메뉴 건너뛰기




Volumn 72, Issue 4, 2013, Pages 501-510

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles

Author keywords

Biomarkers; Exosomes; Extracellular vesicles; Microvesicles

Indexed keywords

NANOPARTICLE; NUCLEIC ACID;

EID: 84875846540     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e3182846e63     Document Type: Article
Times cited : (35)

References (101)
  • 1
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi K, Meehan B, Micallef J, et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol. 2008;10(5):619-624.
    • (2008) Nat Cell Biol. , vol.10 , Issue.5 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3
  • 2
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Würdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470-1476.
    • (2008) Nat Cell Biol. , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    Van Rijn, S.3
  • 4
    • 33645315758 scopus 로고    scopus 로고
    • Tumour-derived micro-vesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes
    • Baj-Krzyworzeka M, Szatanek R, Weglarczyk K, et al. Tumour-derived micro-vesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol Immunother. 2006; 55(7):808-818.
    • (2006) Cancer Immunol Immunother. , vol.55 , Issue.7 , pp. 808-818
    • Baj-Krzyworzeka, M.1    Szatanek, R.2    Weglarczyk, K.3
  • 5
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation: Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation: association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262(19):9412-9420.
    • (1987) J Biol Chem. , vol.262 , Issue.19 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 6
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 2008;15(2):243-250.
    • (2008) Cell Death Differ. , vol.15 , Issue.2 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 7
    • 0030592720 scopus 로고    scopus 로고
    • Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells
    • Takizawa F, Tsuji S, Nagasawa S. Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells. FEBS Lett. 1996;397(2-3):269-272.
    • (1996) FEBS Lett. , vol.397 , Issue.2-3 , pp. 269-272
    • Takizawa, F.1    Tsuji, S.2    Nagasawa, S.3
  • 8
  • 9
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • chap 3, unit 3.22
    • Théry C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006;chap 3, unit 3.22.
    • (2006) Curr Protoc Cell Biol.
    • Théry, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 10
    • 75749091133 scopus 로고    scopus 로고
    • Microfluidic isolation and transcriptome analysis of serum microvesicles
    • Chen C, Skog J, Hsu CH, et al. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip. 2010;10(4):505-511.
    • (2010) Lab Chip. , vol.10 , Issue.4 , pp. 505-511
    • Chen, C.1    Skog, J.2    Hsu, C.H.3
  • 11
    • 38449100167 scopus 로고    scopus 로고
    • Proteomic analysis of secreted exosomes
    • Olver C, Vidal M. Proteomic analysis of secreted exosomes. Subcell Biochem. 2007;43(2):99-131.
    • (2007) Subcell Biochem. , vol.43 , Issue.2 , pp. 99-131
    • Olver, C.1    Vidal, M.2
  • 12
    • 78149420582 scopus 로고    scopus 로고
    • Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
    • Ohshima K, Inoue K, Fujiwara A, et al. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One. 2010;5(10):e13247.
    • (2010) PLoS One. , vol.5 , Issue.10
    • Ohshima, K.1    Inoue, K.2    Fujiwara, A.3
  • 15
    • 77954257796 scopus 로고    scopus 로고
    • Secreted monocytic miR-150 enhances targeted endothelial cell migration
    • Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010;39(1):133-144.
    • (2010) Mol Cell. , vol.39 , Issue.1 , pp. 133-144
    • Zhang, Y.1    Liu, D.2    Chen, X.3
  • 16
    • 76949101800 scopus 로고    scopus 로고
    • Astrocytes and glioblastoma cells release exosomes carrying mtDNA
    • Guescini M, Genedani S, Stocchi V, Agnati LF. Astrocytes and glioblastoma cells release exosomes carrying mtDNA. J Neural Transm. 2010;117(1):1-4.
    • (2010) J Neural Transm. , vol.117 , Issue.1 , pp. 1-4
    • Guescini, M.1    Genedani, S.2    Stocchi, V.3    Agnati, L.F.4
  • 17
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
    • Pan BT, Johnstone RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell. 1983; 33(3):967-978.
    • (1983) Cell. , vol.33 , Issue.3 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 18
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985;101(3):942-948.
    • (1985) J Cell Biol. , vol.101 , Issue.3 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 19
    • 18844395894 scopus 로고    scopus 로고
    • Revisiting the road to the discovery of exosomes
    • Johnstone RM. Revisiting the road to the discovery of exosomes. Blood Cells Mol Dis. 2005;34(3):214-219.
    • (2005) Blood Cells Mol Dis. , vol.34 , Issue.3 , pp. 214-219
    • Johnstone, R.M.1
  • 20
    • 0035494424 scopus 로고    scopus 로고
    • Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells
    • Kleijmeer M, Ramm G, Schuurhuis D, et al. Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol. 2001;155(1):53-63.
    • (2001) J Cell Biol. , vol.155 , Issue.1 , pp. 53-63
    • Kleijmeer, M.1    Ramm, G.2    Schuurhuis, D.3
  • 21
    • 33645357271 scopus 로고    scopus 로고
    • Exosomes are released by cultured cortical neurones
    • Fauré J, Lachenal G, Court M, et al. Exosomes are released by cultured cortical neurones. Mol Cell Neurosci. 2006;31(4):642-648.
    • (2006) Mol Cell Neurosci. , vol.31 , Issue.4 , pp. 642-648
    • Fauré, J.1    Lachenal, G.2    Court, M.3
  • 22
    • 0043092308 scopus 로고    scopus 로고
    • Expulsion of small molecules in vesicles shed by cancer cells: Association with gene expression and chemosensitivity profiles
    • Shedden K, Xie XT, Chandaroy P, Chang YT, Rosania GR. Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles. Cancer Res. 2003;63(15):4331-4337.
    • (2003) Cancer Res. , vol.63 , Issue.15 , pp. 4331-4337
    • Shedden, K.1    Xie, X.T.2    Chandaroy, P.3    Chang, Y.T.4    Rosania, G.R.5
  • 23
    • 27644524811 scopus 로고    scopus 로고
    • Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
    • Safaei R, Larson BJ, Cheng TC, et al. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol Cancer Ther. 2005;4(10):1595-1604.
    • (2005) Mol Cancer Ther. , vol.4 , Issue.10 , pp. 1595-1604
    • Safaei, R.1    Larson, B.J.2    Cheng, T.C.3
  • 24
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived micro-vesicles containing oncogenic EGFR
    • Al-Nedawi K, Meehan B, Kerbel RS, Allison AC, Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived micro-vesicles containing oncogenic EGFR. Proc Natl Acad Sci USA. 2009;106(10): 3794-3799.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , Issue.10 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3    Allison, A.C.4    Rak, J.5
  • 25
    • 84875835580 scopus 로고    scopus 로고
    • Microglia-derived microvesicles represent a new pathway of glia-to-neuron communication and a biomarker of brain Inflammation [abstract]
    • April 2012; Gothenburg Sweden
    • Verderio C, Turola E, Antonucci F, et al. Microglia-derived microvesicles represent a new pathway of glia-to-neuron communication and a biomarker of brain Inflammation [abstract]. Presented at: 2012 International Society for Extracellular Vesicles Meeting; April 2012; Gothenburg, Sweden.
    • 2012 International Society for Extracellular Vesicles Meeting
    • Verderio, C.1    Turola, E.2    Antonucci, F.3
  • 26
    • 84875852104 scopus 로고    scopus 로고
    • Crosstalk between neurons and glia involving exosomes as vesicular carriers of RNA and proteins [abstract]
    • April 2012; Gothenburg Sweden
    • Frohlich D, Fruhbeis C, J. A, et al. Crosstalk between neurons and glia involving exosomes as vesicular carriers of RNA and proteins [abstract]. Presented at: 2012 International Society for Extracellular Vesicles Meeting; April 2012; Gothenburg, Sweden.
    • 2012 International Society for Extracellular Vesicles Meeting
    • Frohlich, D.1    Fruhbeis, C.J.A.2
  • 27
    • 38949191397 scopus 로고    scopus 로고
    • Exosomal transfer of proteins and RNAs at synapses in the nervous system
    • Smalheiser NR. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol Direct. 2007;2:35.
    • (2007) Biol Direct. , vol.2 , pp. 35
    • Smalheiser, N.R.1
  • 29
    • 2442614163 scopus 로고    scopus 로고
    • Trans-endocytosis via spinules in adult rat hippocampus
    • Spacek J, Harris KM. Trans-endocytosis via spinules in adult rat hippocampus. J Neurosci. 2004;24(17):4233-4241.
    • (2004) J Neurosci. , vol.24 , Issue.17 , pp. 4233-4241
    • Spacek, J.1    Harris, K.M.2
  • 30
    • 78751703517 scopus 로고    scopus 로고
    • Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    • Lachenal G, Pernet-Gallay K, Chivet M, et al. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity. Mol Cell Neurosci. 2011;46(2):409-418.
    • (2011) Mol Cell Neurosci. , vol.46 , Issue.2 , pp. 409-418
    • Lachenal, G.1    Pernet-Gallay, K.2    Chivet, M.3
  • 31
    • 84857065319 scopus 로고    scopus 로고
    • Microvesicle and tunneling nanotube mediated intercellular transfer of G-protein coupled receptors in cell cultures
    • Guescini M, Leo G, Genedani S, et al. Microvesicle and tunneling nanotube mediated intercellular transfer of G-protein coupled receptors in cell cultures. Exp Cell Res. 2012;318(5):603-613.
    • (2012) Exp Cell Res. , vol.318 , Issue.5 , pp. 603-613
    • Guescini, M.1    Leo, G.2    Genedani, S.3
  • 33
    • 0036258785 scopus 로고    scopus 로고
    • Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells
    • Baj-Krzyworzeka M, Majka M, Pratico D, et al. Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. Exp Hematol. 2002;30(5):450-459.
    • (2002) Exp Hematol. , vol.30 , Issue.5 , pp. 450-459
    • Baj-Krzyworzeka, M.1    Majka, M.2    Pratico, D.3
  • 34
    • 23944509766 scopus 로고    scopus 로고
    • Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
    • Del Conde I, Shrimpton CN, Thiagarajan P, López JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106(5):1604-1611.
    • (2005) Blood. , vol.106 , Issue.5 , pp. 1604-1611
    • Del Conde, I.1    Shrimpton, C.N.2    Thiagarajan, P.3    López, J.A.4
  • 35
    • 0027495262 scopus 로고
    • Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias
    • Lee YJ, Jy W, Horstman LL, et al. Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias. Thromb Res. 1993; 72(4):295-304.
    • (1993) Thromb Res. , vol.72 , Issue.4 , pp. 295-304
    • Lee, Y.J.1    Jy, W.2    Horstman, L.L.3
  • 36
    • 60849108352 scopus 로고    scopus 로고
    • Lactadherin and clearance of platelet-derived microvesicles
    • Dasgupta SK, Abdel-Monem H, Niravath P, et al. Lactadherin and clearance of platelet-derived microvesicles. Blood. 2009;113(6):1332-1339.
    • (2009) Blood. , vol.113 , Issue.6 , pp. 1332-1339
    • Dasgupta, S.K.1    Abdel-Monem, H.2    Niravath, P.3
  • 37
    • 2942637935 scopus 로고    scopus 로고
    • Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids
    • Zwaal RF, Comfurius P, Bevers EM. Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids. Biochim Biophys Acta. 2004; 1636(2-3):119-128.
    • (2004) Biochim Biophys Acta. , vol.1636 , Issue.2-3 , pp. 119-128
    • Zwaal, R.F.1    Comfurius, P.2    Bevers, E.M.3
  • 38
    • 0031018587 scopus 로고    scopus 로고
    • Characterization of a novel bleeding disorder with isolated prolonged bleeding time and deficiency of platelet microvesicle generation
    • Castaman G, Yu-Feng L, Battistin E, Rodeghiero F. Characterization of a novel bleeding disorder with isolated prolonged bleeding time and deficiency of platelet microvesicle generation. Br J Haematol. 1997;96(3):458-463.
    • (1997) Br J Haematol. , vol.96 , Issue.3 , pp. 458-463
    • Castaman, G.1    Yu-Feng, L.2    Battistin, E.3    Rodeghiero, F.4
  • 39
    • 77952365658 scopus 로고    scopus 로고
    • Micro-vesicles: Mediators of extracellular communication during cancer progression
    • Muralidharan-Chari V, Clancy JW, Sedgwick A, D'Souza-Schorey C. Micro-vesicles: mediators of extracellular communication during cancer progression. J Cell Sci. 2010;123(pt 10):1603-1611.
    • (2010) J Cell Sci. , vol.123 , Issue.PART 10 , pp. 1603-1611
    • Muralidharan-Chari, V.1    Clancy, J.W.2    Sedgwick, A.3    D'Souza-Schorey, C.4
  • 40
    • 0035118749 scopus 로고    scopus 로고
    • Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines
    • Angelucci A, D'Ascenzo S, Festuccia C, et al. Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines. Clin Exp Metastasis. 2000;18(2):163-170.
    • (2000) Clin Exp Metastasis. , vol.18 , Issue.2 , pp. 163-170
    • Angelucci, A.1    D'Ascenzo, S.2    Festuccia, C.3
  • 41
    • 0031760355 scopus 로고    scopus 로고
    • The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness
    • Ginestra A, La Placa MD, Saladino F, Cassarà D, Nagase H, Vittorelli ML. The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res. 1998;18(5A):3433-3437.
    • (1998) Anticancer Res. , vol.18 , Issue.5 A , pp. 3433-3437
    • Ginestra, A.1    La Placa, M.D.2    Saladino, F.3    Cassarà, D.4    Nagase, H.5    Vittorelli, M.L.6
  • 42
    • 57149087260 scopus 로고    scopus 로고
    • Keski-OjaJ. Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes
    • Hakulinen J, Sankkila L, Sugiyama N, Lehti K, Keski-OjaJ. Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. J Cell Biochem. 2008;105(5):1211-1218.
    • (2008) J Cell Biochem. , vol.105 , Issue.5 , pp. 1211-1218
    • Hakulinen, J.1    Sankkila, L.2    Sugiyama, N.3    Lehti, K.4
  • 43
    • 59149083102 scopus 로고    scopus 로고
    • Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: A role for activated fibroblasts and CX3CL1-CX3CR1 axis
    • Castellana D, Zobairi F, Martinez MC, et al. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res. 2009;69(3):785-793.
    • (2009) Cancer Res. , vol.69 , Issue.3 , pp. 785-793
    • Castellana, D.1    Zobairi, F.2    Martinez, M.C.3
  • 44
    • 84867120348 scopus 로고    scopus 로고
    • Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression
    • Bobrie A, Krumeich S, Reyal F, et al. Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 2012;72(19):4920-4930.
    • (2012) Cancer Res. , vol.72 , Issue.19 , pp. 4920-4930
    • Bobrie, A.1    Krumeich, S.2    Reyal, F.3
  • 45
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H, Aleckovic M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18(6):883-891.
    • (2012) Nat Med. , vol.18 , Issue.6 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3
  • 46
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 2011;71(11):3792-3801.
    • (2011) Cancer Res. , vol.71 , Issue.11 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 47
    • 79952261021 scopus 로고    scopus 로고
    • Exosomes and cancer: A newly described pathway of immune suppression
    • Zhang HG, Grizzle WE. Exosomes and cancer: a newly described pathway of immune suppression. Clin Cancer Res. 2011;17(5):959-964.
    • (2011) Clin Cancer Res. , vol.17 , Issue.5 , pp. 959-964
    • Zhang, H.G.1    Grizzle, W.E.2
  • 48
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One. 2010;5(7):e11469.
    • (2010) PLoS One. , vol.5 , Issue.7
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 49
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10(9):942-949.
    • (2004) Nat Med. , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 50
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res. 2005;11(3): 1010-1020.
    • (2005) Clin Cancer Res. , vol.11 , Issue.3 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 51
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola G, Rivoltini L, Castelli C, et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med. 2002;195(10): 1303-1316.
    • (2002) J Exp Med. , vol.195 , Issue.10 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3
  • 52
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9(8):581-593.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.8 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 53
    • 36148959342 scopus 로고    scopus 로고
    • Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
    • Bhatnagar S, Shinagawa K, Castellino FJ, Schorey JS. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood. 2007;110(9):3234-3244.
    • (2007) Blood. , vol.110 , Issue.9 , pp. 3234-3244
    • Bhatnagar, S.1    Shinagawa, K.2    Castellino, F.J.3    Schorey, J.S.4
  • 54
    • 63149192294 scopus 로고    scopus 로고
    • + memory T cells by releasing antigenic exosomes
    • + memory T cells by releasing antigenic exosomes. J Immunol. 2009;182(3):1548-1559.
    • (2009) J Immunol. , vol.182 , Issue.3 , pp. 1548-1559
    • Walker, J.D.1    Maier, C.L.2    Pober, J.S.3
  • 55
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • Admyre C, Johansson SM, Paulie S, Gabrielsson S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur J Immunol. 2006;36(7): 1772-1781.
    • (2006) Eur J Immunol. , vol.36 , Issue.7 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 56
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre F, Schartz NE, Movassagh M, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet. 2002;360(9329):295-305.
    • (2002) Lancet. , vol.360 , Issue.9329 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3
  • 57
    • 0033152288 scopus 로고    scopus 로고
    • Horizontal transfer of DNA by the uptake of apoptotic bodies
    • Holmgren L, Szeles A, Rajnavölgyi E, et al. Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood. 1999;93(11):3956-3963.
    • (1999) Blood. , vol.93 , Issue.11 , pp. 3956-3963
    • Holmgren, L.1    Szeles, A.2    Rajnavölgyi, E.3
  • 58
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
    • (2007) Nat Cell Biol. , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 59
    • 70349316341 scopus 로고    scopus 로고
    • Proteomic and immunologic analyses of brain tumor exosomes
    • Graner MW, Alzate O, Dechkovskaia AM, et al. Proteomic and immunologic analyses of brain tumor exosomes. FASEB J. 2009;23(5):1541-1557.
    • (2009) FASEB J. , vol.23 , Issue.5 , pp. 1541-1557
    • Graner, M.W.1    Alzate, O.2    Dechkovskaia, A.M.3
  • 60
    • 84855784507 scopus 로고    scopus 로고
    • RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls
    • Noerholm M, Balaj L, Limperg T, et al. RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls. BMC Cancer. 2012;12(1):22.
    • (2012) BMC Cancer. , vol.12 , Issue.1 , pp. 22
    • Noerholm, M.1    Balaj, L.2    Limperg, T.3
  • 62
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006): 350-355.
    • (2004) Nature. , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 63
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10(10):704-714.
    • (2009) Nat Rev Genet. , vol.10 , Issue.10 , pp. 704-714
    • Croce, C.M.1
  • 65
    • 48949116262 scopus 로고    scopus 로고
    • MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • Silber J, Lim DA, Petritsch C, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008;6:14.
    • (2008) BMC Med. , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3
  • 66
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005;65(14):6029-6033.
    • (2005) Cancer Res. , vol.65 , Issue.14 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 67
    • 79551608032 scopus 로고    scopus 로고
    • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    • Balaj L, Lessard R, Dai L, et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun. 2011;2:180.
    • (2011) Nat Commun. , vol.2 , pp. 180
    • Balaj, L.1    Lessard, R.2    Dai, L.3
  • 68
    • 85027935991 scopus 로고    scopus 로고
    • Brain tumor microvesicles: Insights into intercellular communication in the nervous system
    • van der Vos KE, Balaj L, Skog J, Breakefield XO. Brain tumor microvesicles: insights into intercellular communication in the nervous system. Cell Mol Neurobiol. 2011;31(6):949-959.
    • (2011) Cell Mol Neurobiol. , vol.31 , Issue.6 , pp. 949-959
    • Van Der Vos, K.E.1    Balaj, L.2    Skog, J.3    Breakefield, X.O.4
  • 69
    • 0037955469 scopus 로고    scopus 로고
    • Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation
    • Mangiacasale R, Pittoggi C, Sciamanna I, et al. Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene. 2003;22(18):2750-2761.
    • (2003) Oncogene. , vol.22 , Issue.18 , pp. 2750-2761
    • Mangiacasale, R.1    Pittoggi, C.2    Sciamanna, I.3
  • 70
    • 84855441538 scopus 로고    scopus 로고
    • Expression of EGFRvIII in glioblastoma: Prognostic significance revisited
    • Montano N, Cenci T, Martini M, et al. Expression of EGFRvIII in glioblastoma: prognostic significance revisited. Neoplasia. 2011;13(12):1113- 1121.
    • (2011) Neoplasia. , vol.13 , Issue.12 , pp. 1113-1121
    • Montano, N.1    Cenci, T.2    Martini, M.3
  • 71
    • 79954539965 scopus 로고    scopus 로고
    • Therapeutic targeting of epidermal growth factor receptor in human cancer: Successes and limitations
    • Wykosky J, Fenton T, Furnari F, Cavenee WK. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chin J Cancer. 2011;30(1):5-12.
    • (2011) Chin J Cancer. , vol.30 , Issue.1 , pp. 5-12
    • Wykosky, J.1    Fenton, T.2    Furnari, F.3    Cavenee, W.K.4
  • 72
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
    • Shao H, Chung J, Balaj L, et al. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med. 2012;18(12): 1835-1840
    • (2012) Nat Med. , vol.18 , Issue.12 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3
  • 73
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455 (7216):1061-1068.
    • (2008) Nature. , vol.455 , Issue.7216 , pp. 1061-1068
  • 74
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff IK, Wang MY, Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005;353 (19):2012-2024.
    • (2005) N Engl J Med. , vol.353 , Issue.19 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 75
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807-1812.
    • (2008) Science. , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 76
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-744.
    • (2009) Nature. , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 78
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAF V600E mutation in 1, 320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1, 320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121(3):397-405.
    • (2011) Acta Neuropathol. , vol.121 , Issue.3 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 79
    • 66849099801 scopus 로고    scopus 로고
    • Activation of the ERK/MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas
    • Forshew T, Tatevossian RG, Lawson AR, et al. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol. 2009;218(2):172-181.
    • (2009) J Pathol. , vol.218 , Issue.2 , pp. 172-181
    • Forshew, T.1    Tatevossian, R.G.2    Lawson, A.R.3
  • 80
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA. 1990;87(21):8602-8606.
    • (1990) Proc Natl Acad Sci USA. , vol.87 , Issue.21 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 81
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA. 1992;89 (7):2965-2969.
    • (1992) Proc Natl Acad Sci USA. , vol.89 , Issue.7 , pp. 2965-2969
    • Wong, A.J.1    Ruppert, J.M.2    Bigner, S.H.3
  • 82
    • 3042757984 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    • Aldape KD, Ballman K, Furth A, et al. Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol. 2004;63(7):700-707.
    • (2004) J Neuropathol Exp Neurol. , vol.63 , Issue.7 , pp. 700-707
    • Aldape, K.D.1    Ballman, K.2    Furth, A.3
  • 83
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
    • (2009) N Engl J Med. , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 84
    • 78349232314 scopus 로고    scopus 로고
    • MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; A novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential
    • Jeuken JW, Wesseling P. MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential. J Pathol. 2010;222(4):324-328.
    • (2010) J Pathol. , vol.222 , Issue.4 , pp. 324-328
    • Jeuken, J.W.1    Wesseling, P.2
  • 85
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res. 2008;68(21):8673-8677.
    • (2008) Cancer Res. , vol.68 , Issue.21 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 86
    • 76549137130 scopus 로고    scopus 로고
    • Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
    • Schiffman JD, Hodgson JG, VandenBerg SR, et al. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 2010;70(2):512-519.
    • (2010) Cancer Res. , vol.70 , Issue.2 , pp. 512-519
    • Schiffman, J.D.1    Hodgson, J.G.2    Vandenberg, S.R.3
  • 87
    • 72049096346 scopus 로고    scopus 로고
    • Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma
    • Yu J, Deshmukh H, Gutmann RJ, et al. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology. 2009;73(19): 1526-1531.
    • (2009) Neurology. , vol.73 , Issue.19 , pp. 1526-1531
    • Yu, J.1    Deshmukh, H.2    Gutmann, R.J.3
  • 88
    • 37349012215 scopus 로고    scopus 로고
    • Tumour-released exosomes and their implications in cancer immunity
    • Iero M, Valenti R, Huber V, et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ. 2008;15(1):80-88.
    • (2008) Cell Death Differ. , vol.15 , Issue.1 , pp. 80-88
    • Iero, M.1    Valenti, R.2    Huber, V.3
  • 89
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010; 120(2):457-471.
    • (2010) J Clin Invest. , vol.120 , Issue.2 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3
  • 90
    • 9744260934 scopus 로고    scopus 로고
    • Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
    • Luciani F, Spada M, De Milito A, et al. Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst. 2004;96(22):1702-1713.
    • (2004) J Natl Cancer Inst. , vol.96 , Issue.22 , pp. 1702-1713
    • Luciani, F.1    Spada, M.2    De Milito, A.3
  • 91
    • 67349114201 scopus 로고    scopus 로고
    • Acid sphingomyelinase activity triggers microparticle release from glial cells
    • Bianco F, Perrotta C, Novellino L, et al. Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 2009;28(8):1043-1054.
    • (2009) EMBO J. , vol.28 , Issue.8 , pp. 1043-1054
    • Bianco, F.1    Perrotta, C.2    Novellino, L.3
  • 92
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calcium-dependent mechanism in K562 cells
    • Savina A, Furlán M, Vidal M, Colombo MI. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem. 2003;278(22):20083-20090.
    • (2003) J Biol Chem. , vol.278 , Issue.22 , pp. 20083-20090
    • Savina, A.1    Furlán, M.2    Vidal, M.3    Colombo, M.I.4
  • 93
    • 84875828133 scopus 로고    scopus 로고
    • Screening a library of shRNA to ESCRT components to analyze their effect on exosome secretion [abstract]
    • April 2012; Gothenburg Sweden
    • Raposo G, Colombo M, Thery C. Screening a library of shRNA to ESCRT components to analyze their effect on exosome secretion [abstract]. Presented at: 2012 International Society for Extracellular Vesicles Meeting; April 2012; Gothenburg, Sweden.
    • 2012 International Society for Extracellular Vesicles Meeting
    • Raposo, G.1    Colombo, M.2    Thery, C.3
  • 94
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • sup pp 11-13
    • Ostrowski M, Carmo NB, Krumeich S, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12(1): 19-30; sup pp 11-13.
    • (2010) Nat Cell Biol. , vol.12 , Issue.1 , pp. 19-30
    • Ostrowski, M.1    Carmo, N.B.2    Krumeich, S.3
  • 95
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
    • Zitvogel L, Regnault A, Lozier A, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med. 1998;4 (5):594-600.
    • (1998) Nat Med. , vol.4 , Issue.5 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3
  • 96
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of the first phase i clinical trial
    • Escudier B, Dorval T, Chaput N, et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med. 2005;3(1):10.
    • (2005) J Transl Med. , vol.3 , Issue.1 , pp. 10
    • Escudier, B.1    Dorval, T.2    Chaput, N.3
  • 97
    • 18144369346 scopus 로고    scopus 로고
    • A phase i study of dexosome immuno-therapy in patients with advanced non-small cell lung cancer
    • Morse MA, Garst J, Osada T, et al. A phase I study of dexosome immuno-therapy in patients with advanced non-small cell lung cancer. J Transl Med. 2005;3(1):9.
    • (2005) J Transl Med. , vol.3 , Issue.1 , pp. 9
    • Morse, M.A.1    Garst, J.2    Osada, T.3
  • 98
    • 41149172340 scopus 로고    scopus 로고
    • Phase i clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S, Wei D, Wu Z, et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther. 2008;16(4): 782-790.
    • (2008) Mol Ther. , vol.16 , Issue.4 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3
  • 99
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341-345.
    • (2011) Nat Biotechnol. , vol.29 , Issue.4 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 100
    • 80052831943 scopus 로고    scopus 로고
    • Exosome nanotechnology: An emerging paradigm shift in drug delivery: Exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers
    • Lakhal S, Wood MJ. Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers. Bioessays. 2011;33(10):737-741.
    • (2011) Bioessays. , vol.33 , Issue.10 , pp. 737-741
    • Lakhal, S.1    Wood, M.J.2
  • 101
    • 80053016211 scopus 로고    scopus 로고
    • Possible new targets for GPCR modulation: Allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms
    • Agnati LF, Guidolin D, Leo G, et al. Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. J Recept Signal Transduct Res. 2011;31(5): 315-331.
    • (2011) J Recept Signal Transduct Res. , vol.31 , Issue.5 , pp. 315-331
    • Agnati, L.F.1    Guidolin, D.2    Leo, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.