Potential hypotensive agents: Synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3177-3180

  Tandon, Vishnu K ^a   Kumar, Manoj ^a   Awasthi, Anoop K ^a   Saxena, Hari O ^a   Goswamy, Gajendra K ^a  

^a UNIVERSITY OF LUCKNOW   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; OXIME DERIVATIVE;

ANESTHESIA; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CAT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; SUBSTITUTION REACTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CATS; OXEPINS; OXIMES;

FELIS CATUS;

EID: 2442614808     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.009     Document Type: Article

References (20)

1. Bisi A., Rampa A., Budreisi R., Gobbi S., Belluti F., Loan P., Valoti E., Chiarini A., Valenti P. Bioorg. Med. Chem. 11:2003;1353
2. McGavin J.K., Keating G.M. Drugs. 62:2002;2677
3. Leclerc G., Mann A., Wermuth C.G., Bieth N., Schwartz J. J. Med. Chem. 20:1977;1657
4. Imbs J.L., Miesch F., Schwartz J., Velly J., Leclerc G., Mann A., Wermuth C.G. Brit. J. Pharmacol. 60:1977;357
5. Leclerc G., Amlaiky N., Rouot B. Eur. J. Med. Chem. 17:1982;69
6. Rakhit S., Bouzoubaa M., Leclerc G., Leger J.M., Carpy A. Eur. J. Med. Chem. 21:1986;411
7. Martani A., Magli M., Orzalesi G., Selleri R. Farmaco Ed. Sci. 30:1975;370
8. Ferrarini P.L., Mori C., Primofiore G., Da Settimo A., Breschi M.C., Martinotti E., Nieri P., Ciucci M.A. Eur. J. Med. Chem. 25:1990;489
9. Watson K.G., Brown R.N., Cameron R., Chalmers O.K., Hamilton S., Jin B., Krippner G.Y., Luttick A., McConnell D.B., Reece P.A., Ryan J., Stanislawski P.C., Tucker S.P., Wu W.Y., Barnard D.L., Sidwell R.W. J. Med. Chem. 46:2003;3181
10. Metodiewa D., Koceva-Chyla A., Kochma A., Skolimowski J., Jozwiak J. Anticancer Res. 19:1999;1255
11. Metodiewa D., Koceva-Chyla A., Kochma A., Skolimowski J., Jozwiak J. Anticancer Res. 19:1999;1249
12. Rossello A., Bertini S., Lapucci A., Macchia M., Martinelli A., Rapposelli S., Herreros E., Macchia B. J. Med. Chem. 45:2002;4903
13. Papadaki-Valiraki A., Papakonstantinou-Garofalias S., Marakos P., Chytyroglou-Lada A., Hosoya M., Balzarini J., de Clercq E. Farmaco. 48:1993;1091
14. Venhuis B.J., Dijkstra D., Wustrow D., Meltzer L.T., Wise L.D., Johnson S.J., Wikstrom H.V. J. Med. Chem. 46:2003;4136
15. El-Hadri A., Nicolle E., Leclerc G. Pharmazie. 58:2003;13
16. The hypotensive activity of oxime ether 1 and 2 was carried out in the pharmacology division of Central Drug Research Institute, Lucknow, India. Cats (2.5-4.0 kg) were anaesthetized with pentobarbitone sodium (35.0 mg/kg ip) and their blood pressure (BP) was recorded from a carotid artery
17. Tandon V.K., Chhor R.B., Goswamy G.K. Ind. J. Chem. 37B:1998;1027
18. Tandon V.K., Khanna J.M., Chandra A., Anand N. Tetrahedron. 46:1990;2871
19. Huckle D., Lockhart I.M., Webb N.E. J. Chem. Soc. 1971;2252
20. 3 (356): C, 70.78; H, 7.86; N, 7.86. Found: C, 70.92; H, 7.66; N, 7.92