Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae

Journal of Reproductive Immunology

Volumn 79, Issue 2, 2009, Pages 163-173

  Verstraelen, Hans ^a   Verhelst, Rita ^a   Nuytinck, Lieve ^b   Roelens, Kristien ^a   De Meester, Els ^b   De Vos, Daniel ^b   Van Thielen, Martine ^b   Rossau, Rudi ^b   Delva, Wim ^a   De Backer, Ellen ^a   Vaneechoutte, Mario ^a   Temmerman, Marleen ^a  

^a GHENT UNIVERSITY   (Belgium)

^b INNOGENETICS   (Belgium)

Author keywords

Atopobium vaginae; Bacterial vaginosis; Single nucleotide polymorphisms; Toll like receptor; Vaginal microflora

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; LIPOPOLYSACCHARIDE BINDING PROTEIN; PROTEIN MD 2; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6;

ANAEROBIC GROWTH; ARTICLE; ATOPOBIUM VAGINAE; BLOOD SAMPLING; CASE CONTROL STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; FIRST TRIMESTER PREGNANCY; GARDNERELLA VAGINALIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GRAM POSITIVE BACTERIUM; GRAM STAINING; HUMAN; MAJOR CLINICAL STUDY; MICROORGANISM DETECTION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; VAGINA FLORA; VAGINA SMEAR; VAGINITIS;

ACTINOBACTERIA; EXONS; FEMALE; GARDNERELLA VAGINALIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRONS; POLYMORPHISM, GENETIC; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROMOTER REGIONS, GENETIC; RECEPTORS, PATTERN RECOGNITION; TOLL-LIKE RECEPTORS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 61849106533     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2008.10.006     Document Type: Article

References (32)

1. Al-Harthi L., Spear G.T., Hashemi F.B., Landay A., Sha B.E., and Roebuck K.A. A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappa B enhancer. J. Infect. Dis. 178 (1998) 1343-1351
2. Cooke G.S., and Hill A.V. Genetics of susceptibility to human infectious disease. Nat. Rev. Genet. 2 (2001) 967-977
3. De Backer E., Verhelst R., Verstraelen H., Alqumber M.A., Burton J.P., Tagg J.R., Temmerman M., and Vaneechoutte M. Quantitative determination by real-time PCR of four vaginal Lactobacillus species. Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners. BMC Microbiol. 7 (2007) 115
4. Fazeli A., Bruce C., and Anumba D.O. Characterization of Toll-like receptors in the female reproductive tract in humans. Hum. Reprod. 20 (2005) 1372-1378
5. Ferris M.J., Masztal A., Aldridge K.E., Fortenberry J.D., Fidel Jr. P.L., and Martin D.H. Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis. BMC Infect. Dis. 4 (2004) 5
6. Fichorova R.N., Cronin A.O., Lien E., Anderson D.J., and Ingalls R.R. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J. Immunol. 168 (2002) 2424-2432
7. Genc M.R., Vardhana S., Delaney M.L., Onderdonk A., Tuomala R., Norwitz E., Witkin S.S., and MAP Study Group. Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women. Eur. J. Obstet. Gynecol. Reprod. Biol. 116 (2004) 152-156
8. Goepfert A.R., Varner M., Ward K., Macpherson C., Klebanoff M., Goldenberg R.L., Mercer B., Meis P., Iams J., Moawad A., Carey J.C., Leveno K., Wapner R., Caritis S.N., Miodovnik M., Sorokin Y., O'Sullivan M.J., Van Dorsten J.P., Langer O., and NICHD Maternal-Fetal Medicine Units Network. Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy. Am. J. Obstet. Gynecol. 193 (2005) 1478-1485
9. Hayashi F., Means T.K., and Luster A.D. Toll-like receptors stimulate human neutrophil function. Blood 102 (2003) 2660-2669
10. Klebanoff S.J., Watts D.H., Mehlin C., and Headley C.M. Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB. J. Infect. Dis. 179 (1999) 653-660
11. Kufer T.A., Banks D.J., and Philpott D.J. Innate immune sensing of microbes by Nod proteins. Ann. N. Y. Acad. Sci. 1072 (2006) 19-27
12. Mares D., Simoes J.A., Novak R.M., and Spear G.T. TLR2-mediated cell stimulation in bacterial vaginosis. J. Reprod. Immunol. 77 (2008) 91-99
13. Menard J.P., Fenollar F., Henry M., Bretelle F., and Raoult D. Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis. Clin. Infect. Dis. 47 (2008) 33-43
14. Nugent R.P., Krohn M.A., and Hillier S.L. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J. Clin. Microbiol. 29 (1991) 297-301
15. Ohashi J., Yamamoto S., Tsuchiya N., Hatta Y., Komata T., Matsushita M., and Tokunaga K. Comparison of statistical power between 2 × 2 allele frequency and allele positivity tables in case-control studies of complex disease genes. Ann. Hum. Genet. 65 (2001) 197-206
16. Pybus V., and Onderdonk A.B. Microbial interactions in the vaginal ecosystem, with emphasis on the pathogenesis of bacterial vaginosis. Microbes Infect. 1 (1999) 285-292
17. Rein M.F., Shih L.M., Miller J.R., and Guerrant R.L. Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis. Sex. Transm. Dis. 23 (1996) 517-521
18. Schroder N.W., and Schumann R.R. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect. Dis. 5 (2005) 156-164
19. Schwebke J.R. Gynecologic consequences of bacterial vaginosis. Obstet. Gynecol. Clin. North. Am. 30 (2003) 685-694
20. Segal S., and Hill A.V. Genetic susceptibility to infectious disease. Trends Microbiol. 11 (2003) 445-448
21. Sobel J.D. Bacterial vaginosis. Annu. Rev. Med. 51 (2000) 349-356
22. St John E., Mares D., and Spear G.T. Bacterial vaginosis and host immunity. Curr. HIV/AIDS Rep. 4 (2007) 22-28
23. St John E.P., Martinson J., Simoes J.A., Landay A.L., and Spear G.T. Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis. Clin. Immunol. 125 (2007) 95-102
24. Stuyver L., Rossau R., Wyseur A., Duhamel M., Vanderborght B., Van Heuverswyn H., and Maertens G. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J. Gen. Virol. 74 (1993) 1093-1102
25. Swidsinski A., Mendling W., Loening-Baucke V., Ladhoff A., Swidsinski S., Hale L.P., and Lochs H. Adherent biofilms in bacterial vaginosis. Obstet. Gynecol. 106 (2005) 1013-1023
26. Verhelst R., Verstraelen H., Claeys G., Verschraegen G., Delanghe J., Van Simaey L., De Ganck C., Temmerman M., and Vaneechoutte M. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol. 4 (2004) 16
27. Verhelst R., Verstraelen H., Claeys G., Verschraegen G., Van Simaey L., De Ganck C., De Backer E., Temmerman M., and Vaneechoutte M. Comparison between Gram stain and culture for the characterization of vaginal microflora: definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora. BMC Microbiol. 14 (2005) 61
28. Verstraelen H., Verhelst R., Claeys G., Temmerman M., and Vaneechoutte M. Culture-independent analysis of vaginal microflora: the unrecognized association of Atopobium vaginae with bacterial vaginosis. Am. J. Obstet. Gynecol. 191 (2004) 1130-1132
29. Verstraelen H., Verhelst R., Roelens K., Claeys G., Weyers S., De Backer E., Vaneechoutte M., and Temmerman M. Modified classification of Gram-stained vaginal smears to predict spontaneous preterm birth: a prospective cohort study. Am. J. Obstet. Gynecol. 196 (2007) 528.e1-528.e6
30. Zariffard M.R., Saifuddin M., Sha B.E., and Spear G.T. Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis. FEMS Immunol. Med. Microbiol. 34 (2002) 277-281
31. Zariffard M.R., Novak R.M., Lurain N., Sha B.E., Graham P., and Spear G.T. Induction of tumor necrosis factor-alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis. J. Infect. Dis. 191 (2005) 1913-1921
32. Zweigner J., Schumann R.R., and Weber J.R. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect. 8 (2006) 946-952