Connexin43 null mutation increases infarct size after stroke

Journal of Comparative Neurology

Volumn 440, Issue 4, 2001, Pages 387-394

  Siushansian, Ramin ^a   Bechberger, John F ^a   Cechetto, David F ^a   Hachinski, Vladimir C ^a   Naus, Christian C G ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Astrocytes; Gap junctions; Ischemia; Neuroprotection; Transgenics

Indexed keywords

CONNEXIN 43;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL COMMUNICATION; CELL INTERACTION; CONTROLLED STUDY; DISEASE MODEL; GAP JUNCTION; GLIA; HETEROZYGOTE; INFORMATION PROCESSING; MIDDLE CEREBRAL ARTERY; MOUSE; MOUSE MUTANT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE; TISSUE SECTION; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CEREBROVASCULAR ACCIDENT; CONNEXIN 43; FEMALE; GAP JUNCTIONS; HETEROZYGOTE; HOMOZYGOTE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, TRANSGENIC;

EID: 0035955824     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.1392     Document Type: Article

References (60)

1. Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemia
2. Taste buds in the vallate papillae of the rat studied with freeze-fracture preparation
3. Microbeam laser-induced neurons increase in vitro astrocytic gap junctional communication as measured by fluorescence recovery after laser photobleaching
4. Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stressinduced disruption of Ca2+ homeostasis and cell death
5. Autonomic and myocardial changes in middle cerebral artery occlusion: Stroke models in the rat
6. Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia
7. Glia-neuron intercellular calcium signaling
8. Colchicine affects cortical and amygdalar neurochemical changes differentially after middle cerebral artery occlusion in rats
9. Neurotransmitter-mediated signalling between axons and glial cells
10. A review and update of experimental and clinical studies of spinal cord injuries
11. Astrocytic gap junctions remain open during ischemic conditions
12. Molecular cloning and functional expression of mouse connexin 30, a gap junction gene highly expressed in adult brain and skin
13. Gap junctions between cultured astrocytes: Immunocytochemical, molecular, and electrophysiological analysis
14. Cell-cell communication in the vessel wall
15. Activation of protein kinase C blocks astroglial gap junction communication and inhibits the spread of calcium waves
16. Gap junctions in cultured astrocytes: Single-channel currents and characterization of channel-forming protein
17. Adrenergic regulation of intercellular communications between cultured striatal astrocytes from the mouse
18. Endothelins inhibit junctional permeability in cultured mouse astrocytes
19. Neuroprotection in brain ischemia: An update
20. The preloading method of evaluating gap junctional communication by dye transfer
21. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
22. Asymmetry of sympathetic consequences of experimental stroke
23. Effects of anoxia on ion distribution in the brain
24. Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture
25. Viability thresholds and the penumbra of focal ischemia
26. Expression of glutamate receptor genes in white matter: Developing and adult rat optic nerve
27. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle
28. The correlation between excitatory amino acid-induced current responses and excitotoxicity in striatal cultures
29. Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition
30. Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischaemia
31. Junctional intercellular communication: The cell-to-cell membrane channel
32. Glia protect hippocampal neurons against amino acid-induced degeneration: Involvement of fibroblast growth factor
33. Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
34. Differential properties of two gap junctional pathways made by all amacrine cells
35. Attenuation of focal ischemic brain injury in mice deficient in the epsilonl (NR2A) subunit of NMDA receptor
36. Evidence for the colocalization of another connexin with connexin- 43 at astrocytic gap junctions in rat brain
37. Connexin30 in rodent, cat and human brain: Selective expression in gray matter astrocytes, co-localization with connexin 43 at gap junctions and late developmental appearance
38. Expression of gap junction genes in astrocytes and C6 glioma cells
39. Altered gap junctional communication, intercellular signaling and growth in cultured astrocytes deficient in connexin 43
40. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells
41. Gap junctions are required for the propagation of spreading depression
42. The GluR2 (GluR-B) hypothesis: Ca2 +-permeable AMPA receptors in neurological disorders
43. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia
44. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke
45. Cardiac malformation in neonatal mice lacking connexin43
46. Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine
47. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
48. Do alterations in intercellular coupling play a role in cardiac contractile dysfunction?
49. Calcium waves between astrocytes from cx43 knockout mice
50. Pathophysiology and treatment of focal cerebral ischemia. I: Pathophysiology
51. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy
52. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction-evidence for chamberspecific molecular determinants of conduction
53. Cyclic adenosine monophosphate stimulates biosynthesis and phosphorylation of the 26 kDa gap junction protein in cultured mouse hepatocytes
54. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes
55. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: A microdialysis study
56. Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level
57. Demonstration of increased endothelial- leukocyte adhesion molecule- 1 mRNA expression in ischemic rat cortex
58. LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain
59. Differential anatomical and cellular patterns of connexin43 expression during postnatal development of rat brain
60. Glioma cells release excitotoxic concentrations of glutamate