Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 7, 2003, Pages 1353-1361

  Bisi, Alessandra ^a   Rampa, Angela ^a   Budriesi, Roberta ^a   Gobbi, Silvia ^a   Belluti, Federica ^a   Ioan, Pierfranco ^a   Valoti, Ermanno ^b   Chiarini, Alberto ^a   Valenti, Piero ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 3 [(2 HYDROXY 3 PHENOXYPROPYL)(METHYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; 3 3 [(2 HYDROXY 3 PHENOXYPROPYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; 3 3 [2 HYDROXY 3 (1 NAPHTHYLOXY)PROPYL(METHYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; 3 3 [2 HYDROXY 3 (2 METHYLPHENOXY)PROPYL(METHYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; 3 3 [2 HYDROXY 3 (2 NITROPHENOXY)PROPYL(METHYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; 3 3 [3 (2 ACETYLPHENOXY) 2 HYDROXYPROPYL(METHYL)AMINO]PROPYL 7,8 DIMETHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 2 ONE; BENZAZEPINE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; CARDIOVASCULAR AGENT; UNCLASSIFIED DRUG; ZATEBRADINE;

ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CHRONOTROPISM; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SPECIFICITY; DRUG SYNTHESIS; ENANTIOMER; INOTROPISM; NONHUMAN; RECEPTOR AFFINITY; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0037375790     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00621-1     Document Type: Article

References (27)

1. Hieble J.P., Bondinell W.E., Ruffolo R.R. J. Med. Chem. 38:1995;3415.
2. Ruffolo R.R., Bondinell W.E., Hieble J.P. J. Med. Chem. 38:1995;3681.
3. Uchida W., Shibasaki K., Asano M., Takenaka T. J. Cardiovasc. Pharmacol. 21:1993;701.
4. Shibasaki K., Uchida W., Shirai Y., Inagaki O., Asano M., Takenaka T. Arch. Int. Pharmacodyn. 328:1994;213.
5. Hieble, J. P. In β-Adrenoceptors: Molecular Biology, Biochemistry and Pharmacology; Ruffolo, R. R., Jr. Ed.; Karger: Basel, 1991; Vol. 7, p 105.
6. Allan G., Cambridge D., Hardy G.W., Follenfant M.J. Br. J. Pharmacol. 90:1987;609.
7. Argentieri T.M., Troy H.H., Carrol M.S., Doroshuk C.M., Sullivan M.E. J. Cardiovasc. Pharmacol. 21:1993;647.
8. Kobinger W., Lillie C. Eur. J. Pharmacol. 104:1984;9.
9. Kobinger W., Lillie C. Eur. Heart J. 8(suppl. L):1987;7.
10. Franke H., Su C.A., Schumacher K., Seiberling M. Eur. Heart J. 8(suppl. L):1987;91.
11. Glasser S.P., Michie D.D., Thadani U., Baiker W.M. Am. J. Cardiol. 79:1997;1401.
12. Kruger C., Landerer V., Zugck C., Ehmke H., Kubler W., Haass M. Cardiovasc. Res. 45:2000;900.
13. Bom A., Booth S., Bruin J., Clark J., Miller S., Wathey B. Bioorg. Med. Chem. Lett. 11:2001;2351.
14. Reiffen M., Eberlein W., Muller P., Psiorz M., Noll K., Heider J., Lillie C., Kobinger W., Luger P. J. Med. Chem. 33:1990;1496.
15. Budriesi R., Rampa A., Bisi A., Fabbri G., Chiarini A., Valenti P. Arzneim.-Forsch./Drug Res. 45:1995;234.
16. Bomhard A., Reiffen M., Heider J., Psiorz M., Lillie C. J. Med. Chem. 34:1991;942.
17. (a) Large M.S., Smith H. J. Med. Chem. 25:1982;1286.
18. (b) Large M.S., Smith H. J. Med. Chem. 25:1982;1417.
19. Large M.S., Smith H. J. Med. Chem. 26:1983;352.
20. Pallavicini M., Valoti E., Villa L., Piccolo O. Tetrahedron Asymmetry. 5:1994;5.
21. Tallarida R.J., Murray R.B. Manual of Pharmacologic Calculations with Computer Programs. 2nd ed. 1992;Springer-Verlag, New York.
22. Hosohata Y., Hattori K., Shen Y., Okuyama M., Kaneko H., Ohnuki T., Suzuki J., Nagatomo T. Pharmacol. 57:1998;180.
23. Chem. Ber. 1891, 24, 2146.
24. Brenans P. Bull. Soc. Chim. Fr. 4:1913;13. 533.
25. Boyd V., Knowlton M. J. Chem. Soc. 95:1909;1805.
26. Beasley Y.M., Petrow V., Stephenson O. J. Pharm. Pharmacol. 10:1958;47.
27. Marle M. J. Chem. Soc. 101:1912;309.