Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation

PLoS Genetics

Volumn 6, Issue 7, 2010, Pages 1-15

  Tokuzawa, Yoshimi ^a   Yagi, Ken ^a   Yamashita, Yzumi ^a   Nakachi, Yutaka ^a   Nikaido, Itoshi ^a   Bono, Hidemasa ^a   Ninomiya, Yuichi ^a   Kanesaki Yatsuka, Yukiko ^a   Akita, Masumi ^a   Motegi, Hiromi ^b   Wakana, Shigeharu ^b   Noda, Tetsuo ^b,c   Sablitzky, Fred ^d   Arai, Shigeki ^a   Kurokawa, Riki ^a   Fukuda, Toru ^a   Katagiri, Takenobu ^a   Schönbach, Christian ^e,f   Suda, Tatsuo ^a   Mizuno, Yosuke ^a   Okazaki, Yasushi ^a   more..

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b RIKEN BIORESOURCE CENTER   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITOR OF DIFFERENTIATION PROTEIN; INHIBITOR OF DIFFERENTIATION PROTEIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY2; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HES1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; IDB4 PROTEIN, MOUSE; RUNX2 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; FEMUR; GENE CLUSTER; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE OVEREXPRESSION; GENE SWITCHING; GENE TARGETING; GENETIC ASSOCIATION; GENETIC STABILITY; HEMATOPOIETIC STEM CELL; KNOCKOUT GENE; MOUSE; NONHUMAN; OSTEOBLAST; SENILE OSTEOPOROSIS; STROMA CELL; TIBIA; TRANSCRIPTION REGULATION; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; OSTEOPOROSIS; PATHOLOGY; PHYSIOLOGY; UPREGULATION;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HOMEODOMAIN PROTEINS; INHIBITOR OF DIFFERENTIATION PROTEINS; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOPOROSIS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 77957367090     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001019     Document Type: Article

References (38)

1. Burkhardt R, Kettner G, Bohm W, Schmidmeier M, Schlag R, et al. (1987) Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 8: 157-164.
2. Nuttall ME, Gimble JM (2004) Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4: 290-294.
3. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, et al. (2004) PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113: 846-855.
4. Kobayashi H, Gao Y, Ueta C, Yamaguchi A, Komori T (2000) Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro. Biochem Biophys Res Commun 273: 630-636.
5. Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, et al. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord 7: 1-16.
6. Nishimura R, Hata K, Ikeda F, Ichida F, Shimoyama A, et al. (2008) Signal transduction and transcriptional regulation during mesenchymal cell differentiation. J Bone Miner Metab 26: 203-212.
7. Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, et al. (2007) A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol 9: 1273-1285.
8. Iwata T, Kawamoto T, Sasabe E, Miyazaki K, Fujimoto K, et al. (2006) Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells. Eur J Cell Biol 85: 423-431.
9. Buskin JN, Hauschka SD (1989) Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. Mol Cell Biol 9: 2627-2640.
10. Arnold HH, Braun T (1996) Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review. Int J Dev Biol 40: 345-353.
11. Kim JB, Spiegelman BM (1996) ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 10: 1096-1107.
12. Ross SE, Greenberg ME, Stiles CD (2003) Basic helix-loop-helix factors in cortical development. Neuron 39: 13-25.
13. Ross DA, Hannenhalli S, Tobias JW, Cooch N, Shiekhattar R, et al. (2006) Functional analysis of Hes-1 in preadipocytes. Mol Endocrinol 20: 698-705.
14. Lee JS, Thomas DM, Gutierrez G, Carty SA, Yanagawa S, et al. (2006) HES1 cooperates with pRb to activate RUNX2-dependent transcription. J Bone Miner Res 21: 921-933.
15. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8: 1224-1234.
16. Hu E, Liang P, Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271: 10697-10703.
17. Bedford L, Walker R, Kondo T, van Cruchten I, King ER, et al. (2005) Id4 is required for the correct timing of neural differentiation. Dev Biol 280: 386-395.
18. Sun XH, Copeland NG, Jenkins NA, Baltimore D (1991) Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 11: 5603-5611.
19. Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, et al. (2001) HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol 21: 6080-6089.
20. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
21. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771.
22. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, et al. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
23. Ducy P, Karsenty G (1995) Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15: 1858-1869.
24. Suh JH, Lee HW, Lee JW, Kim JB (2008) Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation. Biochem Biophys Res Commun 367: 97-102.
25. Kulterer B, Friedl G, Jandrositz A, Sanchez-Cabo F, Prokesch A, et al. (2007) Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics 8: 70.
26. Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, et al. (2007) BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol 211: 728-735.
27. Sciaudone M, Gazzerro E, Priest L, Delany AM, Canalis E (2003) Notch 1 impairs osteoblastic cell differentiation. Endocrinology 144: 5631-5639.
28. Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, et al. (2005) Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J Biol Chem 280: 15842-15848.
29. Maeda Y, Tsuji K, Nifuji A, Noda M (2004) Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J Cell Biochem 93: 337-344.
30. Katagiri T, Imada M, Yanai T, Suda T, Takahashi N, et al. (2002) Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis. Genes Cells 7: 949-960.
31. Lopez-Rovira T, Chalaux E, Massague J, Rosa JL, Ventura F (2002) Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem 277: 3176-3185.
32. Zhang Y, Hassan MQ, Li ZY, Stein JL, Lian JB, et al. (2008) Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation. J Cell Biochem 105: 487-496.
33. Wan Y, Chong LW, Evans RM (2007) PPAR-gamma regulates osteoclastogenesis in mice. Nat Med 13: 1496-1503.
34. Mizuno Y, Yagi K, Tokuzawa Y, Kanesaki-Yatsuka Y, Suda T, et al. (2008) miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. Biochem Biophys Res Commun 368: 267-272.
35. Yang S, Takahashi N, Yamashita T, Sato N, Takahashi M, et al. (2005) Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts. J Immunol 175: 1956-1964.
36. Yagi K, Kondo D, Okazaki Y, Kano K (2004) A novel preadipocyte cell line established from mouse adult mature adipocytes. Biochem Biophys Res Commun 321: 967-974.
37. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15.
38. Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, et al. (2009) The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/ Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 29: 3544-3555.