SPT4 increases UV-induced mutagenesis in yeast through impaired nucleotide excision repair

Molecular and Cellular Toxicology

Volumn 9, Issue 1, 2013, Pages 37-43

  Kang, Mi Sun ^a   Yu, Sung Lim ^a   Kim, Ho Yeol ^a   Lim, Hyun Sook ^a   Lee, Sung Keun ^a  

^a Inha University School of Medicine   (South Korea)

Author keywords

DNA repair; Mutagenesis; RAD2; SPT4; Transcription elongation

Indexed keywords

HUNTINGTIN; MUTANT PROTEIN;

ARTICLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; FUNGAL CELL; FUNGAL GENE; NERVE CELL; NONHUMAN; RADIATION MUTAGENESIS; SPT4 GENE; TRANSCRIPTION ELONGATION; ULTRAVIOLET RADIATION; YEAST;

EID: 84875857592     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-013-0006-3     Document Type: Article

References (32)

1. Bartek, J. & Lukas, J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 19:238-245 (2007).
2. Ljungman, M. & Lane, D. P. Transcription - guarding the genome by sensing DNA damage. Nat Rev Cancer 4:727-737 (2004).
3. Musa, M., Kannan, T. P., Masudi, S. M. & Rahman, I. A. Assessment of DNA damage caused by locally produced hydroxyapatite-silica nanocomposite using comet assay on human lung fibroblast cell line. Mol Cell Tox 8:53-60 (2012).
4. Park, J. Y. & Seo, Y. R. The protective role of Nrf2 in cadmium-induced DNA damage. Mol Cell Tox 7:61-66 (2011).
5. Rouse, J. & Jackson, S. P. Interfaces between the detection, signaling, and repair of DNA damage. Science 297:547-551 (2002).
6. Compe, E. & Egly, J. TFIIH: When transcription met DNA repair. Nat Rev Mol Cell Biol 13:343-354 (2012).
7. Kim, N. & Jinks-Robertson, S. Transcription as a source of genome instability. Nat Rev Genet 13:204-214 (2012).
8. Clarkson, S. G. The XPG story. Biochimie 85:1113-1121 (2003).
9. Lee, S.-K., Yu, S.-L., Prakash, L. & Prakash, S. Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription: Implications for cockayne syndrome. Cell 109:823-834 (2002).
10. Yu, S.-L., Lee, S.-K., Johnson, R. E., Prakash, L. & Prakash, S. The stalling of transcription at abasic sites is highly mutagenic. Mol Cell Biol 23:382-388 (2003).
11. Yu, S.-L. et al. RAD2 and PUF4 regulate nucleotide metabolism related genes, HPT1 and URA3. Mol Cell Tox 4:338-347 (2008).
12. Rondon, A. G., Garcia-Rubio, M., Gonzalez-Barrera, S. & Aguilera, A. Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22:612-620 (2003).
13. Mason, P. & Struhl, K. Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mol Cell 17:831-840 (2005).
14. Hirtreiter, A. et al. Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiledcoil motif. Nucleic Acids Res 38:4040-4051 (2010).
15. Jansen, L. E. et al. Spt4 modulates Rad26 requirement in transcription-coupled nucleotide excision repair. EMBO J 19:6498-6507 (2000).
16. Jansen, L. E., Belo, A. I., Hulsker, R. & Brouwer, J. Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage. Nucleic Acids Res 30:3532-3539 (2002).
17. Gerber, A., Herschlag, D. & Brown, P. Extensive association of functionally and cytotopically related mRNAs with puf family RNA-binding proteins in yeast. PLoS Biol 2:342-354 (2004).
18. Kim, D. K. et al. Structure-function analysis of human Spt4: Evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. Genes Cells 8:371-378 (2003).
19. Yamaguchi, Y., Narita, T., Inukai, N., Wada, T. & Handa, H. SPT genes: Key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129:185-191 (2001).
20. Zhu, W. et al. DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation. Nucleic Acids Res 35:4064-4075 (2007).
21. Hartzog, G. A., Wada, T., Handa, H. & Winston, F. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in saccharomyces cerevisiae. Genes Dev 12:357-369 (1998).
22. Ainbinder, E., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. & Dikstein, R. Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NFkappaB. Mol Cell Biol 24:2444-2454 (2004).
23. Amir-Zilberstein, L. & Dikstein, R. Interplay between E-box and NF-kappaB in regulation of A20 gene by DRB sensitivity-inducing factor (DSIF). J Biol Chem 283:1317-1323 (2008).
24. Malagon, F. & Aguilera, A. Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae. Curr Genet 30:101-106 (1996).
25. Basrai, M., Kingsbury, J., Koshland, D., Spencer, F. & Hieter, P. Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in saccharomyces cerevisiae. Mol Cell Biol 16:2838-2847 (1996).
26. Liu, C. R. et al. Spt4 is selectively required for transcription of extended trinucleotide repeats. Cell 148:690-701 (2012).
27. Stanlie, A., Begum, N. A., Akiyama, H. & Honjo, T. The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination. PLoS Genet 8:e1002675 (2012).
28. Sim III, R., Belotserkovskaya, R. & Reinberg, D. Elongation by RNA polymerase II: The short and long of it. Genes Dev 18:2437-2468 (2004).
29. Exinger, F. & Lacroute, F. 6-azauracil inhibition of GTP biosynthesis in saccharomyces cerevisiae. Curr Genet 22:9-11 (1992).
30. Thompson, B. J. Developmental control of cell growth and division in drosophila. Curr Opin Cell Biol 22:788-794 (2010).
31. Morillon, A. et al. Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell 115:425-435 (2003).
32. Yu, S.-L., Kang, M.-S., Kim, H.-Y., Lee, S. H. & Lee, S.-K. Restoration of proliferation ability with increased genomic instability from Rad2p-induced mitotic catastrophe in saccharomyces cerevisiae. Mol Cell Tox 7:195-206 (2011).