메뉴 건너뛰기




Volumn 110, Issue 15, 2013, Pages 6199-6204

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CALCIUM; CYTOCHROME P450; CYTOCHROME P450 27B1; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHORUS; RECOMBINANT PROTEIN; SCLEROSTIN; SECALCIFEROL; UNCLASSIFIED DRUG;

EID: 84876053276     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221255110     Document Type: Article
Times cited : (113)

References (52)
  • 1
    • 40149102166 scopus 로고    scopus 로고
    • Osteocytederived sclerostin inhibits bone formation: Its role in bone morphogenetic protein and Wnt signaling
    • ten Dijke P, Krause C, de Gorter DJ, Löwik CW, van Bezooijen RL (2008) Osteocytederived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling. J Bone Joint Surg Am 90(Suppl 1):31-35.
    • (2008) J Bone Joint Surg Am , vol.90 , Issue.SUPPL. 1 , pp. 31-35
    • Ten Dijke, P.1    Krause, C.2    De Gorter, D.J.3    Löwik, C.W.4    Van Bezooijen, R.L.5
  • 2
    • 10744221383 scopus 로고    scopus 로고
    • Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
    • Winkler DG, et al. (2003) Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J 22(23):6267-6276.
    • (2003) EMBO J , vol.22 , Issue.23 , pp. 6267-6276
    • Winkler, D.G.1
  • 3
    • 13244298422 scopus 로고    scopus 로고
    • Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
    • Winkler DG, et al. (2005) Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. J Biol Chem 280(4):2498-2502.
    • (2005) J Biol Chem , vol.280 , Issue.4 , pp. 2498-2502
    • Winkler, D.G.1
  • 4
    • 5344234448 scopus 로고    scopus 로고
    • Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation
    • Sutherland MK, et al. (2004) Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation. Bone 35(4):828-835.
    • (2004) Bone , vol.35 , Issue.4 , pp. 828-835
    • Sutherland, M.K.1
  • 5
    • 67449092566 scopus 로고    scopus 로고
    • Characterization of the structural features and interactions of sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
    • Veverka V, et al. (2009) Characterization of the structural features and interactions of sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation. J Biol Chem 284(16):10890-10900.
    • (2009) J Biol Chem , vol.284 , Issue.16 , pp. 10890-10900
    • Veverka, V.1
  • 6
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • Balemans W, et al. (2001) Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet 10(5):537-543.
    • (2001) Hum Mol Genet , vol.10 , Issue.5 , pp. 537-543
    • Balemans, W.1
  • 7
    • 33845994036 scopus 로고    scopus 로고
    • LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    • Semenov MV, He X (2006) LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. J Biol Chem 281(50):38276-38284.
    • (2006) J Biol Chem , vol.281 , Issue.50 , pp. 38276-38284
    • Semenov, M.V.1    He, X.2
  • 8
    • 33846449190 scopus 로고    scopus 로고
    • Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
    • Ellies DL, et al. (2006) Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res 21(11):1738-1749.
    • (2006) J Bone Miner Res , vol.21 , Issue.11 , pp. 1738-1749
    • Ellies, D.L.1
  • 9
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X, et al. (2005) Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 280(20):19883-19887.
    • (2005) J Biol Chem , vol.280 , Issue.20 , pp. 19883-19887
    • Li, X.1
  • 11
    • 78149447051 scopus 로고    scopus 로고
    • Sclerostin-erbB-3 interactions: Modulation of erbB-3 activity by sclerostin
    • Craig TA, Kumar R (2010) Sclerostin-erbB-3 interactions: Modulation of erbB-3 activity by sclerostin. Biochem Biophys Res Commun 402(2):421-424.
    • (2010) Biochem Biophys Res Commun , vol.402 , Issue.2 , pp. 421-424
    • Craig, T.A.1    Kumar, R.2
  • 13
    • 22244474640 scopus 로고    scopus 로고
    • Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
    • Loots GG, et al. (2005) Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res 15(7):928-935.
    • (2005) Genome Res , vol.15 , Issue.7 , pp. 928-935
    • Loots, G.G.1
  • 14
    • 0035089781 scopus 로고    scopus 로고
    • Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
    • Brunkow ME, et al. (2001) Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 68(3):577-589.
    • (2001) Am J Hum Genet , vol.68 , Issue.3 , pp. 577-589
    • Brunkow, M.E.1
  • 15
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, et al. (2008) Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23(6):860-869.
    • (2008) J Bone Miner Res , vol.23 , Issue.6 , pp. 860-869
    • Li, X.1
  • 16
    • 84865552981 scopus 로고    scopus 로고
    • Targeted deletion of Sost distal enhancer increases bone formation and bone mass
    • Collette NM, et al. (2012) Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci USA 109(35):14092-14097.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.35 , pp. 14092-14097
    • Collette, N.M.1
  • 17
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • Lin C, et al. (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24(10):1651-1661.
    • (2009) J Bone Miner Res , vol.24 , Issue.10 , pp. 1651-1661
    • Lin, C.1
  • 18
  • 19
    • 0025164995 scopus 로고
    • Recent advances in calcium transport by the kidney
    • Borke JL, Penniston JT, Kumar R (1990) Recent advances in calcium transport by the kidney. Semin Nephrol 10(1):15-23.
    • (1990) Semin Nephrol , vol.10 , Issue.1 , pp. 15-23
    • Borke, J.L.1    Penniston, J.T.2    Kumar, R.3
  • 20
    • 0016257436 scopus 로고
    • Role of 1, 25-dihydroxyvitamin D3 in maintaining serum phosphorus and curing rickets
    • Tanaka Y, Deluca HF (1974) Role of 1, 25-dihydroxyvitamin D3 in maintaining serum phosphorus and curing rickets. Proc Natl Acad Sci USA 71(4):1040-1044.
    • (1974) Proc Natl Acad Sci USA , vol.71 , Issue.4 , pp. 1040-1044
    • Tanaka, Y.1    Deluca, H.F.2
  • 21
    • 0020464939 scopus 로고
    • Acute effects of a "physiological" dose of 1, 25-dihydroxy vitamin D3 on renal phosphate transport
    • Georgaki H, Puschett JB (1982) Acute effects of a " physiological" dose of 1, 25-dihydroxy vitamin D3 on renal phosphate transport. Endocr Res Commun 9(2):135-143.
    • (1982) Endocr Res Commun , vol.9 , Issue.2 , pp. 135-143
    • Georgaki, H.1    Puschett, J.B.2
  • 22
    • 0015415673 scopus 로고
    • The acute renal tubular effects of 1, 25-dihydroxycholecalciferol
    • Puschett JB, et al. (1972) The acute renal tubular effects of 1, 25-dihydroxycholecalciferol. Proc Soc Exp Biol Med 141(1):379-384.
    • (1972) Proc Soc Exp Biol Med , vol.141 , Issue.1 , pp. 379-384
    • Puschett, J.B.1
  • 23
    • 59849097605 scopus 로고    scopus 로고
    • Novel mechanisms in the regulation of phosphorus homeostasis
    • Berndt T, Kumar R (2009) Novel mechanisms in the regulation of phosphorus homeostasis. Physiology (Bethesda) 24:17-25.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 17-25
    • Berndt, T.1    Kumar, R.2
  • 25
    • 0026523176 scopus 로고
    • Intestinal calcium transport and calcium extrusion processes at the basolateral membrane
    • Suppl
    • Wasserman RH, et al. (1992) Intestinal calcium transport and calcium extrusion processes at the basolateral membrane. J Nutr 122(3, Suppl): (Suppl):662-671.
    • (1992) J Nutr , vol.122 , Issue.3 SUPPL. , pp. 662-671
    • Wasserman, R.H.1
  • 26
    • 0017102419 scopus 로고
    • Metabolism and mechanism of action of vitamin D
    • DeLuca HF, Schnoes HK (1976) Metabolism and mechanism of action of vitamin D. Annu Rev Biochem 45:631-666.
    • (1976) Annu Rev Biochem , vol.45 , pp. 631-666
    • DeLuca, H.F.1    Schnoes, H.K.2
  • 27
    • 0015367525 scopus 로고
    • Control of 25-hydroxycholecalciferol metabolism by parathyroid glands
    • Garabedian M, Holick MF, Deluca HF, Boyle IT (1972) Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. Proc Natl Acad Sci USA 69(7):1673-1676.
    • (1972) Proc Natl Acad Sci USA , vol.69 , Issue.7 , pp. 1673-1676
    • Garabedian, M.1    Holick, M.F.2    Deluca, H.F.3    Boyle, I.T.4
  • 28
    • 0015500937 scopus 로고
    • Regulation of metabolism of 25-hydroxycholecalciferol by kidney tissue in vitro by dietary calcium
    • Omdahl JL, Gray RW, Boyle IT, Knutson J, DeLuca HF (1972) Regulation of metabolism of 25-hydroxycholecalciferol by kidney tissue in vitro by dietary calcium. Nat New Biol 237(71):63-64.
    • (1972) Nat New Biol , vol.237 , Issue.71 , pp. 63-64
    • Omdahl, J.L.1    Gray, R.W.2    Boyle, I.T.3    Knutson, J.4    DeLuca, H.F.5
  • 29
    • 0015583124 scopus 로고
    • The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus
    • Tanaka Y, Deluca HF (1973) The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch Biochem Biophys 154(2):566-574.
    • (1973) Arch Biochem Biophys , vol.154 , Issue.2 , pp. 566-574
    • Tanaka, Y.1    Deluca, H.F.2
  • 30
    • 0347362503 scopus 로고    scopus 로고
    • The phosphatonin pathway: New insights in phosphate homeostasis
    • Schiavi SC, Kumar R (2004) The phosphatonin pathway: New insights in phosphate homeostasis. Kidney Int 65(1):1-14.
    • (2004) Kidney Int , vol.65 , Issue.1 , pp. 1-14
    • Schiavi, S.C.1    Kumar, R.2
  • 31
    • 1642416884 scopus 로고    scopus 로고
    • Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitaminD metabolism
    • Shimada T, et al. (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitaminD metabolism. J Clin Invest 113(4):561-568.
    • (2004) J Clin Invest , vol.113 , Issue.4 , pp. 561-568
    • Shimada, T.1
  • 32
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    • van Bezooijen RL, et al. (2004) Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 199(6):805-814.
    • (2004) J Exp Med , vol.199 , Issue.6 , pp. 805-814
    • Van Bezooijen, R.L.1
  • 33
    • 70350223807 scopus 로고    scopus 로고
    • Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease
    • Pereira RC, et al. (2009) Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. Bone 45(6):1161-1168.
    • (2009) Bone , vol.45 , Issue.6 , pp. 1161-1168
    • Pereira, R.C.1
  • 34
    • 77951253593 scopus 로고    scopus 로고
    • FGF-23 in bone biology
    • Wesseling-Perry K (2010) FGF-23 in bone biology. Pediatr Nephrol 25(4):603-608.
    • (2010) Pediatr Nephrol , vol.25 , Issue.4 , pp. 603-608
    • Wesseling-Perry, K.1
  • 35
    • 38849170631 scopus 로고    scopus 로고
    • Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
    • Yuan B, et al. (2008) Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest 118(2):722-734.
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 722-734
    • Yuan, B.1
  • 36
    • 0034805353 scopus 로고    scopus 로고
    • FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate
    • Bowe AE, et al. (2001) FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem Biophys Res Commun 284(4):977-981.
    • (2001) Biochem Biophys Res Commun , vol.284 , Issue.4 , pp. 977-981
    • Bowe, A.E.1
  • 37
    • 0015113986 scopus 로고
    • Regulation by calcium of in vivo synthesis of 1, 25- dihydroxycholecalciferol and 21, 25-dihydroxycholecalciferol
    • Boyle IT, Gray RW, DeLuca HF (1971) Regulation by calcium of in vivo synthesis of 1, 25-dihydroxycholecalciferol and 21, 25-dihydroxycholecalciferol. Proc Natl Acad Sci USA 68(9):2131-2134.
    • (1971) Proc Natl Acad Sci USA , vol.68 , Issue.9 , pp. 2131-2134
    • Boyle, I.T.1    Gray, R.W.2    DeLuca, H.F.3
  • 38
    • 0019081951 scopus 로고
    • Effects of PTH, ADH, and cyclic AMP on distal tubular Ca and Na reabsorption
    • Costanzo LS, Windhager EE (1980) Effects of PTH, ADH, and cyclic AMP on distal tubular Ca and Na reabsorption. Am J Physiol 239(5):F478-F485.
    • (1980) Am J Physiol , vol.239 , Issue.5
    • Costanzo, L.S.1    Windhager, E.E.2
  • 39
    • 0018847119 scopus 로고
    • Effects of parathyroid hormone and cyclic AMP on distal tubular calcium and sodium transport
    • Costanzo LS, Windhager EE (1980) Effects of parathyroid hormone and cyclic AMP on distal tubular calcium and sodium transport. Contrib Nephrol 20:114-117.
    • (1980) Contrib Nephrol , vol.20 , pp. 114-117
    • Costanzo, L.S.1    Windhager, E.E.2
  • 40
    • 0038023191 scopus 로고    scopus 로고
    • High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    • Valenzuela DM, et al. (2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21(6):652-659.
    • (2003) Nat Biotechnol , vol.21 , Issue.6 , pp. 652-659
    • Valenzuela, D.M.1
  • 41
    • 77955406816 scopus 로고    scopus 로고
    • Archiving and distributing mouse lines by sperm cryopreservation, IVF, and embryo transfer
    • Takahashi H, Liu C (2010) Archiving and distributing mouse lines by sperm cryopreservation, IVF, and embryo transfer. Methods Enzymol 476:53-69.
    • (2010) Methods Enzymol , vol.476 , pp. 53-69
    • Takahashi, H.1    Liu, C.2
  • 42
    • 10744231395 scopus 로고    scopus 로고
    • Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
    • Mödder UI, et al. (2004) Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology 145(2):913-921.
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 913-921
    • Mödder, U.I.1
  • 43
    • 0013890720 scopus 로고
    • Determination of serum calcium by means of orthocresolphthalein complexone
    • Connerty HV, Briggs AR (1966) Determination of serum calcium by means of orthocresolphthalein complexone. Am J Clin Pathol 45(3):290-296.
    • (1966) Am J Clin Pathol , vol.45 , Issue.3 , pp. 290-296
    • Connerty, H.V.1    Briggs, A.R.2
  • 44
    • 0020659674 scopus 로고
    • Direct determination of inorganic phosphorus in serum with a single reagent
    • Muñoz MA, Balón M, Fernandez C (1983) Direct determination of inorganic phosphorus in serum with a single reagent. Clin Chem 29(2):372-374.
    • (1983) Clin Chem , vol.29 , Issue.2 , pp. 372-374
    • Muñoz, M.A.1    Balón, M.2    Fernandez, C.3
  • 45
    • 0030191533 scopus 로고    scopus 로고
    • Comparison of Jaffé rate assay and enzymatic method for the measurement of creatinine clearance
    • Horio M, Orita Y (1996) Comparison of Jaffé rate assay and enzymatic method for the measurement of creatinine clearance. Nippon Jinzo Gakkai Shi 38(7):296-299.
    • (1996) Nippon Jinzo Gakkai Shi , vol.38 , Issue.7 , pp. 296-299
    • Horio, M.1    Orita, Y.2
  • 46
    • 0030051013 scopus 로고    scopus 로고
    • Normal phosphate transport in cells from the S2 and S3 segments of Hyp-mouse proximal renal tubules
    • Nesbitt T, Byun JK, Drezner MK (1996) Normal phosphate transport in cells from the S2 and S3 segments of Hyp-mouse proximal renal tubules. Endocrinology 137(3):943-948.
    • (1996) Endocrinology , vol.137 , Issue.3 , pp. 943-948
    • Nesbitt, T.1    Byun, J.K.2    Drezner, M.K.3
  • 47
    • 0029114670 scopus 로고
    • Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: Evidence that the HYP gene locus product is an extrarenal factor
    • Nesbitt T, et al. (1995) Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: evidence that the HYP gene locus product is an extrarenal factor. J Bone Miner Res 10(9):1327-1333.
    • (1995) J Bone Miner Res , vol.10 , Issue.9 , pp. 1327-1333
    • Nesbitt, T.1
  • 48
    • 33751540403 scopus 로고    scopus 로고
    • TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture
    • Bensamoun SF, et al. (2006) TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone 39(6):1244-1251.
    • (2006) Bone , vol.39 , Issue.6 , pp. 1244-1251
    • Bensamoun, S.F.1
  • 49
    • 77954756294 scopus 로고    scopus 로고
    • Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    • Bouxsein ML, et al. (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25(7):1468-1486.
    • (2010) J Bone Miner Res , vol.25 , Issue.7 , pp. 1468-1486
    • Bouxsein, M.L.1
  • 50
    • 4444250888 scopus 로고    scopus 로고
    • Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice
    • Bouxsein ML, et al. (2004) Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res 19(4):587-599.
    • (2004) J Bone Miner Res , vol.19 , Issue.4 , pp. 587-599
    • Bouxsein, M.L.1
  • 51
    • 40349106218 scopus 로고    scopus 로고
    • Whole-mount histochemical detection of beta-galactosidase activity
    • Pereira FA (2001) Whole-mount histochemical detection of beta-galactosidase activity. Curr Protoc Mol Biol Chapter 14: Unit14.14.
    • (2001) Curr Protoc Mol Biol Chapter , vol.14
    • Pereira, F.A.1
  • 52
    • 84868503739 scopus 로고    scopus 로고
    • Histone deacetylase 3 is required for maintenance of bone mass during aging
    • McGee-Lawrence ME, et al. (2013) Histone deacetylase 3 is required for maintenance of bone mass during aging. Bone 52(1):296-307.
    • (2013) Bone , vol.52 , Issue.1 , pp. 296-307
    • McGee-Lawrence, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.