Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells

Neurobiology of Aging

Volumn 34, Issue 7, 2013, Pages 1921.e1-1921.e7

  Wu, Shyh Jong ^a   Hsieh, Tusty Jiuan ^b   Kuo, Mei Chuan ^b,c   Tsai, Mei Lan ^a   Tsai, Ke Li ^b   Chen, Chun Hung ^c   Yang, Yuan Han ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Alu; Alzheimer's disease; Angiotensin converting enzyme; Insertion deletion polymorphism; Transcriptional activity

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DNA FRAGMENT;

ACE GENE; ALU SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETIC REGULATION; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; NERVE CELL; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REPORTER GENE; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 84875832994     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.01.003     Document Type: Article

References (66)

1. Adalbert R., Gilley J., Coleman M.P. Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection. Trends. Mol. Med. 2007, 13:135-142.
2. Alhenc-Gelas F., Richard J., Courbon D., Warnet J.M., Corvol P. Distribution of plasma angiotensin I-converting enzyme levels in healthy men: relationship to environmental and hormonal parameters. J. Lab. Clin. Med. 1991, 117:33-39.
3. Almeida S.S., Barros C.C., Moraes M.R., Russo F.J., Haro A.S., Rosa T.S., Alves M.F., Pesquero J.B., Carmona A.K., Bacurau R.F., Araujo R.C. Plasma Kallikrein and Angiotensin I-converting enzyme N- and C-terminal domain activities are modulated by the insertion/deletion polymorphism. Neuropeptides 2010, 44:139-143.
4. Alvarez R., Alvarez V., Lahoz C.H., Martinez C., Pena J., Sanchez J.M., Guisasola L.M., Salas-Puig J., Moris G., Vidal J.A., Ribacoba R., Menes B.B., Uria D., Coto E. Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 1999, 67:733-736.
5. Arregui A., Perry E.K., Rossor M., Tomlinson B.E. Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas. J. Neurochem. 1982, 38:1490-1492.
6. Barnes J.M., Barnes N.M., Costall B., Coughlan J., Kelly M.E., Naylor R.J., Tomkins D.M., Williams T.J. Angiotensin-converting enzyme inhibition, angiotensin, and cognition. J. Cardiovasc. Pharmacol. 1992, 19(Suppl 6):S63-S71.
7. Barnes N.M., Cheng C.H., Costall B., Naylor R.J., Williams T.J., Wischik C.M. Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease. Eur. J. Pharmacol. 1991, 200:289-292.
8. Bartres-Faz D., Junque C., Clemente I.C., Serra-Grabulosa J.M., Guardia J., Lopez-Alomar A., Sanchez-Aldeguer J., Mercader J.M., Bargallo N., Olondo M., Moral P. MRI and genetic correlates of cognitive function in elders with memory impairment. Neurobiol. Aging 2001, 22:449-459.
9. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-414.
10. Bekris L.M., Yu C.E., Bird T.D., Tsuang D.W. Genetics of Alzheimer disease. J. Geriatr. Psychiatry Neurol. 2010, 23:213-227.
11. Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39:17-23.
12. Brosius J. RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. Gene 1999, 238:115-134.
13. Brunden K.R., Trojanowski J.Q., Lee V.M. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat. Rev. Drug Discov. 2009, 8:783-793.
14. Chapman J., Wang N., Treves T.A., Korczyn A.D., Bornstein N.M. ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia. Stroke 1998, 29:1401-1404.
15. Cordaux R., Batzer M.A. The impact of retrotransposons on human genome evolution. Nat. Rev. Genet. 2009, 10:691-703.
16. Di Fede G., Catania M., Morbin M., Rossi G., Suardi S., Mazzoleni G., Merlin M., Giovagnoli A.R., Prioni S., Erbetta A., Falcone C., Gobbi M., Colombo L., Bastone A., Beeg M., Manzoni C., Francescucci B., Spagnoli A., Cantu L., Del Favero E., Levy E., Salmona M., Tagliavini F. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 2009, 323:1473-1477.
17. Dong Y.F., Kataoka K., Tokutomi Y., Nako H., Nakamura T., Toyama K., Sueta D., Koibuchi N., Yamamoto E., Ogawa H., Kim-Mitsuyama S. Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB. J 2011, 25:2911-2920.
18. Eckman E.A., Adams S.K., Troendle F.J., Stodola B.A., Kahn M.A., Fauq A.H., Xiao H.D., Bernstein K.E., Eckman C.B. Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J. Biol. Chem. 2006, 281:30471-30478.
19. Edison P., Archer H.A., Hinz R., Hammers A., Pavese N., Tai Y.F., Hotton G., Cutler D., Fox N., Kennedy A., Rossor M., Brooks D.J. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 2007, 68:501-508.
20. Eyries M., Agrapart M., Alonso A., Soubrier F. Phorbol ester induction of angiotensin-converting enzyme transcription is mediated by Egr-1 and AP-1 in human endothelial cells via ERK1/2 pathway. Circ. Res. 2002, 91:899-906.
21. Feng Y., Yang S.G., Du X.T., Zhang X., Sun X.X., Zhao M., Sun G.Y., Liu R.T. Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity. Biochem. Biophys. Res. Commun. 2009, 390:1250-1254.
22. Ferrington L., Palmer L.E., Love S., Horsburgh K.J., Kelly P.A., Kehoe P.G. Angiotensin II-inhibition: effect on Alzheimer's pathology in the aged triple transgenic mouse. Am. J. Transl. Res. 2012, 4:151-164.
23. Fyhrquist F., Saijonmaa O. Renin-angiotensin system revisited. J. Intern. Med. 2008, 264:224-236.
24. Goraya T.Y., Kessler S.P., Kumar R.S., Douglas J., Sen G.C. Identification of positive and negative transcriptional regulatory elements of the rabbit angiotensin-converting enzyme gene. Nucleic Acids Res. 1994, 22:1194-1201.
25. Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell. Biol. 2007, 8:101-112.
26. Handa R.K. Binding and signaling of angiotensin-(1-7) in bovine kidney epithelial cells involves the AT(4) receptor. Peptides 2000, 21:729-736.
27. Hasler J., Strub K. Alu elements as regulators of gene expression. Nucleic Acids Res. 2006, 34:5491-5497.
28. He M., Ohrui T., Maruyama M., Tomita N., Nakayama K., Higuchi M., Furukawa K., Arai H. ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease. Neurology 2006, 67:1309-1310.
29. Hemming M.L., Selkoe D.J., Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol. Dis. 2007, 26:273-281.
30. Hu J., Igarashi A., Kamata M., Nakagawa H. Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity. J. Biol. Chem. 2001, 276:47863-47868.
31. Hubert C., Houot A.M., Corvol P., Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J. Biol. Chem. 1991, 266:15377-15383.
32. Ioannidis J.P., Boffetta P., Little J., O'Brien T.R., Uitterlinden A.G., Vineis P., Balding D.J., Chokkalingam A., Dolan S.M., Flanders W.D., Higgins J.P., McCarthy M.I., McDermott D.H., Page G.P., Rebbeck T.R., Seminara D., Khoury M.J. Assessment of cumulative evidence on genetic associations: interim guidelines. Int. J. Epidemiol. 2008, 37:120-132.
33. Ittner L.M., Gotz J. Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat. Rev. Neurosci. 2011, 12:65-72.
34. Jurka J. Repbase update: a database and an electronic journal of repetitive elements. Trends Genet. 2000, 16:418-420.
35. Kehoe P.G., Russ C., McIlory S., Williams H., Holmans P., Holmes C., Liolitsa D., Vahidassr D., Powell J., McGleenon B., Liddell M., Plomin R., Dynan K., Williams N., Neal J., Cairns N.J., Wilcock G., Passmore P., Lovestone S., Williams J., Owen M.J. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat. Genet. 1999, 21:71-72.
36. Larner A.J., Doran M. Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update. J. Alzheimers Dis. 2009, 17:259-265.
37. Le Goff W., Guerin M., Chapman M.J., Thillet J. A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression. J. Lipid Res. 2003, 44:902-910.
38. Lee K.W., Kim J.B., Seo J.S., Kim T.K., Im J.Y., Baek I.S., Kim K.S., Lee J.K., Han P.L. Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J. Neurochem. 2009, 108:165-175.
39. Lee Y.J., Han S.B., Nam S.Y., Oh K.W., Hong J.T. Inflammation and Alzheimer's disease. Arch. Pharm. Res. 2010, 33:1539-1556.
40. Lehmann D.J., Cortina-Borja M., Warden D.R., Smith A.D., Sleegers K., Prince J.A., van Duijn C.M., Kehoe P.G. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am. J. Epidemiol. 2005, 162:305-317.
41. Lei H., Day I.N., Vorechovsky I. Exonization of AluYa5 in the human ACE gene requires mutations in both 3'and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res. 2005, 33:3897-3906.
42. Li Y., Rinne J.O., Mosconi L., Pirraglia E., Rusinek H., DeSanti S., Kemppainen N., Nagren K., Kim B.C., Tsui W., de Leon M.J. Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging 2008, 35:2169-2181.
43. Lunyak V.V., Prefontaine G.G., Nunez E., Cramer T., Ju B.G., Ohgi K.A., Hutt K., Roy R., Garcia-Diaz A., Zhu X., Yung Y., Montoliu L., Glass C.K., Rosenfeld M.G. Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science 2007, 317:248-251.
44. McKinley M.J., Albiston A.L., Allen A.M., Mathai M.L., May C.N., McAllen R.M., Oldfield B.J., Mendelsohn F.A., Chai S.Y. The brain renin-angiotensin system: location and physiological roles. Int. J. Biochem. Cell Biol. 2003, 35:901-918.
45. Miners J.S., Ashby E., Van Helmond Z., Chalmers K.A., Palmer L.E., Love S., Kehoe P.G. Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol. Appl. Neurobiol. 2008, 34:181-193.
46. Miners S., Ashby E., Baig S., Harrison R., Tayler H., Speedy E., Prince J.A., Love S., Kehoe P.G. Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes. Am. J. Transl. Res. 2009, 1:163-177.
47. Mondragon-Rodriguez S., Basurto-Islas G., Lee H.G., Perry G., Zhu X., Castellani R.J., Smith M.A. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Rev. Neurother. 2010, 10:683-691.
48. Nielsen H.M., Londos E., Minthon L., Janciauskiene S.M. Soluble adhesion molecules and angiotensin-converting enzyme in dementia. Neurobiol. Dis. 2007, 26:27-35.
49. Oba R., Igarashi A., Kamata M., Nagata K., Takano S., Nakagawa H. The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide. Eur. J. Neurosci. 2005, 21:733-740.
50. Parihar M.S., Brewer G.J. Amyloid-beta as a modulator of synaptic plasticity. J. Alzheimers Dis. 2010, 22:741-763.
51. Pimplikar S.W. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int. J. Biochem. Cell Biol. 2009, 41:1261-1268.
52. Ponicsan S.L., Kugel J.F., Goodrich J.A. Genomic gems: SINE RNAs regulate mRNA production. Curr. Opin. Genet. Dev. 2010, 20:149-155.
53. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990, 86:1343-1346.
54. Rosatto N., Pontremoli R., De Ferrari G., Ravazzolo R. Intron 16 insertion of the angiotensin converting enzyme gene and transcriptional regulation. Nephrol. Dial. Transplant 1999, 14:868-871.
55. Savaskan E., Hock C., Olivieri G., Bruttel S., Rosenberg C., Hulette C., Muller-Spahn F. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol. Aging 2001, 22:541-546.
56. Sayed-Tabatabaei F.A., Oostra B.A., Isaacs A., van Duijn C.M., Witteman J.C. ACE polymorphisms. Circ. Res. 2006, 98:1123-1133.
57. Scacchi R., De Bernardini L., Mantuano E., Vilardo T., Donini L.M., Ruggeri M., Gemma A.T., Pascone R., Corbo R.M. DNA polymorphisms of apolipoprotein B and angiotensin I-converting enzyme genes and relationships with lipid levels in Italian patients with vascular dementia or Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 1998, 9:186-190.
58. Tiret L., Rigat B., Visvikis S., Breda C., Corvol P., Cambien F., Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am. J. Hum. Genet. 1992, 51:197-205.
59. Tran M.H., Yamada K., Nabeshima T. Amyloid beta-peptide induces cholinergic dysfunction and cognitive deficits: a minireview. Peptides 2002, 23:1271-1283.
60. Vardy E.R., Rice P.J., Bowie P.C., Holmes J.D., Catto A.J., Hooper N.M. Plasma angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis. 2009, 16:609-618.
61. Wright J.W., Harding J.W. The brain RAS and Alzheimer's disease. Exp. Neurol. 2010, 223:326-333.
62. Wright J.W., Harding J.W. Brain renin-angiotensin-a new look at an old system. Prog. Neurobiol. 2011, 95:49-67.
63. Wu S.J., Chiang F.T., Chen W.J., Liu P.H., Hsu K.L., Hwang J.J., Lai L.P., Lin J.L., Tseng C.D., Tseng Y.Z. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol. Genomics 2004, 17:79-86.
64. Yamada K., Uchida S., Takahashi S., Takayama M., Nagata Y., Suzuki N., Shirakura S., Kanda T. Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease. Brain Res. 2010, 1352:176-186.
65. Yang Y.H., Lai C.L., Tyan Y.C., Chou M.C., Wang L.C., Yang M.H., Liu C.K. Angiotensin-converting enzyme gene and plasma protein level in Alzheimer's disease in Taiwanese. Age Ageing 2011, 40:238-242.
66. Zubenko G.S., Marquis J.K., Volicer L., Direnfeld L.K., Langlais P.J., Nixon R.A. Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study. Biol. Psychiatry 1986, 21:1365-1381.