Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation

Hepatology

Volumn 52, Issue 3, 2010, Pages 1100-1110

  De Rooij, Bert Jan F ^a   Van Hoek, Bart ^a   Ten Hove, W Rogier ^a   Roos, Anja ^a   Bouwman, Lee H ^a   Schaapherder, Alexander F ^a   Porte, Robert J ^b   Daha, Mohamed R ^a   Van Der Reijden, Johan J ^a   Coenraad, Minneke J ^a   Ringers, Jan ^a   Baranski, Andrzej G ^a   Hepkema, Bouke G ^b   Hommes, Daniel W ^a   Verspaget, Hein W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPHOTERICIN B; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CEFUROXIME; CIPROFLOXACIN; CORTICOSTEROID; CYCLOSPORIN; FICOLIN; FICOLIN 2; GENTAMICIN; MANNOSE BINDING LECTIN 2; MBL ASSOCIATED SERINE PROTEASE; MEMBRANE PROTEIN; METRONIDAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEOMYCIN; NORFLOXACIN; PENICILLIN G; POLYMYXIN; TACROLIMUS; UNCLASSIFIED DRUG; LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; MASP2 PROTEIN, HUMAN; MBL2 PROTEIN, HUMAN;

ABDOMINAL INFECTION; ADOLESCENT; ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTERIAL INFECTION; BASE MISPAIRING; COHORT ANALYSIS; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; GRAFT RECIPIENT; HUMAN; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORGAN DONOR; PNEUMONIA; PRIORITY JOURNAL; RISK ASSESSMENT; SEPSIS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE; BACTERIAL INFECTIONS; CLINICAL TRIAL; DONOR; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RISK FACTOR; TRANSPLANTATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BACTERIAL INFECTIONS; COHORT STUDIES; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; FEMALE; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LECTINS; LIVER TRANSPLANTATION; MALE; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RISK FACTORS; TISSUE DONORS; TRANSPLANTATION; YOUNG ADULT;

EID: 77956642615     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23782     Document Type: Article

References (42)

1. Blair JE, Kusne S. Bacterial, mycobacterial, and protozoal infections after liver transplantation. Part I. Liver Transpl 2005;11:1452-1459.
2. Matsushita M, Fujita T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1S-like serine protease. J Exp Med 1992;176:1497-1502.
3. Matsushita M, Endo Y, Fujita T. Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J Immunol 2000;164:2281-2284.
4. Madsen HO, Garred P, Thiel S, Kurtzhals JA, Lamm LU, Ryder LP, et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol 1995;155:3013-3020.
5. Larsen F, Madsen HO, Sim RB, Koch C, Garred P. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J Biol Chem 2004;279:21302-21311. (Pubitemid 38656537)
6. Summerfield JA, Ryder S, Sumiya M, Thursz M, Gorchein A, Monteil MA, et al. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet 1995;345:886-889.
7. Koch A, Melbye M, Sørensen P, Homøe P, Madsen HO, Mølbak K, et al. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001;285:1316-1321.
8. Garred P, Madsen HO, Hofmann B, Svejgaard A. Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency. Lancet 1995;346:941-943.
9. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. BMJ 1997;314:1229-1232. (Pubitemid 27173906)
10. Bouwman LH, Roos A, Terpstra OT, de Knijff P, van Hoek B, Verspaget HW, et al. Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology 2005;129:408-414.
11. Worthley DL, Johnson DF, Eisen DP, Dean MM, Heatley SL, Tung JP, et al. Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation. Clin Infect Dis 2009;48:410-417.
12. Matsushita M, Fujita T. Ficolins and the lectin complement pathway. Immunol Rev 2001;180:78-85.
13. Lynch NJ, Roscher S, Hartung T, Morath S, Matsushita M, Maennel DN, et al. L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of gram-positive bacteria, and activates the lectin pathway of complement. J Immunol 2004;172:1198-1202.
14. Hummelshoj T, Munthe-Fog L, Madsen HO, Fujita T, Matsushita M, Garred P. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hum Mol Genet 2005;14:1651-1658. (Pubitemid 40895517)
15. Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, et al. A second serine protease associated with mannan-binding lectin that activates complement. Nature 1997;386:506-510.
16. Thiel S, Steffensen R, Christensen IJ, Ip WK, Lau YL, Reason IJ, et al. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun 2007;8:154-163.
17. Stengaard-Pedersen K, Thiel S, Gadjeva M, Møller-Kristensen M, Sørensen R, Jensen LT, et al. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med 2003;349:554-560. (Pubitemid 36951367)
18. Sorensen R, Thiel S, Jensenius JC. Mannan-binding-lectin-associated serine proteases, characteristics and disease associations. Springer Semin Immun 2005;27:299-319.
19. Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, et al. The structure of MBL-associated serine protease-2 reveals that identical substrate Specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. J Mol Biol 2004;342:1533-1546. (Pubitemid 39208676)
20. Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, et al. Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and-2: A study on recombinant catalytic fragments. J Immunol 2003;170:1374-1382.
21. Cross TJS, Berry PA, Burroughs AK. Infection in solid-organ transplant recipients. N Engl J Med 2008;358:1302.
22. Holmskov U, Thiel S, Jensenius JC. Collectins and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol 2003;21:547-578. (Pubitemid 37174541)
23. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128-140.
24. Demetrius AJ, Batts KP, Dhillon AP, Ferrell L, Fung J, Stephen A. Geller, et al. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997;25:658-663.
25. Zhou LM, Wang L, Palais R, Pryor R, Wittwer CT. High-resolution DNA melting analysis for simultaneous mutation scanning and genotyping in solution. Clin Chem 2005;51:1770-1777. (Pubitemid 41368166)
26. Berger SP, Roos A, Mallat MJK, Schaapherder AF, Doxiadis II, van Kooten C, et al. Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol 2007;18:2416-2422.
27. Vossen RH, van Duijn M, Daha MR, den Dunnen JT, Roos A. High-throughput genotyping of mannose-binding lectin variants using high-resolution DNA-melting analysis. Hum Mutat 2010;31:E1286-E1293.
28. Garred P, Larsen F, Madsen HO, Koch C. Mannose-binding lectin deficiency - revisited. Mol Immunol 2003;40:73-84.
29. Steffensen R, Thiel S, Varming K, Jersild C, Jensenius JC. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000;241:33-42. (Pubitemid 30468508)
30. Halldorson JB, Bakthavatsalam R, Fix O, Reyes JD, Perkins JD. D-MELD, a simple predictor of post liver transplant mortality for optimization of donor/recipient matching. Am J Transplant 2009;9:318-326.
31. Gastinne H, Wolff M, Delatour F, Faurisson F, Chevret S. A controlled trial in intensive-care units of selective decontamination of the digestive-tract with nonabsorbable antibiotics. N Engl J Med 1992;326:594-599.
32. Bonten MJM, Vantiel FH, Vandergeest S, Stobberingh EE, Gaillard CA. Enterococcus-faecalis pneumonia complicating topical antimicrobial prophylaxis. N Engl J Med 1993;328:209-210.
33. Sánchez Garcia MS, Cambronero Galache JA, López Diaz J, Cerdá Cerdá E, Rubio Blasco J, Gómez Aguinaga MA, et al. Effectiveness and cost of selective decontamination of the digestive tract in critically ill intubated patients. A randomized, double-blind, placebo-controlled, multicenter trial. Am J Resp Crit Care 1998;158:908-916.
34. Ebner W, Kropec-Hubner A, Daschner FD. Bacterial resistance and overgrowth due to selective decontamination of the digestive tract. Eur J Clin Microbiol 2000;19:243-247.
35. Schröder J, Kahlke V, Staubach KH, Zabel P, Stuber F. Gender differences in human sepsis. Arch Surg 1998;133:1200-1204.
36. van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P. Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med 2007;35:1464-1469. (Pubitemid 46809308)
37. Frakking FNJ, Brouwer N, van de Wetering MD, Budde IK, Strengers PF, Huitema AD, et al. Safety and pharmacokinetics of plasma-derived mannose-binding lectin (MBL) substitution in children with chemotherapy-induced neutropaenia. Eur J Cancer 2009;45:505-512.
38. Valdimarsson H, Stefansson M, Vikingsdottir T, Arason GJ, Koch C, Thiel S, et al. Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-deficient humans. Scand J Immunol 1998;48:116-123.
39. Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, et al. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med 2004;199:1379-1390.
40. Cervera C, Balderramo D, Suárez B, Prieto J, Fuster F, Linares L, et al. Donor mannose-binding lectin gene polymorphisms influence the outcome of liver transplantation. Liver Transpl 2009;15:1217-1224.
41. Creagh EM, O'Neill LAJ. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006;27:352-357.
42. Ip WKE, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RAB. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med 2008;205:169-181. (Pubitemid 351185724)