Expanding the scope of replicable unnatural DNA: Stepwise optimization of a predominantly hydrophobic base pair

Journal of the American Chemical Society

Volumn 135, Issue 14, 2013, Pages 5408-5419

  Lavergne, Thomas ^a   Degardin, Mélissa ^a   Malyshev, Denis A ^a   Quach, Henry T ^a   Dhami, Kirandeep ^a   Ordoukhanian, Phillip ^a   Romesberg, Floyd E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIZATIONS; ELECTRONIC EFFECTS; HYDROPHOBIC FORCES; META POSITIONS; METHOXY GROUP; SIZE CONSTRAINT; STEPWISE OPTIMIZATION; UNNATURAL BASE PAIRS;

DNA; EFFICIENCY; HYDROPHOBICITY;

OPTIMIZATION;

ACROLEIN; DNA; DNA DIRECTED DNA POLYMERASE BETA; EXONUCLEASE; HYDROXYL GROUP; NUCLEOPHILE; NUCLEOTIDE; POTASSIUM; REPLICABLE UNNATURAL DNA; TAQ POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONTROLLED STUDY; DEPROTECTION REACTION; HYDROPHOBICITY; IN VIVO STUDY;

BASE PAIRING; DNA; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR STRUCTURE; ORGANIC CHEMICALS;

EID: 84876068777     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja312148q     Document Type: Article

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