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Volumn 91, Issue 2, 2012, Pages 189-200

Pathways to drug development for autism spectrum disorders

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CELL PROTEIN; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; REELIN; VIRUS VECTOR;

EID: 84855931231     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.245     Document Type: Article
Times cited : (48)

References (75)
  • 1
    • 78651456267 scopus 로고    scopus 로고
    • Management of symptoms in children with autism spectrum disorders: A comprehensive review of pharmacologic and complementary-alternative medicine treatments
    • Huffman, L.C., Sutcliffe, T.L., Tanner, I.S. & Feldman, H.M. Management of symptoms in children with autism spectrum disorders: a comprehensive review of pharmacologic and complementary-alternative medicine treatments. J. Dev. Behav. Pediatr. 32, 56-68 (2011).
    • (2011) J. Dev. Behav. Pediatr. , vol.32 , pp. 56-68
    • Huffman, L.C.1    Sutcliffe, T.L.2    Tanner, I.S.3    Feldman, H.M.4
  • 2
    • 79251557516 scopus 로고    scopus 로고
    • Psychopharmacology of autistic spectrum disorders in children and adolescents
    • x
    • Nazeer, A. Psychopharmacology of autistic spectrum disorders in children and adolescents. Pediatr. Clin. North Am. 58, 85-97, x (2011).
    • (2011) Pediatr. Clin. North Am. , vol.58 , pp. 85-97
    • Nazeer, A.1
  • 3
    • 79952361702 scopus 로고    scopus 로고
    • Bridging the gap between MRI and postmortem research in autism
    • Schumann, C.M. & Nordahl, C.W. Bridging the gap between MRI and postmortem research in autism. Brain Res. 1380, 175-186 (2011).
    • (2011) Brain Res. , vol.1380 , pp. 175-186
    • Schumann, C.M.1    Nordahl, C.W.2
  • 4
    • 80054960716 scopus 로고    scopus 로고
    • Review of neuroimaging in autism spectrum disorders: What have we learned and where we go from here
    • Anagnostou, E. & Taylor, M.J. Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here. Mol. Autism 2, 4 (2011).
    • (2011) Mol. Autism , vol.2 , Issue.4
    • Anagnostou, E.1    Taylor, M.J.2
  • 5
    • 0035871530 scopus 로고    scopus 로고
    • Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism
    • DOI 10.1016/S0006-3223(00)01008-8, PII S0006322301010088
    • Pierce, K. & Courchesne, E. Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol. Psychiatry 49, 655-664 (2001). (Pubitemid 32328116)
    • (2001) Biological Psychiatry , vol.49 , Issue.8 , pp. 655-664
    • Pierce, K.1    Courchesne, E.2
  • 6
    • 0030967504 scopus 로고    scopus 로고
    • Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism
    • DOI 10.1016/S0959-4388(97)80016-5
    • Courchesne, E. Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr. Opin. Neurobiol. 7, 269-278 (1997). (Pubitemid 27219864)
    • (1997) Current Opinion in Neurobiology , vol.7 , Issue.2 , pp. 269-278
    • Courchesne, E.1
  • 7
    • 79957461232 scopus 로고    scopus 로고
    • Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome
    • Greco, C.M. et al. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol. Autism 2, 2 (2011).
    • (2011) Mol. Autism , vol.2 , Issue.2
    • Greco, C.M.1
  • 8
    • 79955979597 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration
    • Reith, R.M., Way, S., McKenna, J. 3rd, Haines, K. & Gambello, M.J. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiol. Dis. 43, 113-122 (2011).
    • (2011) Neurobiol. Dis. , vol.43 , pp. 113-122
    • Reith, R.M.1    Way, S.2    McKenna Iii, J.3    Haines, K.4    Gambello, M.J.5
  • 9
    • 75749156601 scopus 로고    scopus 로고
    • Repetitive behavior and increased activity in mice with Purkinje cell loss: A model for understanding the role of cerebellar pathology in autism
    • Martin, L.A., Goldowitz, D. & Mittleman, G. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur. J. Neurosci. 31, 544-555 (2010).
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 544-555
    • Martin, L.A.1    Goldowitz, D.2    Mittleman, G.3
  • 10
    • 78149360411 scopus 로고    scopus 로고
    • Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder
    • Noriuchi, M. et al. Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder. Brain Res. 1362, 141-149 (2010).
    • (2010) Brain Res. , vol.1362 , pp. 141-149
    • Noriuchi, M.1
  • 11
    • 79959262465 scopus 로고    scopus 로고
    • Transcriptomic analysis of autistic brain reveals convergent molecular pathology
    • Voineagu, I. et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474, 380-384 (2011).
    • (2011) Nature , vol.474 , pp. 380-384
    • Voineagu, I.1
  • 13
    • 84855341900 scopus 로고    scopus 로고
    • SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
    • in press, doi: 10.1038/mp.2011.57
    • Durand, C.M. et al. SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. Mol. Psychiatry (in press, doi: 10.1038/mp.2011.57).
    • Mol. Psychiatry
    • Durand, C.M.1
  • 14
    • 79957543879 scopus 로고    scopus 로고
    • Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism
    • Bangash, M.A. et al. Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Cell 145, 758-772 (2011).
    • (2011) Cell , vol.145 , pp. 758-772
    • Bangash, M.A.1
  • 15
    • 72049108920 scopus 로고    scopus 로고
    • Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
    • Hutsler, J.J. & Zhang, H. Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. Brain Res. 1309, 83-94 (2010).
    • (2010) Brain Res. , vol.1309 , pp. 83-94
    • Hutsler, J.J.1    Zhang, H.2
  • 16
    • 60549115413 scopus 로고    scopus 로고
    • Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
    • Tropea, D. et al. Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 106, 2029-2034 (2009).
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2029-2034
    • Tropea, D.1
  • 17
    • 79960779323 scopus 로고    scopus 로고
    • FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    • Darnell, J.C. et al. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146, 247-261 (2011).
    • (2011) Cell , vol.146 , pp. 247-261
    • Darnell, J.C.1
  • 18
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • DOI 10.1016/j.tins.2004.04.009, PII S0166223604001328
    • Bear, M.F., Huber, K.M. & Warren, S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci. 27, 370-377 (2004). (Pubitemid 38829251)
    • (2004) Trends in Neurosciences , vol.27 , Issue.7 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 19
    • 79953708493 scopus 로고    scopus 로고
    • The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome
    • Hampson, D.R., Adusei, D.C. & Pacey, L.K. The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome. Biochem. Pharmacol. 81, 1078-1086 (2011).
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 1078-1086
    • Hampson, D.R.1    Adusei, D.C.2    Pacey, L.K.3
  • 20
    • 78650937072 scopus 로고    scopus 로고
    • Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056
    • Jacquemont, S. et al. Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Sci. Transl. Med. 3, 64ra1 (2011).
    • (2011) Sci. Transl. Med. , vol.3
    • Jacquemont, S.1
  • 22
    • 79953709471 scopus 로고    scopus 로고
    • Fragile X and autism: Intertwined at the molecular level leading to targeted treatments
    • Hagerman, R., Hoem, G. & Hagerman, P. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments. Mol. Autism 1, 12 (2010).
    • (2010) Mol. Autism , vol.1 , pp. 12
    • Hagerman, R.1    Hoem, G.2    Hagerman, P.3
  • 23
    • 34250731835 scopus 로고    scopus 로고
    • Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability
    • DOI 10.1177/0883073807302611
    • Chez, M.G., Burton, Q., Dowling, T., Chang, M., Khanna, P. & Kramer, C. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J. Child Neurol. 22, 574-579 (2007). (Pubitemid 46951501)
    • (2007) Journal of Child Neurology , vol.22 , Issue.5 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 25
    • 77955170379 scopus 로고    scopus 로고
    • Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism
    • Oblak, A.L., Gibbs, T.T. & Blatt, G.J. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J. Neurochem. 114, 1414-1423 (2010).
    • (2010) J. Neurochem. , vol.114 , pp. 1414-1423
    • Oblak, A.L.1    Gibbs, T.T.2    Blatt, G.J.3
  • 26
    • 63449095687 scopus 로고    scopus 로고
    • Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: An in situ hybridization study
    • Yip, J., Soghomonian, J.J. & Blatt, G.J. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2, 50-59 (2009).
    • (2009) Autism Res. , vol.2 , pp. 50-59
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3
  • 27
    • 79956005283 scopus 로고    scopus 로고
    • Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument
    • Harada, M. et al. Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument. J. Autism Dev. Disord. 41, 447-454 (2011).
    • (2011) J. Autism Dev. Disord. , vol.41 , pp. 447-454
    • Harada, M.1
  • 28
    • 78149431869 scopus 로고    scopus 로고
    • Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    • Chao, H.T. et al. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468, 263-269 (2010).
    • (2010) Nature , vol.468 , pp. 263-269
    • Chao, H.T.1
  • 29
    • 79951855583 scopus 로고    scopus 로고
    • Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse
    • Pacey, L.K., Doss, L., Cifelli, C., van der Kooy, D., Heximer, S.P. & Hampson, D.R. Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse. Mol. Cell. Neurosci. 46, 563-572 (2011).
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 563-572
    • Pacey, L.K.1    Doss, L.2    Cifelli, C.3    Van Der Kooy, D.4    Heximer, S.P.5    Hampson, D.R.6
  • 30
    • 67649834454 scopus 로고    scopus 로고
    • Increased GABA(B) receptormediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures
    • Pacey, L.K., Heximer, S.P. & Hampson, D.R. Increased GABA(B) receptormediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures. Mol. Pharmacol. 76, 18-24 (2009).
    • (2009) Mol. Pharmacol. , vol.76 , pp. 18-24
    • Pacey, L.K.1    Heximer, S.P.2    Hampson, D.R.3
  • 31
    • 67749109981 scopus 로고    scopus 로고
    • Association of family history of autoimmune diseases and autism spectrum disorders
    • Atladóttir, H.O. et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 124, 687-694 (2009).
    • (2009) Pediatrics , vol.124 , pp. 687-694
    • Atladóttir, H.O.1
  • 32
    • 79952597943 scopus 로고    scopus 로고
    • Autism spectrum disorders and autistic traits: A decade of new twin studies
    • Ronald, A. & Hoekstra, R.A. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B, 255-274 (2011).
    • (2011) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.156 B , pp. 255-274
    • Ronald, A.1    Hoekstra, R.A.2
  • 33
    • 79952313620 scopus 로고    scopus 로고
    • Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting
    • Betancur, C. Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res. 1380, 42-77 (2011).
    • (2011) Brain Res. , vol.1380 , pp. 42-77
    • Betancur, C.1
  • 34
    • 79955030459 scopus 로고    scopus 로고
    • Autism spectrum disorders-a genetics review
    • Miles, J.H. Autism spectrum disorders-a genetics review. Genet. Med. 13, 278-294 (2011).
    • (2011) Genet. Med. , vol.13 , pp. 278-294
    • Miles, J.H.1
  • 35
    • 77954657070 scopus 로고    scopus 로고
    • Functional impact of global rare copy number variation in autism spectrum disorders
    • Pinto, D. et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 466, 368-372 (2010).
    • (2010) Nature , vol.466 , pp. 368-372
    • Pinto, D.1
  • 36
    • 77950899212 scopus 로고    scopus 로고
    • Connecting genes to brain in the autism spectrum disorders
    • Abrahams, B.S. & Geschwind, D.H. Connecting genes to brain in the autism spectrum disorders. Arch. Neurol. 67, 395-399 (2010).
    • (2010) Arch. Neurol. , vol.67 , pp. 395-399
    • Abrahams, B.S.1    Geschwind, D.H.2
  • 37
    • 79958032110 scopus 로고    scopus 로고
    • Rare de novo and transmitted copy-number variation in autistic spectrum disorders
    • Levy, D. et al. Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron 70, 886-897 (2011).
    • (2011) Neuron , vol.70 , pp. 886-897
    • Levy, D.1
  • 38
    • 43849112803 scopus 로고    scopus 로고
    • Immune transcriptome alterations in the temporal cortex of subjects with autism
    • Garbett, K. et al. Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol. Dis. 30, 303-311 (2008).
    • (2008) Neurobiol. Dis. , vol.30 , pp. 303-311
    • Garbett, K.1
  • 39
    • 77956648119 scopus 로고    scopus 로고
    • Signaling mechanisms regulating synapse formation and function in mental retardation
    • Boda, B., Dubos, A. & Muller, D. Signaling mechanisms regulating synapse formation and function in mental retardation. Curr. Opin. Neurobiol. 20, 519-527 (2010).
    • (2010) Curr. Opin. Neurobiol. , vol.20 , pp. 519-527
    • Boda, B.1    Dubos, A.2    Muller, D.3
  • 41
    • 79651475390 scopus 로고    scopus 로고
    • Rapamycin for treating tuberous sclerosis and autism spectrum disorders
    • Ehninger, D. & Silva, A.J. Rapamycin for treating tuberous sclerosis and autism spectrum disorders. Trends Mol. Med. 17, 78-87 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 78-87
    • Ehninger, D.1    Silva, A.J.2
  • 42
    • 77956209418 scopus 로고    scopus 로고
    • Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    • Gross, C. et al. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J. Neurosci. 30, 10624-10638 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 10624-10638
    • Gross, C.1
  • 43
    • 74949102875 scopus 로고    scopus 로고
    • Dysregulation of mTOR signaling in fragile X syndrome
    • Sharma, A. et al. Dysregulation of mTOR signaling in fragile X syndrome. J. Neurosci. 30, 694-702 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 694-702
    • Sharma, A.1
  • 44
    • 79952032711 scopus 로고    scopus 로고
    • Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model
    • Ricciardi, S. et al. Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum. Mol. Genet. 20, 1182-1196 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1182-1196
    • Ricciardi, S.1
  • 46
    • 78449259794 scopus 로고    scopus 로고
    • Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
    • Osterweil, E.K., Krueger, D.D., Reinhold, K. & Bear, M.F. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J. Neurosci. 30, 15616-15627 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 15616-15627
    • Osterweil, E.K.1    Krueger, D.D.2    Reinhold, K.3    Bear, M.F.4
  • 47
    • 79954627454 scopus 로고    scopus 로고
    • Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links
    • Sokol, D.K., Maloney, B., Long, J.M., Ray, B. & Lahiri, D.K. Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Neurology 76, 1344-1352 (2011).
    • (2011) Neurology , vol.76 , pp. 1344-1352
    • Sokol, D.K.1    Maloney, B.2    Long, J.M.3    Ray, B.4    Lahiri, D.K.5
  • 48
    • 33947195786 scopus 로고    scopus 로고
    • FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    • Westmark, C.J. & Malter, J.S. FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 5, e52 (2007).
    • (2007) PLoS Biol. , vol.5
    • Westmark, C.J.1    Malter, J.S.2
  • 49
    • 77953249227 scopus 로고    scopus 로고
    • HnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
    • Lee, E.K. et al. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat. Struct. Mol. Biol. 17, 732-739 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 732-739
    • Lee, E.K.1
  • 50
    • 77954213032 scopus 로고    scopus 로고
    • Plasma cytokine profiles in Fragile X subjects: Is there a role for cytokines in the pathogenesis?
    • Ashwood, P., Nguyen, D.V., Hessl, D., Hagerman, R.J. & Tassone, F. Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis? Brain Behav. Immun. 24, 898-902 (2010).
    • (2010) Brain Behav. Immun. , vol.24 , pp. 898-902
    • Ashwood, P.1    Nguyen, D.V.2    Hessl, D.3    Hagerman, R.J.4    Tassone, F.5
  • 51
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • DOI 10.1002/ana.20315
    • Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W. & Pardo, C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57, 67-81 (2005). (Pubitemid 40053317)
    • (2005) Annals of Neurology , vol.57 , Issue.1 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 52
    • 77949343048 scopus 로고    scopus 로고
    • The immune system's role in the biology of autism
    • Goines, P. & Van de Water, J. The immune system's role in the biology of autism. Curr. Opin. Neurol. 23, 111-117 (2010).
    • (2010) Curr. Opin. Neurol. , vol.23 , pp. 111-117
    • Goines, P.1    Van De Water, J.2
  • 53
    • 78649758904 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in autism
    • Giulivi, C. et al. Mitochondrial dysfunction in autism. JAMA 304, 2389-2396 (2010).
    • (2010) JAMA , vol.304 , pp. 2389-2396
    • Giulivi, C.1
  • 54
    • 79952448912 scopus 로고    scopus 로고
    • Maternal immune activation and autism spectrum disorder: Interleukin-6 signaling as a key mechanistic pathway
    • Parker-Athill, E.C. & Tan, J. Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway. Neurosignals. 18, 113-128 (2010).
    • (2010) Neurosignals. , vol.18 , pp. 113-128
    • Parker-Athill, E.C.1    Tan, J.2
  • 55
    • 79956040296 scopus 로고    scopus 로고
    • IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    • Wei, H. et al. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J. Neuroinflammation 8, 52 (2011).
    • (2011) J. Neuroinflammation , vol.8 , pp. 52
    • Wei, H.1
  • 57
    • 84855922674 scopus 로고    scopus 로고
    • Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism
    • Wills, S. et al. Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Mol. Autism 2, 5 (2011).
    • (2011) Mol. Autism , vol.2 , pp. 5
    • Wills, S.1
  • 58
    • 79959964671 scopus 로고    scopus 로고
    • Maternal infection and immune involvement in autism
    • Patterson, P.H. Maternal infection and immune involvement in autism. Trends Mol. Med. 17, 389-394 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 389-394
    • Patterson, P.H.1
  • 59
    • 70349794459 scopus 로고    scopus 로고
    • Innate and adaptive autoimmunity directed to the central nervous system
    • Bhat, R. & Steinman, L. Innate and adaptive autoimmunity directed to the central nervous system. Neuron 64, 123-132 (2009).
    • (2009) Neuron , vol.64 , pp. 123-132
    • Bhat, R.1    Steinman, L.2
  • 60
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • Boulanger, L.M. Immune proteins in brain development and synaptic plasticity. Neuron 64, 93-109 (2009).
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 61
    • 77954938884 scopus 로고    scopus 로고
    • Immune dysfunction in autism: A pathway to treatment
    • Careaga, M., Van de Water, J. & Ashwood, P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 7, 283-292 (2010).
    • (2010) Neurotherapeutics , vol.7 , pp. 283-292
    • Careaga, M.1    Van De Water, J.2    Ashwood, P.3
  • 62
    • 77955684004 scopus 로고    scopus 로고
    • Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
    • Morgan, J.T. et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol. Psychiatry 68, 368-376 (2010).
    • (2010) Biol. Psychiatry , vol.68 , pp. 368-376
    • Morgan, J.T.1
  • 63
    • 77951020598 scopus 로고    scopus 로고
    • Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    • Maezawa, I. & Jin, L.W. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J. Neurosci. 30, 5346-5356 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 5346-5356
    • Maezawa, I.1    Jin, L.W.2
  • 64
    • 77949835797 scopus 로고    scopus 로고
    • Astrocytes prevent abnormal neuronal development in the fragile x mouse
    • Jacobs, S. & Doering, L.C. Astrocytes prevent abnormal neuronal development in the fragile x mouse. J. Neurosci. 30, 4508-4514 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 4508-4514
    • Jacobs, S.1    Doering, L.C.2
  • 65
    • 77956650824 scopus 로고
    • Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome
    • Yuskaitis, C.J., Beurel, E. & Jope, R.S. Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome. Biochim. Biophys. Acta 1802, 1006-1012 (2010).
    • (1802) Biochim. Biophys. Acta , pp. 1006-1012
    • Yuskaitis, C.J.1    Beurel, E.2    Jope, R.S.3
  • 66
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • Graeber, M.B. Changing face of microglia. Science 330, 783-788 (2010).
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 67
    • 0035153212 scopus 로고    scopus 로고
    • Immune function of astrocytes
    • DOI 10.1002/glia.1107
    • Dong, Y. & Benveniste, E.N. Immune function of astrocytes. Glia 36, 180-190 (2001). (Pubitemid 33055906)
    • (2001) GLIA , vol.36 , Issue.2 , pp. 180-190
    • Dong, Y.1    Benveniste, E.N.2
  • 68
    • 77957678816 scopus 로고    scopus 로고
    • Open-label add-on treatment trial of minocycline in fragile X syndrome
    • Paribello, C. et al. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 10, 91 (2010).
    • (2010) BMC Neurol. , vol.10 , pp. 91
    • Paribello, C.1
  • 69
    • 80052787159 scopus 로고    scopus 로고
    • Mechanisms of GABA release from human astrocytes
    • Lee, M., McGeer, E.G. & McGeer, P.L. Mechanisms of GABA release from human astrocytes. Glia 59, 1600-1611 (2011).
    • (2011) Glia , vol.59 , pp. 1600-1611
    • Lee, M.1    McGeer, E.G.2    McGeer, P.L.3
  • 70
    • 58249135425 scopus 로고    scopus 로고
    • Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS)
    • D'Hulst, C. et al. Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS). Brain Res. 1253, 176-183 (2009).
    • (2009) Brain Res. , vol.1253 , pp. 176-183
    • D'Hulst, C.1
  • 73
    • 0036428811 scopus 로고    scopus 로고
    • Regulation of gene expression in adeno-associated virus vectors in the brain
    • DOI 10.1016/S1046-2023(02)00226-8, PII S1046202302002268
    • Haberman, R.P. & McCown, T.J. Regulation of gene expression in adeno-associated virus vectors in the brain. Methods 28, 219-226 (2002). (Pubitemid 35341085)
    • (2002) Methods , vol.28 , Issue.2 , pp. 219-226
    • Haberman, R.P.1    McCown, T.J.2
  • 74
    • 33847266846 scopus 로고    scopus 로고
    • Reversal of neurological defects in a mouse model of Rett syndrome
    • DOI 10.1126/science.1138389
    • Guy, J., Gan, J., Selfridge, J., Cobb, S. & Bird, A. Reversal of neurological defects in a mouse model of Rett syndrome. Science 315, 1143-1147 (2007). (Pubitemid 46328028)
    • (2007) Science , vol.315 , Issue.5815 , pp. 1143-1147
    • Guy, J.1    Gan, J.2    Selfridge, J.3    Cobb, S.4    Bird, A.5
  • 75
    • 70249130074 scopus 로고    scopus 로고
    • Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome
    • Zeier, Z., Kumar, A., Bodhinathan, K., Feller, J.A., Foster, T.C. & Bloom, D.C. Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome. Gene Ther. 16, 1122-1129 (2009).
    • (2009) Gene Ther. , vol.16 , pp. 1122-1129
    • Zeier, Z.1    Kumar, A.2    Bodhinathan, K.3    Feller, J.A.4    Foster, T.C.5    Bloom, D.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.