Endotoxin-induced growth hormone resistance in skeletal muscle

Endocrinology

Volumn 150, Issue 8, 2009, Pages 3620-3626

  Chen, Yu ^a   Sood, Sumita ^a   Krishnamurthy, Vidya M R ^b   Rotwein, Peter ^c   Rabkin, Ralph ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ENDOTOXIN; JANUS KINASE 2; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; SOMATOMEDIN C; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENDOTOXEMIA; HORMONE RESISTANCE; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ANIMALS; BLOTTING, WESTERN; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GROWTH HORMONE; IMMUNOPRECIPITATION; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 67651163682     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1703     Document Type: Article

References (33)

1. Lang CH, Frost RA, Vary TC 2007 Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab 293:E453-E459
2. Glass DJ 2005 Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol 37:1974-1984
3. Woelfle J, Chia DJ, Massart-Schlesinger MB, Moyano P, Rotwein P 2005 Molecular physiology, pathology, and regulation of the growth hormone/insulin-like growth factor-I system. Pediatr Nephrol 20:295-302
4. Woelfle J, Rotwein P 2004 In vivo regulation of growth hormone-stimulated gene transcription by STAT5b. Am J Physiol Endocrinol Metab 286:E393-E401
5. Lanning NJ, Carter-Su C 2006 Recent advances in growth hormone signaling. Rev Endocr Metab Disord 7:225-235
6. Rabkin R, Sun DF, Chen Y, Tan J, Schaefer F 2005 Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr Nephrol 20:313-318
7. Waters MJ, Hoang HN, Fairlie DP, Pelekanos RA, Brown RJ 2006 New insights into growth hormone action. J Mol Endocrinol 36:1-7
8. Ram PA, Waxman DJ 1997 Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem 272:17694-17702
9. Tan JC, Rabkin R 2005 Suppressors of cytokine signaling in health and disease. Pediatr Nephrol 20:567-575
10. Lang CH, Hong-Brown L, Frost RA 2005 Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance. Pediatr Nephrol 20:306-312
11. Ahmed T, Yumet G, Shumate M, Lang CH, Rotwein P, Cooney RN 2006 Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol 291:G35-G44
12. Hong-Brown LQ, Brown CR, Cooney RN, Frost RA, Lang CH 2003 Sepsisinduced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Am J Physiol Endocrinol Metab 285:E63-E72
13. Chen Y, Sun D, Krishnamurthy VM, Rabkin R 2007 Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding. Am J Physiol Endocrinol Metab 292:E1856-E1862
14. Defalque D, Brandt N, Ketelslegers JM, Thissen JP 1999 GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors. Am J Physiol 276:E565-E572
15. Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ 2008 Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity. Mol Endocrinol 22:1427-1437
16. Yumet G, Shumate ML, Bryant DP, Lang CH, Cooney RN 2006 Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling. Crit Care Med 34:1420-1427
17. Sun DF, Zheng Z, Tummala P, Oh J, Schaefer F, Rabkin R 2004 Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle. J Am Soc Nephrol 15:2630-2636
18. Schaefer F, Chen Y, Tsao T, Nouri P, Rabkin R 2001 Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia. J Clin Invest 108:467-475
19. Ram PA, Park SH, Choi HK, Waxman DJ 1996 Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J Biol Chem 271:5929-5940
20. Mao Y, Ling PR, Fitzgibbons TP, McCowen KC, Frick GP, Bistrian BR, Smith RJ 1999 Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo. Endocrinology 140:5505-5515
21. Schaefer F, Yoon SA, Nouri P, Tsao T, Tummala P, Deng E, Rabkin R 2004 Growth hormone-mediated Janus associated kinase-signal transducers and activators of transcription signaling in the growth hormone-resistant potassium-deficient rat. J Am Soc Nephrol 15:2299-2306
22. Glantz S 2002 Primer of biostatistics. 5th ed. New York: McGraw-Hill; 92-103
23. Flores-Morales A, Greenhalgh CJ, Norstedt G, Rico-Bautista E 2006 Negative regulation of growth hormone receptor signaling. Mol Endocrinol 20:241-253
24. Hayes VY, Urban RJ, Jiang J, Marcell TJ, Helgeson K, Mauras N 2001 Recombinant human growth hormone and recombinant human insulin-like growth factor I diminish the catabolic effects of hypogonadism in man: metabolic and molecular effects. J Clin Endocrinol Metab 86:2211-2219
25. Colson A, Le Cam A, Maiter D, Edery M, Thissen JP 2000 Potentiation of growth hormone-induced liver suppressors of cytokine signaling messenger ribonucleic acid by cytokines. Endocrinology 141:3687-3695
26. Haeffner-Cavaillon N, Carreno MP, Aussel L, Caroff M 1999 Molecular aspects of endotoxins relevant to their biological functions. Nephrol Dialysis Transplant 14:853-860
27. Park SH, Waxman DJ 2001 Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3β: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. J Biol Chem 276:43031-43039
28. Rønn SG, Billestrup N, Mandrup-Poulsen T 2007 Diabetes and suppressors of cytokine signaling proteins. Diabetes 56:541-548
29. DeVol DL, Rotwein P, Sadow JL, Novakofski J, Bechtel PJ 1990 Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am J Physiol 259:E89-E95
30. Butler AA, Ambler GR, Breier BH, LeRoith D, Roberts Jr CT, Gluckman PD 1994 Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression. Mol Cell Endocrinol 101:321-330
31. Reiter E, Bonnet P, Sente B, Dombrowicz D, de Leval J, Closset J, Hennen G 1992 Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats. Mol Cell Endocrinol 88:77-87
32. O'Bryan MK, Schlatt S, Phillips DJ, de Kretser DM, Hedger MP 2000 Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo. Endocrinology 141:238-246
33. Ko S, Shi L, Kim S, Song CS, Chatterjee B 2008 Interplay of nuclear factor-κB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor α. Mol Endocrinol 22:273-286