Aripiprazole: In the treatment of irritability associated with autistic disorder in pediatric patients

Pediatric Drugs

Volumn 13, Issue 3, 2011, Pages 197-204

  Curran, Monique P ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

Adis Drug Profiles; Autistic disorder; Irritability

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ARIPIPRAZOLE; CARBAMAZEPINE; DEXTROMETHORPHAN; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; ESCITALOPRAM; FLUOXETINE; HISTAMINE H1 RECEPTOR; ITRACONAZOLE; KETOCONAZOLE; LAMOTRIGINE; LITHIUM; LORAZEPAM; OMEPRAZOLE; PAROXETINE; PLACEBO; RISPERIDONE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 7 RECEPTOR; SERTRALINE; VALPROIC ACID; VENLAFAXINE; WARFARIN;

AREA UNDER THE CURVE; ARTICLE; AUTISM; BIPOLAR I DISORDER; CHILDHOOD DISEASE; CHOLESTEROL BLOOD LEVEL; DECREASED APPETITE; DIARRHEA; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG WITHDRAWAL; EXTRAPYRAMIDAL SYNDROME; FATIGUE; FEVER; HUMAN; HYPERSALIVATION; INSOMNIA; IRRITABILITY; IRRITABILITY ASSOCIATED WITH AUTISTIC DISORDER; LETHARGY; MAXIMUM PLASMA CONCENTRATION; MONOTHERAPY; MOOD DISORDER; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RECOMMENDED DRUG DOSE; RHINOPHARYNGITIS; SCHIZOPHRENIA; SEDATION; SIDE EFFECT; SOMNOLENCE; TREMOR; UNSPECIFIED SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; VITAL SIGN; VOMITING; WEIGHT GAIN;

AUTISTIC DISORDER; CHILD; CLINICAL TRIALS AS TOPIC; DRUG DOSAGE CALCULATIONS; HUMANS; IRRITABLE MOOD; PIPERAZINES; QUINOLONES; TIME FACTORS;

EID: 79955078929     PISSN: 11745878     EISSN: 11792019     Source Type: Journal    
DOI: 10.2165/11207230-000000000-00000     Document Type: Article

References (23)

1. Findling RL, Kauffman R, Sallee FR, et al. An open-label study of aripiprazole: pharmacokinetics, tolerability, and effectiveness in children and adolescents with conduct disorder. J Child Adolesc Psychopharmacol 2009; 19 (4): 431-9
2. Robb AS, Andersson C, Bellocchio EE, et al. Safety and tolerability of aripiprazole in the treatment of irritability associated with autistic disorder in pediatric subjects (6-17 years old): results from a pooled analysis of 2 studies. Prim Care Compan CNS Disorder. Epub 2011 Feb 3
3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed., text rev. Washington, DC: American Psychiatric Association, 2000
4. Volkmar F, Cook Jr EH, Pomeroy J, et al. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues. J Am Acad Child Adolesc Psychiatry 1999 Dec; 38 (12 Suppl.): 32-54S
5. Malone RP, Waheed A. The role of antipsychotics in the management of behavioural symptoms in children and adolescents with autism. Drugs 2009; 69 (5): 535-48
6. Ortho-McNeil-Janssen, Inc. Risperdal (risperidone) tablets/oral solution: prescribing information [online]. Available from URL: http://www.risperdal.com/ sites/default/files/shared/pi/risperdal.pdf [Accessed 2010 Dec 13]
7. Bristol-Myers Squibb. Abilify (aripiprazole) tablets: US prescribing information [online]. Available from URL: [Accessed 2011 Jan 10]
8. Sanford M, Keating GM. Aripiprazole: in adolescents with schizophrenia. Paediatr Drugs 2007; 9 (6): 419-23 (Pubitemid 350208916)
9. Lyseng-Williamson KA, Perry CM. Aripiprazole: in acute mania associated with bipolar I disorder. CNS Drugs 2004; 18 (6): 367-76; discussion 377-8 (Pubitemid 38621685)
10. Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs 2004; 64 (15): 1715-36 (Pubitemid 39128008)
11. Davies MA, Sheffler DJ, Roth BL. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev 2004; 10 (4): 317-36 (Pubitemid 40128915)
12. Yokoi F, Grunder G, Biziere K, et al. Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C]raclopride. Neuropsychopharmacology 2002 Aug; 27 (2): 248-59 (Pubitemid 34692591)
13. Mallikaarjun S, Salazar DE, Bramer SL. Pharmacokinetics, tolerability, and safety of aripiprazole following multiple oral dosing in normal healthy volunteers. J Clin Pharmacol 2004 Feb; 44 (2): 179-87 (Pubitemid 38114317)
14. Citrome L,Macher JP, Salazar DE, et al. Pharmacokinetics of aripiprazole and concomitant carbamazepine. J Clin Psychopharmacol 2007 Jun; 27 (3): 279-83
15. Owen R, Sikich L, Marcus RN, et al. Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics 2009 Dec; 124 (6): 1533-40
16. Marcus RN, Owen R,Kamen L, et al. A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry 2009 Nov; 48 (11): 1110-9
17. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994 Oct; 24 (5): 659-85 (Pubitemid 24309810)
18. Aman MG, Singh NN. Aberrant Behavior Checklist: manual. East Aurora (NY): Slosson Educational Publications, 1986
19. Bristol-Myers Squibb. Final study report for study CN138180: a 52-week openlabel multicenter study of the safety and tolerability of aripiprazole flexibly doses in the treatment of children and adolescents with austistic disorder [online]. Available from URL: http://www.clinicalstudyresults.org/ documents/company-study-8998-2.pdf [Accessed 2011 Jan 9]
20. Aman MG, Kasper W, Manos G, et al. Line-item analysis of the Aberrant Behavior Checklist: results from two studies of aripiprazole in the treatment of irritability associated with autistic disorder. J Child Adolesc Psychopharmacol 2010 Oct; 20 (5): 415-22
21. Simpson GM, Angus JW. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl 1970; 212: 11-9
22. Barnes TR. A rating scale for drug-induced akathisia. Br J Psychiatry 1989 May; 154: 672-6 (Pubitemid 19154942)
23. Lau G, Manos G, McQuade R, et al. Safety and tolerability of aripiprazole in the treatment of irritability associated with autistic disorder in pediatric patients (6-17 years old): results from the 52-week open-label study [abstract no. 3.51]. Proceedings of the 57th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; 2010 October 26-31; New York (NY)