Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice

Endocrinology

Volumn 145, Issue 2, 2004, Pages 913-921

  Mödder, Ulrike I L ^a   Sanyal, Arunik ^a   Kearns, Ann E ^a   Sibonga, Jean D ^a   Nishihara, Eijun ^c   Xu, Jianming ^c   O'Malley, Bert W ^c   Ritman, Erik L ^e   Riggs, B Lawrence ^a   Spelsberg, Thomas C ^b   Khosla, Sundeep ^a,d  

^a Mayo Clinic   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MAYO CLINIC   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; STEROID RECEPTOR COACTIVATOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERAL; CANCELLOUS BONE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG EFFICACY; DRUG RESPONSE; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTROGEN THERAPY; FEMALE; KNOCKOUT MOUSE; LUMBAR SPINE; MEASUREMENT; METAPHYSIS; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; SKELETON; TIBIA; WILD TYPE;

ANIMALS; BONE AND BONES; BONE DENSITY; DENSITOMETRY, X-RAY; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN REPLACEMENT THERAPY; FEMALE; GENE EXPRESSION; HISTONE ACETYLTRANSFERASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR RECEPTOR COACTIVATOR 2; ORGAN SIZE; OSTEOPOROSIS; OVARIECTOMY; RECEPTORS, ESTROGEN; RNA, MESSENGER; TOMOGRAPHY, X-RAY COMPUTED; TRANSCRIPTION FACTORS; UTERUS;

EID: 10744231395     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1089     Document Type: Article

References (31)

1. McKenna NJ, Lanz RB, O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321-344
2. Onate SA, Tsai SY, Tsai MJ, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357
3. Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MR 1996 GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci USA 93: 4948-4952
4. Li H, Gomes PJ, Chen JD 1997 RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci USA 94: 8479-8484
5. Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai MJ, O'Malley BW 1998 Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 279:1922-1925
6. Riggs BL, Khosla S, Melton III LJ 2002 Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279-302
7. Khosla S, Melton III LJ, Riggs BL 2002 Clinical review: estrogen and the male skeleton. J Clin Endocrinol Metab 87:1443-1450
8. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86
9. Komm BS, Terpening CM, Benz DJ, Graeme KA, O'Malley BW, Haussler MR 1988 Estrogen binding receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241:81-84
10. Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL 1994 Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci USA 91:5227-5231
11. Spelsberg TC, Subramaniam M, Riggs BL, Khosla S 1999 The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol 13:819-828
12. Monroe DG, Johnsen SA, Subramaniam M, Getz BJ, Khosla S, Riggs BL, Spelsberg TC 2003 Mutual antagonism of estrogen receptors α and β and their preferred interactions with steroid receptor coactivators (SRCs) in human osteoblastic cell lines. J Endocrinol 176:349-357
13. Samuels A, Perry MJ, Tobias JH 1999 High dose estrogen induces de novo medullary bone formation in female mice. J Bone Miner Res 14:178-186
14. Jorgensen SM, Demirkaya O, Ritman EL 1998 Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with X-ray micro-CT. Am J Physiol 275(3 Pt 2):H1103-H1114
15. Herdick M, Carlberg C 2000 Agonist-triggered modulation of the activated and silent state of the vitamin D(3) receptor by interaction with co-repressors and co-activators. J Mol Biol 304:793-801
16. 3-stimulated alkaline phosphatase in human osteosarcoma cells. Calcif Tissue Int 66:370-374
17. Yang NN, Venugopalan M, Hardikar S, Glasebrook A 1996 Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 273:1222-1225
18. McDonnell DP, Norris JD 1997 Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanisms of action of estrogen in bone. Osteoporos Int 7(Suppl 1):S29-S34
19. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katznellenbogen JA, Katznellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC 2001 Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104:1-20
20. Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ, Lanyon LE 2002 Human osteoblasts' proliferative responses to strain and 17β-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res 17:593-602
21. Zaman G, Cheng MZ, Jessop HL, White R, Lanyon LE 2000 Mechanical strain activates estrogen response elements in bone cells. Bone 27:233-239
22. Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L 2003 Bone adaptation requires oestrogen receptor-α. Nature 424:389
23. Shang Y, Brown M 2002 Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468
24. Kousteni S, Han L, Chen J-R, Almeida M, Plotkin LI, Bellido T, Manolagas SC 2003 Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 111:1651-1664
25. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T 1997 Expression of estrogen receptor β in rat bone. Endocrinology 138:4509-4512
26. Bord S, Horner A, Beavan S, Compston J 2001 Estrogen receptors α and β are differentially expressed in developing human bone. J Clin Endocrinol Metab 86:2309-2314
27. Petersson K, Grandien K, Juiper GGJM, Gustafsson JA 1997 Mouse estrogen receptor β forms estrogen response element-binding heterodimers with estrogen receptor α. Mol Endocrinol 11:1486-1496
28. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS 1997 Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα knockout mouse. Endocrinology 138:4613-4621
29. Parisien M, Silverberg SJ, Shane E, Dempster DW, Bilezikian JP 1990 Bone disease in primary hyperparathyroidism. Endocrinol Metab Clin North Am 19:19-34
30. Daci E, Verstuyf A, Moermans K, Bouillon R, Carmeliet G 2000 Mice lacking plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency. J Bone Miner Res 15:1510-1516
31. Poli V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, Ciliberto G, Rodan GA, Constntini F 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 13:1189-1196