Early-onset pneumonia after liver transplantation: Microbiological findings and therapeutic consequences

Liver Transplantation

Volumn 16, Issue 10, 2010, Pages 1178-1185

  Weiss, Emmanuel ^a   Dahmani, Souhayl ^d   Bert, Frederic ^b   Janny, Sylvie ^a   Sommacale, Daniel ^c   Dondero, Federica ^a   Francoz, Claire ^e   Belghiti, Jacques ^c,e   Mantz, Jean ^a,e   Catherine, Paugam Burtz ^a,e,f  

^a Departments of Anesthesiolog and Critical Care   (France)

^b Departments of Microbiology   (France)

^c BEAUJON HOSPITAL   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CEFOXITIN; ANTIINFECTIVE AGENT; VASOCONSTRICTOR AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; EARLY ONSET HOSPITAL ACQUIRED PNEUMONIA; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; HYPERLACTATEMIA; INTENSIVE CARE UNIT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROPHYLAXIS; SCORING SYSTEM; SIMPLIFIED ACUTE PHYSIOLOGY SCORE II; BACTERIAL PNEUMONIA; CROSS INFECTION; DRUG COMBINATION; FRANCE; INTENSIVE CARE; MICROBIOLOGY; MIDDLE AGED; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; TIME; TREATMENT OUTCOME; VENTILATOR ASSOCIATED PNEUMONIA;

ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG THERAPY, COMBINATION; FEMALE; FRANCE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PNEUMONIA, BACTERIAL; PNEUMONIA, VENTILATOR-ASSOCIATED; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS; YOUNG ADULT;

EID: 79952116405     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22132     Document Type: Article

References (38)

1. Bonatti H, Pruett TL, Brandacher G, Hagspiel KD, Housseini AM, Sifri CD, et al. Pneumonia in solid organ recipients: spectrum of pathogens in 217 episodes. Transplant Proc 2009;41:371-374.
2. Hadley S, Samore MH, Lewis WD, Jenkins RL, Karchmer AW, Hammer SM.Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. Transplantation 1995;59:851-859.
3. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007;357:2601-2614.
4. Singh N, Gayowski T, Wagener M, Marino IR, Yu VL. Pulmonary infections in liver transplant recipients receiving tacrolimus. Changing pattern of microbial etiologies. Transplantation 1996;61:396-401.
5. Aduen JF, Hellinger WC, Kramer DJ, Stapelfeldt WH, Bonatti H, Crook JE, et al. Spectrum of pneumonia in the current era of liver transplantation and its effect on survival. Mayo Clin Proc 2005;80:1303-1306.
6. Saner FH, Olde Damink SW, Pavlakovic G, van den Broek MA, Rath PM, Sotiropoulos GC, et al. Pulmonary and blood stream infections in adult living donor and cadaveric liver transplant patients. Transplantation 2008;85:1564-1568.
7. Golfieri R, Giampalma E, Morselli Labate AM, d'Arienzo P, Jovine E, Grazi GL, et al. Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases. Eur Radiol 2000;10:1169-1183.
8. Xia D, Yan LN, Xu L, Li B, Zeng Y, Wen TF, et al. Postoperative severe pneumonia in adult liver transplant recipients. Transplant Proc 2006;38:2974-2978.
9. Bozbas SS, Eyuboglu FO, Ozturk Ergur F, Gullu Arslan N, Sevmis S, Karakayali H, et al. Pulmonary complications and mortality after liver transplant. Exp Clin Transplant 2008;6:264-270.
10. Colonna JO II, Winston DJ, Brill JE, Goldstein LI, Hoff MP, Hiatt JR, et al. Infectious complications in liver transplantation. Arch Surg 1988;123:360-364.
11. Torres A, Ewig S, Insausti J, Guergue JM, Xaubet A, Mas A, et al. Etiology and microbial patterns of pulmonary infiltrates in patients with orthotopic liver transplantation. Chest 2000;117:494-502.
12. Trouillet JL, Chastre J, Vuagnat A, Joly-Guillou ML, Combaux D, Dombret MC, et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998;157:531-539.
13. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416.
14. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
15. Bert F, Galdbart JO, Zarrouk V, Le Mee J, Durand F, Mentre F, et al. Association between nasal carriage of Staphylococcus aureus and infection in liver transplant recipients. Clin Infect Dis 2000;31:1295-1299.
16. Johanson WG Jr, Pierce AK, Sanford JP, Thomas GD. Nosocomial respiratory infections with gram-negative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med 1972;77:701-706.
17. Fabregas N, Ewig S, Torres A, El-Ebiary M, Ramirez J, de La Bellacasa JP, et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax 1999;54:867-873.
18. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stephan F, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med 2000;132: 621-630.
19. Meduri GU, Chastre J. The standardization of bronchoscopic techniques for ventilator-associated pneumonia. Chest 1992;102(SUPPL. 1):557S-564S.
20. Luna CM, Blanzaco D, Niederman MS, Matarucco W, Baredes NC, Desmery P, et al. Resolution of ventilatorassociated pneumonia: prospective evaluation of the Clinical Pulmonary Infection Score as an early clinical predictor of outcome. Crit Care Med 2003;31:676-682.
21. Verhamme KM, De Coster W, De Roo L, De Beenhouwer H, Nollet G, Verbeke J, et al. Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia. Infect Control Hosp Epidemiol 2007;28:389-397.
22. Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000;31:864-871.
23. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/ North American multicenter study. JAMA 1993;270: 2957-2963.
24. Ferrer M, Liapikou A, Valencia M, Esperatti M, Theessen A, Antonio Martinez J, et al. Validation of the American Thoracic Society-Infectious Diseases Society of America guidelines for hospital-acquired pneumonia in the intensive care unit. Clin Infect Dis 2010;50:945-952.
25. Baker AM, Meredith JW, Haponik EF. Pneumonia in intubated trauma patients. Microbiology and outcomes. Am J Respir Crit Care Med 1996;153:343-349.
26. Giard M, Lepape A, Allaouchiche B, Guerin C, Lehot JJ, Robert MO, et al. Early-and late-onset ventilator-associated pneumonia acquired in the intensive care unit: comparison of risk factors. J Crit Care 2008;23: 27-33.
27. Valles J, Pobo A, Garcia-Esquirol O, Mariscal D, Real J, Fernandez R. Excess ICU mortality attributable to ventilator-associated pneumonia: the role of early vs late onset. Intensive Care Med 2007;33:1363-1368.
28. Ibrahim EH, Ward S, Sherman G, Kollef MH. A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting. Chest 2000; 117:1434-1442.
29. Akca O, Koltka K, Uzel S, Cakar N, Pembeci K, Sayan MA, et al. Risk factors for early-onset, ventilator-associated pneumonia in critical care patients: selected multiresistant versus nonresistant bacteria. Anesthesiology 2000;93:638-645.
30. Pellegrino CM, Codeluppi M, Assenza S, Cocchi S, Di Benedetto F, Girardis M. Incidence and clinical outcomes of ventilator-associated pneumonia in liver transplant and non-liver transplant surgical patients. Transplant Proc 2008;40:1986-1988.
31. Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002;122:2115-2121.
32. Nguile-Makao M, Zahar JR, Francais A, Tabah A, Garrouste-Orgeas M, Allaouchiche B, et al. Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models. Intensive Care Med 2010;36: 781-789.
33. Khosravani H, Shahpori R, Stelfox HT, Kirkpatrick AW, Laupland KB. Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill. Crit Care 2009;13: R90.
34. Nichol AD, Egi M, Pettila V, Bellomo R, French C, Hart G, et al. Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study. Crit Care 2010;14:R25.
35. Kusne S, Dummer JS, Singh N, Iwatsuki S, Makowka L, Esquivel C, et al. Infections after liver transplantation. An analysis of 101 consecutive cases. Medicine (Baltimore) 1988;67:132-143.
36. Hedrick TL, Smith RL, McElearney ST, Evans HL, Smith PW, Pruett TL, et al. Differences in early-and late-onset ventilator-associated pneumonia between surgical and trauma patients in a combined surgical or trauma intensive care unit. J Trauma 2008;64:714-720.
37. Goldmann DA, Weinstein RA, Wenzel RP, Tablan OC, Duma RJ, Gaynes RP, et al. Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals. A challenge to hospital leadership. JAMA 1996;275:234-240.
38. Loomba R, Wesley R, Bain A, Csako G, Pucino F. Role of fluoroquinolones in the primary prophylaxis of spontaneous bacterial peritonitis: meta-analysis. Clin Gastroenterol Hepatol 2009;7:487-493.