In vitro assessment of the cytotoxic, apoptotic, and mutagenic potentials of Isatin

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 76, Issue 6, 2013, Pages 354-362

  Cândido Bacani, Priscila De Matos ^a   Mori, Mateus Prates ^a   Calvo, Tamara Regina ^b   Vilegas, Wagner ^b   Varanda, Eliana Aparecida ^b   De Syllos Cólus, Ilce Mara ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ISATIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; APOPTOSIS INDEX; ARTICLE; CELLS; CONTROLLED STUDY; CYTOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; NUCLEAR DIVISION INDEX; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; ISATIN; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; PLANT EXTRACTS; PLANTS, MEDICINAL; TETRAZOLIUM SALTS; THIAZOLES;

COLUS;

EID: 84876125299     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2012.755941     Document Type: Article

References (34)

1. Aardema, M. J., Snyder, R. D., Spicer. C., Divi, K., Morita, T., Mauthe, R. J., Gibson, D. P., Soelter, S., Curry, P. T., Thybaud, V., Lorenzon, G., Marzin, D., and Lorge, E. 2006. SFTG international collaborative study on in vitro micronucleus test III. Using CHO cells. Mutat. Res. 607: 61-87. (Pubitemid 44026680)
2. Bacchi, A., Carcelli, M., Pelagatti, P., Pelizzi, G., Rodriguez-Arguelles, M. C., Rogolino, D., Solinas, C., and Zani, F. 2005. Antimicrobial and mutagenic properties of organotin (IV) complexes with isatin and N-alkylisatin bisthiocarbonohydrazones. J. Inorg. Biochem. 99: 397-408. (Pubitemid 40038314)
3. Calixto, J. B. 2001. Estudo Farmacológico Préclínico de plantas medicinais. In Plantas medicinais sob a ótica da química medicinal moderna, ed. R. A. Yunes and J. B. Calixto, 77-99. Chapecó: Argos.
4. Cândido-Bacani, P. de M., Reis, M. B., Serpeloni, J. M., Calvo, T. R., Vilegas, W., Varanda, E. A., and Cólus, I. M. S. 2011. Mutagenicity and genotoxicity of isatin in mammalian cells in vivo. Mutat. Res. 719: 47-51.
5. Cane, A., Tournaire, M. C., Barritault, D., and Crumeyrolle-Arias, M. 2000. The endogenous oxindoles 5-hydroxyoxindole and isatin are antiproliferative and proapoptotic. Biochem. Biophys. Res. Commun. 276: 379-384.
6. Chambard, J. C., Lefloch, R., Pouysségur, J., and Lenormand, P. 2007. ERK implication in cell cycle regulation. Biochim. Biophys. Acta 1773: 1299-1310. (Pubitemid 47125974)
7. Chu, W., Rothfuss, J., Zhou, D., and Mach, R. H. 2011. Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay. Bioorg. Med. Chem. Lett. 21: 2192-2197.
8. Eastmond, D. A., and Tucker, J. D. 1989. Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ. Mol. Mutagen. 13: 34-43. (Pubitemid 19252654)
9. Ebisuya, M., Kondoh, K., and Nishida, E. 2005. The duration, magnitude and compartmentalization of ERK MAP kinase activity: Mechanisms for providing signaling specificity. J. Cell Sci. 118: 2997-3002. (Pubitemid 41149904)
10. Ebner, H. L., Blatzer, M., Nawaz, M., and Krumschnabel, G. 2007. Activation and nuclear translocation of ERK in response to ligand-dependent and-independent stimuli in liver and gill cells from rainbow trout. J. Exp. Biol. 210: 1036-1045. (Pubitemid 46650607)
11. Ekwall, B., Silano, V., Paganuzzi-Stammati, A., and Zucco, F. 1990. Toxicity tests with mammalian cell cultures. In Short-term toxicity tests for non-genotoxic effects, ed. P. Bourdeau, E. Somers, G. M. Richardson, and J. R. Hickman, 75-97. New York, NY: John Wiley & Sons.
12. Fenech, M. 2000. The in vitro micronucleus technique. Mutat. Res. 455: 81-95.
13. Fenech, M., and Morley, A. A. 1985. Measurement of micronuclei in lymphocytes. Mutat. Res. 147: 29-36. (Pubitemid 15111220)
14. Filomeni, G., Cerchiaro, G., Ferreira, A. M. da C., deMartino, A., Pedersen, J. Z., Rotilio, G., and Ciriolo, M. R. 2007. Pro-apoptotic activity of novel isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage. J. Biol. Chem. 282: 12010-12021. (Pubitemid 47100713)
15. Filomeni, G., Piccirillo, S., Graziani, I., Cardaci, S., Ferreira, A. M. da C., Rotilio, G., and Ciriolo, M. R. 2009. The isatin-Schiff base copper(II) complex Cu (isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis. Carcinogenesis 30: 1115-1124.
16. Hou, L., Ju, C., Zhang, J., Song, J., Ge, Y., and Yue, W. 2008. Antitumor effects of isatin on human neuroblastoma cell line (SHSY5Y) and the related mechanism. Eur. J. Pharmacol. 589: 27-31.
17. Igosheva, N., Lorz, C., O'Conner, E., Glover, V., and Mehmet, H. 2005. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose-and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem. Int. 47: 216-224. (Pubitemid 40848684)
18. Jiang, Y., and Hansen, T. V. 2011. Isatin 1,2,3-triazoles as potent inhibitors against caspase-3. Bioorg. Med. Chem. Lett. 21: 1626-1629.
19. Jordan, M. A., and Wilson, L. 1998. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy. Curr. Opin. Cell Biol. 10: 123-130. (Pubitemid 28066130)
20. Matheus, M. E., Violante, F. de A., Garden, S. J., Pinto, A. C., and Fernandes, P. D. 2007. Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Eur. J. Pharmacol. 556: 200-206. (Pubitemid 46074000)
21. Maugard, T., Enaud, E., Choisy, P., and Legoy, M. D. 2001. Identification of an indigo precursor from leaves of Isatis tinctoria (Woad). Phytochemistry 58: 897-904. (Pubitemid 33086215)
22. McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboudi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., and Green, D. R. 1995. The end of the (cell) line: Methods for the study of apoptosis in vitro. In Methods in cell biology, ed. L. M. Schurartz and B. A. Osbourne, vol. 46, 153-184. San Diego, CA: Academic Press.
23. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63. (Pubitemid 14203433)
24. Mothana, R. A., Lindequist, U., Gruenert, R., and Bednarski, P. J. 2009. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. BMC Complementary Altern. Med. 9: 7.
25. Pandeya, S. N., Smitha, S., Jyoti, M., and Sridhar, S. K. 2005. Biological activities of isatin and its derivatives. Acta Pharm. 55: 27-46. (Pubitemid 40562617)
26. Quiles, J. L., Huertas, J. R., Battino, M., Mataix, J., and Ramírez-Tortosa, M. C. 2002. Antioxidant nutrients and adriamycin toxicity. Toxicology 180: 79-95. (Pubitemid 35248094)
27. Rannung, U., Bramstedt, H., and Nilsson, U. 1992. The presence of genotoxic and bioactive components in indigo dyed fabrics-A possible health risk? Mutat. Res. 282: 219-225.
28. Rodeiro, I., Cancino, L., González, J. E., Morffi, J., Garrido, G., González, R. M., Nunez, A., and Delgado, R. 2006. Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food Chem. Toxicol. 44: 1707-1713.
29. Sabet, R., Mohammadpour, M., Sadeghi, A., and Fassihi, A. 2010. QSAR study of isatin analogues as in vitro anti-cancer agents. Eur. J. Med. Chem. 45: 1113-1118.
30. Silva, J. F. M. da, Garden, S. J., and Pinto, A. C. 2001. The chemistry of isatins: A review from 1975 to 1999. J. Braz. Chem. Soc. 12: 273-324.
31. Singh, P., Sharma, P., Anand, A., Bedi, P. M. S., Kaur, T., Saxena, A. K., and Kumar, V. 2012. Azide-alkyne cycloaddition en route to novel 1H-1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation. Eur. J. Med. Chem. 55: 455-461.
32. Vine, K. L., Locke, J. M., Ranson, M., Benkendorff, K., Pyne, S. G., and Bremner, J. B. 2007. In vitro cytotoxicity evaluation of some substituted isatin derivatives. Bioorg. Med. Chem. 15: 931-938. (Pubitemid 44880712)
33. Vine, K. L., Matesic, L., Locke, J. M., Ranson, M., and Skropeta, D. 2009. Cytotoxic and anticancer activities of isatin and its derivatives: A comprehensive review from 2000-2008. Anticancer Agents Med. Chem. 9: 397-414.
34. Vukicevic, V., Kampfinger, K., and Stopper, H. 2004. Influence of altered apoptosis in human lymphoblastoid cell lines on micronucleus frequency. Toxicol. Lett. 147: 187-195. (Pubitemid 38130187)