Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

EMBO Journal

Volumn 32, Issue 7, 2013, Pages 1036-1051

  Pfeiffer, Natalie V ^a   Dirndorfer, Daniela ^a   Lang, Sven ^b   Resenberger, Ulrike K ^a   Restelli, Lisa M ^c   Hemion, Charles ^c   Miesbauer, Margit ^a,e   Frank, Stephan ^c   Neutzner, Albert ^c   Zimmermann, Richard ^b   Winklhofer, Konstanze F ^a,d   Tatzelt, Jörg ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF BASEL   (Switzerland)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e ROCHE INNOVATION CENTER MUNICH   (Germany)

Author keywords

endoplasmic reticulum; intrinsically disordered; mitochondria; neurodegeneration; signal peptide

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; SECRETORY PROTEIN; SIGNAL PEPTIDE; SOMATOSTATIN;

ARTICLE; BINDING SITE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CYTOSOLIC FRACTION; ENDOPLASMIC RETICULUM; GENE SILENCING; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SECRETORY PATHWAY; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL; TRANSIENT EXPRESSION;

ENDOPLASMIC RETICULUM; GPI-LINKED PROTEINS; HELA CELLS; HUMANS; MITOCHONDRIA; NERVE TISSUE PROTEINS; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SOMATOSTATIN;

EUKARYOTA;

EID: 84875962374     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.46     Document Type: Article

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