Genetic polymorphisms in innate immunity receptors do not predict the risk of bacterial and fungal infections and acute rejection after liver transplantation

Transplant Infectious Disease

Volumn 15, Issue 2, 2013, Pages 120-133

  de Mare Bredemeijer, E L D ^a   Mancham, S ^a   Utomo, W K ^a   de Canck, I ^b   van Thielen, M ^b   de Meester, E ^b   Rossau, R ^b   van der Laan, L J W ^a   Hansen, B E ^a   Tilanus, H W ^a   Kazemier, G ^a   Janssen, H L A ^a   Metselaar, H J ^a   Kwekkeboom, J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RandD Discovery Innogenetics   (Belgium)

Author keywords

Infection; Innate immunity; Liver transplantation; Rejection; Single nucleotide polymorphism

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; FICOLIN 1; FICOLIN 2; FICOLIN 3; INTERLEUKIN RECEPTOR; LECTIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE 1; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE 2; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE 3; PROTEIN MD 2; SERINE PROTEINASE; SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 RELATED RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; FALSE POSITIVE RESULT; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GRAFT INFECTION; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; LIVER TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MYCOSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; BACTERIAL INFECTIONS; CHILD; COHORT STUDIES; FEMALE; GENOTYPING TECHNIQUES; GRAFT REJECTION; HUMANS; IMMUNITY, INNATE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MYCOSES; POLYMORPHISM, GENETIC; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; RECEPTORS, IMMUNOLOGIC; RISK FACTORS; TISSUE DONORS; YOUNG ADULT;

EID: 84875924040     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/tid.12034     Document Type: Article

References (52)

1. Otero-Ravina F, Rodriguez-Martinez M, Selles CF, et al. Analysis of survival after liver transplantation in Galicia, Spain. Transplant Proc 2005; 37 (9): 3913-3915.
2. Blair JE, Kusne S. Bacterial, mycobacterial, and protozoal infections after liver transplantation-part I. Liver Transpl 2005; 11 (12): 1452-1459.
3. Schroder NW, Schumann RR. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005; 5 (3): 156-164.
4. Misch EA, Hawn TR. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond) 2008; 114 (5): 347-360.
5. Agnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002; 186 (10): 1522-1525.
6. Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002; 162 (9): 1028-1032.
7. Child NJ, Yang IA, Pulletz MC, et al. Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem Soc Trans 2003; 31 (Pt 3): 652-653.
8. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33 (3): 638-644.
9. Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000; 68 (11): 6398-6401.
10. Ogus AC, Yoldas B, Ozdemir T, et al. The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004; 23 (2): 219-223.
11. Henckaerts L, Nielsen KR, Steffensen R, et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 2009; 37 (1): 192-201, e191-193.
12. Ducloux D, Deschamps M, Yannaraki M, et al. Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int 2005; 67 (6): 2454-2461.
13. Palmer SM, Burch LH, Mir S, et al. Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clin Transplant 2006; 20 (1): 30-36.
14. Cervera C, Lozano F, Saval N, et al. The influence of innate immunity gene receptors polymorphisms in renal transplant infections. Transplantation 2007; 83 (11): 1493-1500.
15. Kruger B, Banas MC, Walberer A, et al. A comprehensive genotype-phenotype interaction of different Toll-like receptor variations in a renal transplant cohort. Clin Sci (Lond) 2010; 119 (12): 535-544.
16. Bouwman LH, Roos A, Terpstra OT, et al. Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology 2005; 129 (2): 408-414.
17. Worthley DL, Johnson DF, Eisen DP, et al. Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation. Clin Infect Dis 2009; 48 (4): 410-417.
18. de Rooij BJ, van Hoek B, ten Hove WR, et al. Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology 2010; 52 (3): 1100-1110.
19. Cervera C, Balderramo D, Suarez B, et al. Donor mannose-binding lectin gene polymorphisms influence the outcome of liver transplantation. Liver Transpl 2009; 15 (10): 1217-1224.
20. Curvelo LA, de Mare-Bredemeijer E, de Canck I, et al. Does the donor mannose-binding lectin genotype really predict the risk of bacterial infections after liver transplantation? Hepatology 2011; 53 (5): 1786-1787.
21. Lee SO, Brown RA, Kang SH, Abdel-Massih RC, Razonable RR. Toll-like receptor 2 polymorphism and Gram-positive bacterial infections after liver transplantation. Liver Transpl 2011; 17 (9): 1081-1088.
22. Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev 2009; 227 (1): 221-233.
23. Andrade CF, Waddell TK, Keshavjee S, Liu M. Innate immunity and organ transplantation: the potential role of toll-like receptors. Am J Transplant 2005; 5 (5): 969-975.
24. Goldstein DR. The identity of innate immune activators in organ transplantation: origins from within or exterior to the host? Am J Transplant 2007; 7 (7): 1692-1694.
25. Alegre ML, Leemans J, LeMoine A, et al. The multiple facets of toll-like receptors in transplantation biology. Transplantation 2008; 86 (1): 1-9.
26. Goldstein DR, Palmer SM. Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. J Heart Lung Transplant 2005; 24 (11): 1721-1729.
27. Goldstein DR, Tesar BM, Akira S, Lakkis FG. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 2003; 111 (10): 1571-1578.
28. Tesar BM, Zhang J, Li Q, Goldstein DR. TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant 2004; 4 (9): 1429-1439.
29. Chen L, Wang T, Zhou P, et al. TLR engagement prevents transplantation tolerance. Am J Transplant 2006; 6 (10): 2282-2291.
30. Thornley TB, Brehm MA, Markees TG, et al. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol 2006; 176 (3): 1561-1570.
31. Porrett PM, Yuan X, LaRosa DF, et al. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008; 181 (3): 1692-1699.
32. Wang T, Chen L, Ahmed E, et al. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol 2008; 180 (9): 5991-5999.
33. McDaniel DO, Zhou X, Moore CK, Aru G. Cardiac allograft rejection correlates with increased expressions of Toll-like receptors 2 and 4 and allograft inflammatory factor 1. Transplant Proc 2010; 42 (10): 4235-4237.
34. Testro AG, Visvanathan K, Skinner N, et al. Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4. J Gastroenterol Hepatol 2011; 26 (1): 155-163.
35. Deng JF, Geng L, Qian YG, et al. The role of toll-like receptors 2 and 4 in acute allograft rejection after liver transplantation. Transplant Proc 2007; 39 (10): 3222-3224.
36. Palmer SM, Burch LH, Davis RD, et al. The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med 2003; 168 (6): 628-632.
37. Hwang YH, Ro H, Choi I, et al. Impact of polymorphisms of TLR4/CD14 and TLR3 on acute rejection in kidney transplantation. Transplantation 2009; 88 (5): 699-705.
38. Palmer SM, Klimecki W, Yu L, et al. Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. Am J Transplant 2007; 7 (3): 693-699.
39. Hattersley AT, McCarthy MI. What makes a good genetic association study? Lancet 2005; 366 (9493): 1315-1323.
40. Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008; 48 (1): 322-335.
41. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16 (3): 128-140.
42. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997; 25 (3): 658-663.
43. Verstraelen H, Verhelst R, Nuytinck L, et al. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. J Reprod Immunol 2009; 79 (2): 163-173.
44. Piselli P, Zanfi C, Corazza V, et al. Incidence and timing of infections after liver transplant in Italy. Transplant Proc 2007; 39 (6): 1950-1952.
45. Kusne S, Blair JE. Viral and fungal infections after liver transplantation-part II. Liver Transpl 2006; 12 (1): 2-11.
46. Palomo Sanchez JC, Jimenez C, Moreno Gonzalez E, et al. Effects of intraoperative blood transfusion on postoperative complications and survival after orthotopic liver transplantation. Hepatogastroenterology 1998; 45 (22): 1026-1033.
47. Asensio A, Ramos A, Cuervas-Mons V, et al. Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant. Liver Transpl 2008; 14 (6): 799-805.
48. Patel R, Badley AD, Larson-Keller J, et al. Relevance and risk factors of enterococcal bacteremia following liver transplantation. Transplantation 1996; 61 (8): 1192-1197.
49. Dummer JS, Hardy A, Poorsattar A, Ho M. Early infections in kidney, heart, and liver transplant recipients on cyclosporine. Transplantation 1983; 36 (3): 259-267.
50. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270 (24): 2957-2963.
51. Golfieri R, Giampalma E, Morselli Labate AM, et al. Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases. Eur Radiol 2000; 10 (7): 1169-1183.
52. Weiss E, Dahmani S, Bert F, et al. Early-onset pneumonia after liver transplantation: microbiological findings and therapeutic consequences. Liver Transpl 2010; 16 (10): 1178-1185.