Synthesis of oxypropanolamine derivatives of 3,4-dihydro-2H-1,4- benzoxazine, β-adrenergic affinity, inotropic, chronotropic and coronary vasodilating activities

European Journal of Medicinal Chemistry

Volumn 34, Issue 11, 1999, Pages 903-917

  Iakovou, Kriton ^a   Kazanis, Michalis ^a   Vavayannis, Andreas ^a   Bruni, Giancarlo ^b   Romeo, Maria Raffaella ^b   Massarelli, Paola ^b   Teramoto, Shuji ^c   Fujiki, Hiroyuki ^c   Mori, Toyoki ^c  

^a Univ A   (Greece)

^b UNIVERSITY OF SIENA   (Italy)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

1,4 benzoxazine; Cardiovascular effects; Oxypropanolamines; adrenoceptor affinity

Indexed keywords

3,4 DIHYDRO 2H 1,4 BENZOXAZINE DERIVATIVE; 4 ACETYL 6 (3 TERT BUTYLAMINO 2 HYDROXY)PROPOXY 3,4 DIHYDRO 2H 1,4 BENZOXAZINE; 4 ACETYL 6 [3 (3,4 DIMETHOXYBENZYL)AMINO 2 HYDROXY]PROPOXY 3,4 DIHYDRO 2H 1,4 BENZOXAZINE; 4 ACETYL 7 [3 (3,4 DIMETHOXYBENZYL)AMINO 2 HYDROXY]PROPOXY 3,4 DIHYDRO 2H 1,4 BENZOXAZINE; 7 (3 TERT BUTYLAMINO 2 HYDROXY)PROPOXY N BUTYRYL 3,4 DIHYDRO 2H 1,4 BENZOXAZINE; BENZOXAZINE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARTEOLOL; PROPANOLAMINE DERIVATIVE; PROPRANOLOL; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR EFFECT; CHRONOTROPISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; INOTROPISM; MALE; NONHUMAN; RAT; VASODILATATION;

EID: 0032730818     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00109-9     Document Type: Article

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