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Volumn 52, Issue 1, 2013, Pages 296-307

Histone deacetylase 3 is required for maintenance of bone mass during aging

Author keywords

DNA damage; Histone deacetylase; Osteoblast; Osteocalcin Cre; Osteocyte

Indexed keywords

CRE RECOMBINASE; DNA; HISTONE; HISTONE DEACETYLASE 3; LYSINE; OSTEOCALCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR ZFP521; UNCLASSIFIED DRUG;

EID: 84868503739     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.10.015     Document Type: Article
Times cited : (66)

References (51)
  • 1
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of non-histone proteins
    • Glozak M.A., Sengupta N., Zhang X., Seto E. Acetylation and deacetylation of non-histone proteins. Gene 2005, 363:15-23.
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, X.3    Seto, E.4
  • 2
    • 33745196250 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates Runx2 acetylation
    • Jeon E.J., Lee K.Y., Choi N.S., Lee M.H., Kim H.N., Jin Y.H., et al. Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem 2006, 281:16502-16511.
    • (2006) J Biol Chem , vol.281 , pp. 16502-16511
    • Jeon, E.J.1    Lee, K.Y.2    Choi, N.S.3    Lee, M.H.4    Kim, H.N.5    Jin, Y.H.6
  • 3
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • Schroeder T.M., Kahler R.A., Li X., Westendorf J.J. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 2004, 279:41998-42007.
    • (2004) J Biol Chem , vol.279 , pp. 41998-42007
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 4
    • 78650749107 scopus 로고    scopus 로고
    • Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
    • Hesse E., Saito H., Kiviranta R., Correa D., Yamana K., Neff L., et al. Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J Cell Biol 2010, 191:1271-1283.
    • (2010) J Cell Biol , vol.191 , pp. 1271-1283
    • Hesse, E.1    Saito, H.2    Kiviranta, R.3    Correa, D.4    Yamana, K.5    Neff, L.6
  • 5
    • 0034617261 scopus 로고    scopus 로고
    • Histone deacetylases specifically down-regulate p53-dependent gene activation
    • Juan L.J., Shia W.J., Chen M.H., Yang W.M., Seto E., Lin Y.S., et al. Histone deacetylases specifically down-regulate p53-dependent gene activation. J Biol Chem 2000, 275:20436-20443.
    • (2000) J Biol Chem , vol.275 , pp. 20436-20443
    • Juan, L.J.1    Shia, W.J.2    Chen, M.H.3    Yang, W.M.4    Seto, E.5    Lin, Y.S.6
  • 6
    • 0034676439 scopus 로고    scopus 로고
    • Deacetylation of p53 modulates its effect on cell growth and apoptosis
    • Luo J., Su F., Chen D., Shiloh A., Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000, 408:377-381.
    • (2000) Nature , vol.408 , pp. 377-381
    • Luo, J.1    Su, F.2    Chen, D.3    Shiloh, A.4    Gu, W.5
  • 7
    • 79951571473 scopus 로고    scopus 로고
    • Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis
    • Zhang F., Shi Y., Wang L., Sriram S. Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. PLoS One 2011, 6:e16795.
    • (2011) PLoS One , vol.6
    • Zhang, F.1    Shi, Y.2    Wang, L.3    Sriram, S.4
  • 8
    • 67650572769 scopus 로고    scopus 로고
    • Epigenetic control of skull morphogenesis by histone deacetylase 8
    • Haberland M., Mokalled M.H., Montgomery R.L., Olson E.N. Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev 2009, 23:1625-1630.
    • (2009) Genes Dev , vol.23 , pp. 1625-1630
    • Haberland, M.1    Mokalled, M.H.2    Montgomery, R.L.3    Olson, E.N.4
  • 9
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega R.B., Matsuda K., Oh J., Barbosa A.C., Yang X., Meadows E., et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 2004, 119:555-566.
    • (2004) Cell , vol.119 , pp. 555-566
    • Vega, R.B.1    Matsuda, K.2    Oh, J.3    Barbosa, A.C.4    Yang, X.5    Meadows, E.6
  • 10
    • 40749161986 scopus 로고    scopus 로고
    • Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
    • Zhang Y., Kwon S., Yamaguchi T., Cubizolles F., Rousseaux S., Kneissel M., et al. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol 2008, 28:1688-1701.
    • (2008) Mol Cell Biol , vol.28 , pp. 1688-1701
    • Zhang, Y.1    Kwon, S.2    Yamaguchi, T.3    Cubizolles, F.4    Rousseaux, S.5    Kneissel, M.6
  • 11
    • 79954548904 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts
    • McGee-Lawrence M.E., McCleary-Wheeler A.L., Secreto F.J., Razidlo D.F., Zhang M., Stensgard B.A., et al. Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts. Bone 2011, 48:1117-1126.
    • (2011) Bone , vol.48 , pp. 1117-1126
    • McGee-Lawrence, M.E.1    McCleary-Wheeler, A.L.2    Secreto, F.J.3    Razidlo, D.F.4    Zhang, M.5    Stensgard, B.A.6
  • 12
    • 78650506912 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    • Pratap J., Akech J., Wixted J.J., Szabo G., Hussain S., McGee-Lawrence M.E., et al. The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther 2010, 9:3210-3220.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3210-3220
    • Pratap, J.1    Akech, J.2    Wixted, J.J.3    Szabo, G.4    Hussain, S.5    McGee-Lawrence, M.E.6
  • 13
    • 77954651350 scopus 로고    scopus 로고
    • Adverse effects of valproate on bone: defining a model to investigate the pathophysiology
    • Senn S.M., Kantor S., Poulton I.J., Morris M.J., Sims N.A., O'Brien T.J., et al. Adverse effects of valproate on bone: defining a model to investigate the pathophysiology. Epilepsia 2010, 51:984-993.
    • (2010) Epilepsia , vol.51 , pp. 984-993
    • Senn, S.M.1    Kantor, S.2    Poulton, I.J.3    Morris, M.J.4    Sims, N.A.5    O'Brien, T.J.6
  • 14
    • 34948880682 scopus 로고    scopus 로고
    • Histone deacetylases in control of skeletogenesis
    • Westendorf J.J. Histone deacetylases in control of skeletogenesis. J Cell Biochem 2007, 102:332-340.
    • (2007) J Cell Biochem , vol.102 , pp. 332-340
    • Westendorf, J.J.1
  • 15
    • 0036840499 scopus 로고    scopus 로고
    • Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter
    • Westendorf J.J., Zaidi S.K., Cascino J.E., Kahler R., van Wijnen A.J., Lian J.B., et al. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol 2002, 22:7982-7992.
    • (2002) Mol Cell Biol , vol.22 , pp. 7982-7992
    • Westendorf, J.J.1    Zaidi, S.K.2    Cascino, J.E.3    Kahler, R.4    van Wijnen, A.J.5    Lian, J.B.6
  • 16
    • 41549156540 scopus 로고    scopus 로고
    • Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
    • Bhaskara S., Chyla B.J., Amann J.M., Knutson S.K., Cortez D., Sun Z.W., et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 2008, 30:61-72.
    • (2008) Mol Cell , vol.30 , pp. 61-72
    • Bhaskara, S.1    Chyla, B.J.2    Amann, J.M.3    Knutson, S.K.4    Cortez, D.5    Sun, Z.W.6
  • 17
    • 77955349977 scopus 로고    scopus 로고
    • Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat
    • Razidlo D.F., Whitney T.J., Casper M.E., McGee-Lawrence M.E., Stensgard B.A., Li X., et al. Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat. PLoS One 2010, 5:e11492.
    • (2010) PLoS One , vol.5
    • Razidlo, D.F.1    Whitney, T.J.2    Casper, M.E.3    McGee-Lawrence, M.E.4    Stensgard, B.A.5    Li, X.6
  • 18
    • 84870394039 scopus 로고    scopus 로고
    • Hdac3 Controls Growth Plate Matrix Secretion and Akt/mTOR Pathway Activation
    • American Society for Bone and Mineral Research, San Diego, CA
    • Bradley E.W., Razidlo D.R., Stensgard B., Westendorf J.J. Hdac3 Controls Growth Plate Matrix Secretion and Akt/mTOR Pathway Activation. ASBMR 2011 Annual Meeting 2011, FR0086. American Society for Bone and Mineral Research, San Diego, CA.
    • (2011) ASBMR 2011 Annual Meeting
    • Bradley, E.W.1    Razidlo, D.R.2    Stensgard, B.3    Westendorf, J.J.4
  • 19
    • 0347721834 scopus 로고    scopus 로고
    • Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    • Zhang M., Xuan S., Bouxsein M.L., von Stechow D., Akeno N., Faugere M.C., et al. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 2002, 277:44005-44012.
    • (2002) J Biol Chem , vol.277 , pp. 44005-44012
    • Zhang, M.1    Xuan, S.2    Bouxsein, M.L.3    von Stechow, D.4    Akeno, N.5    Faugere, M.C.6
  • 20
    • 41949120723 scopus 로고    scopus 로고
    • Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
    • Knutson S.K., Chyla B.J., Amann J.M., Bhaskara S., Huppert S.S., Hiebert S.W. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 2008, 27:1017-1028.
    • (2008) EMBO J , vol.27 , pp. 1017-1028
    • Knutson, S.K.1    Chyla, B.J.2    Amann, J.M.3    Bhaskara, S.4    Huppert, S.S.5    Hiebert, S.W.6
  • 21
    • 0030851006 scopus 로고    scopus 로고
    • Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes
    • Clemens T.L., Tang H., Maeda S., Kesterson R.A., Demayo F., Pike J.W., et al. Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes. J Bone Miner Res 1997, 12:1570-1576.
    • (1997) J Bone Miner Res , vol.12 , pp. 1570-1576
    • Clemens, T.L.1    Tang, H.2    Maeda, S.3    Kesterson, R.A.4    Demayo, F.5    Pike, J.W.6
  • 22
    • 63249129856 scopus 로고    scopus 로고
    • Transgenic mouse strains for conditional gene deletion during skeletal development
    • VanKoevering K.K., Williams B.O. Transgenic mouse strains for conditional gene deletion during skeletal development. IBMS BoneKEy 2008, 5:151-170.
    • (2008) IBMS BoneKEy , vol.5 , pp. 151-170
    • VanKoevering, K.K.1    Williams, B.O.2
  • 23
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 25
    • 51849116311 scopus 로고    scopus 로고
    • Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation
    • Norman J., Shapter J.G., Short K., Smith L.J., Fazzalari N.L. Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation. J Biomed Mater Res A 2008, 87:196-202.
    • (2008) J Biomed Mater Res A , vol.87 , pp. 196-202
    • Norman, J.1    Shapter, J.G.2    Short, K.3    Smith, L.J.4    Fazzalari, N.L.5
  • 26
    • 33748998751 scopus 로고    scopus 로고
    • The effects of embedding material, loading rate and magnitude, and penetration depth in nanoindentation of trabecular bone
    • Mittra E., Akella S., Qin Y.X. The effects of embedding material, loading rate and magnitude, and penetration depth in nanoindentation of trabecular bone. J Biomed Mater Res A 2006, 79:86-93.
    • (2006) J Biomed Mater Res A , vol.79 , pp. 86-93
    • Mittra, E.1    Akella, S.2    Qin, Y.X.3
  • 27
    • 0242577996 scopus 로고    scopus 로고
    • Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice
    • Chen Q., Rho J.Y., Fan Z., Laulederkind S.J., Raghow R. Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice. Calcif Tissue Int 2003, 73:387-392.
    • (2003) Calcif Tissue Int , vol.73 , pp. 387-392
    • Chen, Q.1    Rho, J.Y.2    Fan, Z.3    Laulederkind, S.J.4    Raghow, R.5
  • 28
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 29
    • 50349096522 scopus 로고    scopus 로고
    • Primary culture and phenotyping of murine chondrocytes
    • Gosset M., Berenbaum F., Thirion S., Jacques C. Primary culture and phenotyping of murine chondrocytes. Nat Protoc 2008, 3:1253-1260.
    • (2008) Nat Protoc , vol.3 , pp. 1253-1260
    • Gosset, M.1    Berenbaum, F.2    Thirion, S.3    Jacques, C.4
  • 31
    • 79952724921 scopus 로고    scopus 로고
    • Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway
    • Bradley E.W., Drissi M.H. Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway. J Cell Physiol 2011, 226:1683-1693.
    • (2011) J Cell Physiol , vol.226 , pp. 1683-1693
    • Bradley, E.W.1    Drissi, M.H.2
  • 32
    • 77954978666 scopus 로고    scopus 로고
    • WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways
    • Bradley E.W., Drissi M.H. WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways. Mol Endocrinol 2010, 24:1581-1593.
    • (2010) Mol Endocrinol , vol.24 , pp. 1581-1593
    • Bradley, E.W.1    Drissi, M.H.2
  • 33
    • 79952529158 scopus 로고    scopus 로고
    • A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
    • Feng D., Liu T., Sun Z., Bugge A., Mullican S.E., Alenghat T., et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 2011, 331:1315-1319.
    • (2011) Science , vol.331 , pp. 1315-1319
    • Feng, D.1    Liu, T.2    Sun, Z.3    Bugge, A.4    Mullican, S.E.5    Alenghat, T.6
  • 34
    • 80052992257 scopus 로고    scopus 로고
    • Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle
    • Sun Z., Singh N., Mullican S.E., Everett L.J., Li L., Yuan L., et al. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem 2011, 286:33301-33309.
    • (2011) J Biol Chem , vol.286 , pp. 33301-33309
    • Sun, Z.1    Singh, N.2    Mullican, S.E.3    Everett, L.J.4    Li, L.5    Yuan, L.6
  • 36
    • 77955602968 scopus 로고    scopus 로고
    • Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice
    • Zhou X., Zhang Z., Feng J.Q., Dusevich V.M., Sinha K., Zhang H., et al. Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A 2010, 107:12919-12924.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12919-12924
    • Zhou, X.1    Zhang, Z.2    Feng, J.Q.3    Dusevich, V.M.4    Sinha, K.5    Zhang, H.6
  • 37
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6
  • 38
    • 84862784199 scopus 로고    scopus 로고
    • Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification
    • Oh J.H., Park S.Y., de Crombrugghe B., Kim J.E. Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun 2012, 418:634-640.
    • (2012) Biochem Biophys Res Commun , vol.418 , pp. 634-640
    • Oh, J.H.1    Park, S.Y.2    de Crombrugghe, B.3    Kim, J.E.4
  • 43
    • 39249083918 scopus 로고    scopus 로고
    • Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model
    • Rissanen J.P., Suominen M.I., Peng Z., Halleen J.M. Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 2008, 82:108-115.
    • (2008) Calcif Tissue Int , vol.82 , pp. 108-115
    • Rissanen, J.P.1    Suominen, M.I.2    Peng, Z.3    Halleen, J.M.4
  • 44
    • 33645334941 scopus 로고    scopus 로고
    • Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss
    • Aguirre J.I., Plotkin L.I., Stewart S.A., Weinstein R.S., Parfitt A.M., Manolagas S.C., et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res 2006, 21:605-615.
    • (2006) J Bone Miner Res , vol.21 , pp. 605-615
    • Aguirre, J.I.1    Plotkin, L.I.2    Stewart, S.A.3    Weinstein, R.S.4    Parfitt, A.M.5    Manolagas, S.C.6
  • 45
    • 33846601758 scopus 로고    scopus 로고
    • Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts
    • Hedgecock N.L., Hadi T., Chen A.A., Curtiss S.B., Martin R.B., Hazelwood S.J. Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts. Bone 2007, 40:627-637.
    • (2007) Bone , vol.40 , pp. 627-637
    • Hedgecock, N.L.1    Hadi, T.2    Chen, A.A.3    Curtiss, S.B.4    Martin, R.B.5    Hazelwood, S.J.6
  • 46
    • 0036236905 scopus 로고    scopus 로고
    • Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?
    • Verborgt O., Tatton N.A., Majeska R.J., Schaffler M.B. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?. J Bone Miner Res 2002, 17:907-914.
    • (2002) J Bone Miner Res , vol.17 , pp. 907-914
    • Verborgt, O.1    Tatton, N.A.2    Majeska, R.J.3    Schaffler, M.B.4
  • 47
    • 80054976334 scopus 로고    scopus 로고
    • Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression
    • Cheung W.Y., Simmons C.A., You L. Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone 2012, 50:104-110.
    • (2012) Bone , vol.50 , pp. 104-110
    • Cheung, W.Y.1    Simmons, C.A.2    You, L.3
  • 48
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism
    • Bellido T., Ali A.A., Plotkin L.I., Fu Q., Gubrij I., Roberson P.K., et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 2003, 278:50259-50272.
    • (2003) J Biol Chem , vol.278 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6
  • 50
    • 84864804112 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteonecrosis
    • Weinstein R.S. Glucocorticoid-induced osteonecrosis. Endocrinol Metab Clin North Am Sep 2012, 41(3):595-611.
    • (2012) Endocrinol Metab Clin North Am , vol.41 , Issue.3 , pp. 595-611
    • Weinstein, R.S.1
  • 51
    • 0034456539 scopus 로고    scopus 로고
    • Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip
    • Weinstein R.S., Nicholas R.W., Manolagas S.C. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J Clin Endocrinol Metab 2000, 85:2907-2912.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2907-2912
    • Weinstein, R.S.1    Nicholas, R.W.2    Manolagas, S.C.3


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