Spt4 modulates Rad26 requirement in transcription-coupled nucleotide excision repair

EMBO Journal

Volumn 19, Issue 23, 2000, Pages 6498-6507

  Jansen, L E T ^a   Den Dulk, H ^a   Brouns, R M ^a   De Ruijter, M ^a   Brandsma, J A ^a   Brouwer, J ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Nucleotide excision repair; RAD26; SPT4; Transcription coupled repair

Indexed keywords

DNA; ELONGATION FACTOR; GENE PRODUCT; NUCLEOTIDE; PROTEIN RAD26; PROTEIN SPT4; UNCLASSIFIED DRUG;

ARTICLE; COCKAYNE SYNDROME; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST; YEAST CELL;

SACCHAROMYCES CEREVISIAE;

EID: 0034388027     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.23.6498     Document Type: Article

References (42)

1. Regulation of the Saccharomyces cerevisiae DNA repair gene RAD16
2. Damage recognition in nucleotide excision repair of DNA
3. Large-scale analysis of gene expression, protein localization and gene disruption in Saccharomyces cerevisiae
4. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
5. Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein
6. The role of multisite phosphorylation in the regulation of RNA polymerase II activity
7. Molecular mechanism of nucleotide excision repair
8. A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexes
9. 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae
10. Improved method for high efficiency transformation of intact yeast cells
11. RAD26, the yeast homolog of human Cockayne's syndrome group B gene, encodes a DNA-dependent ATPase
12. Yeast Rad7-Rad16 complex, specific for the nucleotide excision repair of the nontranscribed DNA strand, is an ATP-dependent DNA damage sensor
13. Evidence that Spt4, Spt5 and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae
14. Dissecting the regulatory circuitry of a eukaryotic genome
15. Transcription-coupled repair of 8-oxoguanine: Requirement for XPG, TFIIH and CSB and implications for Cockayne syndrome
16. Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae
17. Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis
18. The general transcription factors of RNA polymerase II
19. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation
20. A novel yeast gene, TH02, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination
21. Recombination between DNA repeats in yeast hpr1Δ cells is linked to transcription elongation
22. Large-scale analysis of the yeast genome by transposon tagging and gene disruption
23. Molecular mechanism of transcription-repair coupling
24. Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II
25. SPT4, SPT5 and SPT6 interactions: Effects on transcription and viability in Saccharomyces cerevisiae
26. RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components Xeroderma pigmentosum B and p62
27. Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation cornplexes
28. Transcription-coupled and global genome repair in the Saccharomyces cerevisiae RPB2 gene at nucleotide resolution
29. Transitions in the coupling of transcription and nucleotide excision repair within RNA polyrnerase II-transcribed genes of Saccharomyces cerevisiae
30. ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes
31. Basic mechanisms of transcript elongation and its regulation
32. RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6
33. The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex
34. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA
35. The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of the nontranscribed strand of an active gene in Saccharomyces cerevisiae
36. Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair
37. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs
38. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH
39. Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae
40. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation
41. Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2 and 5S genes
42. Recycling of the general transcription factors during RNA polymerase II transcription