Links between growth hormone and aging

Endokrynologia Polska

Volumn 64, Issue 1, 2013, Pages 46-52

  Bartke, Andrzej ^a   Westbrook, Reyhan ^a   Sun, Liou ^a   Ratajczak, Mariusz ^b  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Ames dwarf mice; Calorie restriction (CR); Growth hormone (GH); Growth hormone receptor knockout (GHRKO) mice; Insulin like growth factor (IGF 1)

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CYTOKINE; GROWTH HORMONE; INSULIN; INTERLEUKIN 6; SOMATOMEDIN C;

ADIPOSE TISSUE; AGING; BONE MARROW; ENERGY EXPENDITURE; ENERGY METABOLISM; ENVIRONMENTAL TEMPERATURE; GENE EXPRESSION; INSULIN SENSITIVITY; LONGEVITY; NONHUMAN; OXYGEN CONSUMPTION; PHENOTYPE; PLURIPOTENT STEM CELL; REVIEW; SIGNAL TRANSDUCTION; STRESS; THERMOGENESIS;

ADIPONECTIN; ADIPOSE TISSUE; AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BONE MARROW CELLS; CALORIC RESTRICTION; ENERGY METABOLISM; GROWTH HORMONE; HUMANS; LONGEVITY; MICE; MODELS, ANIMAL; OXYGEN CONSUMPTION; RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION;

EID: 84876175450     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Bartke A. Can growth hormone accelerate aging? Evidence from GHtransgenic mice. Neuroendocrinology 2003; 78: 210-216.
2. Brown-Borg HM, Borg KE, Meliska CJ et al. Dwarf mice and the aging process. Nature 1996; 384: 33.
3. Flurkey K, Papaconstantinou J, Miller RA et al. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 2001; 98: 6736-6741.
4. Coschigano KT, Holland AN, Riders ME et al. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 2003; 144: 3799-3810.
5. Bartke A. Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci 2011; 366: 28-34.
6. Kinney BA, Meliska CJ, Steger RW, Bartke A. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm Behav 2001; 39: 277-284.
7. Ikeno Y, Bronson RT, Hubbard GB, Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci 2003; 58: 291-296.
8. Ikeno Y, Hubbard GB, Lee S et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 2009; 64: 522-529.
9. Vergara M, Smith-Wheelock M, Harper JM et al. Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci 2004; 59: 1244-1250.
10. Brown-Borg H, Johnson WT, Rakoczy S et al. Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. J Amer Aging Assoc 2001; 24: 85-96.
11. Brown-Borg H. Longevity in mice: is stress resistance a common factor? Age (Dordr) 2006: 28: 145-162.
12. Salmon AB, Murakami S, Bartke A et al. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab 2005; 289: E23-E29.
13. Page MM, Salmon AB, Leiser SF et al. Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic Biol Med 2009; 46: 1109-1118.
14. Sharp ZD, Bartke A. Evidence for down-regulation of phosphoinositide 3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci 2005; 60: 293-300.
15. Al-Regaiey KA, Masternak MM, Bonkowski M et al. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction. Endocrinology 2005; 146: 851-860.
16. Bonkowski MS, Rocha JS, Masternak MM et al. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci USA 2006; 103: 7901-7905.
17. Masternak MM, Panici JA, Bonkowski MS et al. Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci 2009; 64: 516-521.
18. Roberts RC. The lifetime growth and reproduction of selected strains of mice. Heredity 1961; 16: 369-381.
19. Miller RA, Harper JM, Galecki A et al. Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice. Aging Cell 2002; 1: 22-29.
20. Yuan R, Tsaih SW, Petkova SB et al. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 2009; 8: 277-287.
21. Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 1998; 148: 703-717.
22. Kimura KD, Tissenbaum HA, Liu Y et al. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277: 942-946.
23. Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulinlike signals. Science 2003; 299: 1346-1351.
24. Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 2003; 299: 1342-1346.
25. Jadresic A, Banks LM, Child DF et al. The acromegaly syndrome. Relation between clinical features, growth hormone values and radiological characteristics of the pituitary tumours. Q J Med 1982; 51: 189-204.
26. Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A, Jr. et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults. J Clin Endocrinol Metab 2007; 92: 4664-4670.
27. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 2011; 3: 70ra13.
28. Burgers AM BN, Schoones JW, Pereira AM et al. Meta-analysis and doseresponse metaregression: Circulating insulin-like growth factor I (IGF-1) and mortality. J Clin Endocrinol Metab 2011; 96: 2912-2920.
29. Shechter M, Ginsberg S, Scheinowitz M et al. Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function. Growth Horm IGF Res 2007; 17: 165-170.
30. Shevah O, Laron Z. Patients with congenital deficiency of IGF-I seem protecte from the development of malignancies: a preliminary report. Growth Horm IGF Res 2007; 17: 54-57.
31. Steuerman R, Shevah O, Laron Z. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur J Endocrinol 2011; 164: 485-489.
32. Westbrook R, Bonkowski MS, Strader AD et al. Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci 2009; 64: 443-451.
33. Heiman M, Tinsley F, Mattison J et al. Body composition of prolactin-, growth hormone-, and thyrotropin-deficient Ames dwarf mice. Endocrine 2003; 20: 149-154.
34. Bonkowski MS, Pamenter RW, Rocha JS et al. Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci 2006; 61: 562-567.
35. Berryman DE, List EO, Palmer AJ et al. Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci 2010; 65: 31-40.
36. Koizumi A WY, Tuskada M, Kayo T et al. A tumor preventive effect of dietary restriction is antagonized by a high housing temperature through deprivation of torpor. Mech Ageing Dev 1996; 92: 67-82.
37. Franceschi C, Olivieri F, Marchegiani F et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev 2005; 126: 351-361.
38. Finch CE, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science 2004; 305: 1736-1739.
39. Deepak D DC, Javadpour M, Clark D, Perry Y, Pinkney J, Macfarlane IA. The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency. Growth Horm IGF Res 2010; 20: 220-225.
40. Yi C CY, Mao SH, Liu H et al. Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis. Inflamm Res 2009; 58: 855-862.
41. Wang Z, Masternak MM, Al-Regaiey KA et al. Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology 2007; 148: 2845-2853.
42. Gaspari S, Marcovecchio ML, Breda L et al. Growth in juvenile idiopathic arthritis: the role of inflammation. Clin Exp Rheumatol 2011; 29: 104-110.
43. Chen Y, Sood S, Krishnamurthy VM et al. Endotoxin-induced growth hormone resistance in skeletal muscle. Endocrinology 2009; 150: 3620-3626.
44. Berryman DE, List EO, Coschigano KT et al. Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res 2004; 14: 309-318.
45. Wang Z, Al-Regaiey KA, Masternak MM et al. Adipocytokines and lipid levels in Ames dwarf and caloric restricted mice. J Gerontol A Biol Sci Med Sci 2006; 61A: 323-331.
46. Muzumdar R, Allison DB, Huffman DM et al. Visceral adipose tissue modulates mammalian longevity. Aging Cell 2008; 7: 438-440.
47. Masternak MM, Bartke A, Wang F et al. Metabolic effects of intraabdominal fat in GHRKO mice. Aging Cell 2012; 11: 73-81.
48. Dhahbi J, Li X, Tran T et al. Circulating blood leukocyte gene expression profiles: Effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Experimental Gerontology 2007; 42: 772-788.
49. Ratajczak MZ, Zuba-Surma EK, Wysoczynski M et al. Hunt for pluripotent stem cell-regenerative medicine search for almighty cell. Journal of autoimmunity 2008; 30: 151-162.
50. D'Ippolito G, Diabira S, Howard GA et al. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. Journal of Cell Science 2004; 117: 2971-2981.
51. Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49.
52. Beltrami AP, Cesselli D, Bergamin N et al. Multipotent cells can be generated in vitro from several adult human organs (heart, liver and bone marrow). Blood 2007; 110: 3438-3446.
53. Kucia M, Reca R, Campbell F et al. A population of very small embryoniclike (VSEL) CXCR4+ SSEA-1+ Oct-4+ stem cells identified in adult bone marrow. Leukemia 2006; 20: 857-869.
54. Kucia M, Wysoczynski M, Ratajczak J et al. Identification of very small embryonic like (VSEL) stem cells in bone marrow. Cell and Tissue Research 2008; 331: 125-134.
55. Ratajczak J, Wysoczynski M, Zuba-Surma E et al. Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells. Exp Hematol 2011; 39: 225-237.
56. Taichman RS, Wang Z, Shiozawa Y et al. Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivo. Stem Cells Dev 2010; 19: 1557-70.
57. Ratajczak MZ, Zuba-Surma EK, Shin D-M et al. Very small embryoniclike (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity. Experimental Gerontology 2008; 43: 1009-1017.
58. Ratajczak MZ, Shin DM, Liu R et al. Very small embryonic/epiblastlike stem cells (VSELs) and their potential role in aging and organ rejuvenation-an update and comparison to other primitive small stem cells isolated from adult tissues. Aging 2012; 4: 235-246.
59. Shin DM, Zuba-Surma EK, Wu W et al. Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrowderived Oct4+ very small embryonic-like stem cells. Leukemia 2009; 23: 2042-2051.
60. Ratajczak J, Shin DM, Wan W et al. Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice-novel view on Igf-1, stem cells and aging. Leukemia 2011; 25: 729-733.
61. Kucia M, Masternak M, Liu R et al. The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) 2012. [Epub ahead of print]
62. Kucia M, Shin DM, Liu R et al. Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging. Leukemia 2011; 25: 1370-1374.
63. Patronek GJ, Waters DJ, Glickman LT. Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol A Biol Sci Med Sci 1997; 52A: B171-B178.
64. Paradis MR. Demographics of health and disease in the geriatric horse. Vet Clin North Am Equine Pract 2002; 18: 391-401.
65. Samaras TT. Human body size and the laws of scaling: physiological, performance, growth, longevity and ecological ramifications. Nova Science Publishers, Inc., Hauppauge, N.Y. 2007.
66. Vergara M, Smith-Wheelock M, Harper JM et al. Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci 2004; 59: 1244-1250.
67. Panici JA, Harper JM, Miller RA et al. Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J 2010; 24: 5073-5079.
68. Kopchick JJ, Andry JM. Growth hormone (GH), GH receptor, and signal transduction. Mol Genet Metab 2000; 71: 293-314.
69. Sun L SAA, Miller RA, Harper JM. Life-span extension in mice by preweaning food restriction and by methionine restriction in middleage. J Gerontol A Biol Sci Med Sci 2009; 64: 711-722.
70. Sonntag WE, Carter CS, Ikeno Y et al. Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology 2005; 146: 2920-2932.
71. Hoy WE, Rees M, Kile E et al. A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 1999; 56: 1072-1077.
72. Roseboom TJ, van der Meulen JH, Osmond C et al. Adult survival after prenatal exposure to the Dutch famine 1944-45. Paediatr Perinat Epidemiol 2001; 15: 220-225.