Hydroxysteroid Sulfotransferase SULT2B1b Promotes Hepatocellular Carcinoma Cells Proliferation In Vitro and In Vivo

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Yang, Xiaoming ^a,b   Xu, Yali ^a   Guo, Fenghua ^c   Ning, Yanxia ^a   Zhi, Xiuling ^a   Yin, Lianhua ^a   Li, Xiaobo ^a  

^a FUDAN UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; FAS ANTIGEN; HYDROXYSTEROID SULFOTRANSFERASE; HYDROXYSTEROID SULFOTRANSFERASE 2B1B; MYC PROTEIN; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; TRANSIENT TRANSFECTION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PRIMERS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICE; MICROSCOPY, FLUORESCENCE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFOTRANSFERASES;

LENTIVIRUS; MUS MUSCULUS;

EID: 84876111512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060853     Document Type: Article

References (28)

1. Sato K, Mori M, (2011) Evolving molecular mechanism-based strategies for control of hepatocellular carcinoma. Curr Med Chem 18: 4375-4388.
2. Aravalli RN, Steer CJ, Cressman EN, (2008) Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063.
3. Wu JM, Skill NJ, Maluccio MA, (2010) Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma. HPB (Oxford) 12: 625-636.
4. Morales A, Mari M, Garcia-Ruiz C, Colell A, Fernandez-Checa JC, (2012) Hepatocarcinogenesis and ceramide/cholesterol metabolism. Anticancer Agents Med Chem 12: 364-375.
5. Jusakul A, Yongvanit P, Loilome W, Namwat N, Kuver R, (2011) Mechanisms of oxysterol-induced carcinogenesis. Lipids Health Dis 10: 44.
6. Linseisen J, Wolfram G, Miller AB, (2002) Plasma 7beta-hydroxycholesterol as a possible predictor of lung cancer risk. Cancer Epidemiol Biomarkers Prev 11: 1630-1637.
7. Torres CG, Ramirez ME, Cruz P, Epunan MJ, Valladares LE, et al. (2011) 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncol Rep 26: 389-397.
8. Yoon JH, Werneburg NW, Higuchi H, Canbay AE, Kaufmann SH, et al. (2002) Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism. Cancer Res 62: 6500-6505.
9. Falany CN, He D, Dumas N, Frost AR, Falany JL, (2006) Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization. J Steroid Biochem Mol Biol 102: 214-221.
10. He D, Falany CN, (2007) Inhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells. Prostate 67: 1318-1329.
11. Li X, Pandak WM, Erickson SK, Ma Y, Yin L, et al. (2007) Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. J Lipid Res 48: 2587-2596.
12. He D, Meloche CA, Dumas NA, Frost AR, Falany CN, (2004) Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. Biochem J 379: 533-540.
13. Hevir N, Sinkovec J, Rizner TL, (2011) Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. Mol Cell Endocrinol 331: 158-167.
14. Bieche I, Girault I, Urbain E, Tozlu S, Lidereau R, (2004) Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma. Breast Cancer Res 6: R252-R263.
15. Tozlu S, Girault I, Vacher S, Vendrell J, Andrieu C, et al. (2006) Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach. Endocr Relat Cancer 13: 1109-1120.
16. Lo SG, Celli N, Caboni M, Murzilli S, Salvatore L, et al. (2010) Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes. Hepatology 51: 1334-1344.
17. Zhang X, Bai Q, Xu L, Kakiyama G, Pandak WM Jr, et al. (2012) Cytosolic Sulfotransferase 2B1b Promotes Hepatocyte Proliferation Gene Expression In Vivo And In Vitro. Am J Physiol Gastrointest Liver Physiol 303(3): G344-355.
18. Bai Q, Xu L, Kakiyama G, Runge-Morris MA, Hylemon PB, et al. (2011) Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. Atherosclerosis 214: 350-356.
19. Shimizu C, Fuda H, Yanai H, Strott CA, (2003) Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1. Endocrinology 144: 1186-1193.
20. Ren S, Li X, Rodriguez-Agudo D, Gil G, Hylemon P, et al. (2007) Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun 360: 802-808.
21. Wang X, Seed B, (2003) A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res 31: e154.
22. Ren S, Hylemon P, Marques D, Hall E, Redford K, et al. (2004) Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis. J Lipid Res 45: 2123-2131.
23. Fu J, Weise AM, Falany JL, Falany CN, Thibodeau BJ, et al. (2010) Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression. Breast Cancer Res Treat 120: 35-45.
24. Dumas NA, He D, Frost AR, Falany CN, (2008) Sulfotransferase 2B1b in human breast: differences in subcellular localization in African American and Caucasian women. J Steroid Biochem Mol Biol 111: 171-177.
25. Zhang X, Bai Q, Kakiyama G, Xu L, Kim JK, et al. (2012) Cholesterol metabolite, 5-cholesten-3beta-25-diol-3-sulfate, promotes hepatic proliferation in mice. J Steroid Biochem Mol Biol 132(3-5): 262-270.
26. Greenbaum LE, (2004) Cell cycle regulation and hepatocarcinogenesis. Cancer Biol Ther 3: 1200-1207.
27. Xu K, Liang X, Wang F, Xie L, Xu Y, et al. (2011) Induction of G2/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. Anticancer Drugs 22: 875-885.
28. Cook IT, Duniec-Dmuchowski Z, Kocarek TA, Runge-Morris M, Falany CN, (2009) 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. Drug Metab Dispos 37: 2069-2078.