Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6490-6493

  Bai, Renren ^a   Liu, Jie ^a   Zhu, Yao ^a   Yang, Xue ^a   Yang, Chen ^a   Kong, Lingyi ^a   Wang, Xiaobing ^a   Zhang, Hengyuan ^a   Yao, Hequan ^a   Shen, Mingqin ^b   Wu, Xiaoming ^a   Xu, Jinyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Provincial Institute of Traditional Chinese Medicine   (China)

Author keywords

Antihypertensive activity; Chiral separation; Circular dichroism; Enantiomers; Isochromanone

Indexed keywords

7,8 DIHYDROXY 3 METHYLISOCHROMANONE 4; ANTIHYPERTENSIVE AGENT; CAPTOPRIL; CHROMAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HYPERTENSION; NONHUMAN; RAT; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CHROMONES; CIRCULAR DICHROISM; HYPERTENSION; MUSA; RATS; RATS, INBRED SHR; STEREOISOMERISM;

MUSA X PARADISIACA;

EID: 84866729029     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.040     Document Type: Article

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