Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 9, 2013, Pages 2495-2502

  Bai, Renren ^a   Huang, Xiaojing ^a   Yang, Xue ^a   Hong, Wen ^a   Tang, Yiqun ^a   Yao, Hequan ^a   Jiang, Jieyun ^b   Liu, Jie ^a   Shen, Mingqin ^c   Wu, Xiaoming ^a   Xu, Jinyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Jiangsu Provincial Institute of Traditional Chinese Medicine   (China)

Author keywords

Adrenoceptor blockers; Antihypertensive activity; Hybrids; Isochroman 4 one; Isopropanolamine

Indexed keywords

6 (3 BUTYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 (3 DIMETHYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 (3 ETHYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 [2 HYDROXY 3 (ISOPROPYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 [2 HYDROXY 3 (METHYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 [2 HYDROXY 3 (PROPYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 [3 (TERT BUTYLAMINO) 2 HYDROXYPROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 6 METHOXY 3 METHYL 7 (OXIRAN 2 YLMETHOXY)ISOCHROMAN 4 ONE; 7 (3 BUTYLAMINO 2 HYDROXYPROPOXY) 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 (3 DIMETHYLAMINO 2 HYDROXYPROPOXY) 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 (3 ETHYLAMINO 2 HYDROXYPROPOXY) 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 [2 HYDROXY 3 (ISOPROPYLAMINO)PROPOXY] 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 [2 HYDROXY 3 (METHYLAMINO)PROPOXY] 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 [2 HYDROXY 3 (PROPYLAMINO)PROPOXY] 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 [3 (TERT BUTYLAMINO) 2 HYDROXYPROPOXY] 6 METHOXY 3 METHYLISOCHROMAN 4 ONE; 7 METHOXY 3 METHYL 6 (OXIRAN 2 YLMETHOXY)ISOCHROMAN 4 ONE; 7 METHOXY 3 METHYL 8 (OXIRAN 2 YLMETHOXY)ISOCHROMAN 4 ONE; 7,8 DIHYDROXY 3 METHYL ISOCHROMAN 4 ONE DERIVATIVE; 8 (3 BUTYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 (3 DIMETHYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 (3 ETHYLAMINO 2 HYDROXYPROPOXY) 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 [2 HYDROXY 3 (ISOPROPYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 [2 HYDROXY 3 (METHYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 [2 HYDROXY 3 (PROPYLAMINO)PROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; 8 [3 (TERT BUTYLAMINO) 2 HYDROXYPROPOXY] 7 METHOXY 3 METHYLISOCHROMAN 4 ONE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ISOCHROMAN DERIVATIVE; PROPANOLAMINE DERIVATIVE; PROPRANOLOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART PROTECTION; HYPERTENSION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION; MALE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876112682     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.044     Document Type: Article

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