, E.W.1    Müller, U.2    Li, X.3    Ma, L.4    Luo, W.5    Haworth, I.S.6
  • 45
    • 0034074417 scopus 로고    scopus 로고
    • Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
    • Wilkie, A.O., Tang, Z., Elanko, N., Walsh, S., Twigg, S.R., Hurst, J.A., et al. Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification. Nat Genet 24, 387, 2000.
    • (2000) Nat Genet , vol.24 , pp. 387
    • Wilkie, A.O.1    Tang, Z.2    Elanko, N.3    Walsh, S.4    Twigg, S.R.5    Hurst, J.A.6
  • 46
    • 0034029571 scopus 로고    scopus 로고
    • Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    • Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., et al. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24, 391, 2000.
    • (2000) Nat Genet , vol.24 , pp. 391
    • Satokata, I.1    Ma, L.2    Ohshima, H.3    Bei, M.4    Woo, I.5    Nishizawa, K.6
  • 47
    • 0346252654 scopus 로고    scopus 로고
    • Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault
    • Ishii, M., Merrill, A.E., Chan, Y.S., Gitelman, I., Rice, D.P., Sucov, H.M., et al. Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development 130, 6131, 2003.
    • (2003) Development , vol.130 , pp. 6131
    • Ishii, M.1    Merrill, A.E.2    Chan, Y.S.3    Gitelman, I.4    Rice, D.P.5    Sucov, H.M.6
  • 48
    • 35348884251 scopus 로고    scopus 로고
    • Msx2-/-transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis
    • Äoub, M., Lézot, F., Molla, M., Castaneda, B., Robert, B., Goubin, G., et al. Msx2-/-transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis. Bone 41, 851, 2007.
    • (2007) Bone , vol.41 , pp. 851
    • Äoub, M.1    Lézot, F.2    Molla, M.3    Castaneda, B.4    Robert, B.5    Goubin, G.6
  • 49
    • 0242664267 scopus 로고    scopus 로고
    • MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors
    • Cheng, S.L., Shao, J.S., Charlton-Kachigian, N., Loewy, A.P., and Towler, D.A. MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J Biol Chem 278, 45969, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 45969
    • Cheng, S.L.1    Shao, J.S.2    Charlton-Kachigian, N.3    Loewy, A.P.4    Towler, D.A.5
  • 50
    • 0033562384 scopus 로고    scopus 로고
    • Ectopic Msx2 overexpression inhibits and Msx2 antisense stimulates calvarial osteoblast differentiation
    • Dodig, M., Tadic, T., Kronenberg, M.S., Dacic, S., Liu, Y.H., Maxson, R., et al. Ectopic Msx2 overexpression inhibits and Msx2 antisense stimulates calvarial osteoblast differentiation. Dev Biol 209, 298, 1999.
    • (1999) Dev Biol , vol.209 , pp. 298
    • Dodig, M.1    Tadic, T.2    Kronenberg, M.S.3    Dacic, S.4    Liu, Y.H.5    Maxson, R.6
  • 51
    • 57649231166 scopus 로고    scopus 로고
    • BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation
    • Matsubara, T., Kida, K., Yamaguchi, A., Hata, K., Ichida, F., Meguro, H., et al. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 283, 29119, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 29119
    • Matsubara, T.1    Kida, K.2    Yamaguchi, A.3    Hata, K.4    Ichida, F.5    Meguro, H.6
  • 52
  • 53
    • 0027411688 scopus 로고
    • Fusion between a novel Krü ppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    • Chen, Z., Brand, N.J., Chen, A., Chen, S.J., Tong, J.H., Wang, Z.Y., et al. Fusion between a novel Krü ppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 12, 1161, 1993.
    • (1993) EMBO J , vol.12 , pp. 1161
    • Chen, Z.1    Brand, N.J.2    Chen, A.3    Chen, S.J.4    Tong, J.H.5    Wang, Z.Y.6
  • 54
    • 14844318507 scopus 로고    scopus 로고
    • The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of RUNX2
    • Ikeda, R., Yoshida, K., Tsukahara, S., Sakamoto, Y., Tanaka, H., Furukawa, K., et al. The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of RUNX2. J Biol Chem 280, 8523, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 8523
    • Ikeda, R.1    Yoshida, K.2    Tsukahara, S.3    Sakamoto, Y.4    Tanaka, H.5    Furukawa, K.6
  • 55
    • 80052313294 scopus 로고    scopus 로고
    • Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair
    • Liu, T.M., Guo, X.M., Tan, H.S., Hui, J.H., Lim, B., and Lee, E.H. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum 63, 2711, 2011.
    • (2011) Arthritis Rheum , vol.63 , pp. 2711
    • Liu, T.M.1    Guo, X.M.2    Tan, H.S.3    Hui, J.H.4    Lim, B.5    Lee, E.H.6
  • 56
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J.M., Behringer, R.R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17, 2002.
    • (2002) Cell , vol.108 , pp. 17
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6
  • 58
    • 77955084141 scopus 로고    scopus 로고
    • Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta
    • Lapunzina, P., Aglan, M., Temtamy, S., Caparró s-Mart́n, J.A., Valencia, M., Letó n, R., et al. Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. Am J Hum Genet 87, 110, 2010.
    • (2010) Am J Hum Genet , vol.87 , pp. 110
    • Lapunzina, P.1    Aglan, M.2    Temtamy, S.3    Caparrós-Mart́n, J.A.4    Valencia, M.5    Letón, R.6
  • 59
  • 61
    • 0042662937 scopus 로고
    • Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
    • Kim, S., Koga, T., Isobe, M., Kern, B.E., Yokochi, T., Chin, Y.E., et al. Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev 17, 1979, 2003.
    • (1979) Genes Dev , vol.17 , pp. 2003
    • Kim, S.1    Koga, T.2    Isobe, M.3    Kern, B.E.4    Yokochi, T.5    Chin, Y.E.6
  • 62
    • 1842457741 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    • Zaidi, S.K., SulliVan, A.J., Medina, R., Ito, Y., Van Wijnen, A.J., Stein, J.L., et al. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J 23, 790, 2004.
    • (2004) EMBO J , vol.23 , pp. 790
    • Zaidi, S.K.1    Sullivan, A.J.2    Medina, R.3    Ito, Y.4    Van Wijnen, A.J.5    Stein, J.L.6
  • 63
    • 0035947630 scopus 로고    scopus 로고
    • Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development
    • Jheon, A.H., Ganss, B., Cheifetz, S., and Sodek J. Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development. J Biol Chem 276, 18282, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 18282
    • Jheon, A.H.1    Ganss, B.2    Cheifetz, S.3    Sodek, J.4
  • 64
    • 33847648883 scopus 로고    scopus 로고
    • The suppressive effect of myeloid Elf-1-like factor (MEF) in osteogenic differentiation
    • Kim, Y.J., Kim, B.G., Lee, S.J., Lee, H.K., Lee, S.H., Ryoo, H.M., et al. The suppressive effect of myeloid Elf-1-like factor (MEF) in osteogenic differentiation. J Cell Physiol 211, 253, 2007.
    • (2007) J Cell Physiol , vol.211 , pp. 253
    • Kim, Y.J.1    Kim, B.G.2    Lee, S.J.3    Lee, H.K.4    Lee, S.H.5    Ryoo, H.M.6
  • 65
    • 33745871571 scopus 로고    scopus 로고
    • Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation
    • Hinoi, E., Fujimori, S., Wang, L., Hojo, H., Uno, K., and Yoneda, Y. Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation. J Biol Chem 281, 18015, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 18015
    • Hinoi, E.1    Fujimori, S.2    Wang, L.3    Hojo, H.4    Uno, K.5    Yoneda, Y.6
  • 66
    • 34447125073 scopus 로고    scopus 로고
    • The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the RUNX2 transcription factor thereby increasing its activity
    • Luan, Y., Yu, X.P., Xu, K., Ding, B., Yu, J., Huang, Y., et al. The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the RUNX2 transcription factor thereby increasing its activity. J Biol Chem 282, 16860, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 16860
    • Luan, Y.1    Yu, X.P.2    Xu, K.3    Ding, B.4    Yu, J.5    Huang, Y.6
  • 68
    • 0036900947 scopus 로고    scopus 로고
    • Core-binding factor beta interacts with Runx2 and is required for skeletal development
    • Yoshida, C.A., Furuichi,T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., et al. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet 32, 633, 2002.
    • (2002) Nat Genet , vol.32 , pp. 633
    • Yoshida, C.A.1    Furuichi, T.2    Fujita, T.3    Fukuyama, R.4    Kanatani, N.5    Kobayashi, S.6
  • 69
    • 0037126380 scopus 로고    scopus 로고
    • Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein
    • Lee, K.S., Hong, S.H., and Bae, S.C. Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene 21, 7156, 2002.
    • (2002) Oncogene , vol.21 , pp. 7156
    • Lee, K.S.1    Hong, S.H.2    Bae, S.C.3
  • 70
    • 23644431709 scopus 로고    scopus 로고
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    • Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074, 2005.
    • (2005) Science , vol.309 , pp. 1074
    • Hong, J.H.1    Hwang, E.S.2    McManus, M.T.3    Amsterdam, A.4    Tian, Y.5    Kalmukova, R.6
  • 71
    • 77957367090 scopus 로고    scopus 로고
    • Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation
    • Tokuzawa, Y., Yagi, K., Yamashita, Y., Nakachi, Y., Nikaido, I., Bono, H., et al. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet 6, e1001019, 2010.
    • (2010) PLoS Genet , vol.6
    • Tokuzawa, Y.1    Yagi, K.2    Yamashita, Y.3    Nakachi, Y.4    Nikaido, I.5    Bono, H.6
  • 72
    • 34347400475 scopus 로고    scopus 로고
    • Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
    • Shimoyama, A., Wada, M., Ikeda, F., Hata, K., Matsubara, T., Nifuji, A., et al. Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell 18, 2411, 2007.
    • (2007) Mol Biol Cell , vol.18 , pp. 2411
    • Shimoyama, A.1    Wada, M.2    Ikeda, F.3    Hata, K.4    Matsubara, T.5    Nifuji, A.6
  • 73
    • 84861745683 scopus 로고    scopus 로고
    • Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity
    • Lee, K.N., Jang, W.G., Kim, E.J., Oh, S.H., Son, H.J., Kim, S.H., et al. Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity. J Biol Chem 287, 18888, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 18888
    • Lee, K.N.1    Jang, W.G.2    Kim, E.J.3    Oh, S.H.4    Son, H.J.5    Kim, S.H.6
  • 74
    • 11144357428 scopus 로고    scopus 로고
    • ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; Implication for Coffin-Lowry syndrome
    • Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H.C., Schinke, T., et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry syndrome. Cell 117, 387, 2004.
    • (2004) Cell , vol.117 , pp. 387
    • Yang, X.1    Matsuda, K.2    Bialek, P.3    Jacquot, S.4    Masuoka, H.C.5    Schinke, T.6
  • 75
    • 0033529549 scopus 로고    scopus 로고
    • Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogenactivated protein kinase-activated protein kinase family
    • Poteet-Smith, C.E., Smith, J.A., Lannigan, D.A., Freed, T.A., and Sturgill, T.W. Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogenactivated protein kinase-activated protein kinase family. J Biol Chem 274, 22135, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 22135
    • Poteet-Smith, C.E.1    Smith, J.A.2    Lannigan, D.A.3    Freed, T.A.4    Sturgill, T.W.5
  • 76
    • 15844384047 scopus 로고    scopus 로고
    • Leptin regulation of bone resorption by the sympathetic nervous system and CART
    • Elefteriou, F., Ahn, J.D., Takeda, S., Starbuck, M., Yang, X., Liu, X., et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434, 514, 2005.
    • (2005) Nature , vol.434 , pp. 514
    • Elefteriou, F.1    Ahn, J.D.2    Takeda, S.3    Starbuck, M.4    Yang, X.5    Liu, X.6
  • 77
    • 77955286526 scopus 로고    scopus 로고
    • Activating transcription factor 4 regulates osteoclast differentiation in mice
    • Cao, H., Yu, S., Yao, Z., Galson, D.L., Jiang, Y., Zhang, X., et al. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest 120, 2755, 2010.
    • (2010) J Clin Invest , vol.120 , pp. 2755
    • Cao, H.1    Yu, S.2    Yao, Z.3    Galson, D.L.4    Jiang, Y.5    Zhang, X.6
  • 78
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbau, S.L., and Ross, F.P. Genetic regulation of osteoclast development and function. Nat Rev Genet 4, 638, 2003.
    • (2003) Nat Rev Genet , vol.4 , pp. 638
    • Teitelbau, S.L.1    Ross, F.P.2
  • 79
    • 30644469500 scopus 로고    scopus 로고
    • RANKL-RANK signaling in osteoclastogenesis and bone disease
    • Wada, T., Nakashima, T., Hiroshi, N., and Penninger, J.M. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med 12, 17, 2006.
    • (2006) Trends Mol Med , vol.12 , pp. 17
    • Wada, T.1    Nakashima, T.2    Hiroshi, N.3    Penninger, J.M.4
  • 80
    • 61849130657 scopus 로고    scopus 로고
    • Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo
    • Wu, M., Hesse, E., MorVan, F., Zhang, J.P., Correa, D., Rowe, G.C., et al. Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo. Bone 44, 528, 2009.
    • (2009) Bone , vol.44 , pp. 528
    • Wu, M.1    Hesse, E.2    Morvan, F.3    Zhang, J.P.4    Correa, D.5    Rowe, G.C.6
  • 82
    • 77957883340 scopus 로고    scopus 로고
    • Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes
    • Correa, D., Hesse, E., Seriwatanachai, D., Kiviranta, R., Saito, H., Yamana, K., et al. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell 19, 533, 2010.
    • (2010) Dev Cell , vol.19 , pp. 533
    • Correa, D.1    Hesse, E.2    Seriwatanachai, D.3    Kiviranta, R.4    Saito, H.5    Yamana, K.6
  • 83
    • 78650749107 scopus 로고    scopus 로고
    • Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
    • Hesse, E., Saito,H., Kiviranta, R., Correa,D., Yamana, K.,Neff, L., et al. Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J Cell Biol 191, 1271, 2010.
    • (2010) J Cell Biol , vol.191 , pp. 1271
    • Hesse, E.1    Saito, H.2    Kiviranta, R.3    Correa, D.4    Yamana, K.5    Neff, L.6
  • 84
    • 80052672717 scopus 로고    scopus 로고
    • Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia
    • Seriwatanachai, D., Densmore, M.J., Sato, T., Correa, D., Neff, L., Baron, R., et al. Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia. FASEB J 25, 3057, 2011.
    • (2011) FASEB J , vol.25 , pp. 3057
    • Seriwatanachai, D.1    Densmore, M.J.2    Sato, T.3    Correa, D.4    Neff, L.5    Baron, R.6
  • 85
    • 33745196250 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates Runx2 acetylation
    • Jeon, E.J., Lee, K.Y., Choi, N.S., Lee, M.H., Kim, H.N., Jin, Y.H., et al. Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem 281, 16502, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 16502
    • Jeon, E.J.1    Lee, K.Y.2    Choi, N.S.3    Lee, M.H.4    Kim, H.N.5    Jin, Y.H.6
  • 86
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega, R.B., Matsuda, K., Oh, J., Barbosa, A.C., Yang, X., Meadows, E., et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119, 555, 2004.
    • (2004) Cell , vol.119 , pp. 555
    • Vega, R.B.1    Matsuda, K.2    Oh, J.3    Barbosa, A.C.4    Yang, X.5    Meadows, E.6
  • 87
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • Schroeder, T.M., Kahler, R.A., Li, X., and Westendorf, J.J. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 279, 41998, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 41998
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 88
    • 0036840499 scopus 로고    scopus 로고
    • Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter
    • Westendorf, J.J., Zaidi, S.K., Cascino, J.E., Kahler, R., Van Wijnen, A.J., Lian, J.B., et al. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol 22, 7982, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 7982
    • Westendorf, J.J.1    Zaidi, S.K.2    Cascino, J.E.3    Kahler, R.4    Van Wijnen, A.J.5    Lian, J.B.6
  • 89
    • 39749130325 scopus 로고    scopus 로고
    • Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner
    • Jensen, E.D., Schroeder, T.M., Bailey, J., Gopalakrishnan, R., and Westendorf, J.J. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res 23, 361, 2008.
    • (2008) J Bone Miner Res , vol.23 , pp. 361
    • Jensen, E.D.1    Schroeder, T.M.2    Bailey, J.3    Gopalakrishnan, R.4    Westendorf, J.J.5
  • 90
    • 74849098404 scopus 로고    scopus 로고
    • Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210
    • Smits, P., Bolton, A.D., Funari, V., Hong, M., Boyden, E.D., Lu, L., et al. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med 362, 206, 2010.
    • (2010) N Engl J Med , vol.362 , pp. 206
    • Smits, P.1    Bolton, A.D.2    Funari, V.3    Hong, M.4    Boyden, E.D.5    Lu, L.6
  • 91
    • 11144238386 scopus 로고    scopus 로고
    • Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization
    • Byers, B.A., Guldberg, R.E., and Garća, A.J. Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng 10, 1757, 2004.
    • (2004) Tissue Eng , vol.10 , pp. 1757
    • Byers, B.A.1    Guldberg, R.E.2    Garća, A.J.3
  • 92
    • 33645321143 scopus 로고    scopus 로고
    • Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects
    • Byers, B.A., Guldberg, R.E., Hutmacher, D.W., and Garća, A.J. Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects. J Biomed Mater Res A 76, 646, 2006.
    • (2006) J Biomed Mater Res A , vol.76 , pp. 646
    • Byers, B.A.1    Guldberg, R.E.2    Hutmacher, D.W.3    Garća, A.J.4
  • 93
    • 77956071511 scopus 로고    scopus 로고
    • Runx2 overexpression in bone marrow stromal cells accelerates bone formation in critical-sized femoral defects
    • Wojtowicz, A.M., Templeman, K.L., Hutmacher, D.W., Guldberg, R.E., and Garća, A.J. Runx2 overexpression in bone marrow stromal cells accelerates bone formation in critical-sized femoral defects. Tissue Eng Part A 16, 2795, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 2795
    • Wojtowicz, A.M.1    Templeman, K.L.2    Hutmacher, D.W.3    Guldberg, R.E.4    Garća, A.J.5
  • 94
    • 33746824572 scopus 로고    scopus 로고
    • Mineralization capacity of Runx2/Cbfa1-genetically engineered fibroblasts is scaffold dependent
    • Phillips, J.E., Hutmacher, D.W., Guldberg, R.E., and Garća, A.J. Mineralization capacity of Runx2/Cbfa1-genetically engineered fibroblasts is scaffold dependent. Biomaterials 27, 5535, 2006.
    • (2006) Biomaterials , vol.27 , pp. 5535
    • Phillips, J.E.1    Hutmacher, D.W.2    Guldberg, R.E.3    Garća, A.J.4
  • 95
    • 34548067391 scopus 로고    scopus 로고
    • Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering
    • Phillips, J.E., Guldberg, R.E., and Garća, A.J. Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering. Tissue Eng 13, 2029, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 2029
    • Phillips, J.E.1    Guldberg, R.E.2    Garća, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.