The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood

Advances in Experimental Medicine and Biology

Volumn 734, Issue , 2013, Pages 123-136

  Brekke, O L ^a,b   Waage, C ^a,b   Christiansen, D ^a,b   Fure, H ^a,b   Qu, H ^a,b   Lambris, John D ^a,b   Osterud, B ^a,b   Nielsen, E W ^a,b   Mollnes, T E ^a,b  

^a NORDLAND HOSPITAL   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIBODY F(AB) FRAGMENT; CD14 ANTIGEN; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT FACTOR; COMPLEMENT INHIBITOR; COMPSTATIN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPIRUDIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR BB; THROMBOPLASTIN; UNCLASSIFIED DRUG; COMPLEMENT; COMPLEMENT COMPONENT C5A RECEPTOR ANTAGONIST; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY;

ADULT; BLOOD; CELL SURFACE; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MEMBRANE MICROPARTICLE; MONOCYTE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; UPREGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 84934438226     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4118-2_8     Document Type: Conference Paper

References (45)

1. Brandtzaeg P, Mollnes TE, Kierulf P (1989) Complement activation and endotoxin levels in systemic meningococcal disease. J Infect Dis 160(1):58-655
2. Brekke OL, Christiansen D, Fure H, Fung M, Mollnes TE (2007) The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli -induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood. J Leukoc Biol 81(6):1404-14133
3. Brekke OL, Christiansen D, Fure H, Pharo A, Fung M, Riesenfeld J et al (2008) Combined inhibition of complement and CD14 abolish E. coli -induced cytokine-, chemokine- and growth factor-synthesis in human whole blood. Mol Immunol 45(14):3804-38133
4. Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature 407(6801):258-2644
5. Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA (2005) Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 106(5):1604-16111
6. Eligini S, Brambilla M, Ban fi C, Camera M, Sironi L, Barbieri SS et al (2002) Oxidized phospholipids inhibit cyclooxygenase- 2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms. Cardiovasc Res 55(2):406-4155
7. Engstad CS, Lia K, Rekdal O, Olsen JO, Osterud B (1995) A novel biological effect of platelet factor 4 (PF4): enhancement of LPS-induced tissue factor activity in monocytes. J Leukoc Biol 58(5):575-5811
8. Ernofsson M, Siegbahn A (1996) Platelet-derived growth factor-BB and monocyte chemotactic protein-1 induce human peripheral blood monocytes to express tissue factor. Thromb Res 83(4):307-3200
9. Ernofsson M, Tenno T, Siegbahn A (1996) Inhibition of tissue factor surface expression in human peripheral blood monocytes exposed to cytokines. Br J Haematol 95(2):249-2577
10. Gabay C, Lamacchia C, Palmer G (2010) IL-1 pathways in in flammation and human diseases. Nat Rev Rheumatol 6(4):232-2411
11. Gregory SA, Morrissey JH, Edgington TS (1989) Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin. Mol Cell Biol 9(6):2752-27555
12. Henriksson CE, Klingenberg O, Ovstebo R, Joo GB, Westvik AB, Kierulf P (2005) Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis. Thromb Haemost 94(6):1236-12444
13. Hiller E, Saal JG, Riethmuller G (1977) Procoagulant activity of activated monocytes. Haemostasis 6(6):347-3500
14. Huber-Lang MS, Riedeman NC, Sarma JV, Younkin EM, McGuire SR, Laudes IJ et al (2002) Protection of innate immunity by C5aR antagonist in septic mice. FASEB J 16(12):1567-15744
15. Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR et al (2006) Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 12(6):682-6877
16. Janssen BJ, Halff EF, Lambris JD, Gros P (2007) Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem 282(40):29241-292477
17. Kambas K, Markiewski M, Pneumatikos I, Rafail S, Theodorou V, Konstantonis D et al (2008) C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. J Immunol 180:7368-73755
18. Kappelmayer J, Bernabei A, Edmunds LH Jr, Edgington TS, Colman RW (1993) Tissue factor is expressed on monocytes during simulated extracorporeal circulation. Circ Res 72(5):1075-10811
19. Katragadda M, Magotti P, Sfyroera G, Lambris JD (2006) Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem 49(15):4616-46222
20. Lappegard KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J et al (2009) Human genetic de ficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci USA 106:15861-158666
21. Levi M, de Jonge E, van der Poll T (2006) Plasma and plasma components in the management of disseminated intravascular coagulation. Best Pract Res Clin Haematol 19(1):127-1422
22. Lyberg T, Prydz H (1982) Thromboplastin (factor III) activity in human monocytes induced by immune complexes. Eur J Clin Invest 12(3):229-2344
23. Mackman N (2009) The many faces of tissue factor. J Thromb Haemost 7(Suppl 1):136-1399
24. Malarstig A, Siegbahn A (2007) The intersubject variability of tissue factor mRNA production in human monocytes- relation with the toll-like receptor 4. Thromb Res 120(3):407-4133
25. Meszaros K, Aberle S, Dedrick R, Machovich R, Horwitz A, Birr C et al (1994) Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein. Blood 83(9):2516-25255
26. Mohan Rao LV, Mackman N (2010) Factor VIIa and tissue factor - from cell biology to animal models. Thromb Res 125(S1):S1-S33
27. Mollnes TE, Lea T, Froland SS, Harboe M (1985) Quanti fication of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex. Scand J Immunol 22(2):197-2022
28. Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G et al (2002) Essential role of the C5a receptor in E. coli -induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of in flammation. Blood 100(5):1869-18777
29. Nakae H, Endo S, Inada K, Yoshida M (1996) Chronological changes in the complement system in sepsis. Surg Today 26(4):225-2299
30. Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD (2007) The role of complement in biomaterial-induced in flammation. Mol Immunol 44(1-3):82-944
31. Oeth PA, Parry GC, Kunsch C, Nantermet P, Rosen CA, Mackman N (1994) Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site. Mol Cell Biol 14(6):3772-37811
32. Osnes LT, Westvik AB, Joo GB, Okkenhaug C, Kierulf P (1996) Inhibition of IL-1 induced tissue factor (TF) synthesis and procoagulant activity (PCA) in puri fied human monocytes by IL-4, IL-10 and IL-13. Cytokine 8(11):822-8277
33. Osterud B (1995) Cellular interactions in tissue factor expression by blood monocytes. Blood Coagul Fibrinolysis 6(Suppl 1):S20-S255
34. Osterud B, Olsen JO, Benjaminsen AW (1984) The role of complement in the induction of thromboplastin synthesis. Haemostasis 14(5):386-3922
35. Osterud B, Breimo ES, Olsen JO (2008) Blood borne tissue factor revisited. Thromb Res 122(3):432-4344
36. Prydz H, Allison AC, Schorlemmer HU (1977) Further link between complement activation and blood coagulation. Nature 270(5633):173-1744
37. Riedemann NC, Guo RF, Ward PA (2003) A key role of C5a/C5aR activation for the development of sepsis. J Leukoc Biol 74(6):966-9700
38. Sahu A, Kay BK, Lambris JD (1996) Inhibition of human complement by a C3-binding peptide isolated from a phagedisplayed random peptide library. J Immunol 157(2):884-8911
39. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC et al (1990) Structure and function of lipopolysaccharide binding protein. Science 249(4975):1429-14311
40. Siegbahn A (2000) Cellular consequences upon factor VIIa binding to tissue factor. Haemostasis 30(Suppl 2):41-477
41. Siegbahn A, Johnell M, Sorensen BB, Petersen LC, Heldin CH (2005) Regulation of chemotaxis by the cytoplasmic domain of tissue factor. Thromb Haemost 93(1):27-344
42. Steinemann S, Ulevitch RJ, Mackman N (1994) Role of the lipopolysaccharide (LPS)-binding protein/CD14 pathway in LPS induction of tissue factor expression in monocytic cells. Arterioscler Thromb 14(7):1202-12099
43. Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE et al (2003) The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 198(6):913-9233
44. Van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA (2011) Inflammasome activation and IL-1beta and IL-188 processing during infection. Trends Immunol 32(3):110-1166
45. Ward PA (2004) The dark side of C5a in sepsis. Nat Rev Immunol 4(2):133-1422