MRI and genetic correlates of cognitive function in elders with memory impairment

Neurobiology of Aging

Volumn 22, Issue 3, 2001, Pages 449-459

  Bartrés Faz, David ^a   Junqué, Carme ^a   Clemente, Imma C ^a   Serra Grabulosa, Josep M ^a   Guardia, Joan ^a   López Alomar, Antoni ^a   Sánchez Aldeguer, Josep ^b   Mercader, Josep M ^c   Bargalló, Núria ^c   Olondo, Miren ^c   Moral, Pedro ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN C1; APOLIPOPROTEIN D; APOLIPOPROTEIN E; DIPEPTIDYL CARBOXYPEPTIDASE;

AGED; ALLELE; AMNESIA; ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; FEMALE; FRONTAL LOBE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SUBICULUM; WHITE MATTER;

AGED; AGED, 80 AND OVER; AGING; APOLIPOPROTEIN C-I; APOLIPOPROTEINS C; APOLIPOPROTEINS E; BRAIN; FEMALE; FRONTAL LOBE; GENOTYPE; HIPPOCAMPUS; HUMANS; HYPERTENSION; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MEMORY DISORDERS; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0034990808     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00207-X     Document Type: Article

References (81)

1. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging
2. Are genetic factors important in the aetiology of leucoaraiosis? Results from a memory clinic population
3. The deletion allele of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment
4. Angiotensin converting enzyme in Alzheimer's disease increase activity in caudate nucleus and cortical areas
5. Apolipoprotein E ε4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias
6. Hippocampal sulcal cavities on MRI: Relationship to age and apolipoprotein E
7. Angiotensin II inhibits acetylcholine release from human temporal cortex: Implications for cognition
8. Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease
9. Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment: Relationship with cognitive performance
10. Apo E influences declarative and procedural learning in age-associated memory impairment
11. Incidental white-matter foci on MRI in "healthy" subjects: Evidence of subtile cognitve dysfunction
12. Neuropsychological correlates of white matter lesions in healthy elderly subjects
13. MR signal abnormalities in memory disorders and dementia
14. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging
15. Cerebral white matter lesions, vascular risk factors and cognitive function in a population-based study. The Rotterdam study
16. MRI of the normal hippocampus
17. White matter lesions in Alzheimer patients are influenced by apolipoprotein E genotype
18. Expression of human apolipoprotein E3 or E4 in the brains of apoE -/- mice: Isoform-specific effects on neurodegeneration
19. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
20. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
21. Angiotensin-converting enzyme insertion/deletion polymorphism and cerebrovascular disease
22. Age-associated memory impairment: Proposed diagnostic criteria and measurements of clinical change. Report of a National Institute of Mental Health workgroup
23. Cerebral white matter lesions and cognitive function: The Rotterdam Scan Study
24. The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults
25. Impact of apolipoprotein ε4 and vascular disease on brain morphology in men from the NHLBI twin study
26. Role of APOE in dementia: A critical reappraisal
27. Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease
28. Association between angiotensin-converting enzyme and Alzheimer's disease
29. Preservation of normal cognitive functioning in elderly subjects with extensive white-matter lesions of long duration
30. ACE gene typing
31. Periventricular white matter changes and dementia: Clinical, neuropsychological, radiological, and pathological correlation
32. Leuko-araiosis
33. A follow-up study of age-associated memory impairment: Neuropsychological predictors of dementia
34. Decline of frontal lobe funtions in subjects with age-associated memory impairment
35. Foci of increased T2 signal intensity on brain MR scans of healthy elderly subjects
36. Effect of the apolipoprotein E ε4 allele on white matter hyperintensities in dementia
37. Clinical significance of white matter lesions in the elderly
38. Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
39. Leuko-araiosis on magnetic resonance imaging and speed of mental processing
40. Ischemic stroke and the gene for angiotensin-converting enzyme in Japanese hypertensives
41. Age-dependent association of apolipoprotein E genotypes with stroke subtypes in a Japanese rural population
42. Relationship between Apo E, MRI findings and cognitive function in the cardiovascular health study
43. How does the apolipoprotein E genotype modulate the brain in aging and in Alzhimer's disease? A review of neuroimaging studies
44. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people
45. Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma
46. Incidental brain lesions on magnetic resonance imaging and neurobebavioral functions in the apparently healthy elderly
47. APOE genotype as a risk factor for ischemic cerebrovascular disease. A meta-analysis
48. Polymorphism of angiotensin convertingn enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease
49. Human Apo CI HpaI restriction site polymorphism reveladed by the polymerase chain reaction (PCR)
50. Evaluation of genetic risk factors for silent brain infarction
51. The APOE epsilon 4 allele is associated with decline on delayed recall performance in communitiy dwelling older adults
52. Angiotensin converting enzyme deletion allele in different kinds of dementia disorders
53. The significance of cerebral white matter abnormalities 100 years after binswanger's report. A review
54. 99mTc-HMPAO-SPECT in normal aging, Age-Associated Memory Impairment, and probable Alzheimer's disease
55. The apolipoprotein CI A allele as a risk factor for Alzheimer's disease
56. A closely linked gene to apolipoprotein E may serve as an additional risk factor for Alzheimer's disease
57. Neuropsychological test findings in subjects with leukoaraiosis
58. Effect of the angiontensin I-converting enzyme I/D polymorphism on cognitive decline
59. Neurpsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy
60. Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's disease
61. A semiquantitative rating scale for the assessment of signal hyperintenstities on magnetic resonance imaging
62. Apolipoprotein E e4 allele in the normal elderly: Neuropsychological and brain MRI correlates
63. Magnetic resonance imaging, cerebral abnormalities and neuropsychological test performance in elderly hypertensive subjects: A case-control study
64. Neuropsychologic correlates of MRI white matter hyperintensities
65. Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals
66. Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study
67. MRI white matter hyperintenstities. Three-year follow-up of the Austrian Stroke Prevention Study
68. Is APOE-ε4 a risk factor for cognitive decline impairment in normal aging?
69. Apolipoprotein E: High-avidity binding to b-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
70. Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy
71. Association of midle blood pressure to late-life cognitive decline and brain morphology
72. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apolipoprotein E locus
73. Neuropsychological importance of subcortical white matter hyperintensity
74. Hypertension in the elderly is associated with white matter lesions and cognitive decline
75. Angiotensin-converting enzyme gene I/D polymorphism and carotid plaques in Japanese
76. Apolipoprotein E genotyping by one-stage PCR
77. A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of the apolipoprotein E
78. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women
79. White matter changes in healthy elderly persons correlate with attention and speed of mental processing
80. Dose-dependent association of apolipoprotein E allele ε4 with late-onset, sporadic Alzheimer's disease