Zinc finger protein 521, a new player in bone formation

Annals of the New York Academy of Sciences

Volumn 1192, Issue , 2010, Pages 32-37

  Hesse, Eric ^a   Kiviranta, Riku ^a   Wu, Meilin ^a   Saito, Hiroaki ^a   Yamana, Kei ^a   Correa, Diego ^a   Atfi, Azeddine ^a   Baron, Roland ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Bone formation; Osteoblast; Runx2; Zfp521

Indexed keywords

NUCLEAR PROTEIN; PARATHYROID HORMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; ZINC FINGER PROTEIN;

BONE MASS; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CONFERENCE PAPER; GERM LINE GENE THERAPY; IN VIVO STUDY; MATURATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; OSTEOPENIA; PERIOSTEUM; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 77950667954     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05347.x     Document Type: Conference Paper

References (29)

1. Jilka, R.L. 2003. Biology of the basic multicellular unit and the pathophysiology of osteoporosis. Med. Pediatr. Oncol. 41: 182-185.
2. Parfitt, A.M. 2002. Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression. Bone 30: 5-7.
3. Harada, S. & G.A. Rodan. 2003. Control of osteoblast function and regulation of bone mass. Nature 423: 349-355.
4. Karsenty, G. & E.F. Wagner. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2: 389-406.
5. Karsenty, G., H.M. Kronenberg & C. Settembre. 2009. Genetic control of bone formation. Annu. Rev. Cell Dev. Biol. 25: 629-648.
6. Ducy, P. et al. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
7. Komori, T. et al. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
8. Otto, F. et al. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771.
9. Maruyama, Z. et al. 2007. Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev. Dyn. 236: 1876-1890.
10. Geoffroy,V. et al. 2002.High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol. Cell Biol. 22: 6222-6233.
11. Liu, W. et al. 2001. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J. Cell Biol. 155: 157-166.
12. Van Der Horst, G. et al. (2005. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J. Bone Miner. Res. 20: 1867-1877.
13. Li, X. et al. 2005. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat. Genet. 37: 945-952.
14. Rodda, S.J. & A.P. McMahon. 2006. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133: 3231-3244.
15. Bond, H.M. et al. 2004. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood 103: 2062-2070.
16. Warming, S. et al. 2003. Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein. Blood 101: 1934-1940.
17. Hata,A. et al. 2000.OAZuses distinctDNA- and proteinbinding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100: 229-240.
18. Tsai, R.Y.L. & R.R. Reed. 1997. Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. J. Neurosci. 17: 4159-4169.
19. Tsai, R.Y.L. & R.R. Reed. 1998. Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Mol. Cell Biol. 18: 6447-6456.
20. Horowitz, M.C. et al. 2005. B cells and osteoblast and osteoclast development. Immunol. Rev. 208: 141-153.
21. Kieslinger, M. et al. 2005. EBF2 regulates osteoblastdependent differentiation of osteoclasts.Dev.Cell 9: 757-767.
22. Wu, M. et al. 2009. Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo. Bone 44: 528-536.
23. Hentges, K.E. et al. 2005. Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia. Oncogene 24: 1220-1230.
24. Hesslein, D.G. et al. 2009. Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone 44: 537-546.
25. Warming, S. et al. 2004. Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas. Oncogene 23: 2727-2731.
26. Liberg, D., M. Sigvardsson & P. Akerblad. 2002. The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers. Mol. Cell Biol. 22: 8389-8397.
27. Van Der Horst, G. et al. 2005. Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells. J. Bone Miner. Res. 20: 2233-2244.
28. Zerega,B. et al. 1999.Parathyroid hormone[PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1- 34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. J. Bone Miner. Res. 14: 1281-1289.
29. Martinez, M.E. et al. 1997. C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells. J. BoneMiner. Res. 12: 778-785.