The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

Journal of Cell Biology

Volumn 168, Issue 6, 2005, Pages 899-910

  Schmidt, Katy ^a   Schinke, Thorsten ^b   Haberland, Michael ^b   Priemel, Matthias ^b   Schilling, Arndt F ^b   Mueldner, Cordula ^b   Rueger, Johannes M ^b   Sock, Elisabeth ^a   Wegner, Michael ^a   Amling, Michael ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b University of Medical School Hamburg Eppendorf   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX8; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE MASS; BONE MINERALIZATION; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HIGH MOBILITY GROUP PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); STAINING AND LABELING; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 20144376339     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200408013     Document Type: Article

References (45)

1. Akiyama, H., M.C. Chaboissier, J.F. Martin, A. Schedl, and B. de Crombrugghe. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16:2813-2828.
2. Amling, M., M. Priemel, T. Holzmann, K. Chapin, J.M. Rueger, R. Baron, and M.B. Demay. 1999. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of a normal mineral ion homeostasis: formal histomorphometric and biochemical analyses. Endocrinology. 140:4982-4987.
3. Amling, M., S. Takeda, and G. Karsenty. 2000. A neuro (endo)crine regulation of bone remodeling. Bioessays. 22:970-975.
4. Bialek, P., B. Kern, X. Yang, M. Schrock, D. Sosic, N. Hong, H. Wu, K. Yu, D.M. Ornitz, E.N. Olson, et al. 2004. A twist code determines the onset of osteoblast differentiation. Dev. Cell. 6:423-435.
5. Bianco, P., F.D. Cancedda, M. Riminucci, and R. Cancedda. 1998. Bone formation via cartilage models: the "borderline" chondrocyte. Matrix Biol. 17:185-192.
6. Bonnerot, C., and J.F. Nicolas. 1993. Guide to techniques in mouse development. Methods Enzymol. 225:747-799.
7. Bowles, J., G. Schepers, and P. Koopman. 2000. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev. Biol. 227:239-255.
8. Britsch, S., D.E. Goerich, D. Riethmacher, R.I. Peirano, M. Rossner, K.A. Nave, C. Birchmeier, and M. Wegner. 2001. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 15:66-78.
9. Chimal-Monroy, J., J. Rodriguez-Leon, J.A. Montero, Y. Ganan, D. Macias, R. Merino, and J.M. Hurle. 2003. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev. Biol. 257:292-301.
10. Corral, D.A., M. Amling, M. Priemel, E. Loyer, S. Fuchs, P. Ducy, R. Baron, and G. Karsenty. 1998. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc. Natl. Acad. Sci. USA. 95:13835-13840.
11. De Crombrugghe, B., V. Lefebvre, and K. Nakashima. 2001. Regulatory mechanisms in the pathways of cartilage and bone formation. Curr. Opin. Cell Biol. 13:721-727.
12. Ducy, P., R. Zhang, V. Geoffroy, R.L. Ridall, and G. Karsenty. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 89:747-754.
13. Ducy, P., M. Starbuck, M. Priemel, J. Shen, G. Pinero, V. Geoffroy, M. Amling, and G. Karsenty. 1999. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 13:1025-1036.
14. Ducy, P., M. Amling, S. Takeda, M. Priemel, A.F. Schilling, F.T. Beil, J. Shen, C. Vinson, J.M. Rueger, and G. Karsenty. 2000. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 100:197-207.
15. Foster, J.W., M.A. Dominguez-Steglich, S. Guioli, G. Kowk, P.A. Weller, M. Stevanovic, J. Weissenbach, S. Mansour, I.D. Young, P.N. Goodfellow, et al. 1994. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature. 372:525-530.
16. Geoffroy, V., M. Kneissel, B. Fournier, A. Boyde, and P. Matthias. 2002. High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol. Cell. Biol. 22:6222-6233.
17. Harada, S., and G.A. Rodan. 2003. Control of osteoblast function and regulation of bone mass. Nature. 423:349-355.
18. Herbarth, B., V. Pingault, N. Bondurand, K. Kuhlbrodt, I. Hermans-Borgmeyer, A. Puliti, N. Lemort, M. Goossens, and M. Wegner. 1998. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc. Natl. Acad. Sci. USA. 95:5161-5165.
19. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Staining for beta-galactosidase (lacZ) activity. In Manipulating the Mouse Embryo. A Laboratory Manual, Second edition. Trans., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 373-375.
20. Karsenty, G. 1999. The genetic transformation of bone biology. Genes Dev. 13:3037-3051.
21. Kato, M., M.S. Patel, R. Levasseur, I. Lobov, B.H. Chang, D.A. Glass II, C. Hartmann, L. Li, T.H. Hwang, C.F. Brayton, et al. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157:303-314.
22. Kim, J., L. Lo, E. Dormand, and D.J. Anderson. 2003. SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron. 38:17-31.
23. Kim, S., T. Koga, M. Isobe, B.E. Kern, T. Yokochi, Y.E. Chin, G. Karsenty, T. Taniguchi, and H. Takayanagi. 2003. Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev. 17:1979-1991.
24. Komori, T. 2002. Runx2, a multifunctional transcription factor in skeletal development. 3. Cell Biochem. 87:1-8.
25. Komori, T., H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y.H. Gao, M. Inada, et al. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:755-764.
26. Kronenberg, H.M. 2003. Developmental regulation of the growth plate. Nature. 423:332-336.
27. Lee, B., K. Thirunavukkarasu, L. Zhou, L. Pastore, A. Baldini, J. Hecht, V. Geoffroy, P. Ducy, and G. Karsenty. 1997. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat. Genet. 16:307-310.
28. Liu, W., S. Toyosawa, T. Furuichi, N. Kanatani, C. Yoshida, Y. Liu, M. Himeno, S. Narai, A. Yamaguchi, and T. Komori. 2001. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J. Cell Biol. 155:157-166.
29. McLeod, M.J. 1980. Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology. 22:299-301.
30. Mundlos, S., F. Otto, C. Mundlos, J.B. Mulliken, A.S. Aylsworth, S. Albright, D. Lindhout, W.O. Cole, W. Henn, J.H. Knoll, et al. 1997. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell. 89:773-779.
31. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, R.R. Behringer, and B. de Crombrugghe. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 108:17-29.
32. Olsen, B.R., A.M. Reginato, and W. Wang. 2000. Bone development. Annu. Rev. Cell Dev. Biol. 16:191-220.
33. Otto, F., A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, I.R. Rosewell, G.W. Stamp, R.S. Beddington, S. Mundlos, B.R. Olsen, et al. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 89:765-771.
34. Parfitt, A.M. 1983. The physiologic and clinical significance of bone histomorphometric data. In Bone Histomorphometric Techniques and Interpretation. R.R. Recker, editor. CRC Press, Boca Raton, FL. 143-223.
35. Pfeifer, D., F. Poulat, E. Holinski-Feder, F. Kooy, and G. Scherer. 2000. The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. Genomics. 63:108-116.
36. Pratap, J., M. Galindo, S.K. Zaidi, D. Vradii, B.M. Bhat, J.A. Robinson, J.Y. Choi, T. Komori, J.L. Stein, J.B. Lian, et al. 2003. Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 63:5357-5362.
37. Rossert, J., H. Eberspaecher, and B. de Crombrugghe. 1995. Separate cis-acting DNA elements of the mouse pro-alpha 1(1) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J. Cell Biol. 129:1421-1432.
38. Rossert, J.A., S.S. Chen, H. Eberspaecher, C.N. Smith, and B. de Crombrugghe. 1996. Identification of a minimal sequence of the mouse pro-alpha 1(1) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc. Natl. Acad. Sci. USA. 93:1027-1031.
39. Schepers, G.E., M. Bullejos, B.M. Hosking, and P. Koopman. 2000. Cloning and characterisation of the sry-related transcription factor gene sox8. Nucleic Acids Res. 28:1473-1480.
40. Sock, E., K. Schmidt, I. Hermanns-Borgmeyer, M.R. Bosl, and M. Wegner. 2001. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol. Cell Biol. 21:6951-6959.
41. Southard-Smith, E.M., L. Kos, and W.J. Pavan. 1998. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat. Genet. 18:60-64.
42. Stolt, C.C., S. Rehberg, M. Ader, P. Lommes, D. Riethmacher, M. Schachner, U. Bartsch, and M. Wegner. 2002. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 16:165-170.
43. Takeda, S., J.P. Bonnamy, M.J. Owen, P. Ducy, and G. Karsenty. 2001. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 15:467-481.
44. Wagner, T., J. Wirth, J. Meyer, B. Zabel, M. Held, J. Zimmer, J. Pasantes, F.D. Bricarelli, J. Keutel, E. Hustert, et al. 1994. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell. 79:1111-1120.
45. Wegner, M. 1999. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 27:1409-1420.