Synthesis and in vitro evaluation of derivatives of the β 1-adrenergic receptor antagonist HX-CH 44

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5506-5509

  Stephenson, Karin A ^a   Wilson, Alan A ^a   Houle, Sylvain ^a   Vasdev, Neil ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adrenergic receptors; Blocker; Fluorine; HX CH 44; In vitro; X ray crystallography

Indexed keywords

2 (4 HYDROXYPHENYL) 6 METHOXY3 METHYLQUINAZOLIN 4(3H) ONE; 2 [4 [3 (TERTBUTYL AMINO) 2 HYDROXYPROPOXY]PHENYL] 3 METHYL 6 METHOXY 4(3H) QUINAZOLINONE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; X RAY CRYSTALLOGRAPHY;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROPANOLAMINES; QUINAZOLINONES; RECEPTORS, ADRENERGIC, BETA-1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051929474     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.106     Document Type: Article

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