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Volumn 75, Issue 3, 2013, Pages 256-267

Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury

Author keywords

Connexin; Cytokines; Mimetic peptide; Neuroinflammation; Neuroprotection; Spinal cord injury

Indexed keywords

CARPROFEN; CEFALOTIN; CONNEXIN 43; PEPTIDE DERIVATIVE; PEPTIDE5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84875956067     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2013.01.004     Document Type: Article
Times cited : (89)

References (84)
  • 1
    • 0028919411 scopus 로고
    • A sensitive and reliable Locomotor Rating Scale for open field testing in rats
    • Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable Locomotor Rating Scale for open field testing in rats. J. Neurotrauma 1995, 12:1-21.
    • (1995) J. Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 3
    • 0032739262 scopus 로고    scopus 로고
    • Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats
    • Bethea J.R., Nagashima H., Acosta M.C., Briceno C., Gomez F., Marcillo A.E., Loor K., Green J., Dietrich W.D. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma 1999, 16:851-863.
    • (1999) J. Neurotrauma , vol.16 , pp. 851-863
    • Bethea, J.R.1    Nagashima, H.2    Acosta, M.C.3    Briceno, C.4    Gomez, F.5    Marcillo, A.E.6    Loor, K.7    Green, J.8    Dietrich, W.D.9
  • 4
    • 0033724953 scopus 로고    scopus 로고
    • Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells
    • Boitano S., Evans W.H. Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 279:L623-L630.
    • (2000) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.279
    • Boitano, S.1    Evans, W.H.2
  • 5
    • 0242380340 scopus 로고    scopus 로고
    • Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells
    • Braet K., Aspeslagh S., Vandamme W., Willecke K., Martin P.E., Evans W.H., Leybaert L. Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells. J. Cell. Physiol. 2003, 197:205-213.
    • (2003) J. Cell. Physiol. , vol.197 , pp. 205-213
    • Braet, K.1    Aspeslagh, S.2    Vandamme, W.3    Willecke, K.4    Martin, P.E.5    Evans, W.H.6    Leybaert, L.7
  • 6
    • 22344431751 scopus 로고    scopus 로고
    • Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury
    • Brambilla R., Bracchi-Ricard V., Hu W.H., Frydel B., Bramwell A., Karmally S., Green E.J., Bethea J.R. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J. Exp. Med. 2005, 202:145-156.
    • (2005) J. Exp. Med. , vol.202 , pp. 145-156
    • Brambilla, R.1    Bracchi-Ricard, V.2    Hu, W.H.3    Frydel, B.4    Bramwell, A.5    Karmally, S.6    Green, E.J.7    Bethea, J.R.8
  • 7
    • 0032174031 scopus 로고    scopus 로고
    • Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?
    • Budd S.L., Lipton S.A. Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?. Nat. Neurosci. 1998, 1:431-432.
    • (1998) Nat. Neurosci. , vol.1 , pp. 431-432
    • Budd, S.L.1    Lipton, S.A.2
  • 8
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • Bush T.G., Puvanachandra N., Horner C.H., Polito A., Ostenfeld T., Svendsen C.N., Mucke L., Johnson M.H., Sofroniew M.V. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 1999, 23:297-308.
    • (1999) Neuron , vol.23 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3    Polito, A.4    Ostenfeld, T.5    Svendsen, C.N.6    Mucke, L.7    Johnson, M.H.8    Sofroniew, M.V.9
  • 9
    • 0030015076 scopus 로고    scopus 로고
    • Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
    • Carriedo S.G., Yin H.Z., Weiss J.H. Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J. Neurosci. 1996, 16:4069-4079.
    • (1996) J. Neurosci. , vol.16 , pp. 4069-4079
    • Carriedo, S.G.1    Yin, H.Z.2    Weiss, J.H.3
  • 14
    • 52049127024 scopus 로고    scopus 로고
    • Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury
    • Cronin M., Anderson P.N., Cook J.E., Green C.R., Becker D.L. Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury. Mol. Cell. Neurosci. 2008, 39:152-160.
    • (2008) Mol. Cell. Neurosci. , vol.39 , pp. 152-160
    • Cronin, M.1    Anderson, P.N.2    Cook, J.E.3    Green, C.R.4    Becker, D.L.5
  • 18
    • 33846100604 scopus 로고    scopus 로고
    • Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor
    • De Vuyst E., Decrock E., De Bock M., Yamasaki H., Naus C.C., Evans W.H., Leybaert L. Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol. Biol. Cell 2007, 18:34-46.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 34-46
    • De Vuyst, E.1    Decrock, E.2    De Bock, M.3    Yamasaki, H.4    Naus, C.C.5    Evans, W.H.6    Leybaert, L.7
  • 19
    • 38749086493 scopus 로고    scopus 로고
    • Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
    • Donnelly D.J., Popovich P.G. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp. Neurol. 2008, 209:378-388.
    • (2008) Exp. Neurol. , vol.209 , pp. 378-388
    • Donnelly, D.J.1    Popovich, P.G.2
  • 20
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • Dusart I., Schwab M.E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur. J. Neurosci. 1994, 6:712-724.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 21
    • 33751576863 scopus 로고    scopus 로고
    • Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureus
    • Esen N., Shuffield D., Syed M.M., Kielian T. Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureus. Glia 2007, 55:104-117.
    • (2007) Glia , vol.55 , pp. 104-117
    • Esen, N.1    Shuffield, D.2    Syed, M.M.3    Kielian, T.4
  • 22
    • 0035957352 scopus 로고    scopus 로고
    • Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha
    • Eugenin E.A., Eckardt D., Theis M., Willecke K., Bennett M.V., Saez J.C. Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:4190-4195.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4190-4195
    • Eugenin, E.A.1    Eckardt, D.2    Theis, M.3    Willecke, K.4    Bennett, M.V.5    Saez, J.C.6
  • 23
    • 50949116679 scopus 로고    scopus 로고
    • ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia
    • Faigle M., Seessle J., Zug S., El Kasmi K.C., Eltzschig H.K. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS ONE 2008, 3:e2801.
    • (2008) PLoS ONE , vol.3
    • Faigle, M.1    Seessle, J.2    Zug, S.3    El Kasmi, K.C.4    Eltzschig, H.K.5
  • 25
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • Fitch M.T., Doller C., Combs C.K., Landreth G.E., Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J. Neurosci. 1999, 19:8182-8198.
    • (1999) J. Neurosci. , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 26
    • 0036498359 scopus 로고    scopus 로고
    • Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
    • Fonseca C.G., Green C.R., Nicholson L.F. Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy. Brain Res. 2002, 929:105-116.
    • (2002) Brain Res. , vol.929 , pp. 105-116
    • Fonseca, C.G.1    Green, C.R.2    Nicholson, L.F.3
  • 29
    • 26844515789 scopus 로고    scopus 로고
    • Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia
    • Garg S., Md Syed M., Kielian T. Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia. J. Neurochem. 2005, 95:475-483.
    • (2005) J. Neurochem. , vol.95 , pp. 475-483
    • Garg, S.1    Md Syed, M.2    Kielian, T.3
  • 33
    • 0035220555 scopus 로고    scopus 로고
    • Spatiotemporal depletion of connexins using antisense oligonucleotides
    • Humana Press Inc., Totawa, NJ, R. Bruzzone, C. Giaume (Eds.)
    • Green C.R., Law L.-Y., Lin J.S., Becker D.L. Spatiotemporal depletion of connexins using antisense oligonucleotides. Methods in Molecular Biology: Connexin Methods and Protocols 2001, 175-185. Humana Press Inc., Totawa, NJ. R. Bruzzone, C. Giaume (Eds.).
    • (2001) Methods in Molecular Biology: Connexin Methods and Protocols , pp. 175-185
    • Green, C.R.1    Law, L.-Y.2    Lin, J.S.3    Becker, D.L.4
  • 35
    • 34247377375 scopus 로고    scopus 로고
    • Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury
    • Haupt C., Witte O.W., Frahm C. Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury. Mol. Cell. Neurosci. 2007, 35:89-99.
    • (2007) Mol. Cell. Neurosci. , vol.35 , pp. 89-99
    • Haupt, C.1    Witte, O.W.2    Frahm, C.3
  • 36
    • 0038340422 scopus 로고    scopus 로고
    • Post-traumatic inflammation following spinal cord injury
    • Hausmann O.N. Post-traumatic inflammation following spinal cord injury. Spinal Cord 2003, 41:369-378.
    • (2003) Spinal Cord , vol.41 , pp. 369-378
    • Hausmann, O.N.1
  • 37
    • 77955467019 scopus 로고    scopus 로고
    • Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury
    • Hawat G., Benderdour M., Rousseau G., Baroudi G. Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury. Pflugers Arch. 2010, 460:583-592.
    • (2010) Pflugers Arch. , vol.460 , pp. 583-592
    • Hawat, G.1    Benderdour, M.2    Rousseau, G.3    Baroudi, G.4
  • 38
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • Horn K.P., Busch S.A., Hawthorne A.L., van Rooijen N., Silver J. Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J. Neurosci. 2008, 28:9330-9341.
    • (2008) J. Neurosci. , vol.28 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    van Rooijen, N.4    Silver, J.5
  • 40
    • 0033612963 scopus 로고    scopus 로고
    • IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels
    • John G.R., Scemes E., Suadicani S.O., Liu J.S., Charles P.C., Lee S.C., Spray D.C., Brosnan C.F. IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:11613-11618.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 11613-11618
    • John, G.R.1    Scemes, E.2    Suadicani, S.O.3    Liu, J.S.4    Charles, P.C.5    Lee, S.C.6    Spray, D.C.7    Brosnan, C.F.8
  • 43
    • 48249146963 scopus 로고    scopus 로고
    • Glial connexins and gap junctions in CNS inflammation and disease
    • Kielian T. Glial connexins and gap junctions in CNS inflammation and disease. J. Neurochem. 2008, 106:1000-1016.
    • (2008) J. Neurochem. , vol.106 , pp. 1000-1016
    • Kielian, T.1
  • 44
    • 0030746939 scopus 로고    scopus 로고
    • Effects of pro-inflammatory cytokines in experimental spinal cord injury
    • Klusman I., Schwab M.E. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 1997, 762:173-184.
    • (1997) Brain Res. , vol.762 , pp. 173-184
    • Klusman, I.1    Schwab, M.E.2
  • 45
    • 0033745550 scopus 로고    scopus 로고
    • Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes
    • Kondo R.P., Wang S.Y., John S.A., Weiss J.N., Goldhaber J.I. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J. Mol. Cell. Cardiol. 2000, 32:1859-1872.
    • (2000) J. Mol. Cell. Cardiol. , vol.32 , pp. 1859-1872
    • Kondo, R.P.1    Wang, S.Y.2    John, S.A.3    Weiss, J.N.4    Goldhaber, J.I.5
  • 46
    • 0029028478 scopus 로고
    • The temporal and spatial activation of microglia in fiber tracts undergoing anterograde and retrograde degeneration following spinal cord lesion
    • Koshinaga M., Whittemore S.R. The temporal and spatial activation of microglia in fiber tracts undergoing anterograde and retrograde degeneration following spinal cord lesion. J. Neurotrauma 1995, 12:209-222.
    • (1995) J. Neurotrauma , vol.12 , pp. 209-222
    • Koshinaga, M.1    Whittemore, S.R.2
  • 47
    • 0033135290 scopus 로고    scopus 로고
    • Selective inhibition of gap junction channel activity by synthetic peptides
    • Kwak B.R., Jongsma H.J. Selective inhibition of gap junction channel activity by synthetic peptides. J. Physiol. 1999, 516(Pt 3):679-685.
    • (1999) J. Physiol. , vol.516 , Issue.PART 3 , pp. 679-685
    • Kwak, B.R.1    Jongsma, H.J.2
  • 48
    • 21644484590 scopus 로고    scopus 로고
    • Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury
    • Lee I.H., Lindqvist E., Kiehn O., Widenfalk J., Olson L. Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. J. Comp. Neurol. 2005, 489:1-10.
    • (2005) J. Comp. Neurol. , vol.489 , pp. 1-10
    • Lee, I.H.1    Lindqvist, E.2    Kiehn, O.3    Widenfalk, J.4    Olson, L.5
  • 50
    • 77957086962 scopus 로고    scopus 로고
    • Role of microglia in neurotrauma
    • Loane D.J., Byrnes K.R. Role of microglia in neurotrauma. Neurotherapeutics 2010, 7:366-377.
    • (2010) Neurotherapeutics , vol.7 , pp. 366-377
    • Loane, D.J.1    Byrnes, K.R.2
  • 51
    • 15944401408 scopus 로고    scopus 로고
    • Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells
    • Martin P.E., Wall C., Griffith T.M. Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br. J. Pharmacol. 2005, 144:617-627.
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 617-627
    • Martin, P.E.1    Wall, C.2    Griffith, T.M.3
  • 52
    • 33847696120 scopus 로고    scopus 로고
    • Dual regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade
    • Morita M., Saruta C., Kozuka N., Okubo Y., Itakura M., Takahashi M., Kudo Y. Dual regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade. Glia 2007, 55:508-515.
    • (2007) Glia , vol.55 , pp. 508-515
    • Morita, M.1    Saruta, C.2    Kozuka, N.3    Okubo, Y.4    Itakura, M.5    Takahashi, M.6    Kudo, Y.7
  • 53
    • 0142153881 scopus 로고    scopus 로고
    • Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat
    • Mulcahy N.J., Ross J., Rothwell N.J., Loddick S.A. Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br. J. Pharmacol. 2003, 140:471-476.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 471-476
    • Mulcahy, N.J.1    Ross, J.2    Rothwell, N.J.3    Loddick, S.A.4
  • 54
    • 33749508895 scopus 로고    scopus 로고
    • Essential protective roles of reactive astrocytes in traumatic brain injury
    • Myer D.J., Gurkoff G.G., Lee S.M., Hovda D.A., Sofroniew M.V. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 2006, 129:2761-2772.
    • (2006) Brain , vol.129 , pp. 2761-2772
    • Myer, D.J.1    Gurkoff, G.G.2    Lee, S.M.3    Hovda, D.A.4    Sofroniew, M.V.5
  • 55
    • 2442707974 scopus 로고    scopus 로고
    • Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes
    • Nakase T., Sohl G., Theis M., Willecke K., Naus C.C. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am. J. Pathol. 2004, 164:2067-2075.
    • (2004) Am. J. Pathol. , vol.164 , pp. 2067-2075
    • Nakase, T.1    Sohl, G.2    Theis, M.3    Willecke, K.4    Naus, C.C.5
  • 56
    • 0025809366 scopus 로고
    • Expression of gap junction genes in astrocytes and C6 glioma cells
    • Naus C.C., Bechberger J.F., Caveney S., Wilson J.X. Expression of gap junction genes in astrocytes and C6 glioma cells. Neurosci. Lett. 1991, 126:33-36.
    • (1991) Neurosci. Lett. , vol.126 , pp. 33-36
    • Naus, C.C.1    Bechberger, J.F.2    Caveney, S.3    Wilson, J.X.4
  • 57
    • 1942425481 scopus 로고    scopus 로고
    • The pathology of human spinal cord injury: defining the problems
    • Norenberg M.D., Smith J., Marcillo A. The pathology of human spinal cord injury: defining the problems. J. Neurotrauma 2004, 21:429-440.
    • (2004) J. Neurotrauma , vol.21 , pp. 429-440
    • Norenberg, M.D.1    Smith, J.2    Marcillo, A.3
  • 58
    • 48449084169 scopus 로고    scopus 로고
    • Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury
    • O'Carroll S.J., Alkadhi M., Nicholson L.F., Green C.R. Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. Cell Commun. Adhes. 2008, 15:27-42.
    • (2008) Cell Commun. Adhes. , vol.15 , pp. 27-42
    • O'Carroll, S.J.1    Alkadhi, M.2    Nicholson, L.F.3    Green, C.R.4
  • 59
    • 0035478279 scopus 로고    scopus 로고
    • Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and nhanced vulnerability of Cx32 knock-out mice
    • Oguro K., Jover T., Tanaka H., Lin Y., Kojima T., Oguro N., Grooms S.Y., Bennett M.V., Zukin R.S. Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and nhanced vulnerability of Cx32 knock-out mice. J. Neurosci. 2001, 21:7534-7542.
    • (2001) J. Neurosci. , vol.21 , pp. 7534-7542
    • Oguro, K.1    Jover, T.2    Tanaka, H.3    Lin, Y.4    Kojima, T.5    Oguro, N.6    Grooms, S.Y.7    Bennett, M.V.8    Zukin, R.S.9
  • 60
    • 77955071188 scopus 로고    scopus 로고
    • Temporal and spatial profile of phosphorylated connexin43 after traumatic brain injury in rats
    • Ohsumi A., Nawashiro H., Otani N., Ooigawa H., Toyooka T., Shima K. Temporal and spatial profile of phosphorylated connexin43 after traumatic brain injury in rats. J. Neurotrauma 2010, 27:1255-1263.
    • (2010) J. Neurotrauma , vol.27 , pp. 1255-1263
    • Ohsumi, A.1    Nawashiro, H.2    Otani, N.3    Ooigawa, H.4    Toyooka, T.5    Shima, K.6
  • 62
    • 80051759671 scopus 로고    scopus 로고
    • ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    • Orellana J.A., Froger N., Ezan P., Jiang J.X., Bennett M.V., Naus C.C., Giaume C., Saez J.C. ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J. Neurochem. 2011, 118:826-840.
    • (2011) J. Neurochem. , vol.118 , pp. 826-840
    • Orellana, J.A.1    Froger, N.2    Ezan, P.3    Jiang, J.X.4    Bennett, M.V.5    Naus, C.C.6    Giaume, C.7    Saez, J.C.8
  • 63
    • 75849165091 scopus 로고    scopus 로고
    • Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    • Orellana J.A., Hernandez D.E., Ezan P., Velarde V., Bennett M.V., Giaume C., Saez J.C. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia 2010, 58:329-343.
    • (2010) Glia , vol.58 , pp. 329-343
    • Orellana, J.A.1    Hernandez, D.E.2    Ezan, P.3    Velarde, V.4    Bennett, M.V.5    Giaume, C.6    Saez, J.C.7
  • 69
    • 33645238079 scopus 로고    scopus 로고
    • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents
    • Retamal M.A., Cortes C.J., Reuss L., Bennett M.V., Saez J.C. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:4475-4480.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 4475-4480
    • Retamal, M.A.1    Cortes, C.J.2    Reuss, L.3    Bennett, M.V.4    Saez, J.C.5
  • 70
    • 37249015389 scopus 로고    scopus 로고
    • Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia
    • Retamal M.A., Froger N., Palacios-Prado N., Ezan P., Saez P.J., Saez J.C., Giaume C. Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J. Neurosci. 2007, 27:13781-13792.
    • (2007) J. Neurosci. , vol.27 , pp. 13781-13792
    • Retamal, M.A.1    Froger, N.2    Palacios-Prado, N.3    Ezan, P.4    Saez, P.J.5    Saez, J.C.6    Giaume, C.7
  • 72
    • 84860468574 scopus 로고    scopus 로고
    • AGEs-RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells
    • Shaikh S.B., Uy B., Perera A., Nicholson L.F. AGEs-RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells. Neurochem. Int. 2012, 60:640-651.
    • (2012) Neurochem. Int. , vol.60 , pp. 640-651
    • Shaikh, S.B.1    Uy, B.2    Perera, A.3    Nicholson, L.F.4
  • 75
    • 77957763712 scopus 로고    scopus 로고
    • Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus
    • Takahashi D.K., Vargas J.R., Wilcox K.S. Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus. Neurobiol. Dis. 2010, 40:573-585.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 573-585
    • Takahashi, D.K.1    Vargas, J.R.2    Wilcox, K.S.3
  • 76
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H., Jin S., Wang J., Zhang G., Kawanokuchi J., Kuno R., Sonobe Y., Mizuno T., Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 2006, 281:21362-21368.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 77
    • 0031548034 scopus 로고    scopus 로고
    • Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury
    • Theriault E., Frankenstein U.N., Hertzberg E.L., Nagy J.I. Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury. J. Comp. Neurol. 1997, 382:199-214.
    • (1997) J. Comp. Neurol. , vol.382 , pp. 199-214
    • Theriault, E.1    Frankenstein, U.N.2    Hertzberg, E.L.3    Nagy, J.I.4
  • 78
    • 0342657086 scopus 로고    scopus 로고
    • Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS
    • Tsang Y.M., Chiong F., Kuznetsov D., Kasarskis E., Geula C. Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS. Brain Res. 2000, 861:45-58.
    • (2000) Brain Res. , vol.861 , pp. 45-58
    • Tsang, Y.M.1    Chiong, F.2    Kuznetsov, D.3    Kasarskis, E.4    Geula, C.5
  • 80
    • 0035006281 scopus 로고    scopus 로고
    • Cellular localization of tumor necrosis factor-alpha following acute spinal cord injury in adult rats
    • Yan P., Li Q., Kim G.M., Xu J., Hsu C.Y., Xu X.M. Cellular localization of tumor necrosis factor-alpha following acute spinal cord injury in adult rats. J. Neurotrauma 2001, 18:563-568.
    • (2001) J. Neurotrauma , vol.18 , pp. 563-568
    • Yan, P.1    Li, Q.2    Kim, G.M.3    Xu, J.4    Hsu, C.Y.5    Xu, X.M.6
  • 81
    • 2342596444 scopus 로고    scopus 로고
    • Early expression and cellular localization of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injury
    • Yang L., Blumbergs P.C., Jones N.R., Manavis J., Sarvestani G.T., Ghabriel M.N. Early expression and cellular localization of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injury. Spine 2004, 29:966-971.
    • (2004) Spine , vol.29 , pp. 966-971
    • Yang, L.1    Blumbergs, P.C.2    Jones, N.R.3    Manavis, J.4    Sarvestani, G.T.5    Ghabriel, M.N.6
  • 83
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: a novel mechanism of glutamate release
    • Ye Z.C., Wyeth M.S., Baltan-Tekkok S., Ransom B.R. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J. Neurosci. 2003, 23:3588-3596.
    • (2003) J. Neurosci. , vol.23 , pp. 3588-3596
    • Ye, Z.C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4
  • 84
    • 78650176658 scopus 로고    scopus 로고
    • Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion
    • Yoon J.J., Green C.R., O'Carroll S.J., Nicholson L.F. Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion. Epilepsy Res. 2010, 92:153-162.
    • (2010) Epilepsy Res. , vol.92 , pp. 153-162
    • Yoon, J.J.1    Green, C.R.2    O'Carroll, S.J.3    Nicholson, L.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.